SNPMiner Trials (Home Page)
Report for Mutation T334G
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Role of Genetic Factors in the Response to Digoxin in the Acute Treatment of Atrial Fibrillation
This study tested the hypothesis that response to digoxin is modulated by single Nucleotid Polymorphism (SNP): - Multi Drug Resistance (MDR1) gene haplotypes and Solute carrier organic anion transporter family member 1B3 (SLCO1B3) gene Polymorphism and their role in the response to treatement. - Aldosterone synthase (CYP11B2) gene and sodium channel, voltage-gated, type V alpha subunit gene (SCN5A) correlated with atrial fibrillation and their roles in response to digoxin.
NCT02167165 Atrial Fibrillation Drug: Digoxin Injection MeSH:Atrial Fibrillation
HPO:Atrial fibrillation Paroxysmal atrial fibrillation
In this study we will also investigate the relationship between two deletion polymorphisms (from －28 to －11 deletion) and (from－7 to －4 deletion), T334G (Ser112Ala) and G699A (Met233Ile) SNPs in the SLCO1B3gene and their role in response to digoxin. --- T334G ---
Primary Outcomes
Description: In the current study we aimed at outlining the different MDR-1, SLCO1B3, CYP11B12 and SCN5A genotypes in a sample of Tunisian patients, suffering from AF and taking digoxin, to assess the role of SNPs in affecting serum digoxin concentrations, and studying the consequences on patients' clinical outcome. Patients will be monitored for 24 hours in an intensive care unit;
Measure: Correlation between the response to digoxin and the genotypes of the patients Time: 24 hoursSecondary Outcomes
Description: Rhythm control: rate and delay of return to sinusal rhythm. Rate control: reduction of heart rate : HR <100 bpm or 20% reduction from baseline
Measure: Rhythm and Rate control Time: 24 hoursOther Outcomes
Description: hypotension during hospitalisation, bradycardia, chest pain, allergic reaction
Measure: Arterial hypotension Bradycardia (HR <45 bpm) Other (chest pain, allergic reaction……) Time: 24 hours