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D009422: Nervous System Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug626 COVID-19 swap test PCR Wiki 0.50
drug2999 Semi-structured telephone questionnaire Wiki 0.50
drug2596 Primary exposure is hypoxia (no intervention) Wiki 0.50
Name (Synonyms) Correlation
drug805 Collection of odour samples Wiki 0.50
drug3702 blood sample Wiki 0.16

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D003072 Cognition Disorders NIH 0.50
D009468 Neuromuscular Diseases NIH 0.50
D004827 Epilepsy NIH 0.50
Name (Synonyms) Correlation
D012640 Seizures NIH 0.35
D009461 Neurologic Manifestations NIH 0.20
D060825 Cognitive Dysfunction NIH 0.17
D020521 Stroke NIH 0.13
D014777 Virus Diseases NIH 0.05

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0001250 Seizure HPO 0.29
HP:0001268 Mental deterioration HPO 0.17
HP:0001297 Stroke HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 COVID-19 Prevalence, Morbidity and Long Term Cognitive Deficits in Consecutive Patients Presenting With Acute Neurological Symptoms

The purpose is to investigate the COVID-19 prevalence, associated morbidity and long-term cognitive deficits in consecutive patients presenting with acute neurological symptoms

NCT04377425
Conditions
  1. Neurological Diseases or Conditions
  2. Stroke, Acute
  3. Seizure Disorder
Interventions
  1. Diagnostic Test: COVID-19 swap test PCR
MeSH:Stroke Seizures Nervous System Diseases Epilepsy Cognition Disorders Cognitive Dysfunction
HPO:Bilateral tonic-clonic seizure Cognitive impairment Focal sensory seizure Focal-onset seizure Generalized-onset seizure Mental deterioration Seizure Stroke

Primary Outcomes

Description: To investigate the prevalence of COVID-19 infections in consecutive patients with acute onset of neurological symptoms (with or without prior neurological disease)

Measure: Prevalence of COVID-19 infection in consecutive patients with neurological symptoms

Time: 6 months

Secondary Outcomes

Description: Three months cognitive function (Montreal Cognitive Assessment) of COVID-19 positive patients compared to COVID-19 negative patients

Measure: Three months cognitive function of COVID-19 positive patients

Time: 3 months

Description: Characterization of the neurological symptoms in neurological COVID-19 positive patients (exploratory endpoint)

Measure: Clinical presentation of neurological symptoms in COVID-19 positive patients

Time: 6 months

Description: Prevalence of pre-symptomatic and asymptomatic COVID-19pos in acutely admitted patients with a primary complaint of neurological symptoms.

Measure: Prevalence of pre- and asymptomatic COVID-19 positive patients in acutely admitted neurological patients

Time: 6 months

Description: Prevalence of anosmia in COVID-19pos patients compared to COVID-19neg patients

Measure: Anosmia in COVID-19 positive patients

Time: 6 months

Description: Neuro-specific and inflammatory blood- and cerebrospinal fluid markers in COVID-19 positive patients compared to COVID-19 negative matched controls

Measure: Exploratory analysis on neuro-specific and inflammatory blood and cerebrospinal fluid markers of COVID-19 infection

Time: 24 months

Description: Functional and immunologic plasma assays will be employed to analyze proteins and pathways in coagulation and fibrinolysis

Measure: Exploratory analysis of the coagulation profile of COVID-19 positive patients compared to COVID-19neg patients

Time: 24 months
2 Evaluation of Biological Response to SARS-COV2 in Patients With Pre-existing Neurological Disease or With New Neurological Manifestations of COVID-19

Patients with neurological or psychiatric symptoms or pre-existing disease will be sampled (blood for serum and DNA or saliva for DNA) at inclusion and at M6 (blood) and M12 (blood) depending on their pathology. Sampling will be done either at hospital if patient is on site for routine care or at home if no consultation is scheduled at hospital.

NCT04568707
Conditions
  1. Covid19
  2. Neurologic Manifestations
  3. Psychiatric Manifestations
Interventions
  1. Other: blood sample
MeSH:Nervous System Diseases Neurologic Manifestations

Primary Outcomes

Description: dosage of seric markers (anti-SARS-CoV2 IgG) or genetic markers (genetic variants) observed during COVID 19 infection in patients

Measure: dosage of seric markers (anti-SARS-CoV2 IgG) or genetic markers (genetic variants) observed during COVID 19 infection in patients

Time: 12 months

Secondary Outcomes

Description: Neurodegenerative markers (e.g., neurofilaments) associated with a neurological or psychiatric manifestation of Covid-19 infection

Measure: Serum neurofilaments

Time: 12 months
3 Perceptions of the Clinical and Psychosocial Impact of Covid-19 in Patients With Neuromuscular and Neurological Disorders

This study aims to evaluate perceived clinical and psychosocial experiences of patients and their families during the Covid-19 pandemic. it is important to understand the implications of the pandemic for this population, particularly given its likely protracted course, and resultant limitations to daily activities and clinical care. This will help clinicians plan support and adaptations to the services they provide in the medium to long term.

