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D007154: Immune System Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug1801 Local standard of care Wiki 0.45
drug953 DWJ1248 Wiki 0.45
drug1211 Exercise training group Wiki 0.45
Name (Synonyms) Correlation
drug665 CYNK-001 Wiki 0.45
drug486 Blood tests sputum, nasal lavage and brushing Wiki 0.45
drug791 Colchicine Wiki 0.12
drug2448 Placebo Wiki 0.02

Correlated MeSH Terms (18)


Name (Synonyms) Correlation
D006453 Hemoglobinopathies NIH 0.45
D030341 Nidovirales Infections NIH 0.32
D051436 Renal Insufficiency, Chronic NIH 0.26
Name (Synonyms) Correlation
D007674 Kidney Diseases NIH 0.20
D002908 Chronic Disease NIH 0.20
D003333 Coronaviridae Infections NIH 0.20
D012327 RNA Virus Infections NIH 0.16
D008171 Lung Diseases, NIH 0.10
D012140 Respiratory Tract Diseases NIH 0.09
D012141 Respiratory Tract Infections NIH 0.07
D011024 Pneumonia, Viral NIH 0.05
D014777 Virus Diseases NIH 0.05
D012128 Respiratory Distress Syndrome, Adult NIH 0.03
D003141 Communicable Diseases NIH 0.03
D011014 Pneumonia NIH 0.02
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (5)


Name (Synonyms) Correlation
HP:0012622 Chronic kidney disease HPO 0.32
HP:0000077 Abnormality of the kidney HPO 0.22
HP:0002088 Abnormal lung morphology HPO 0.10
Name (Synonyms) Correlation
HP:0011947 Respiratory tract infection HPO 0.07
HP:0002090 Pneumonia HPO 0.02

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 A Phase I/II Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) for the Treatment of Adults With COVID-19

This study is a Phase 1 / 2 trial to determine the safety and efficacy of CYNK-001, an immunotherapy containing Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded, in patients with moderate COVID-19 disease.

NCT04365101
Conditions
  1. Coronavirus
  2. Coronavirus Infection
  3. Severe Acute Respiratory Syndrome Coronavirus 2
  4. Pneumonia
  5. Pneumonia, Viral
  6. Lung Diseases
  7. Respiratory Tract Disease
  8. Respiratory Tract Infections
  9. Coronaviridae Infections
  10. Nidovirales Infections
  11. RNA Virus Infections
  12. Virus Disease
  13. Immunologic Disease
  14. ARDS
  15. Immunologic Factors
  16. Physiological Effects of Drugs
  17. Antiviral Agents
  18. Anti-infective Agents
  19. Analgesics
  20. Antimetabolites, Antineoplastic
Interventions
  1. Biological: CYNK-001
MeSH:Infection Communicable Diseases Respiratory Tract Infections Virus Diseases Coronavirus I Coronavirus Infections Severe Acute Respiratory Syndrome Pneumonia, Viral RNA Virus Infections Coronaviridae Infections Nidovirales Infections Pneumonia Lung Diseases Respiratory Tract Diseases Immune System Diseases
HPO:Abnormal lung morphology Pneumonia Respiratory tract infection

Primary Outcomes

Description: Number and severity of adverse events

Measure: Phase 1: Frequency and Severity of Adverse Events (AE)

Time: Up to 6 months

Description: Proportion of subjects with "negative" measurement of COVID-19 by rRT-PCR

Measure: Phase 1: Rate of clearance of SARS-CoV-2

Time: Up to 6 months

Description: Proportion of subjects who improved clinical symptoms related to lower respiratory tract infection, as measured by National Early Warning Score 2 (NEWS2) score.

Measure: Phase 1: Rate of clinical improvement

Time: Up to 6 months

Description: Time from the date of randomization to the clearance of SARS-CoV-2 by rRT-PCR. Negative results will need to be confirmed by a second negative result in the same sample type at least 24 hours after the first negative result.

