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Airway pressure release ventilationWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)

Name (Synonyms) Correlation
drug1303 L-ascorbic acid Wiki 0.71
drug1822 Placebo Wiki 0.06

Correlated MeSH Terms (4)

Name (Synonyms) Correlation
D014947 Wounds and Injuries NIH 0.22
D055370 Lung Injury NIH 0.21
D055371 Acute Lung Injury NIH 0.10
D012128 Respiratory Distress Syndrome, Adult NIH 0.09

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Evaluation of Airway Pressure Release Ventilation on Oxygenation in Acute Respiratory Distress Syndrome in Adult Patients With COVID-19 Pneumonia

The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit). The investigators hypothesize that airway pressure release ventilation (APRV) could be beneficial in patients with ARDS secondary to SARS-COV2 viral pneumonia.

NCT04386369 ARDS COVID19 Other: Airway pressure release ventilation

Primary Outcomes

Description: Increase of at least 20% of the PaO2/FiO2 ratio

Measure: Proportion of patients improving PaO2/FiO2 ratio at 6 hours of APRV

Time: 6 hours after starting APRV

Secondary Outcomes

Description: Number of interventions by the physician on APRV settings

Measure: Number of interventions on ventilator settings

Time: 6 hours after starting APRV

Description: Variations of blood pressure in millimeters of mercury

Measure: Change in mean blood pressure

Time: 6 hours after starting APRV

Description: Variations of heart rate in beats per minute

Measure: Change in heart rate

Time: 6 hours after starting APRV

Description: Variations of catecholamine doses in milligrams per hours

Measure: Changes in catecholamine doses

Time: 6 hours after starting APRV

Description: Static compliance (Cstat) defined as : Cstat = (VT/(Pplat-PEPtot)) Tidal Volume (VT), Plateau pressure (Pplat) and Total Positive End-expiratory Pressure (PEEPtot)

Measure: Changes in static compliance at the end of 6 hours of APRV

Time: 6 hours after starting APRV

Description: Minute ventilation in liters per minute

Measure: Variations of minute ventilation

Time: 6 hours after starting APRV

Description: Static compliance (Cstat) defined as : Cstat = (VT/(Pplat-PEPtot)) Tidal Volume (VT), Plateau pressure (Pplat) and Total Positive End-expiratory Pressure (PEEPtot)

Measure: Changes in static compliance 4 hours after stopping APRV

Time: 4 hours after stopping APRV

Description: Percentage of patients with a decrease of the PaO2/FiO2 ratio

Measure: Proportion of patients with a decrease of the PaO2/FiO2 ratio

Time: 4 hours after stopping APRV

No related HPO nodes (Using clinical trials)