NCT04581577
Conditions
  1. Neuromuscular Diseases
  2. Neurological Diseases or Conditions
Interventions
  1. Other: Semi-structured telephone questionnaire
MeSH:Neuromuscular Diseases Nervous System Diseases

Primary Outcomes

Description: Evaluation of semi-structured questionnaires using thematic analysis

Measure: Qualitative evaluation of the perceived clinical and psychosocial impact of the Covid-19 pandemic in patients with neuromuscular and neurological disorders

Time: 4 months

Secondary Outcomes

Description: Quantitative analysis of the proportion of questionnaire respondents reporting confirmed or suspected Covid-19 infection

Measure: Quantification of the proportion of patients with NMD who have had suspected or confirmed Covid-19 infection during the pandemic

Time: 4 months

Description: Qualitative analysis describing the social environment of patients with NMDs

Measure: Qualitative evaluation of the social environment of patients with NMDs

Time: 4 months

Description: Qualitative analysis describing the social activities of patients with NMDs

Measure: Qualitative evaluation of the social activities of patients with NMDs

Time: 4 months

Description: Qualitative analysis describing the professional activities of patients with NMDs

Measure: Qualitative evaluation of the professional activities of patients with NMDs

Time: 4 months

Description: Evaluation of semi-structured questionnaires using thematic analysis

Measure: Qualitative evaluation of the impact of the Covid-19 pandemic on families of patients with neuromuscular and neurological disorders

Time: 4 months

Description: Evaluation of semi-structured questionnaires using thematic analysis

Measure: Qualitative evaluation of concerns regarding medical care from the perspective of patients with NMDs and their families during the Covid-19 pandemic

Time: 4 months
4 COVID-19 Neurological Disease: A Prospective Study in Brazil, India and Malawi

Background: Recent reports increasingly recognize neurological manifestations in COVID-19 patients. However, the full spectrum of the disease and risk factors are not well understood. Aim: To describe the full spectrum of neurological manifestations in COVID-19 and assess the clinical characteristics, risks and prognostic factors. Outcomes: Identification of COVID-19 associated neurological disease is the primary outcome while requirement for admission to critical care unit, mortality, length of hospital stay, quality of life, and neurological disability are the secondary outcomes. Participants: Patients above Age more than 18 years enrolled based on new-onset acute neurological disease and COVID19 positive will serve as cases while patient with confirmed COVID-19 without neurological manifestation will serve as controls. Design and Procedures: The study is prospective case control in design and is divided into three phases in India, Brazil and Malawi ; the first phase will address role of hypoxia in causation of neurological diseases, the second phase will compare characteristics of patients hospitalized with COVID-19 with and without neurological disease and the third phase will assess the long-term follow up (at 3 months and 9 months) of cases.

NCT04672590
Conditions
  1. Diseases of the Nervous System
  2. Other Specified Viral Diseases
Interventions
  1. Other: Primary exposure is hypoxia (no intervention)
MeSH:Virus Diseases Nervous System Diseases

Primary Outcomes

Measure: Acute new-onset neurological disease

Time: Day 30 of admission, or at discharge, or at death, whichever is earlier

Secondary Outcomes

Measure: Admission to a critical (intensive/high dependency) care unit

Time: Day 30 of admission, or at discharge, or at death, whichever is earlier

Measure: Time to discharge from hospital

Time: Day 30 of admission, or at discharge, or at death, whichever is earlier

Description: A score made up of 11 elements. Total min 0; max 42. Lower is better; 0 can be scored if the person has full function in every element of the assessment.

Measure: Severity of stroke using National Institutes of Health Stroke Scale (NIHSS)

Time: Day 30 of admission, or at discharge, or at death, whichever is earlier

Description: An ordinal scale, from 1 = death (minimum; worst outcome) to 8 = upper good recovery (maximum; best outcome).

Measure: Glasgow Outcome Scale Extended

Time: Discharge (or day 30), 3 months and 9 months

Description: Modified Rankin Score using a simplified algorithm by Bruno et al 2010. An ordinal scale, from 0 = no symptoms at all (minimum; best outcome) to 6 = dead (maximum; worst outcome).

Measure: Modified Rankin Score

Time: Discharge (or day 30), 3 months and 9 months

Description: Montreal Cognitive Assessment (MoCA), using a full test at discharge (or day 30) and a telephone test at 3 months and 9 months

Measure: Montreal Cognitive Assessment (MoCA)

Time: Discharge (or day 30), 3 months and 9 months

Description: Development of new onset neurological sequelae e.g.epilepsy, new/recurrent stroke, cognitive decline, encephalitis

Measure: Development of new onset neurological sequelae

Time: Discharge (or day 30), 3 months and 9 months

Description: A questionnaire scoring 5 domains of quality of life at ordinal levels of 1-3 each (1 = best; 3 = worst), plus an overall health state score from 0 to 100 on a visual analog scale (0 = worst; 100 = best).

Measure: European QoL-5D (EQ-5D-3L) overall health utility quality of life score

Time: Discharge (or day 30), 3 months and 9 months

Measure: Death

Time: In-hospital (up to 30 days from admission), and at 3 months and 9 months

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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