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D001249: Asthma

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug416 Best Standard of Care Wiki 0.58
drug3833 insurance navigation Wiki 0.58
drug505 Breath sample Wiki 0.58
Name (Synonyms) Correlation
drug417 Best Standard of Care + CARDIO Wiki 0.58
drug504 Breath biopsy sampling using the ReCIVA Breath Sampler Wiki 0.58
drug508 Brequinar Wiki 0.41
drug2448 Placebo Wiki 0.03

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D011657 Pulmonary Eosinophilia NIH 0.58

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002099 Asthma HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Randomized, Open-label, Parallel Study to Investigate Safety and Efficacy of CARDIO Softgels Plus Best Standard-of-care vs. Best Standard-of-care Alone on a Former Smoker and/or Steroid-resistant Asthma Population With COVID-19 Infection

Corona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, a plus-sense single-stranded RNA virus. After an incubation period, which typically lasts for 5-6 days, COVID-19 patients present with a mild illness that lasts for a few days. Common symptoms are reminiscent of the flu, and include fever, dry cough and dyspnea. A large percentage of patients resolve the infection whereas others progress onto adult respiratory distress syndrome (ARDS) which impedes gas exchange between the alveolar space and the bloodstream and creates the need for assisted respiration.The objectives of this randomized, open-label, parallel study is to investigate the safety and efficacy of CARDIO plus best standard-of-care in reducing the need for mechanical respiratory support, alleviating respiratory symptoms and reducing mortality in hospitalized former smoker and steroid-resistant asthma patients with COVID-19 infection.

NCT04465513
Conditions
  1. Asthma; Eosinophilic
  2. COVID
  3. Covid-19
Interventions
  1. Dietary Supplement: Best Standard of Care + CARDIO
  2. Dietary Supplement: Best Standard of Care
MeSH:Asthma Pulmonary Eosinophilia
HPO:Asthma

Primary Outcomes

Description: Oxygen saturation rates (Best Standard of Care treatment (BSC) plus CARDIO vs. BSC alone)

Measure: Oxygenation requirements during hospital stay (oxygen saturation rates)

Time: On day of discharge if earlier than 28 days from baseline, then 28 days from baseline

Description: Requirement for supplemental oxygen (Best Standard of Care treatment (BSC) plus CARDIO vs. BSC alone)

Measure: Oxygenation requirements during hospital stay (supplemental Oxygen)

Time: On day of discharge if earlier than 28 days from baseline, then 28 days from baseline

Description: Requirement for advanced ventilator support (Best Standard of Care treatment (BSC) plus CARDIO vs. BSC alone)

Measure: Oxygenation requirements during hospital stay (ventilator support)

Time: On day of discharge if earlier than 28 days from baseline, then 28 days from baseline

Secondary Outcomes

Description: Assessed by the National Early Warning Score (NEWS) which is a standardized tool that assesses disease severity and monitoring of patients in hospital. An aggregate score of respiration rate, oxygen saturation, systolic blood pressure, pulse rate, level of consciousness and temperature and the score is increased if supplemental oxygen is required. Each parameter is based on a scale of 0 - 3. 0=good, 3=poor

Measure: Clinical improvement

Time: Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Assessed by the WHO Ordinal Scale for Clinical Improvement which examines changes in clinical status and/or survival specific to COVID-19. This 8-point scale measures illness severity over time. 0 = no infection and 8 = dead

Measure: Clinical status

Time: Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Serial chest CT or X-ray findings for the CARDIO softgel + BSC group will be compared with those of the BSC group.

Measure: Serial chest CT or X-ray findings

Time: Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: This is defined as sustained normalization of fever, respiratory rate, oxygen saturation, and alleviation of cough for at least 72 hours

Measure: Time to clinical recovery

Time: Day 28 from baseline or day of discharge

Description: increase in SpO2/FiO2 of 50 mmHg or greater compared to the nadir SpO2/FiO2

Measure: Time to improvement in oxygenation for at least 48 hours

Time: Day 28 from baseline or day of discharge

Description: The number of days from hospital admission to hospital discharge

Measure: Hospitalization period

Time: Day 28 from baseline or day of discharge

Description: The total number of days on ventilator

Measure: Amount of time on Ventilator

Time: Day 28 from baseline or day of discharge

Description: number of days in intensive care unit (ICU)

Measure: Intensive Care stay

Time: Day 28 from baseline or day of discharge

Description: assessed by the COVID-19 QoL questionnaire which asks questions about incident of different parameters related to deteriorating. It is on a scale of 1-5. 1=completely disagree, 5 = completely agree

Measure: Quality of life (QoL)

Time: Day1, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Death due to COVID-19 and other reasons

Measure: All-cause mortality

Time: Day 28 from baseline or day of discharge

Description: Body temperatures

Measure: Temperature measurements

Time: Day 28 from baseline or day of discharge

Description: measured using a pulse oximetry device, which is a non-invasive method to measure arterial oxygen saturation level.