Measure: Phase 2: Time to Clearance of SARS-CoV-2

Time: Up to 28 days

Description: Time from the date of randomization to the first date of improved clinical symptoms related to lower respiratory tract infection. Improvement as measured by National Early Warning Score 2 (NEWS2) Score.

Measure: Phase 2: Time to Clinical Improvement by NEWS2 Score

Time: Up to 28 days

Secondary Outcomes

Description: Proportion of subjects with "negative" measurement of COVID-19 by rRT-PCR

Measure: Rate of Clearance of SARS-CoV-2

Time: Up to 6 months

Description: Number and severity of adverse events

Measure: Phase 2: Frequency and Severity of Adverse Events (AE)

Time: up to 6 months

Description: Time to medical discharge as an assessment of overall clinical benefit

Measure: Overall Clinical Benefit by time to medical discharge

Time: up to 6 months

Description: Hospital utilization will be measured as an assessment of overall clinical benefit

Measure: Overall Clinical Benefit by hospital utilization

Time: up to 6 months

Description: Mortality rate will be measured as an assessment of overall clinical benefit

Measure: Overall Clinical Benefit by measuring mortality rate

Time: up to 6 months

Description: Assess the impact of CYNK-001 on changes in sequential organ failure assessment (SOFA) score.

Measure: Impact of CYNK-001 on sequential organ failure assessment (SOFA) score

Time: Up to 28 days

Description: Time from randomization to the date of disappearance of virus from lower respiratory tract infection (LRTI) specimen where it has previously been found (induced sputum, endotracheal aspirate).

Measure: Time to Pulmonary Clearance

Time: Up to 28 days

Description: For ventilatory support subjects, the days with supplemental oxygen-free.

Measure: Supplemental oxygen-free days

Time: Up to 28 days

Description: Proportion of subjects who need invasive or non-invasive ventilation

Measure: Proportion of subjects requiring ventilation

Time: Up to 28 days
2 Whole Blood Immune Cells Characterization in Critically Ill COVID-19 Patients: A Prospective Study

SARS-CoV-2 outbreak causes a spectrum of clinical patterns that varies from asymptomatic infection to mildly symptomatic manifestations and more-severe forms that need intensive care. Until now, the immune response to SARS-CoV-2 virus infection has been poorly reported to help decision for immune modulation therapies. As a consequence, trials have been designed to test both anti-inflammatory molecules as steroids or anti-bodies against IL-6, and others proposing to "boost" immunity with interferon beta based on similar inclusion criteria. The immune response to infective agents including viruses may have a complex time evolution with early and late phases corresponding to different patterns, oscillating between pro-inflammation and immune-depression. The potential window to improve outcome in COVID-19 by therapeutic intervention aimed at a fine tuning between immune toxicity and immunodepression requires a longitudinal assessment during the course of illness, especially for the patients who develop acute respiratory failure. Immune monitoring of both innate and adaptive immunity would then be essential to appropriately design clinical trials. The whole blood cells evaluation was recorded according to the time intervals between the onset of symptoms and the sampling after ICU admission. Patients' care was standardized, especially with regard to ventilation, sedation, and antimicrobial treatment. In this study the investigators prospectively perform a longitudinal study of both innate and adaptive immunity on patients admitted to ICU for an COVID-19 related acute respiratory failure. The data will be analyzed in reference to the onset of initial symptoms and also to the admission in ICU. The primary end point is the evolution of the characterization of monocytes and their subsets in term of number and expression of HLA-DR. A similar approach is used for lymphocytes and their subtypes with in addition, an ex vivo testing of their capabilities to be stimulated by SARS-CoV-2 viral proteins in term of TNFalpha, INFgamma, and IL1beta production. The secondary end-point was to test the association with outcomes and other non-specific markers of inflammation as CRP (C reactive protein), PCT (procalcitonin), DDimers and ferritin.

