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D014376: Tuberculosis

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (8)

Name (Synonyms) Correlation
drug536 CAD4COVID+WBC and COVID-19 RDT for SARS-CoV-2 infection Wiki 0.50
drug105 ART Therapy Wiki 0.50
drug142 Accuracy of CAD4TB and Afinion CRP assay for pulmonary TB Wiki 0.50
Name (Synonyms) Correlation
drug1603 Impact of respiratory isolation on quality of life Wiki 0.50
drug2385 Patient-centred advice on Telephone Consultation in TB Patients: Wiki 0.50
drug2843 Routine care for COVID-19 patients Wiki 0.35
drug1262 Favipiravir Wiki 0.10
drug1472 Hydroxychloroquine Wiki 0.05

Correlated MeSH Terms (6)

Name (Synonyms) Correlation
D014397 Tuberculosis, Pulmonary NIH 0.50
D055985 Latent Tuberculosis NIH 0.50
D006505 Hepatitis NIH 0.50
Name (Synonyms) Correlation
D006526 Hepatitis C NIH 0.35
D003141 Communicable Diseases NIH 0.04
D007239 Infection NIH 0.02

Correlated HPO Terms (0)

Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials

1 To Assess the Efficiency and Satisfaction of Pharmacist Giving Patient-centred Advice on Telephone Consultation in TB Patients: Experience of the COVID-19 Pandemic

The COVID-19 pandemic might be an opportunity to review and refine our practices in anti TB treatment. For the follow-up of selected patients, telephone consultations may be efficient and cost-effective. The aim of the study is to assess the efficiency and the satisfaction with telephone consultation for the pharmacist and the TB patient. The study was conducted in tertiary care hospital TB control centres patients.

  1. TB - Tuberculosis
  2. Patient Satisfaction
  1. Behavioral: Patient-centred advice on Telephone Consultation in TB Patients:

Primary Outcomes

Description: To improve patient centered care/patient prescription refill

Measure: Efficiency of the telephone consultation,

Time: 2 Months

Description: Patient satisfaction Patient satisfaction resulting from pharmacist-led pharmaceutical care will be assessed Patient satisfaction feedback (PSF)

Measure: Patient satisfaction

Time: 2 Month

Secondary Outcomes

Measure: Adherence Rate

Time: 2 Months
2 Prospective, Multicentre Evaluation of the Accuracy of CAD4TB and C-reactive Protein Assay as Triage Tests for the Diagnosis of Pulmonary Tuberculosis in Presumptive Adult TB Patients (TB TRIAGE+ Accuracy)

In the TB TRIAGE+ ACCURACY study, the accuracy of the following products will be determined: - CAD4TB (Delft Imaging System, NL), a digital chest x-ray analysis software - Afinion CRP assay (Alere Afinion, USA), which detects a cytokine induced acute phase protein CAD4TB and the C-reactive protein assay are two tests with great potential of becoming a triage test for the diagnosis of tuberculosis (TB). These potential triage tests for TB are intended to serve as rule-out tests with a high sensitivity and negative predictive value. Before impact and cost-effectiveness of new TB triage tests for intensified active case finding can be determined, the diagnostic test accuracy needs to be assessed in comparison to confirmatory reference tests. This accuracy study will define cut-off values for CAD4TB as well as for the Afinion CRP assay to be used in a future cluster-randomised trial on impact and cost-effectiveness of TB triage strategies for intensified active case finding in Lesotho and KwaZulu-Natal, South Africa. A sub-study (detailed in a separate study protocol), hereafter called AHD-FEASIBILITY, explores the feasibility of implementing a series of point-of-care tests, including the new VISITECT CD4 Advanced Disease Test (Omega Diagnostics, UK) as part of the WHO-recommended advanced HIV Disease care package in the context of community-based HIV/TB campaigns. Due to the coinciding pandemics and the overlapping symptoms of TB and COVID-19, it is critical to test for SARS-Cov-2 infections in the study population. In addition, this study will contribute to the evaluation of a novel SARS-Cov-2 antigen rapid diagnostic test (from the diagnostic pipeline of FIND) and CAD4COVID, a digital chest x-ray analysis software (Delft Imaging System, NL) in combination with differential white blood cell count.

