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Report for Mutation T92A
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases
Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2 gene are associated with thyroid disease in Mexican pregnant women.
NCT03612908 Pregnancy Related Hypothyroidism Hyperthyroidism MeSH:Hypothyroidism Hyperthyroidism
HPO:Hyperthyroidism Hypothyroidism
TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases. --- Thr92Ala ---
TSHβX1 and D2 THR92ALA in Pregnancy Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. --- THR92ALA ---
This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2 gene are associated with thyroid disease in Mexican pregnant women. --- Thr92Ala ---
TSHβX1 splice variant expression.. Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.. D2 Thr92Ala polymorphism.. Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.. Inclusion Criteria: - Pregnant women attended at the "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Health Institute of the State of Mexico (ISEM), Toluca, Mexico. --- Thr92Ala ---
TSHβX1 splice variant expression.. Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.. D2 Thr92Ala polymorphism.. Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.. Inclusion Criteria: - Pregnant women attended at the "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Health Institute of the State of Mexico (ISEM), Toluca, Mexico. --- Thr92Ala --- --- Thr92Ala ---
Primary Outcomes
Description: Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.
Measure: TSHβX1 splice variant expression. Time: Baseline.Secondary Outcomes
Description: Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.
Measure: D2 Thr92Ala polymorphism. Time: Baseline.