SNPMiner Trials (Home Page)
Report for Mutation E27Q
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Genetic Influences of Albuterol Response In Children With Bronchiolitis
Bronchiolitis is a significant cause of morbidity and hospitalization in children, accounting for approximately 125,000 hospitalizations per year in the U.S. Recently, genetic variations of the β2-adrenergic receptor (β2-AR) have been shown to influence response to β2-AR agonist therapy in children with asthma. We suspect that genetic variations of the β2-AR also affect response to β2-AR agonist therapy in children with bronchiolitis.
NCT00570297 Bronchiolitis MeSH:Bronchiolitis
HPO:Bronchiolitis
The next most common polymorphism of the β2-AR gene, glutamine to glutamic acid at position 27 (Glu27Gln), may be associated with the development of asthma and airway hyperresponsiveness, but these relationships are less clear. --- Glu27Gln ---
Primary Outcomes
Description: The primary end point is change in lung resistance following a single dose of inhaled b2-AR agonist therapy (albuterol).
Measure: Change in lung resistance Time: ImmediateSecondary Outcomes
Description: To assess the change in lung compliance following a single dose of inhaled b2-AR agonist therapy (albuterol)
Measure: Change in lung compliance Time: Duration of hospitalizationDescription: To compare duration of mechanical ventilation and ICU hospital length of stay by genotype
Measure: Comparison by genotype Time: Duration of Hospitalization