Name (Synonyms) | Correlation | |
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drug579 | Inhaled beclomethasone Wiki | 1.00 |
drug839 | Peripheral blood draw Wiki | 0.71 |
drug850 | Placebo Wiki | 0.09 |
Name (Synonyms) | Correlation | |
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D014777 | Virus Diseases NIH | 0.14 |
D003141 | Communicable Diseases NIH | 0.11 |
D007239 | Infection NIH | 0.07 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
The exceedingly high mortality rates of severe and critical COVID-19 warrant the identification and evaluation of novel therapies that could potentially mitigate the advanced disease manifestations. Based on preclinical data from this institution and others, the investigators hypothesize that PI3K inhibition with duvelisib could potentially quell aberrant hyperactivtation of the innate immune system, preferentially polarize macrophages, reduce pulmonary inflammation, and limit viral persistence, thereby improving patient outcomes.
Description: -Defined as increase in viral load of >0.5 log on two consecutive days, or >1 log increase in one day, not in keeping with any baseline trend of rising viral loads during the pre-treatment viral testing
Measure: Viral kinetics as measured by virologic failure Time: Through completion of follow-up (estimated to be 7 months)