CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Data collection and clinical testing of subjectsWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (0)


Name (Synonyms) Correlation

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D015428 Myocardial Reperfusion Injury NIH 1.00
D015427 Reperfusion Injury NIH 1.00
D014947 Wounds and Injuries NIH 0.22
D002318 Cardiovascular Diseases NIH 0.21

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0001626 Abnormality of the cardiovascular system HPO 0.21

There is one clinical trial.

Clinical Trials


1 Short-term Physical Function Outcomes in Severe COVID-19 Patients Admitted to ICU for Invasive Mechanical Ventilation: A Cross-sectional Study

Little is known about the physical function outcomes in patients with severe COVID-19 patients who are admitted to Intensive Care Unit (ICU) for invasive mechanical ventilation. The purpose of this study is to evaluate the short-term impact on physical function before hospital discharge in subjects with severe COVID-19 who have survived ICU admission for invasive mechanical ventilation.

NCT04400461 COVID-19 Other: Data collection and clinical testing of subjects

Primary Outcomes

Description: Physical examination will be performed to carry out manual muscle testing of strength in 6 different muscle groups of the upper limb and lower limb on both sides of the body.

Measure: Medical Research Council sum score (MRC- SS).

Time: < 48 hours before ICU discharge

Description: Physical examination will be performed to carry out manual muscle testing of strength in 6 different muscle groups of the upper limb and lower limb on both sides of the body.

Measure: Medical Research Council sum score (MRC- SS).

Time: < 24 hours before hospital discharge

Description: The Functional Status Score for the ICU (FSS-ICU) will be used to evaluate 5 functional tasks. Each task is evaluated using an 8-point ordinal scale ranging from 0 (not able to perform) to 7 (complete independence).The total FSS-ICU score ranges from 0 to 35, with higher scores indicating better physical functioning.

Measure: The Functional Status Score for the ICU (FSS-ICU)

Time: < 24 hours before hospital discharge

Secondary Outcomes

Description: Age in years

Measure: Age

Time: Through study completion, up to 6 months

Description: Male vs Female

Measure: Sex

Time: Throughout study completion , up to 6 month

Description: kg/m2

Measure: Body Mass Index

Time: Throughout study completion, up to 6 months

Description: Baseline mobility

Measure: Baseline mobility

Time: First day the patient can cooperate with assessment according to the ' 5 Standard Questions' test.

Description: Acute Physiology and Chronic Health Evaluation II score.The APACHE II score ranges from 0 to 71 points. Higher scores correspond to more severe disease and a higher risk of death.

Measure: APACHE II score

Time: <24 hours after ICU admission

Description: Number of days of stay in ICU

Measure: Length of stay in ICU

Time: Throughout the study completion, up to 6 months

Description: Number of days on mechanical ventilation

Measure: Number of days on mechanical ventilation

Time: Throughout the study completion, up to 6 months

Description: Clinical or EMG polyneuropathy diagnosis confirmation

Measure: Polyneuropathy diagnosis

Time: Throughout the study completion, up to 6 months

Description: Number of days on NMB during mechanical ventilation

Measure: Number of days on Neuromuscular Blockers

Time: Throughout the study completion, up to 6 months

Description: Number of prone positioning episodes during ICU stay

Measure: Episodes of prone positioning

Time: Throughout the study completion, up to 6 months

Description: Total number of days admitted to hospital

Measure: Length of stay in hospital

Time: Throughout the study completion, up to 6 months

Description: Home with no follow-up physiotherapy, home with domiciliary or out-patient physiotherapy, rehabilitation facility, care home, transfer to another acute hospital.

Measure: Continuation of care

Time: Throughout the study completion, up to 6 months


No related HPO nodes (Using clinical trials)