Covid 19 Research using Clinical Trials (Home Page)
Intermittent prone positioning instructionsWiki
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
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drug1214 | Usual care positioning with no instructions Wiki | 1.00 |
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There is one clinical trial.
Clinical Trials
Acute respiratory distress syndrome (ARDS) is a major complication among patients with severe
disease. In a report of 138 patients with COVID-19, 20% developed ARDS at a median of 8 days
after the onset of symptoms, with 12.3% of patients requiring mechanical ventilation.
Efficacious therapies are desperately needed. Supportive care combined with intermittent
prone positioning may improve outcomes.
Prone positioning (PP) of patients with severe ARDS (when combined with other lung-protective
ventilation strategies) is associated with a significant mortality benefit. In addition, PP
for >12 hours in severe ARDS is strongly recommended by clinical practice guidelines. The aim
of this study is to compare the outcomes of prone positioning versus usual care positioning
in non-intubated patients hospitalized for COVID-19.
NCT04368000 Respiratory Failure COVID-19 Behavioral: Intermittent prone positioning instructions Behavioral: Usual care positioning with no instructions
Primary Outcomes
Measure: Change in imputed partial pressure of oxygen over fraction of inspired oxygen (PaO2/FiO2) from peripheral capillary oxygen saturation over fraction of inspired oxygen (SpO2/FiO2) Time: 72 hours
Secondary Outcomes
Measure: Change in imputed PaO2/FiO2 from SpO2/FiO2 Time: 48 hours
Measure: Proportion of participants requiring endotracheal intubation Time: Up to 8 weeks
Measure: Proportion of participants requiring mechanical ventilation Time: Up to 8 weeks
Measure: Proportion of participants transferred to intensive care for worsening respiratory failure Time: Up to 8 weeks
Measure: Proportion of participants who had escalated oxygen delivery needs Time: Up to 8 weeks
Measure: Average number of days hospitalized Time: Up to 8 weeks
Measure: Average number of ventilator-free days Time: Up to 8 weeks
Measure: Proportion of participants discharged from hospital on hospice Time: Up to 8 weeks
Measure: Proportion of participants with all-cause inpatient mortality Time: Up to 8 weeks
No related HPO nodes (Using clinical trials)