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D024821: Metabolic Syndrome

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug3872 metformin glycinate Wiki 1.00
drug2858 SARS-CoV-2 Wiki 0.50
drug2514 Placebo oral tablet Wiki 0.17

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D003924 Diabetes Mellitus, Type 2 NIH 0.29
D013577 Syndrome NIH 0.10
D045169 Severe Acute Respiratory Syndrome NIH 0.04
Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0005978 Type II diabetes mellitus HPO 0.29

Clinical Trials

Navigate: Correlations   HPO

There is one clinical trial.


1 Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.

The purpose of this study is to evaluate the efficacy and safety of metformin glycinate at dose of 620 mg twice per day plus standard treatment comparing to standard treatment alone (we will use placebo) of patients who have metabolic syndrome or type 2 diabetes, which have severe acute respiratory syndrome secondary to SARS-CoV-2.

NCT04626089
Conditions
  1. Severe Acute Respiratory Syndrome Coronavirus 2
  2. Metabolic Syndrome
  3. Type 2 Diabetes
Interventions
  1. Drug: metformin glycinate
  2. Drug: Placebo oral tablet
MeSH:Coronavirus Infections Severe Acute Resp Severe Acute Respiratory Syndrome Diabetes Mellitus, Type 2 Metabolic Syndrome Syndrome
HPO:Type II diabetes mellitus

Primary Outcomes

Description: Assess differences in SARS-CoV-2 viral load between participants that receive placebo vs metformin glycinate

Measure: Viral Load

Time: Day 0 to Day 8 or patient discharge day

Secondary Outcomes

Description: Assess length of supplementary oxygen

Measure: Days of supplementary oxygen if apply

Time: Day 0 to day 28 or patient discharge day

Description: Assess length of mechanical ventilation

Measure: Days of supplementary mechanical ventilation if apply

Time: Day 0 to day 28 or patient discharge day

Description: Assess length of hospitalization

Measure: Days of Hospitalization

Time: Day 0 to day 28 or patients discharge day

Description: Assess the difference in the Proportion of participants with normalization of fever between participants that receive placebo vs the patients with metformin glycinate

Measure: Normalization of fever

Time: Day 0 to day 28 or patient discharge day

Description: Assess the difference in the Proportion of participants with normalization of oxygen saturation between participants that receive placebo vs the patients with metformin glycinate

Measure: Normalization of oxigen saturation

Time: Day 0 to day 28 or patient discharge day

Description: Assess the difference in the number of deaths between participants who received placebo versus the patients with metformin glycinate

Measure: Number of deaths

Time: Day 0 to day 28 or patient discharge day

Description: Evaluate if the level increase or decrease in serum creatinine compared to baseline. units: mg/dl

Measure: Change in Serum creatinine levels

Time: Day 0 to day 28 or patients discharge day

Description: Evaluate if the level increase or decrease in serum Creatine kinase-MB compared to baseline. Units: UI/l

Measure: Change in serum Troponin I

Time: Day 0 to day 28 or patients discharge day

Description: Evaluate if the level increase or decrease in serum aspartate aminotransferase compared to baseline. units: IU/l

Measure: Change in serum aspartate aminotransferase levels

Time: Day 0 to day 28 or patients discharge day

Description: Evaluate if the level increase or decrease in serum Creatine kinase-MB compared to baseline. Units: UI/l

Measure: Change in serum Creatine kinase-MB levels

Time: Day 0 to day 28 or patients discharge day

Description: Assess by incidence of grade 3, grade 4 and Serious adverse events

Measure: Incidence of adverse event

Time: Day 0 to day 28 or patients discharge day

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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Python example via Google Colab Notebook