NCT04386395
Conditions
  1. SARS-CoV-2
  2. Immune System Disorder
MeSH:Immune System Diseases

Primary Outcomes

Description: circulating immune cell characterization

Measure: Changes in monocytes HLA-DR expression

Time: through ICU stay, an average of 30 days

Description: circulating immune cell characterization

Measure: Changes in lymphocytes subpopulations numbers

Time: through ICU stay, an average of 30 days

Description: circulating immune cell characterization

Measure: Changes in monocytes number

Time: through ICU stay, an average of 30 days

Secondary Outcomes

Description: stimulation by SARS-CoV-2 viral proteins

Measure: TNFalpha level

Time: 4 hours

Description: stimulation by SARS-CoV-2 viral proteins

Measure: INFgamma level

Time: 4 hours

Description: stimulation by SARS-CoV-2 viral proteins

Measure: IL1beta level

Time: 4 hours

Description: Sequential Organ dysfunction assessement, ranging from 0 (better) to 24 (worst) outcome

Measure: SOFA score

Time: through ICU stay, an average of 30 days

Description: mortality

Measure: number of recorded deaths

Time: through study completion, an average of 6 months

Description: infectious complications

Measure: presence of pneumonia

Time: through ICU stay, an average of 30 days

Description: infectious complications

Measure: presence of bacteremia

Time: through ICU stay, an average of 30 days

Description: infectious complications

Measure: presence of urinary tract infection

Time: through ICU stay, an average of 30 days

Description: inflammation marker

Measure: C reactive protein

Time: through ICU stay, an average of 30 days

Description: inflammation marker

Measure: D Dimers

Time: through ICU stay, an average of 30 days
3 PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

DESIGN Longitudinal prospective observational multicentre study. Primary objective: Understand the immune mechanisms driving COVID-19 disease in patients with a history of lung disease

NCT04444609
Conditions
  1. COVID-19
  2. SARS-CoV 2
  3. ARDS, Human
  4. Immune System Disorder
Interventions
  1. Other: Blood tests sputum, nasal lavage and brushing
MeSH:Respiratory Distress Syndrome, Adult Immune System Diseases

Primary Outcomes

Description: Anti-viral cytokine protein concentration in blood samples by ELISA

Measure: Anti-viral cytokine levels in blood samples in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Inflammatory cytokine protein concentration in sputum samples by ELISA

Measure: Anti-viral cytokines profiles within sputum samples in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Inflammatory cytokine protein concentration in nasal lavage samples by ELISA

Measure: Anti-viral cytokine profiles within nasal lavage samples in chronic respiratory disease associated with susceptibility to severe COVID-19 infection associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Inflammatory gene expression in upper airway respiratory epithelial cells by RNA sequencing.

Measure: Expression of inflammatory gene expression in upper respiratory epithelial airway cells using nasal brush specimens in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Secondary Outcomes

Description: Analysis of viral components recognized by the adaptive immune system

Measure: Identify the T cell antigens and B cell epitopes in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Cytokine protein concentration following PBMC stimulation to pathogen recognition receptor agonists by Elispot

Measure: Peripheral blood mononuclear cell (PBMC) interferon mediated immune responses to pathogen recognition receptor agonists in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Analysis of endothelial function

Measure: Identify endothelial function in chronic respiratory disease associated with susceptibility to severe COVID-19 infection using EndoPAT testing

Time: Through study completion an average of 1 year

Description: Serum and plasma protein concentration of endothelial cell inflammation biomarkers by ELISA

Measure: Endothelial cell inflammation biomarkers in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Analysis of sputum microbiome

Measure: Identify sputum 16S rRNA and ITS sequences in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Analysis of nasal microbiome

Measure: Identify nasal lavage 16S rRNA and ITS sequences in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year

Description: Study participant survey

Measure: Identify quality of life markers in chronic respiratory disease associated with susceptibility to severe COVID-19 infection

Time: Through study completion an average of 1 year
4 Retrospective and Prospective Database of COVID-19 Prevalence and Clinical Course in Pediatric and Young Adult Hematology/ Oncology/Stem Cell Therapy Patients in the New York Tri-State Area.

