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D012772: Shock, Septic

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug291 Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay Wiki 0.71
drug2158 Nitazoxanide with ivermectin Wiki 0.71
drug3389 Toraymyxin PMX-20R (PMX Cartridge) Wiki 0.71
Name (Synonyms) Correlation
drug3742 convalescent plasma Wiki 0.29
drug1705 Ivermectin Wiki 0.15

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D019446 Endotoxemia NIH 0.71
D012769 Shock, NIH 0.53
D004211 Disseminated Intravascular Coagulation NIH 0.32
Name (Synonyms) Correlation
D018805 Sepsis NIH 0.25
D045169 Severe Acute Respiratory Syndrome NIH 0.03
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0005521 Disseminated intravascular coagulation HPO 0.32
HP:0100806 Sepsis HPO 0.25

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 Prospective Evaluation of PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock Patients. Impact of Platelets Metabolism to Inflammatory Response.

Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more particularly platelets inflammatory mediators content, coming from AA and lipids.

NCT04107402
Conditions
  1. Septic Shock
  2. Platelet Signal Processing Defect
  3. Inflammatory Response
  4. Disseminated Intravascular Coagulation
  5. Covid19
  6. Neutrophil Extracellular Trap Formation
Interventions
  1. Other: Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
MeSH:Shock, Septic Disseminated Intravascular Coagulation Shock
HPO:Disseminated intravascular coagulation

Primary Outcomes

Description: ACC phosphorylation on Ser79 (phosphoACC) in platelets of patients will be assessed using western blotting. Results will be expressed in arbitrary units (A.U). A signal above 0.5 A.U. has already been shown to be above 2 standard deviation in a healthy population.

Measure: Platelets Acetyl-CoA Carboxylase phosphorylation rate

Time: At the time of inclusion

Secondary Outcomes

Description: Sepsis severity will be assessed using the SOFA score (Sepsis-related Organ Failure Assessment). Range from 0( less severe) to 24 (more severe).

Measure: Sepsis severity

Time: At the time of inclusion

Description: Sepsis severity will be assessed using the APACHE II score) Acute Physiology And Chronic Health Evaluation) Range 0 (less severe) to 299 (more severe).

Measure: Sepsis severity

Time: At the time of inclusion

Measure: Mortality rate

Time: 30 days and 1-year follow-up

Description: Platelet function will be assessed using platelets aggregometry. The Aggregation (in AU), the maximum height of the curve during the measurement period will be assessed.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: Platelet function will be assessed using platelets aggregometry. Area Under the aggregation Curve (AUC) will be assessed and recorded as Units or U.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: Platelet function will be assessed using platelets aggregometry. Velocity (in AU/min), the maximum slope of the curve will be assessed.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: D-Dimers (ng/ml)

Measure: Thrombin generation marker rate

Time: At the time of inclusion

Description: Urinary Thrombin-antithrombin complex (ng/mL)

Measure: Thrombin generation marker rate

Time: At the time of inclusion

Description: Tubulin acetylation will be assessed using western blotting. Results will be expressed in arbitrary units (A.U).

Measure: Tubulin acetylation rate

Time: At the time of inclusion

Description: Total platelets lipid content and composition will be assessed using metabolomics approach by Mass Spectrometry. Fold-change estimates and corresponding P values were derived from regression models for each lipid species and each predictor. To control for multiple testing, all P values will be further adjusted for Benjamini-Hochberg false discovery rate (FDR), with a FDR <0.05 considered statistically significant

Measure: Total platelets lipid content and composition

Time: At the time of inclusion

Description: Myeloperoxidase MPO (ng/mL)

Measure: Neutrophils extracellular trap formation

Time: At the time of inclusion

Description: Citrulinated Histon 3 H3-Cit (ng/mL)

Measure: Neutrophils extracellular trap formation

Time: At the time of inclusion

Description: Soluble CD62P (ng/mL)

Measure: Platelets activation

Time: At the time of inclusion

Description: PaO2/FiO2

Measure: Respiratory failure

Time: At the time of inclusion and through study completion up to day 30
2 Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19

Prospective, observational, clinical investigation of PMX cartridge use in COVID 19 patients with septic shock

NCT04352985
Conditions
  1. Septic Shock
  2. Endoto
  3. Endotoxemia
  4. COVID
  5. Corona Virus Infection
  6. Sepsis, Severe
Interventions
  1. Device: Toraymyxin PMX-20R (PMX Cartridge)
MeSH:Shock, Septic Endotoxemia Sepsis Coronavirus Infections Severe Acute Respiratory Syndrome Shock
HPO:Sepsis


HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

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4,818 reports on interventions/drugs

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706 reports on MeSH terms

HPO

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