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D009196: Myeloproliferative Disorders

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug1140 Electronic Health Record Review Wiki 0.41
drug1011 Diagnostic Laboratory Biomarker Analysis Wiki 0.41
drug453 Biospecimen Collection Wiki 0.29
Name (Synonyms) Correlation
drug2687 Questionnaire Administration Wiki 0.17

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D009190 Myelodysplastic Syndromes NIH 0.41
D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma NIH 0.41
D015451 Leukemia, Lymphocytic, Chronic, B-Cell NIH 0.33
Name (Synonyms) Correlation
D007938 Leukemia, NIH 0.29
D008223 Lymphoma, NIH 0.24
D009369 Neoplasms, NIH 0.21

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0005547 Myeloproliferative disorder HPO 0.82
HP:0002664 Neoplasm HPO 0.11

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Myeloproliferative Neoplasms (MPN) and COVID-19

An increased risk of both venous and arterial thromboembolism was noted in reports from SARS-CoV-2-infected patients in China and has been confirmed in autopsy findings from patients who experienced sudden death. Myeloproliferative Neoplasms (MPNs), which encompass polycythemia vera, essential thrombocythemia and primary myelofibrosis, are thrombophilic disorders with a natural propensity to thrombosis that is fuelled by the intrinsic activation of inflammatory cytokines. It therefore follows that an underlying diagnosis of MPN may increase the risk of worse clinical outcomes and death during periods of active Covid-19 disease. This ambispective, observational study aims to elucidate the key factors which affect the clinical course of patients with MPN who develop Covid-19 disease.

NCT04385160
Conditions
  1. Myeloproliferative Neoplasm
  2. COVID
MeSH:Neoplasms Myeloproliferative Disorders
HPO:Myeloproliferative disorder Neoplasm

Primary Outcomes

Description: Incidence of cases of MPN patients with COVID-19 experiencing pulmonary embolism

Measure: pulmonary embolism (PE)

Time: 2 and a half months

Secondary Outcomes

Description: Incidence of cases reporting at least one fatal or non fatal thrombotic event reported in therapy of MPN

Measure: fatal or non fatal thrombotic event

Time: 2 and a half months

Description: Incidence of cases reporting at least one COVID-19 worsening outcome as Continuous Positive Airway Pressure (CPAP)

Measure: Continuous Positive Airway Pressure (CPAP)

Time: 2 and a half months

Description: Incidence of cases reporting at least one COVID-19 worsening outcome as invasive ventilation

Measure: invasive ventilation

Time: 2 and a half months

Description: Incidence of cases reporting at least one COVID-19 worsening outcome as Intensive Care Unit (ICU)

Measure: admission in Intensive Care Unit (ICU)

Time: 2 and a half months

Description: incidence of death

Measure: death

Time: 2 and a half months

Description: Type of treatments and interventions applied for MPN during COVID-19 and any change reported in therapy of MPN

Measure: treatments and interventions applied for MPN

Time: 2 and a half months

Description: Type of treatments and interventions applied for COVID-19

Measure: treatments and interventions applied for COVID-19

Time: 2 and a half months

Description: Odds Ratios (ORs) of the outcome and 95% Confidence Intervals (CIs) associated with patients' characteristics and treatments

Measure: thrombotic events association to patients characteristic and treatments

Time: 2 and a half months
2 Observational Study of the Impact of the COronaVirus Disease 2019 (COVID-19) Epidemic on Patients With Myeloproliferative Neoplasias

The classic myeloproliferative neoplasias (MNP), including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) or secondary to PV or ET, are among the most frequent of malignant hemopathies, with overall prevalence estimated at around 10,000 patients followed in France. Due to the median age of patients around 65, the frequency of cardiovascular complications of these thrombogenic diseases and the impact of cytoreductive treatments on immune cells, these patients are considered to be at risk of developing forms severe of COVID-19. This study will assess the impact of MNPs on the risk of developing a severe form of COVID-19, identify new risk factors linked to the disease as well as the impact of treatments for MNPs according to their pharmacological class.

NCT04416438
Conditions
  1. Myeloproliferative Neoplasm
  2. COVID-19 Infection
MeSH:Myeloproliferative Disorders
HPO:Myeloproliferative disorder

Primary Outcomes

Description: The crude rate of cumulative incidence of serious infection proven to COVID-19, compared to the population of the same age, same sex, same region of residence during the epidemic period.

Measure: Rate of serious coronavirus infection in different MNP patient subgroups

Time: Through inclusion period, an average of 6 months

Description: Number of MNP patients who had COVID-19 compared to general population in France

Measure: Proportion of MNP patients who had COVID-19 infection during the 2020 epidemic.