Measure: Oxygen saturation measurements

Time: Day 28 from baseline or day of discharge

Description: assessed by the COVID-19 QoL questionnaire which asks questions about incident of different parameters related to deteriorating. It is on a scale of 1-5. 1=completely disagree, 5 = completely agree

Measure: COVID-19 QoL measurements

Time: Day 28 from baseline or day of discharge

Other Outcomes

Description: Incidence of pre-emergent and post-emergent adverse events (AEs) and serious adverse events (SAEs)

Measure: Adverse Events

Time: During 15 days of supplementation or until day of discharge and during home follow up

Description: systolic and diastolic

Measure: Blood pressure

Time: From baseline to 28 days thereafter

Description: Heart rate values for the CARDIO softgel + BSC group will be compared with those of the BSC group using

Measure: Heart rate

Time: Everyday From baseline to 28 days thereafter

Description: Frequency of clinically significant laboratory abnormalities.

Measure: Abnormality in laboratory tests

Time: Day 28 from baseline or day of discharge

Description: BMI values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Body mass Index (BMI)

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: CBC values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Complete blood count (CBC)

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: AST values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Aspartate transaminase (AST)

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: ALT values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Alanine transaminase (ALT)

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: ALP values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Alkaline phosphatase (ALP)

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Bilirubin values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Bilirubin

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Sodium ion values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Sodium ion

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Potassium ion values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Potassium ion

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Chloride ion values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Chloride ion

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: Creatinine values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Creatinine

Time: Daily From baseline to 28 days thereafter

Description: eGFR values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: eGFR

Time: Daily From baseline to 28 days thereafter

Description: HbA1c values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: HbA1c

Time: Daily From baseline to 28 days thereafter

Description: eGFR values for the CARDIO softgel + BSC group will be compared with those of the BSC group using statistical analysis to determine significant difference between the two groups. Samples are taken in the days stated below.

Measure: Glucose

Time: Day 0, Day 10, Day 14, from baseline, Day 28 from baseline or day of discharge

Description: CRP value only taken at baseline for every participant

Measure: C-Reactive protein (CRP)

Time: Baseline only
2 Health-Related Quality of Life of Patients With Asthma and Its Associated Factors During the Pandemic of COVID-19

Nowadays, the COVID-19 epidemic causes stress not only to healthy people but also to people with unhealthy conditions. Excess psychological stress (either in quality, quantity, frequency, and/or duration) could push susceptible individuals to ultimately develop clinical asthma. Depression was significantly associated with asthma interference with daily activities, breathlessness, night symptoms, use of bronchodilators, and poor compliance with medical treatment. Covid-19 pandemic induced the countries around the world to require from its citizens not to ask for health care support rather than in emergency situations and through utilizing telemedicine. This action aims to control spreading the infection with viruses as well as to reduce the workload on the healthcare providers. Although asthma is not listed as one of the chronic conditions that might complicate coronavirus infections, asthma people might have a high-stress level that might induce their asthma attack which consequentially reflects on their quality of life. People with asthma have a unique experience rather than people with other health conditions during COVID-19. Patients with asthma experience a lot of stressors that might induce asthma and impaired their HRQOL such as overuse of antiseptic substances, stay home with a sedentary lifestyle, the sudden shift to telemedicine, and electronic work from home. Also, as a result of the similarity of asthma symptoms with coronavirus symptoms, the patient might have a continuous sense of uncertainty that s/he is infected with the COVID-19 virus, and this suspicion can increase the psychological overburden on these patients. Therefore, all these stressors should be evaluated to recognize their health needs and the kind of social and health support that should be provided to them during the pandemic time. Also, Identifying the predictors of HRQOL among patients with asthma during the pandemic of COVID-19 is urgently required.

