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D012818: Signs and Symptoms, Respiratory

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug213 Anakinra plus oSOC Wiki 0.50
drug3788 gammaCore® Sapphire (non-invasive vagus nerve stimulator) Wiki 0.50
drug3915 oSOC Wiki 0.50
Name (Synonyms) Correlation
drug3152 Standard of care therapies Wiki 0.50
drug3787 gammaCore® (Vagus nerve stimulation) Wiki 0.50
drug3554 Vielight RX Plus Wiki 0.50
drug184 Airway pressure release ventilation Wiki 0.50

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D013577 Syndrome NIH 0.05
D012127 Respiratory Distress Syndrome, Newborn NIH 0.04
D055371 Acute Lung Injury NIH 0.04
Name (Synonyms) Correlation
D012128 Respiratory Distress Syndrome, Adult NIH 0.04
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Efficacy and Safety of ANAkinra During Adult " COVID-19 " With Aggravating Respiratory Symptoms: a Multicenter Open-label Controlled Randomized Trial

The main objective of the ANACONDA-COVID-19 trial is to assess the efficacy of Anakinra + optimized Standard of Care (oSOC) as compared to oSOC alone on the condition of patients with COVID-19 infection and worsening respiratory symptoms. Success defined as patient alive and free of invasive mechanical ventilation (IMV) and free of Extracorporeal Membrane Oxygenation (ECMO) at Day 14.

NCT04364009
Conditions
  1. COVID-19 Infection
  2. ANAKINRA Treatment
  3. Optimized Standard of Care (oSOC)
Interventions
  1. Drug: Anakinra plus oSOC
  2. Drug: oSOC
MeSH:Signs and Symptoms, Respiratory

Primary Outcomes

Description: The primary endpoint is treatment success at Day 14, defined as a patient alive and not requiring any of the following: Invasive mechanical ventilation (IMV) or Extracorporeal membrane oxygenation (ECMO).

Measure: Treatment success

Time: After 14 days of treatment

Secondary Outcomes

Description: Defined as a patient alive and not requiring any of the following: Invasive mechanical ventilation (IMV) or Extracorporeal membrane oxygenation (ECMO).

Measure: Treatment success

Time: After 3 days, 10 days and 28 days of treatment

Description: 1. Not hospitalized, no limitations on activities 2. Not hospitalized, limitation on activities; 3. Hospitalized, not requiring supplemental oxygen; 4. Hospitalized, requiring supplemental oxygen; 5. Hospitalized, on non-invasive ventilation or high flow oxygen devices;6. Hospitalized, on invasive mechanical ventilation or ECMO;7. Death.

Measure: OMS progression scale (on a 7 point ordinal scale)

Time: After 3 days, 10 days, 14 days and 28 days of treatment

Description: Overall survival

Measure: Overall survival

Time: After 3 days, 10 days, 14 days and 28 days of treatment

Description: Time to ICU admission

Measure: Time to ICU admission

Time: Up to 28 days

Description: Time to ventilatory support : extracorporeal membrane oxygenation (ECMO), invasive mechanical ventilation, non-invasive ventilation, high flow oxygen therapy)

Measure: Time to ventilatory support

Time: Up to 28 days

Description: The National Early Warning Score (NEWS) determines the degree of illness of a patient using six physiological findings and one observation. Score from 0 to 20, 0 mean a worse outcome, 20 mean a better outcome

Measure: Change in National Early Warning Score (NEW)from baseline to Day 3, Day 10, Day 14 and Day 28

Time: After 3 days, 10 days, 14 days and 28 days of treatment

Description: C-reactive proteine (mg/L)

Measure: Change in inflammatory parameter

Time: From baseline to Day 3, Day 10, Day 14 and Day 28

Description: ferritin (ng/mL)

Measure: Change in inflammatory parameter

Time: From baseline to Day 3, Day 10, Day 14 and Day 28

Description: lymphocyte count (G/L)

Measure: Change in inflammatory parameter

Time: From baseline to Day 3, Day 10, Day 14 and Day 28

Description: fibrinogen (g/l)

Measure: Change in inflammatory parameter

Time: From baseline to Day 3, Day 10, Day 14 and Day 28

Description: Hospital length of stay

Measure: Hospital length of stay

Time: Up to 28 days

Description: Need for Vasopressors (yes or no)

Measure: ICU parameter

Time: Up to 28 days

Description: Evolution of SpO2/FIO2 ratio (no unit)

Measure: ICU parameter

Time: Up to 28 days

Description: Evolution of PaO2/FiO2 ratio (no unit)

Measure: ICU parameter

Time: Up to 28 days

Description: Occurrence of serious adverse events during the study, including infection (bacterial, parasitic, mycotic and viral infection), septic shock, Ankanira hypersensitivity, hepatic damages (SGOT/SGPT, alkaline phosphatase, gammaGT) and neutropenia (Blood count).

Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

Time: Up to 28 days

Description: The correlation between several of clinical parameters at inclusion (including level of oxygen requirement (saturation), respiratory rate (per min), temperature (°C)…), biological parameters :including, CRP (mg/L), ferritin (µg/L), LDH (UI/L), lymphocyte count (G/L), eosinophil count (G/L), Ddimers (ng/mM), platelet count (G/L), polymorphonuclear count (G/L)...with the primary end point will be explored.

