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D001930: Brain Injuries

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (12)


Name (Synonyms) Correlation
drug609 COVID-19 convalescent hyperimmune plasma Wiki 0.45
drug1910 Magnetic Resonance Spectroscopy (MRS). Wiki 0.45
drug683 Cannabis, Medical Wiki 0.45
Name (Synonyms) Correlation
drug607 COVID-19 antibody point of care test kit Wiki 0.45
drug2198 Non-convalescent fresh frozen plasma (Standard plasma) Wiki 0.45
drug456 Blink and Masseter Inhibitory Reflex Wiki 0.45
drug608 COVID-19 barrier box Wiki 0.45
drug606 COVID-19 antibodies testing Wiki 0.45
drug313 Auditory Evoked Potentials (AEP) Wiki 0.45
drug376 BNT162b1 Wiki 0.26
drug377 BNT162b2 Wiki 0.22
drug2448 Placebo Wiki 0.02

Correlated MeSH Terms (33)


Name (Synonyms) Correlation
D000070642 Brain Injuries, Traumatic NIH 0.63
D000070627 Chronic Traumatic Encephalopathy NIH 0.45
D013226 Status Epilepticus NIH 0.45
Name (Synonyms) Correlation
D002543 Cerebral Hemorrhage NIH 0.45
D013345 Subarachnoid Hemorrhage NIH 0.45
D005879 Tourette Syndrome NIH 0.45
D003424 Crohn Disease NIH 0.45
D005356 Fibromyalgia NIH 0.32
D000690 Amyotrophic Lateral Sclerosis NIH 0.32
D012640 Seizures NIH 0.32
D016472 Motor Neuron Disease NIH 0.32
D006526 Hepatitis C NIH 0.32
D001714 Bipolar Disorder NIH 0.32
D013119 Spinal Cord Injuries NIH 0.26
D006470 Hemorrhage NIH 0.26
D014947 Wounds and Injuries NIH 0.25
D000755 Anemia, Sickle Cell NIH 0.22
D001927 Brain Diseases NIH 0.20
D010300 Parkinsonian NIH 0.18
D009461 Neurologic Manifestations NIH 0.18
D009103 Multiple Sclerosis NIH 0.17
D015212 Inflammatory Bowel Diseases NIH 0.17
D012598 Scoliosi NIH 0.16
D059350 Chronic Pain NIH 0.15
D020521 Stroke NIH 0.12
D004194 Disease NIH 0.09
D040921 Stress Disorders, Traumatic NIH 0.09
D013313 Stress Disorders, Post-Traumatic NIH 0.08
D013577 Syndrome NIH 0.04
D003141 Communicable Diseases NIH 0.03
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (12)


Name (Synonyms) Correlation
HP:0002133 Status epilepticus HPO 0.45
HP:0002138 Subarachnoid hemorrhage HPO 0.45
HP:0001342 Cerebral hemorrhage HPO 0.45
Name (Synonyms) Correlation
HP:0100280 Crohn's disease HPO 0.45
HP:0006802 Abnormal anterior horn cell morphology HPO 0.32
HP:0100754 Mania HPO 0.32
HP:0007354 Amyotrophic lateral sclerosis HPO 0.32
HP:0001250 Seizure HPO 0.26
HP:0001298 Encephalopathy HPO 0.20
HP:0002037 Inflammation of the large intestine HPO 0.17
HP:0012532 Chronic pain HPO 0.15
HP:0001297 Stroke HPO 0.12

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

NCT03944447
Conditions
  1. Chronic Pain
  2. Chronic Pain Syndrome
  3. Chronic Pain Due to Injury
  4. Chronic Pain Due to Trauma
  5. Fibromyalgia
  6. Seizures
  7. Hepatitis C
  8. Cancer
  9. Crohn Disease
  10. HIV/AIDS
  11. Multiple Sclerosis
  12. Traumatic Brain Injury
  13. Sickle Cell Disease
  14. Post Traumatic Stress Disorder
  15. Tourette Syndrome
  16. Ulcerative Colitis
  17. Glaucoma
  18. Epilepsy
  19. Inflammatory Bowel Diseases
  20. Parkinson Disease
  21. Amyotrophic Lateral Sclerosis
  22. Chronic Traumatic Encephalopathy
  23. Anxiety
  24. Depression
  25. Insomnia
  26. Autism
  27. Opioid-use Disorder
  28. Bipolar Disorder
  29. Covid19
  30. SARS-CoV Infection
  31. COVID-19
  32. Corona Virus Infection
  33. Coronavirus
Interventions
  1. Drug: Cannabis, Medical
MeSH:Infection Communicable Diseases Hepatitis C Coronavirus Infections Severe Acute Respiratory Syndrome Fibromyalgia Crohn Disease Inflammatory Bowel Diseases Parkin Parkinson Disease Multiple Sclerosis Brain Injuries Brain Injuries, Traumatic Seizures Motor Neuron Disease Amyotrophic Lateral Sclerosis Brain Diseases Tourette Syndrome Chronic Traumatic Encephalopathy Anemia, Sickle Cell Disease Syndrome Sclerosis Chronic Pain Wounds and Injuries Stress Disorders, Traumatic Bipolar Disorder Stress Disorders, Post-Traumatic
HPO:Abnormal anterior horn cell morphology Amyotrophic lateral sclerosis Bilateral tonic-clonic seizure Bipolar affective disorder Chronic pain Crohn's disease Encephalopathy Focal-onset seizure Generalized-onset seizure Inflammation of the large intestine Mania Seizure

