There is one clinical trial.
The 2019-20 coronavirus disease, caused by COVID-19, is an ongoing pandemic.So far, no specific treatment has proven efficacy. Recent case series reported the use of Hyperbaric Oxygen Therapy (HBOT) on 5 severe COVID-19 patients who developed respiratory insufficiency. HBOT mechanisms of tissue oxygenation and anti-inflammatory effect may explain these findings. The purpose of the current study is the evaluate the efficacy of HBOT in moderate-severe COVID-19 patients in a randomized controlled manner.
Description: Oxygenation index of the lungs calculated PaO2 measured in the blood divided by the inhaled FiO2
Measure: PaO2/FiO2 Time: 1 day and 7 days after the last intervention sessionDescription: Oxygen saturation measured in %
Measure: SpO2 Time: One hour prior to and after every intervention session, 1 day and 7 days after the last intervention sessionDescription: Early Warning Score (NEWS) calculated by the patient's vitals and condition
Measure: NEWS Score Time: One hour prior to and after every intervention session, 1 day and 7 days after the last intervention sessionDescription: blood CRP level
Measure: Inflammation level -CRP Time: 1 day and 7 days after the last intervention sessionDescription: erythrocyte sedimentation rate
Measure: Inflammation level - ESR Time: 1 day and 7 days after the last intervention sessionDescription: white blood cells number
Measure: white blood cells number Time: 1 day and 7 days after the last intervention sessionDescription: blood IL1 level
Measure: Cytokines - IL1 Time: 1 day and 7 days after the last intervention sessionDescription: blood IL2 level
Measure: Cytokines - IL2 Time: 1 day and 7 days after the last intervention sessionDescription: blood IL6 level
Measure: Cytokines - IL6 Time: 1 day and 7 days after the last intervention sessionDescription: blood IL10 level
Measure: Cytokines - IL10 Time: 1 day and 7 days after the last intervention sessionDescription: blood TNFalpha level
Measure: Cytokines - TNFalpha Time: 1 day and 7 days after the last intervention sessionDescription: blood procalcitonin level
Measure: Inflammation level - procalcitonin Time: 1 day and 7 days after the last intervention sessionDescription: blood ferritin level
Measure: Inflammation level - ferritin Time: 1 day and 7 days after the last intervention sessionDescription: Patient's reported symptoms including cough, dyspnea, etc.
Measure: Symptoms level Time: 1 day and 7 days after the last intervention sessionDescription: Oxygen amount supplied measured in IU
Measure: Average oxygen supply per day Time: 1 day and 7 days after the last intervention sessionDescription: Quantitative measurement of viral load in the blood using quantitative RT-PCR
Measure: Viral load Time: 1 day and 7 days after the last intervention sessionDescription: Chest xray changes evaluated qualitatively and quantitatively
Measure: Chest Xray changes Time: 1 day and 7 days after the last intervention sessionDescription: number of patients who developed SARS-CoV-2 IgG antibodies
Measure: Number of patients with IgG seroconversion Time: 1 day and 7 days after the last intervention sessionDescription: number of patients who developed SARS-CoV-2 IgM antibodies
Measure: Number of patients with IgM seroconversion Time: 1 day and 7 days after the last intervention sessionDescription: Pulmonary function tests performed bedside
Measure: FEV1/FVC Time: 1 day and 7 days after the last intervention sessionDescription: The measured time the patient suffered symptoms until complete recovery
Measure: Time to symptoms recovery Time: Within 30 daysDescription: The number of patients who required invasive ventilation during the trial
Measure: Number of patients who required invasive ventilation Time: Within 30 daysDescription: The measured time until the patient had two negative SARS-CoV-2 PCR
Measure: Time to negative virus PCR Time: Within 30 daysDescription: The number of patients who died
Measure: Mortality rate Time: Within 30 daysDescription: The number of adverse events in each arm
Measure: Number of barotrauma events (safety) Time: Within 7 days after the last session