SNPMiner Trials by Shray Alag

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Report for Mutation G594A

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 A Case-control Study of the Molecular Genetics of Menstrual Migraine (Pure Menstrual and Menstrually-related Migraine)

The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approach. The aim of the study is to identify genes, genetic regions, and the effect of hormones on expression profiles in women with menstrual migraine compared to a control population with no personal or first-degree family history of migraine. In this case control study, saliva samples will be taken from 300 cases and 300 controls for DNA analysis. Blood samples from 30 cases and 30 controls will be taken during the follicular phase as well as the luteal phase of the menstrual cycle for ribonucleic acid (RNA) analysis.

NCT00904150 Migraine
MeSH:Migraine Disorders
HPO:Migraine

ESR1 G594A. --- G594A ---

Primary Outcomes

Description: PR PROGINS

Measure: Progesterone Receptor Gene Polymorphism PROGINS in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: ESR1 G594A

Measure: Estrogen Receptor 1 G594a Polymorphism in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: ESR1 C325G

Measure: Estrogen Receptor 1 C325G Polymorphism in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: PgR and ESR

Measure: Menstrual Cycle Expression of PGR and ESR in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Secondary Outcomes

Description: TNF

Measure: Tumour Necrosis Factor Genotype in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: SYNE1

Measure: SYNE1 Genotype in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: TNF and SYNE1

Measure: Menstrual Cycle Expression of TNF and SYNE1 in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

HPO Nodes

HP:0002076: Migraine
Genes 180
TWIST1 IL12A TWNK CACNA1A TREX1 RPS15A RPS24 GATA1 ENG POLG SLC1A3 NF2 COX2 MYORG COX1 TRNF SCN8A PMS2 MVK PGK1 BMPR1A CSNK1D GDF2 EPCAM TRNW NOTCH3 GCDH APP MEFV CACNA1A TRNF PDGFRB IL12A-AS1 GABRG2 SLC6A19 RELA SRPX2 MLX RPL5 FGFR3 IL10 IL12B RRM2B GRIN2A KCNA1 RPS26 PEX11B RPL18 STAT4 GP1BA TRNC FGFR2 SH2B1 NFIX IL23R PRRT2 ERAP1 RPS27 RPS7 RPL26 RPS29 SMAD4 CCR1 NOP56 TRNS2 ACVRL1 TRNK TRNL1 ND1 ND4 PDGFB PRRT2 MLH3 TSR2 MSH2 KLRC4 ACSF3 KCNQ3 COL5A1 COX1 ACVRL1 SCN2A TWNK MSH6 PMS1 TRNW TNF ATP1A2 COX3 TRNQ GPR101 SMARCB1 ND5 CACNA1A SLC2A1 RPS10 FGFR3 ADAMTSL1 GATA2 MLH1 PGK1 ND6 ADA2 SCN1A RRM2B HLA-B KRAS MYD88 ND5 CYTB SMAD3 SLC1A3 TRNV RPS17 COL1A1 AIP C11ORF95 TGFBR2 SLC2A1 NLRP3 RNASEH1 COX3 TREX1 HLA-B GP1BB RPL35 TNFRSF1A C4A UBAC2 APP RPS28 POLG SCN8A RPL35A RPS20 CACNA1A NOTCH3 POLG TRNS1 RPL11 COX2 COL5A2 COL4A1 RPL31 GP9 RPL15 SEMA4A TWNK POLG2 TRNS2 KCNQ2 VHL PRRT2 EDNRA NDP TRNQ RPS19 CACNA1A ENG HTR1A PRRT2 RPL27 DNM1L ND6 TRNS1 TLR4 AMACR STIM1 ADA2 SLC25A4 TRNL1 PIK3CA ESR1 TWNK TRNH FAN1 FAS COL3A1 ND1 OPA1
Protein Mutations 2
C325G G594A
SNP 1
rs13208321