Primary Outcomes

Description: Covid-19 infection rates in cannabis users will be compared to rates in the general population. Our online questionnaire responses will compare infection rates of cannabis users in this study against the Johns Hopkins University Coronavirus Research Center data (https://coronavirus.jhu.edu).

Measure: Prevention of COVID-19

Time: Five years

Description: Severity of persistent symptoms in cannabis users testing positive for active infection and/or antibodies will also be compared to the general population. Patients will answer the widely used FLU-PRO questionnaire, which asks about flu symptoms and severity, to capture diagnoses, symptoms, and medical interventions related to COVID-19. The data from cannabis user patients will be compared with national and international data surveys, such as the Covid Symptom Study (https://covid.joinzoe.com/us-2).

Measure: Treatment of COVID-19

Time: Five years

Description: The primary objective is to assess the efficacy and safety of medical cannabis as medicine for treatment of chronic pain and other chronic debilitating diseases. Pain will be measured by Brief Pain Inventory (BPI) numeric scale. Change from baseline in BPI will be assessed at 3-month intervals. For prospective associations between cannabis use and outcomes, use of a lagged mixed-effects models will examine temporal associations between cannabis use and pain severity, opioid sparing, and patient satisfaction. Data will be analyzed from baseline and the annual follow-up waves.

Measure: Treatment of Symptoms

Time: Five years

Secondary Outcomes

Description: Secondary objectives include evaluating increases or decreases in quality of life, and increases or decreases in concomitant opioid use. Satisfaction with treatment will be measured by a Visual Analog Score (VAS). Change From baseline in Satisfaction with treatment measured by (VAS) be assessed at 3-month intervals.

Measure: Cannabis Impact on Quality of Life

Time: Five years

Description: Tertiary objectives will examine preferences for routes of administration, and preferences for THC / CBD ratios. Categorical factors will be summarized using frequencies and percentages, while continuous measure distributions will be described using means, standard deviations, and quartiles of interest.

Measure: Cannabis Route and Dosing

Time: Five years

Description: Incidence of Treatment-Related Adverse Events will be measured by Physician Global Assessment (PGA) numeric scale. Number of participants with Treatment-Related Adverse Events will be assessed by CTCAE v4.0.

Measure: Monitoring Adverse Events

Time: Five years
2 Exploring Brain Damages After COVID-19 Infection

Although direct evidence is currently lacking, the high identity between SARS-CoV-1 and SARS-CoV-2 suggests, that the latter viral strain could also infect the Central Nervous System (CNS). Indeed, some cases of SARS-COV2 encephalitis begin to be described and CNS damages are increasingly highlighted in the literature, but still not objectified by imaging and do not allow to explain the entire clinical patterns. We hypothesise that these CNS damages are not always objectified by Magnetic Resonance Imaging (MRI) but could be indirectly observed by a physiological dysfunction of neural conduction in the brainstem. We will explore brainstem disruption through an electrophysiological approach.

NCT04405986
Conditions
  1. SARS-CoV 2
Interventions
  1. Procedure: Auditory Evoked Potentials (AEP)
  2. Procedure: Blink and Masseter Inhibitory Reflex
MeSH:Brain Injuries

Primary Outcomes

Description: Latencies of electrophysiological responses with Auditory Evoked Potentials

Measure: Latency of electrophysiological response

Time: Inclusion (T0)

Description: Delay of Muscle contraction (Blink reflex)

Measure: Delay of Muscle contraction

Time: Inclusion (T0)

Description: Delay of silent period while the patient is asked to tighten the jaws (Masseter Inhibitory Reflex)

Measure: Delay of silent period

Time: Inclusion (T0)

Description: Duration of silent period while the patient is asked to tighten the jaws (Masseter Inhibitory Reflex)

Measure: Duration of silent period

Time: Inclusion (T0)

Description: Inhibition rate while the patient is asked to tighten the jaws (Masseter Inhibitory Reflex)

Measure: Inhibition rate

Time: Inclusion (T0)
3 COVID-19 and Disability: The Impact of a Societal Lockdown on Those With Spinal Cord and Brain Injuries

Document and evaluate the impact of societal restrictions due to the pandemic on SCI- and ABI-related disability and functional impairments, and the resultant effects on psychological wellbeing, physical wellbeing and quality of life for those with SCI/ABI.