  1. Pulmonary Tuberculosis
  2. Tuberculosis Diagnosis
  3. Covid-19
  4. HIV
  1. Diagnostic Test: Accuracy of CAD4TB and Afinion CRP assay for pulmonary TB
  2. Diagnostic Test: CAD4COVID+WBC and COVID-19 RDT for SARS-CoV-2 infection
MeSH:Tuberculosis Tuberculosis, Pulmonary

Primary Outcomes

Description: Receiver operating characteristic analysis (ROC) of CAD4TB against a composite microbiological reference standard (mycobacterial culture [MGIT] or Xpert MTB/RIF) to define an acceptable diagnostic cut-off value.

Measure: Determine CAD4TB cut-off value

Time: 15 months after first patient visit

Description: Receiver operating characteristic analysis (ROC) of Afinion CRP assay against a composite microbiological reference standard (mycobacterial culture [MGIT] or Xpert MTB/RIF) to define an acceptable diagnostic cut-off value.

Measure: Determine Afinion CRP assay cut-off value

Time: 15 months after first patient visit

Secondary Outcomes

Description: Receiver operating characteristic analysis (ROC) of CAD4TB against a single microbiological reference standard (mycobacterial culture [MGIT] alone, Xpert MTB/RIF alone, Xpert MTB/RIF Ultra alone), against a composite reference standard and against a radiological reference standard

Measure: Evaluate CAD4TB ROC against reference standard

Time: 15 months after first patient visit

Description: Receiver operating characteristic analysis (ROC) of Afinion CRP assay against a single microbiological reference standard (mycobacterial culture [MGIT] alone, Xpert MTB/RIF alone, Xpert MTB/RIF Ultra alone) and against a composite reference standard

Measure: Evaluate Afinion CRP assay ROC against reference standard

Time: 15 months after first patient visit

Description: Receiver operating characteristic analysis (ROC) of CAD4COVID combined with differential white blood cell count and point estimates of sensitivity and specificity the novel SARS-Cov-2 antigen rapid diagnostic test, both against a single microbiological reference standard (SARS-Cov-2 real-time PCR)

Measure: Evaluate CAD4COVID and COVID-19 RDT ROC against reference standard

Time: 15 months after first patient visit
3 Impact of the Respiratory Isolation on the Quality of Life in Patients Hospitalized for Tuberculosis or COVID-19

The respiratory isolation could have a harmful impact on the well-being of patients, especially in a psychological point of view such as anxiety and depression disorders or through the relationship with medical team and/or relatives but also in terms of informations. The evaluation of the impact of respiratory isolation in patients hospitalized for tuberculosis or COVID-19 could allow to identify the different kinds of problems encountered by these patients (physical, psychological, sociological, informations, ...) in order to adapt the environment for efficient care and to improve patient's well-being. The purpose of this research is to evaluate the psychological impact of the respiratory isolation on the quality of life in patients hospitalized for tuberculosis or COVID-19.

  1. Tuberculosis
  2. Covid19
  1. Other: Impact of respiratory isolation on quality of life

Primary Outcomes

Description: Quality of life will be assessed using semi-structured interview.

Measure: Quality of life using semi-structured interview.

Time: at 28 days respiratory isolation

Description: Quality of life will be assessed using SF-36. SF-36 is a set of generic, coherent, and easily administered quality-of-life measures. These measures rely upon patient self-reporting. Items are grouped into three categories: functional status, well-being, overall health assessment. The scores for the different items are coded and then summed and transformed linearly on a scale ranging from 0 to 100.

Measure: Quality of life using 36-Item Short Form Health Survey (SF-36)

Time: at 28 days respiratory isolation

Description: The State-Trait Anxiety Inventory is a self-rated scale. Each type of anxiety has its own scale of 20 different questions that are scored. STAY-YA and STAY-YB Scores range from 20 to 80. A higher score is higher anxiety.

Measure: Quality of life using State-Trait Anxiety Inventory (STAY) A+B scale

Time: at 28 days respiratory isolation

Description: It is a self-rated scale. each item is made up of 4 sentences corresponding to 4 degrees of intensity of increase in a symptom: from 0 to 3. The overall score is obtained by adding the scores of the 13 items. The range of the scale is 0 to 39.

Measure: Quality of life using Beck Depressive Inventory (BDI) -13

Time: at 28 days respiratory isolation
4 European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC): Paediatric Protocol

Across Europe and worldwide, there are many studies following groups (cohorts) of children living with human immunodeficiency virus (HIV) and other infections over time, to monitor their long-term health. Some of these infections are rare: for example, few children in Western Europe are living with HIV, so the studies often have fairly small numbers of participants. This can make it difficult to answer research questions in these cohorts and means that doctors and researchers working with these patients in different countries need to work together. This is particularly important as children are not often included in clinical trials of treatments and other interventions. The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) is an international network of researchers working together in this way. Researchers in the network represent cohort studies of pregnant women and children with, or at risk of, infections from across Europe and Thailand. The research focuses on infections in pregnant women and children, particularly HIV, hepatitis B and C virus, and tuberculosis, and, from 2020, novel coronavirus (COVID-19). By combining data from many cohorts, the researchers aim to answer questions that could not be answered by one study individually (for example, because a large number of pregnant women or children are needed to answer the question). This protocol focuses on the paediatric component of EPPICC's research, which focuses on the treatment of children at risk of and living with infections. For example, what medicines are used most often and how do they affect children's health? EPPICC is an observational study, which means that children do not receive any extra treatment as part of the study. Instead, children are "observed" during their routine medical care. Each cohort keeps records of the children's health collected at routine clinic visits, including information such as date of birth and sex, results of diagnostic tests, treatments received, and any illnesses or other events that the children have had. The EPPICC study combines and analyses data from all of the cohorts that take part, to answer questions about the risks and benefits of different diagnosis or treatment strategies, the long-term effects of infection and treatment during childhood and young adulthood, and regional variations (e.g. between Western and Eastern Europe) in the risk and management of infections. All of the data collected through the EPPICC Paediatric Protocol are stored securely at the Medical Research Council Clinical Trials Unit (MRC CTU) at UCL. Data collection and storage are governed by the General Data Protection Regulation. A Steering Committee guides the research to make sure it is relevant and of high quality. Public and patient involvement (PPI) may be provided by individual cohorts' own groups, as well as by the interlinked Penta organisation, which is a network of paediatricians and researchers working in infections in Europe and globally. The PPI groups help with release of the results of the research. The results are also published on the Penta Foundation's public website (, and presented at conferences and published in Open Access scientific journals.

  1. HIV Infections
  2. Tuberculosis Infection
  3. Hepatitis C
  4. Covid19
  1. Drug: ART Therapy
MeSH:Infection Communicable Diseases Tuberculosis Latent Tuberculosis Hepatitis C Hepatitis

Primary Outcomes

Measure: CD4 count in adulthood of young people with HIV assessed using routine clinical data

Time: through study completion, an average of 5 year

Measure: 2. Viral suppression in adulthood of young people with HIV assessed using routine clinical data

Time: through study completion, an average of 5 year

Measure: Viral suppression defined as <50 copies, <400 copies and 1000 copies/mL) upto 144 weeks.

Time: up to 144 weeks

Measure: CD4 change from drug start up to 144 weeks

Time: up to 144 weeks

Measure: Cumulative incidence of virological failure (>1000 copies/mL)

Time: through study completion, an average of 5 years

Measure: From start of novel drug of interest through to earliest date of the following: death, loss to follow-up, discontinuation of drug or last visit

Time: From date of novel drug initiation until earliest date of death, loss to follow-up, discontinuation of drug or last visit assessed up to 36 months

HPO Nodes


Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials

HPO Nodes


Data processed on December 13, 2020.

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