Time: Through inclusion period, an average of 6 months

Description: Number of MNP patients who died from COVID-19

Measure: Rate of death of MNP patients who had COVID-19

Time: Through study completion, an average of 1 year

Description: Number of MNP patients hospitalized in intensive care with need for mechanical ventilation

Measure: Rate of passages in intensive care with need for mechanical ventilation

Time: Through study completion, an average of 1 year
3 Observational Study of SARS-CoV-2 Donor-Recipient Immunity Transfer

This study investigates whether donors with previous exposure to COVID-19 can pass their immunity by hematopoietic (blood) stem cell transplant (HCT) donation to patients that have not been exposed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the COVID19 infection. This study may provide critical information for medical decision-making and possible immunotherapy interventions in immunocompromised transplant recipients, who are at high risk for COVID19 severe illness.

NCT04666025
Conditions
  1. Accelerated Phase CML, BCR-ABL1 Positive
  2. Acute Lymphoblastic Leukemia
  3. Acute Myeloid Leukemia
  4. Chronic Lymphocytic Leukemia
  5. Chronic Phase CML, BCR-ABL1 Positive
  6. COVID-19 Infection
  7. Hematopoietic and Lymphoid Cell Neoplasm
  8. Hodgkin Lymphoma
  9. Lymphoblastic Lymphoma
  10. Myelodysplastic Syndrome
  11. Myelofibrosis
  12. Myeloproliferative Neoplasm
  13. Non-Hodgkin
  14. Non-Hodgkin Lymphoma
Interventions
  1. Procedure: Biospecimen Collection
  2. Other: Diagnostic Laboratory Biomarker Analysis
  3. Other: Electronic Health Record Review
  4. Other: Questionnaire Administration
MeSH:Lymphoma Leukemia Neoplasms Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Lymphocytic, Chronic, B-Cell Myelodysplastic Syndromes Myeloproliferative Disorders
HPO:Chronic lymphatic leukemia Leukemia Lymphoma Myelodysplasia Myeloproliferative disorder Neoplasm

Primary Outcomes

Description: Testing for SARS-CoV-2 antibodies will be performed on serum samples using in house developed enzyme-linked immunosorbent assay (ELISA). The qualitative assays will be developed to investigate Spike subunit 1 (S1)-specific antibodies of the IgG, IgM and IgA subclasses in serum and saliva samples. All SARS-Cov-2 seropositive donor-HCT recipient pairs patients will undergo cellular immunogenicity evaluations using flow cytometry. The data analysis for estimating the effect of donor immunity transfer on functional cellular immunity through time will be exploratory in nature and will focus on graphical display and summary statistics. Longitudinal levels of T cells specific for SARS-CoV-2 S will be measured as a correlate of immunity transfer efficiency.

Measure: Severe acute respiratory syndrome (SARS)-Coronavirus 2 (CoV-2) Spike protein (S)-specific IgG concentration and T cell levels

Time: Up to 180 days post-hematopoietic stem cell transplant (HCT)

Description: Testing for SARS-CoV-2 antibodies will be performed on serum samples using in house developed ELISA. The qualitative assays will be developed to investigate nucleocapsid (N)-specific antibodies of the IgG, IgM and IgA subclasses in serum and saliva samples. All SARS-Cov-2 seropositive donor-HCT recipient pairs patients will undergo cellular immunogenicity evaluations using flow cytometry. The data analysis for estimating the effect of donor immunity transfer on functional cellular immunity through time will be exploratory in nature and will focus on graphical display and summary statistics. Longitudinal levels of T cells specific for SARS-CoV-2 N antigens will be measured as a correlate of immunity transfer efficiency.

Measure: SARS-CoV-2 nucleocapsid protein (N) -specific IgG concentration and T cell levels

Time: Up to 180 days post-HCT

Description: Evaluation of SARS-CoV-2 neutralizing antibody titers in serum samples will be performed using SARS-CoV-2 lentiviral-pseudovirus based on published protocols. Spike incorporation into the pseudovirus will be verified and quantified by western blot using Spike-specific antibodies (Sino Biological) and by ELISA using Spike Detection kit (Sino Biological), respectively.

Measure: SARS-CoV-2 neutralizing antibodies

Time: Up to 180 days post-HCT

Secondary Outcomes

Description: Testing for SARS-CoV-2 antibodies will be performed on serum samples using in house developed ELISA.

Measure: SARS-CoV-2 IgA concentration

Time: Up to 180 days post-HCT

Other Outcomes

Description: The data analysis for estimating the effect of donor immunity transfer on functional cellular immunity through time will be exploratory in nature and will focus on graphical display and summary statistics. Longitudinal levels of T cells specific for SARS-CoV-2 S or SARS-CoV-2 N antigens will be measured as a correlate of immunity transfer efficiency.

Measure: SARS-CoV-2 -specific T cell memory profile and associated function

Time: Up to 180 days post-HCT

HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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