SNPMiner Trials (Home Page)
Report for Mutation N312S
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There are 3 clinical trials
Clinical Trials
1 Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response
Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
NCT03388099 antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response
To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.. polymorphisms in the LH receptor (LHR) variant N312S. --- N680S --- --- N312S ---
To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.. Doses of gonadotrophin needed and polymorphisms. --- N312S ---
Primary Outcomes
Description: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
Measure: Gonadotrophin receptor polymorphisms and ovarian response and AMH value Time: 1 yearSecondary Outcomes
Description: To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.
Measure: polymorphisms in the FSH receptor (FSHR) variant N680S Time: 1 yearDescription: To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.
Measure: polymorphisms in the LH receptor (LHR) variant N312S Time: 1 yearDescription: To analyse the doses of gonadotrophins needed for stimulation on each group of patients
Measure: Doses of gonadotrophin needed and polymorphisms Time: 1 year2 Prospective Randomised Clinical Study on Pharmacogenetics of Gonadotropin Receptors in Relation to Pregnancy and Life Birth Rate as Well as Unwanted Side Effects Such as Ovarian Hyper Stimulation Syndrome During Assisted Reproduction.
The aim is to be able to predict the hormonal response according to gonadotropin receptor genotype and hormone type used for treatment of women undergoing in vitro fertilization or egg donation. Outcome will be measured as pregnancy success, live born babies and unwanted side effects.
NCT03737253 Female Infertility Drug: Follitropin alpha Drug: Menotropin MeSH:Infertility Infertility, Female
HPO:Female infertility Infertility
This assumption is supported by a recent study on more than 600 women undergoing in vitro fertilization, demonstrating that whereas only 10% of women with asparagine in both genes (FSHR N680S and LHR N312S) became pregnant, 40% of those with serine did (Lindgren I et al. --- N680S --- --- N312S ---
Primary Outcomes
Description: Association between pregnancy rate and genotype is evaluated
Measure: Pregnancy Time: up to 12 months after treatmentSecondary Outcomes
Description: Number of eggs developed in response to drug according to genotype is measured
Measure: Number of oocytes Time: up to 6 months after treatmentDescription: Live birth rate according to genotype is analyzed
Measure: live birth Time: up to 12 months after treatmentOther Outcomes
Description: Association between overreaction to hormonal stimulation and genotype is analysed
Measure: Ovarian hyper stimulation syndrome Time: Up to 6 months after treatmentDescription: No or poor development of eggs in response to drug is analysed, genotype taken into account
Measure: Poor response Time: Up to 6 months after treatment3 Study of the N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in Controlled Ovarian Stimulation
This project wants to determinate whether there is a relationship between the N680S polymorphism genotype of the FSHR gene and the nature of the FSH used in controlled ovarian stimulation. It is a non-interventional, observational, cross-sectional and retrospective, national and multicenter study, in which a genetic test will be carried out to determine the genotype of the N680S polymorphism in samples of blood of patients who have undergone two cycles of controlled ovarian stimulation in the last 8 months.
NCT04122729 In Vitro Fertilization Controlled Ovarian Stimulation
Genotype of the N312S polymorphism of the LHCGR gene. --- N312S ---
Genotype of the N312S polymorphism of the LHCGR gene will be tested on blood samples. --- N312S ---
Primary Outcomes
Description: Number of oocytes retrieved in each IVF/ICSI cycle with controlled ovarian stimulation used different nature of the FSH in each one (human FSH and recombinant FSH).
Measure: Oocytes retrieved Time: Through study completion, an average of 1 yearDescription: Genotype of the N680S polymorphism of the FSHR gene will be tested on blood samples
Measure: Genotype of the N680S polymorphism of the FSHR gene Time: Through study completion, an average of 1 yearSecondary Outcomes
Description: Genotype of the N312S polymorphism of the LHCGR gene will be tested on blood samples
Measure: Genotype of the N312S polymorphism of the LHCGR gene Time: Through study completion, an average of 1 year