NCT04613245
Conditions
  1. Asthma Chronic
  2. Bronchial Asthma
MeSH:Asthma
HPO:Asthma

Primary Outcomes

Description: ACQ has a multidimensional construct assessing symptoms (5 items--self-administered) and rescue in bronchodilator use (1 item-self-administered), and FEV1% (1 item) completed by clinic staff, but it will not be applied in the current study as it will be difficult to be self-reported by the participants. 7-point scale (0=no impairment, 6= maximum impairment for symptoms. Scores range between 0 (totally controlled) and 6 (severely uncontrolled).

Measure: Asthma Control Questionnaire (ACQ)

Time: One week

Secondary Outcomes

Description: The MiniAQLQ will be utilized to investigate the HRQoL of the participants. The Mini AQLQ-S has 15 questions that gives an overall summary index and four domains: activity limitation, symptoms, emotional function, and environmental stimuli. The questions all refer to the "last two weeks" and use seven Likert-type response options e.g., seven response options ranging from "all of the time" to "none of the time".

Measure: Mini Asthma Quality of Life Questionnaire

Time: two weeks

Description: Perceived Stress Scale is a self-reported measure of the degree to which situations in an individual's life are perceived as stressful. PSS has 14 items can assess the degree to which individuals found their life unpredictable, uncontrollable, and overloaded.

Measure: Perceived Stress Scale

Time: month
3 Comparing Patient-Centered Outcomes for Adults and Children With Asthma in High-Deductible Health Plans With and Without Preventive Drug Lists: COVID Enhancement

In addition to its impact on health, the COVID-19 pandemic has led to increased unemployment and loss of employer-sponsored insurance coverage. Obtaining coverage can be challenging and eligibility for public programs and subsidies can be limited, and those who do not qualify can face steep premiums, high-deductibles, and high out-of-pocket costs. Patients with asthma are at risk for adverse health outcomes during the COVID-19 pandemic, and disruptions to employment and insurance coverage during the pandemic threaten to negatively affect asthma care and outcomes. Our PCORI-funded parent project, Asthma in Families Facing Out-of-pocket Requirements with Deductibles (AFFORD), found that patients with asthma may be particularly vulnerable to insurance-related cost barriers and challenges navigating health insurance. Together with the Asthma and Allergy Foundation of America (AAFA), the investigators developed an asthma chat bot to help patients with asthma navigate insurance benefits and optimize health care decisions. The chat bot is an artificial intelligence-enabled interactive online tool that can answer clinical and insurance-related questions and provide information on coverage and how to find lower-cost alternatives for asthma care. In this supplement to the AFFORD project, the investigators propose a new study to understand and address the insurance and health care cost challenges faced by patients with asthma who lose employer-sponsored coverage due to COVID-19. Our Aims are: 1) to conduct a pilot randomized controlled trial to evaluate the effectiveness and feasibility and acceptability of an insurance navigation intervention, including the chat bot, to help patients with asthma regain coverage after the loss of job-related insurance during the COVID-19 pandemic; and 2) to qualitatively explore the experiences of Aim 1 participants to understand barriers and facilitators to accessing coverage and asthma care more broadly during the COVID-19 pandemic The study hypothesis is that participants receiving the intervention will be more likely to have coverage after four months and less likely to report non-adherence to asthma medications, delayed/forgone asthma care, and financial burden than those receiving usual care. Findings will provide evidence about the effectiveness of strategies to obtain coverage and maintain access to affordable asthma care and can inform ongoing and future decision making in response to the COVID-19 pandemic and other public health and economic threats.

NCT04613739
Conditions
  1. Asthma
Interventions
  1. Behavioral: insurance navigation
MeSH:Asthma
HPO:Asthma

Primary Outcomes

Description: Change in coverage status (has any insurance coverage or not)

Measure: Insurance coverage

Time: From baseline to follow-up (four months)

Secondary Outcomes

Description: Change in report of using less asthma medication than prescribed because of cost

Measure: Medication adherence

Time: From baseline to follow-up (four months)

Description: Change in report of: 1) problems paying medical bills for asthma care, or 2) having to borrow money because of the amount required to pay for asthma care

Measure: Financial burden

Time: From baseline to follow-up (four months)

Description: Change in report of: 1) using less asthma medication than prescribed because of cost,or 2) delaying or avoiding going to the doctor for asthma because of cost

Measure: Delayed/forgone care due to cost

Time: From baseline to follow-up (four months)

HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook