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D007511: Ischemia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug311 Attention control Wiki 0.58
drug3913 not required Wiki 0.58
drug2049 Motivational social support from nurse with additional support from significant other Wiki 0.58
Name (Synonyms) Correlation
drug1939 Mechanical Trombectomy Wiki 0.58
drug2048 Motivational social support from nurse Wiki 0.58
drug1271 Favipiravir and Hydroxychloroquine Wiki 0.58
drug575 COVID 19 impact Wiki 0.58

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D003324 Coronary Artery Disease NIH 0.29
D006331 Heart Diseases NIH 0.22
D009203 Myocardial Ischemia NIH 0.17
Name (Synonyms) Correlation
D020521 Stroke NIH 0.15
D004630 Emergencies NIH 0.10

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0001677 Coronary artery atherosclerosis HPO 0.29
HP:0001658 Myocardial infarction HPO 0.17
HP:0001297 Stroke HPO 0.15

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 A Randomized Controlled Trial to Reduce Hopelessness Through Enhanced Physical Activity in Adults With Ischemic Heart Disease

After a 30-year decline, heart disease is projected to increase up to 18% by 2030. Participation rates in cardiac rehabilitation remain extremely low and hopeless individuals are less likely to participate. This innovative study has the potential to advance science, improve patient care, and improve patient outcomes by demonstrating the effectiveness of the Heart Up! program to increase physical activity and reduce hopelessness in patients with heart disease. Hopelessness is associated with a 3.4 times increased risk of mortality or nonfatal myocardial infarction in patients with ischemic heart disease (IHD), independent of depression. Hopelessness has been identified in 27-52% of patients with IHD and can persist for up to 12 months after hospital discharge. Hopelessness, a negative outlook and sense of helplessness toward the future, can be a temporary response to an event (state) or a habitual outlook (trait). Hopelessness is associated with decreased physical functioning and lower physical activity (PA) levels in individuals with IHD. While research has investigated strategies to increase PA among IHD patients in general, the study team is the only group to design an intervention to promote PA specifically in hopeless IHD patients. The purpose of this randomized controlled trial is to establish the effectiveness of our 6-week mHealth intervention (Heart Up!) to promote increased PA in hopeless patients with IHD. A total of 225 hopeless IHD patients will be enrolled from a large community teaching hospital in the Midwest. Patients will be randomized (75 per group) to one of three groups: 1) motivational social support (MSS) from a nurse, 2) MSS from a nurse with additional significant other support (SOS), or 3) attention control (AC). It is hypothesized that 1) The MSS with SOS group will have the greatest increase in average minutes of moderate to vigorous PA per day at 8 and 24 weeks as compared to the MSS only or AC groups; 2) Greater increase in minutes of moderate to vigorous PA per day will be associated with decreased state hopelessness levels from baseline to weeks 8 and 24; and 3) Increased social support and increased motivation will mediate the effects of Heart Up! on a greater increase in moderate to vigorous PA at 8 and 24 weeks. The findings from this study could transform care for IHD patients who are hopeless by promoting self-management of important PA goals that can contribute to better health outcomes.

NCT03907891
Conditions
  1. Ischemic Heart Disease
  2. Hopelessness
  3. Physical Activity
  4. Motivation
  5. Social Support
  6. Covid19
Interventions
  1. Behavioral: Motivational social support from nurse
  2. Behavioral: Motivational social support from nurse with additional support from significant other
  3. Behavioral: Attention control
MeSH:Heart Diseases Myocardial Ischemia Coronary Artery Disease Ischemia
HPO:Coronary artery atherosclerosis Myocardial infarction

Primary Outcomes

Description: Mean minutes/day moderate to vigorous physical activity

Measure: ActiGraph GT9X Link Accelerometer

Time: Month 12

Description: Participant's report of current level of state hopelessness. Total score range= 1 (better) to 4 (worse).

Measure: State-Trait Hopelessness Scale

Time: Month 12

Secondary Outcomes

Description: Participant's report of exercise self-regulation level. Total score range= 1 (worse) to 7 (better).

Measure: Exercise Self-Regulation Questionnaire

Time: Month 12

Description: Participant's report of perceived social support level. Total score range= 1 (worse) to 30 (better).

Measure: ENRICHD Social Support Inventory

Time: Month 12

Other Outcomes

Description: Comorbidity score based on medical record abstraction. Total score range= 0 (better) to 100 (worse).

Measure: Charlson Comorbidity Index

Time: Week 1

Description: Participant's report of participation level with exercise in home, community or cardiac rehabilitation program

Measure: Cardiac Rehabilitation Exercise Participation Tool

Time: Month 12

Description: Participant's report of mean level of depressive symptoms. Total score range= 0 (better) to 27 (worse).

Measure: Patient Health Questionnaire-9

Time: Month 12

Description: Participant's report of mean level of well-being. Total score range= 4 (better) to 20 (worse).

Measure: PROMIS-29

Time: Month 12

Description: Participant's report of mean level state and trait hope. Total score range= 8 (worse) to 64 (better).

Measure: Snyder State Trait Scales

Time: Month 12

Description: Participant's report of mean level of quality of life. Total score range= 1 (better) to 5 (worse).

Measure: EuroQol (EQ-5d-5L)

Time: Month 12

Description: Participant's report of COVID-19 symptoms, diagnosis, testing, and social distancing. No score range (14 items).

Measure: Multi-Ethnic Study of Atherosclerosis (MESA) COVID-19 Questionnaire

Time: Month 12

Description: Participant's report of impact on routine; income/ employment; access to food, medical and mental health care, extended family; and stress. No range (12 items)

Measure: Coronavirus Impact Scale

Time: Month 12
2 Endovascular Thrombectomy in COVID-19 Infected Patients: Intrahospital and Peri-operative Outcomes

About 5% of COVID-19 patients may present symptoms related to acute ischemic stroke (AIS). Treatment-management and outcomes related to mechanical thrombectomy (MT) for COVID-19 infected patients harboring large vessel occlusion is largely unknown. This multicentric study aims to investigate morbidity, mortality and neurological outcomes after MT performed in patients with COVID-19 infection.

NCT04406090
Conditions
  1. Ischemic Stroke
  2. Covid 19
Interventions
  1. Other: Mechanical Trombectomy
MeSH:Stroke Ischemia
HPO:Stroke

Primary Outcomes

Description: Intrahospital mortality after MT for COVID-19 infected patients harboring large vessel occlusion

Measure: Intrahospital mortality

Time: 1day

Description: short-term morbidity after MT for COVID-19 infected patients harboring large vessel occlusion

Measure: short-term morbidity

Time: 1 day

Secondary Outcomes

Description: Angiographic success after MT for COVID-19 infected patients harboring large vessel occlusion

Measure: Angiographic success

Time: 1 day
3 The Impact of COVID-19 Pandemic on Critical Limb Threatening Ischemia and Emergency Vascular Practice

This is a retrospective analytical study conducted at Vascular and Endovascular surgery Department, Mansoura University Hospital, including all patients admitted at the two periods first six months of 2019 and 2020.To demonstrate the effect of COVID-19 pandemic on the practice of emergency vascular surgery and critical limb threatening ischemia interventions by comparison two periods first six months of 2019 and 2020.

NCT04452682
Conditions
  1. COVID
  2. Critical Limb Ischemia
Interventions
  1. Other: COVID 19 impact
MeSH:Emergencies Ischemia

Primary Outcomes

Description: The ICU admission caused by Pneumonia proved radio-logically at both periods

Measure: The ICU admission with associated Pneumonia

Time: 6 months

Description: percentage of different diagnoses at both periods

Measure: Impact of COVID-19 on the different presentation of vascular surgery at the emergency

Time: 6 months

Secondary Outcomes

Description: Mortality percentages at both periods

Measure: Mortality rates

Time: 6 months

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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