NCT04426071
Conditions
  1. Brain Injuries
  2. Stroke
  3. Spinal Cord Injuries
MeSH:Brain Injuries Spinal Cord Injuries Wounds and Injuries

Primary Outcomes

Description: Fear of COVID-19 Questionnaire

Measure: Change in Fear of COVID-19

Time: baseline, 3 months, 6 months

Secondary Outcomes

Description: NeuroQol SF v1.0 - Ability to Part. in SRA

Measure: Change in ability to participate in social roles and activities

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Depression

Measure: Change in depressive symptoms

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Pos. Affect & Well-Being

Measure: Change in positive affect and well-being

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Anxiety

Measure: Change in anxiety

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Fatigue

Measure: Change in fatigue

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Emotional & Beh. Dyscontrol

Measure: Change in emotional and behavioural dyscontrol

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Satisfaction w SRA

Measure: Change in satisfaction with social roles and activities

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Sleep Disturbance

Measure: Change in sleep disturbance

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Stigma

Measure: Change in stigma

Time: baseline, 3 months, 6 months

Description: NeuroQol SF v1.0 - Cognitive Function

Measure: Change in cognitive function

Time: baseline, 3 months, 6 months

Description: 23 questions about strategies to social distance

Measure: Change in social distancing strategies used

Time: baseline, 3 months, 6 months

Description: 22 questions about social distancing

Measure: Change in thoughts and feelings about social distancing

Time: baseline, 3 months, 6 months
4 Severe Neurologic Injury Outcomes During COVID-19 Crisis

A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.

NCT04496076
Conditions
  1. Sars-CoV2
  2. Severe Neurologic Injury
  3. Ischemic Stroke
  4. Hemorrhagic Stroke
  5. Intracerebral Hemorrhage
  6. Subarachnoid Hemorrhage
  7. Traumatic Brain Injury
  8. Status Epilepticus
MeSH:Stroke Brain Injuries Brain Injuries, Traumatic Subarachnoid Hemorrhage Cerebral Hemorrhage Status Epilepticus Hemorrhage Wounds and Injuries
HPO:Cerebral hemorrhage Status epilepticus Stroke Subarachnoid hemorrhage

Primary Outcomes

Measure: In-hospital Mortality

Time: At hospital discharge, approximately 1 month

Measure: 30-day mortality

Time: 30 days post-hospital discharge

Secondary Outcomes

Description: Care treatment such as ventilator use, intubation, and/or tracheostomy

Measure: Limitations of patient care- Frequency of care not being provided

Time: During In-hospital course, up to 1 month

Measure: Limitations of patient care- Conversion of DNR/DNI/CMO status

Time: During In-hospital course, up to 1 month
5 Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients

Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications. At the actual context of the pandemic Coronavirus disease 2019 (COVID-19), neurological manifestations seem to be confirmed since in 85% of COVID-19 patients, present neurological symptoms, including anosmia, ageusia, periorbital pain, dizziness, fatigue, even moderate headache, moderate memory and/or behavioral disorders. However, these neurological manifestations are not well studied and their radiological features are not well described. It is therefore important to assess these potential neurological complications in COVID-19 patients. To the investigator knowledge, there is no previous study in the literature describing spectral brain changes in COVID + patients. Thus, the goal of this work is to describe the radiological semiology using MRI and particularly Magnetic Resonance Spectroscopic (MRS) biomarkers in the evaluation of acute and / or delayed brain damage in COVID + patients presenting a neurological manifestations that are initially related to the cranial nerves damage.

NCT04546737
Conditions
  1. Covid19
  2. Neurological Manifestations
  3. Brain Damage
Interventions
  1. Other: Magnetic Resonance Spectroscopy (MRS).
MeSH:Brain Injuries Neurologic Manifestations

Primary Outcomes

Description: The radiological semiology as described by MRI and particularly Magnetic Resonance Spectroscopic (MRS) biomarkers in the COVID-19 patients presenting neurological manifestations related initially to the cranial nerves damage.

Measure: Variation from baseline of MRI radiological semiology in COVID-19 patients

Time: 9 months after patient inclusion

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook