SNPMiner Trials by Shray Alag

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Report for Mutation S9333A

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Determining the Clinicopathological Significance of CaMKIIgamma Activation in AML

RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at blood and bone marrow samples from patients with previously untreated primary acute myeloid leukemia.

NCT00899743 Leukemia Genetic: polyacrylamide gel electrophoresis Genetic: western blotting Other: immunologic technique Other: laboratory biomarker analysis
MeSH:Leukemia
HPO:Leukemia

S9333A Study of Blood and Bone Marrow Samples From Patients With Previously Untreated Primary Acute Myeloid Leukemia RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. --- S9333A ---

Primary Outcomes

Measure: Association of specific clinicopathological variables and outcomes with calmodulin-dependent protein kinase II-γ (CaMKIIγ) activation (autophosphorylation)

Time: upon receipt of specimens

HPO Nodes

HP:0001909: Leukemia
Genes 190
TREM2 CBL TERT CEP57 PICALM ATRX TERT FANCD2 RPS15A RPS24 FANCE PIK3R1 GATA1 STS ELANE WIPF1 JAK2 GATA1 SRP54 LIG4 POT1 GATA2 PTPN11 MLH1 XRCC4 SRP54 TET2 TET2 LIG4 EP300 NPM1 RARA SH3GL1 PDGFRA RPL5 ERBB3 RUNX1 KRAS PIGL GATA2 NUTM1 ETV6 PIGL THPO DYNC2LI1 RPS26 GFI1 CBL WAS RPL18 SH2B3 ABL1 LPP ATM SRSF2 TP53 NRAS DNMT3A DNAJC21 RPS27 RPS7 MPL RPL26 DNMT3A RPS29 CALR ASXL1 CEBPA ELANE TSR2 RUNX1 DKC1 APC ADAR NUP214 GLI1 HAX1 IFIH1 SCN9A MYD88 EVC RUNX1 SAMHD1 NSUN2 CREBBP TRIP13 SRP54 SBDS SH2B3 RUNX1 DNAJC21 TP53 RPS10 MPL BCR GATA2 CALR BUB1B FLT3 CALR NRAS SETBP1 MSH2 SH2B3 SAMD9L FANCC BCR TCIRG1 BLM ADA2 PIK3CA SRSF2 FANCG GATA2 MYD88 KIF11 TET2 FLT3 JAK2 KIT RPS17 NBN RB1 NUMA1 BRD4 TREX1 THPO SMPD1 RPL35 BUB3 RNASEH2C PDGFRB SF3B1 RPS28 MSH6 DDX41 PMS2 RPL35A BAX BUB1 TERC TET2 DNAJC21 RPL11 CHIC2 BLM FANCA KIT RPL31 MLLT10 RPL15 RNASEH2A KRAS TAL2 EVC2 RPS14 SCN10A RPS19 MPL ASXL1 SAMD9L RNASEH2B CBL JAK2 NF1 ABL1 CBFB ARHGAP26 BUB1B NBN SCN11A TET2 MPL JAK2 F13A1 RPL27 BCR BRCA2 SBDS F13B GNB1 TAL1 PIGA NUP214 TYROBP EFL1 GFI1 TET2 JAK2 KRAS
Protein Mutations 56
C282Y C481S D816V D835Y E255K E255V F317C F317L F317S F317V F31I F359C F359V G250E G71R H369P H63D L248R L248V L265P L858R N291S N682S P13K P140K P1446A P4503A Q12H Q252H R132C R132G R132H R132L R132S R132V R140L R140Q R140W R172G R172K R172M R172S R172W S1612C S9333A T315A T315I T351I T790M V158M V299L V57I V600E V617F V66M Y253H
SNP 17
rs10509681 rs11572080 rs12459419 rs172378 rs2032582 rs230561 rs25531 rs3816527 rs396991 rs429358 rs4880 rs4958351 rs6190 rs628031 rs7412 rs776746 rs904627