Name (Synonyms) | Correlation | |
---|---|---|
drug1263 | all treatment about COVID-2019 Wiki | 1.00 |
drug850 | Placebo Wiki | 0.09 |
Name (Synonyms) | Correlation |
---|
There is one clinical trial.
This is a randomized, double-blind, placebo-controlled, multi-center trial to evaluate the safety and efficacy of TJ003234 administered as an intravenous (IV) infusion in subjects with severe COVID-19 under supportive care, and to assess the effect of TJ003234 on the levels of cytokines.
Description: 8-category ordinal scale
Measure: Proportion (%) of subjects experiencing deterioration in clinical status Time: Changes from baseline on Day 14Description: Per CTCAE
Measure: Treatment Emergent Adverse Events Time: Up to 30 days after drug administrationDescription: 8-category ordinal scale
Measure: Proportion (%) of subjects experiencing deterioration in clinical status Time: Changes from baseline on Day 7 and Day 30Description: 8-category ordinal scale: 8, Death; 7, ventilation in addition to extracorporeal membrane oxygen (ECMO), continuous renal replacement therapy (CRRT) or pressors; 6, Intubation and mechanical ventilation; 5, non-invasive mechanical ventilation (NIV) or high-flow oxygen; 4,Oxygen by mask or nasal prongs; 3, Hospitalization without oxygen supplementation; 2, Limitation of activities, discharge from hospital; and 1, No limitation of activities, discharge from hospital
Measure: Clinical status Time: On Day 7, Day 14 and Day 30Description: 8-category ordinal scale: 8, Death; 7, ventilation in addition to extracorporeal membrane oxygen (ECMO), continuous renal replacement therapy (CRRT) or pressors; 6, Intubation and mechanical ventilation; 5, non-invasive mechanical ventilation (NIV) or high-flow oxygen; 4,Oxygen by mask or nasal prongs; 3, Hospitalization without oxygen supplementation; 2, Limitation of activities, discharge from hospital; and 1, No limitation of activities, discharge from hospital
Measure: Improvement in clinical status Time: On Day 7, Day 14 and Day 30Description: The score is based on six different scores, one each for the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems. A higher score predicts a worse clinical outcome.
Measure: Sequential Organ Failure Assessment (SOFA) score Time: On Day 7 and Day 14Description: Defined as SpO2≥94% sustained minimum 24 hours
Measure: Length of time to normalization of oxygen saturation Time: Up to 30 days after drug administration