Measure: Predictors of efficacy of Anakinra

Time: After 14 days of treatment
2 A Prospective, Randomized, Controlled Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIOR)

The purpose of this study is to asses the efficacy of the Gammacore device reducing the need for mechanical ventilation in patients diagnosed of Covid-19

NCT04368156
Conditions
  1. Covid-19
Interventions
  1. Device: gammaCore® (Vagus nerve stimulation)
MeSH:Signs and Symptoms, Respiratory

Primary Outcomes

Measure: Need for mechanical ventilation

Time: From randomization to hospital discharge or ICU admission, whatever occurs first, assessed up to two months

Secondary Outcomes

Measure: Supplemental oxygen requirements

Time: From randomization to hospital discharge or ICU admission, whatever occurs first, assessed up to two months

Measure: Mortality

Time: From randomization to hospital discharge or ICU admission, whatever occurs first, assessed up to two months

Measure: Delay onset of ventilation

Time: From randomization to the day of need for mechanical ventilation or hospital discharge, whatever occurs first, assessed up to two months

Measure: Cytokine levels

Time: From randomization to hospital discharge or ICU admission, whatever occurs first, assessed up to two months
3 A Prospective, Randomized, Controlled Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIORII)

The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care (active) vs. standard of care alone (SoC), the control group. The gammaCore® (nVNS) treatments will be used acutely and prophylactically. The active and control groups will be diseased and severity matched. The primary objective is to reduce initiation of mechanical ventilation in patients with CoViD-19 compared to the control group. Secondary objectives are to evaluate cytokine trends/prevent cytokine storms, evaluate supplemental oxygen requirements, decrease mortality of CoViD-19 patients and to delay the onset of mechanical ventilation.

NCT04382391
Conditions
  1. COVID
  2. Corona Virus Infection
  3. Respiratory Failure
  4. Respiratory Distress Syndrome, Adult
  5. ARDS, Human
  6. SARS (Severe Acute Respiratory Syndrome)
Interventions
  1. Device: gammaCore® Sapphire (non-invasive vagus nerve stimulator)
  2. Other: Standard of care therapies
MeSH:Severe Acute Respiratory Syndrome Coronavirus Infections Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Respiratory Insufficiency Acute Lung Injury Syndrome Signs and Symptoms, Respiratory

Primary Outcomes

Description: measure the change (in hours) between the control group and treatment group

Measure: change in initiation of mechanical ventilation in patients with CoViD-19 compared to the control group.

Time: From the time of randomization until the time of initiation of mechanical ventilation, assessed up to day of discharge or death, whichever occurs first, assessed up to 3 months

Secondary Outcomes

Description: measure the changes in the serum/plasma concentrations of TH1 and TH2-type cytokines

Measure: evaluate cytokine trends

Time: From the time of initial blood draw until the time of final blood draw, assessed up to date of mechanical ventilation, death, or discharge from hospital, whichever occurs first,assessed up to 3 months

Description: compare the difference in oxygen requirements (liters/min) between the control group and active group for patients admitted to the hospital for CoViD-19.

Measure: evaluate supplemental oxygen requirements

Time: From the time of randomization, assessed up to time of mechanical ventilation, day of discharge or death, whichever occurs first,assessed up to 3 months

Description: measure the change (in hours) to death between control group and treatment group

Measure: decrease mortality of CoViD-19 patients

Time: From the time or randomization until the date of death from any cause, assessed up to day of discharge or death,assessed up to 3 months

Description: measure the change (in hours) to time of mechanical ventilation between control group and treatment group

Measure: delay onset of ventilation

Time: From the time of randomization until the time of initiation of mechanical ventilation, assessed up to day of discharge or death, whichever occurs first,assessed up to 3 months
4 A Randomized Study Evaluating the Efficacy of the Vielight RX Plus in the Treatment of COVID-19 Respiratory Symptoms

The objective of this study is to obtain data on the efficacy of the Vielight RX Plus in decreasing time to recovery of symptoms in subjects with COVID-19. The study will be conducted among COVID-19 positive subjects at home in self-isolation via electronic data collection (EDC). There will be no physical contact between the subjects and the Qualified Investigator (QI) or other study staff. This study aims to demonstrate that the Vielight RX Plus is a useful adjunct to standard of care (SOC). We hypothesize that the Vielight RX Plus will accelerate recovery and reduce viral infection severity.

NCT04418505
Conditions
  1. COVID-19
Interventions
  1. Device: Vielight RX Plus
MeSH:Signs and Symptoms, Respiratory

Primary Outcomes

Measure: Time to recovery

Time: 30 days

Secondary Outcomes

Measure: Time to elimination of COVID-19 related symptoms

Time: 30 days

Measure: Mean number of days with mild COVID-19 related symptoms

Time: 30 days

Measure: Mean number of days with mild overall respiratory symptoms

Time: 30 days

Measure: Time to symptom reduction

Time: 30 days

Measure: Time to elimination of symptoms

Time: 30 days

Measure: Average number of days with mild respiratory symptoms

Time: 30 days

Measure: Oxygen saturation

Time: 30 days

Measure: Hospitalization rate

Time: 30 days

Measure: Mortality

Time: 30 days

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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706 reports on MeSH terms

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