CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

Normal salineWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation

Correlated Drug Terms (5)

Name (Synonyms) Correlation
drug2 (Standard of Care) SoC Wiki 0.71
drug888 Povidone-Iodine Wiki 0.50
drug60 Anakinra Wiki 0.27
drug957 Remdesivir Wiki 0.21
drug505 Hydroxychloroquine Wiki 0.08

Correlated MeSH Terms (5)

Name (Synonyms) Correlation
D055371 Acute Lung Injury NIH 0.09
D012127 Respiratory Distress Syndrome, Newborn NIH 0.09
D045169 Severe Acute Respiratory Syndrome NIH 0.08
D012128 Respiratory Distress Syndrome, Adult NIH 0.08
D018352 Coronavirus Infections NIH 0.07

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There are 2 clinical trials

Clinical Trials

1 Early Identification and Treatment of Cytokine Storm Syndrome in Covid-19

This proposal addresses the problem of preventing the very high mortality and morbidity associated with the development of Cytokine Storm Syndrome (CSS) associated respiratory failure in Covid-19 infection.

NCT04362111 Cytokine Storm COVID-19 Drug: Anakinra Drug: Normal saline

Primary Outcomes

Description: Supplemental oxygen requirement to maintain oxygen saturation >90% stable or decreased without escalation of respiratory measures (addition of CPAP, initiation of mechanical ventilation)

Measure: No increase in oxygen requirement and no increase in respiratory support measures

Time: 48 hours

Secondary Outcomes

Description: 25% decrease in noted baseline elevations of serum ferritin, LDH, CRP, and d-dimer.

Measure: Improvement in Cytokine Storm markers

Time: 72 hours

Description: Subjects discharged from hospital without the need for mechanical ventilation

Measure: No requirement for mechanical ventilation

Time: Day 5 (120 hours)

2 Can a Sinus Rinse and Mouth Wash Reduce Viral Load in COVID-19 Positive Individuals and Their Co-residents?

COVID-19 is highly infectious and transmission of the virus is thought to be similar to that of influenza which can be transferred through droplets released when a person coughs, sneezes or talks. Studies have shown that nasal rinsing and mouth washes may be an important way to deliver treatments that could reduce the amount of a virus that is present in the nose and mouth. This also could mean that there is less virus available to pass on to others. We want to see if the use of nose rinses and mouth washes using Povidone-Iodine will reduce the the amount of virus in the nose and throat of people who have tested positive for COVID-19 disease and also reduce the spread of infection within their household.

NCT04393792 Coronavirus Infection Drug: Povidone-Iodine Drug: Normal saline
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome

Primary Outcomes

Description: viral load as measured by real time polymerase chain reaction (PCR)

Measure: Change in viral load in the oral and nasopharyngeal cavity

Time: Day 0, 2, 3, 7, 14

Secondary Outcomes

Description: Visual analogue score 1-5 per symptom via a smartphone app

Measure: Symptom severity in primary participants and co-residents

Time: Days 0 to 14

No related HPO nodes (Using clinical trials)