New York City (NYC) has become the epicenter of the worldwide pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). By collecting and summarizing the experience with other major health care providers in the tristate (New York (NY), New Jersey (NJ) and Connecticut (CT)) are, the investigators are uniquely positioned to inform the rest of the country about what to expect and how to manage children and young adults with hematological, oncological or stem cell transplant diagnoses during the pandemic.

NCT04445402
Conditions
  1. Pediatric Cancer
  2. Immune System Disorder
  3. COVID-19
  4. Hemoglobinopathies
MeSH:Hemoglobinopathies Immune System Diseases

Primary Outcomes

Description: To measure the success of the data registry in how many patients agreed to participate and completed the one year follow up. A confirmed case of COVID-19 is defined as a positive result on a reverse-transcriptase- polymerase-chain-reaction (RT-PCR) assay of a specimen collected on a nasopharyngeal swab, or a serum antibody test. Only laboratory-confirmed cases will be described as positive.

Measure: Number of tristate area pediatric HOT patients tested for COVID-19 that completed 1 year follow-up

Time: One year

Secondary Outcomes

Description: To analyze effect of COVID-19 on patients and their families mental health. PROMIS® (Patient-Reported Outcomes Measurement Information System) is a set of person-centered measures that evaluates and monitors physical, mental, and social health in adults and children. Each item on the measure is rated on a 5-point scale (1=never; 2=rarely; 3=sometimes; 4=often; and 5=always) with a range in score from 8 to 40 with higher scores indicating greater severity of depression.

Measure: Change in PROMIS T-score

Time: Baseline, 3 Months, 6 Months

Description: To examine if the pandemic has effects on the patients' nutrition and microbiome. Each patient is given an opportunity to provide stool samples in addition to survey response.

Measure: Number of collected and analyzed stool samples

Time: Up to one year
5 Online, Home-based, Aerobic Training Program Among Adolescents With Chronic Diseases During COVID-19 Pandemic: A Randomized Controlled Trial

Data show that the coronavirus disease 2019 (COVID-19) symptoms can be severe in 4% and 3% of the adolescents aged 11-15 years and ≥ 16 years, respectively. In addition, the prevalence of chronic diseases among adolescents has increased in the last years. About 20% of the adolescents have some chronic disease, resulting in increased morbidity and mortality. In march, 2020, the quarantine was officially implemented in Sao Paulo, while elective medical appointments for adolescents with chronic disease were temporarily suspended. To mitigate the deleterious effect of the social isolation on physical and mental health among these patients, this study aims to test the effects of an online, home-based, exercise training program.

NCT04458246
Conditions
  1. Chronic Disease
  2. Chronic Diseases in Adolescence
  3. Chronic Disease of Immune System
  4. Chronic Kidney Diseases
Interventions
  1. Other: Exercise training group
MeSH:Kidney Diseases Renal Insufficiency, Chronic Immune System Diseases Chronic Disease
HPO:Abnormality of the kidney Chronic kidney disease Nephropathy

Primary Outcomes

Description: Semi structured interview

Measure: Safety and efficacy of a home-based exercise training program

Time: From baseline to 3 months of follow-up

Secondary Outcomes

Description: Semi structured interview

Measure: Patients perceptions during social isolation

Time: From baseline to 3 months of follow-up

Description: Quality of life will be assessed by means of Pediatric Quality of Life inventory (PedsQLTM 4.0)

Measure: Adolescents quality of life

Time: From baseline to 3 months of follow-up

Description: Will be assessed by means of a visual analog scale (from 0 - no disease activity) to 10 - maximum disease activity).

Measure: Disease activity

Time: From baseline to 3 months of follow-up

Description: Will be assessed using the visual analog scale from 0 (very good condition) to 10 (very poor condition).

Measure: Disease overall assessment

Time: From baseline to 3 months of follow-up

Description: Will be assessed by means of Strengths & Difficulties Questionnaires

Measure: Strengths and difficulties

Time: From baseline to 3 months of follow-up

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook