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D000505: Alopecia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug364 BGB DXP593 Wiki 0.71
drug537 CAG length <22 Wiki 0.71
drug538 CAG length >=22 Wiki 0.71
Name (Synonyms) Correlation
drug1080 Dutasteride Wiki 0.71
drug2636 Proxalutamide Wiki 0.71
drug362 BCG-Denmark Wiki 0.41
drug2938 Saline Wiki 0.22
drug2153 Nitazoxanide Wiki 0.18
drug333 Azithromycin Wiki 0.11
drug2448 Placebo Wiki 0.03

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D011470 Prostatic Hyperplasia NIH 0.71
D006965 Hyperplasia NIH 0.71
D045169 Severe Acute Respiratory Syndrome NIH 0.03
Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002293 Alopecia of scalp HPO 1.00
HP:0008711 Benign prostatic hyperplasia HPO 0.71

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity

The COVID-19 Androgen Sensitivity Test is a non-invasive In-Vitro Diagnostic device that utilizes Next Generation Sequencing Technology (NGS). The results of the test are used by a physician to assess the risk of developing severe symptoms following COVID-19 infection, The COVID-19 Androgen Sensitivity Test requires a health care professional to collect a DNA sample using an FDA cleared DNA sample collection kit.

NCT04368897
Conditions
  1. SARS-CoV 2
  2. COVID
  3. COVID-19
  4. Androgenetic Alopecia
  5. Androgen Receptor Abnormal
  6. Androgen Deficiency
Interventions
  1. Diagnostic Test: CAG length <22
  2. Diagnostic Test: CAG length >=22
MeSH:Alopecia
HPO:Alopecia Alopecia of scalp Frontal balding

Primary Outcomes

Description: Defined as 28 days minus the number of days from randomization to discharge home. If a patient has not been discharged home prior to day 28 or dies prior to day 28, hospital free days will be zero.

Measure: Hospital-free days to Day 28 [ Time Frame: 28 days]

Time: 28 days

Description: Defined as discharged, hospitalization, admission to intensive care unit [ICU] and death

Measure: 1. Severity of Disease

Time: Day 28
2 Anti-Androgen Treatment for COVID-19

This study is intended to explore the possible protective role of anti-androgens in SARS-CoV-2 infection

NCT04446429
Conditions
  1. COVID-19
  2. SARS-CoV2
  3. Androgenetic Alopecia
  4. Prostate Cancer
  5. Benign Prostatic Hyperplasia
  6. SARS (Severe Acute Respiratory Syndrome)
Interventions
  1. Drug: Dutasteride
  2. Drug: Nitazoxanide
  3. Drug: Azithromycin
  4. Drug: Proxalutamide
MeSH:Severe Acute Respiratory Syndrome Coronavirus Infections Prostatic Hyperplasia Alopecia Hyperplasia
HPO:Alopecia Alopecia of scalp Benign prostatic hyperplasia Frontal balding

Primary Outcomes

Description: Percentage of subjects hospitalized due to COVID-19

Measure: COVID-19 hospitalization

Time: 30 days

Description: COVID Ordinal Scale defined as: Death Hospitalized on invasive mechanical ventilation or ECMO ( extracorporeal membrane oxygenation) Hospitalized on non-invasive ventilation or high flow nasal cannula Hospitalized on supplemental oxygen Hospitalized not on supplemental oxygen Not hospitalized with limitation in activity (continued symptoms) Not hospitalized without limitation in activity (no symptoms)

Measure: COVID-19 Ordinal Outcomes Scale

Time: 30 days

Secondary Outcomes

Description: Symptoms severity of COVID-19 using Brescia-COVID Respiratory Severity Scale (BCRSS)/Algorithm

Measure: Symptoms severity of COVID-19

Time: 30 days

HPO Nodes


HP:0001596: Alopecia
Genes 293
ALOX12B CHD7 SOX18 BCS1L PADI3 NXN VDR UBR1 LMNA ECM1 NFKB2 COL3A1 ARHGAP31 SOX18 HLCS HR TINF2 TP63 KRT81 KRAS DDB2 SLC39A4 EBP RBM28 LAMA3 ANTXR1 SLC29A3 EDARADD LMNA BMP2 ZNF341 DCAF17 ACVR1 RAG2 FGFR1 TP63 HLA-DRA GJB2 FZD2 GNA11 FOXN1 ALX4 RECQL4 TGM1 COL7A1 ZMPSTE24 ANTXR1 AEBP1 PARN KRT16 COL17A1 XPA GJB6 HRAS PLEC KRT74 TINF2 TNFRSF1B WNT10A MPLKIP GJB2 ITGB4 EDAR TGM1 LAMC2 LMNA RAG1 TARS1 SMARCA2 LMNA TTC7A FLI1 KRAS PIK3R1 TRPV3 DSG4 LAMC2 UROS IKBKG MCCC2 CLDN1 PERP EPS8L3 GJA1 COL3A1 HLCS PORCN HFE STAT4 NOTCH1 KRT86 FOXP3 SLC30A2 ABCA12 LPAR6 CERS3 CD28 MBTPS2 EDNRA HRAS TRPV3 RNF113A MBTPS2 SNRPE NOP10 FAM111B KDSR RHOA HR KRT83 NRAS ERCC3 ABHD5 GJB6 ERCC2 DOCK6 BLM FOXN1 DVL1 ALX4 TERC KRT86 OFD1 ITGB4 TERT TNFRSF1B RTEL1 IL7R JUP TGM3 USB1 RPL21 ARHGAP31 LSS PKP1 LSS GJA1 HR MBTPS2 MGP IL2RA ALOXE3 LMNA EBP EOGT IKBKG KDM5C RNU4ATAC EXOSC2 SREBF1 AHSG COL17A1 GJA1 DCLRE1C ALMS1 RAG1 ABCD1 CLDN1 GJB3 TINF2 ECM1 ERCC2 DCAF17 DMPK CASR NFKB1 ERCC5 GJB4 LAMA3 BTD WRAP53 AHSG LMNA SLC29A3 DKC1 ALOXE3 AIRE DLL4 MBTPS2 LAMB3 RMRP RIPK4 SLITRK1 UQCRFS1 KRAS IRAK1 KANSL1 GTF2H5 TERT ZMPSTE24 RECQL4 PEX7 HTRA1 AP1B1 PNPLA6 RBM28 ALOX12B FGFR1 RIN2 BTK OFD1 LAMB3 SLC39A4 PNPLA1 ADA WNT10A NSDHL ATR CTLA4 SOX18 SNRPE KDM5C MBTPS2 APCDD1 FTL KRT17 NRAS KRT6A KRT14 TGM1 HFE CD28 SPP1 LSS PRKACA CTC1 RIPK4 UROD RBPJ WNT5A PTPN22 FOXP3 PORCN ACVR1 DMXL2 CTLA4 GJB6 ITGB6 KLHL24 CSTB KRT6B KANSL1 MBTPS2 COL18A1 GJB2 TERC KRT85 ZMPSTE24 ODC1 DSP HLA-DRB1 MMP1 AIRE NECTIN4 LIG4 PARN NFKB2 LIPH PRKCD DKC1 EPS8L3 TP63 DVL3 HR DCLRE1C PLEC ABHD5 GTF2E2 DSP VDR NHP2 NPM1 STUB1 KRT83 SASH1 ANAPC1 DSG4 IL2RG KRT81 TP63 IL7R ERCC4 DSP ERCC3 BCS1L NECTIN1 RAG2 TP63 NIPAL4 ROR2 BTNL2 XPC BTD
Protein Mutations 0
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0001596: Alopecia
Genes 293
ALOX12B CHD7 SOX18 BCS1L PADI3 NXN VDR UBR1 LMNA ECM1 NFKB2 COL3A1 ARHGAP31 SOX18 HLCS HR TINF2 TP63 KRT81 KRAS DDB2 SLC39A4 EBP RBM28 LAMA3 ANTXR1 SLC29A3 EDARADD LMNA BMP2 ZNF341 DCAF17 ACVR1 RAG2 FGFR1 TP63 HLA-DRA GJB2 FZD2 GNA11 FOXN1 ALX4 RECQL4 TGM1 COL7A1 ZMPSTE24 ANTXR1 AEBP1 PARN KRT16 COL17A1 XPA GJB6 HRAS PLEC KRT74 TINF2 TNFRSF1B WNT10A MPLKIP GJB2 ITGB4 EDAR TGM1 LAMC2 LMNA RAG1 TARS1 SMARCA2 LMNA TTC7A FLI1 KRAS PIK3R1 TRPV3 DSG4 LAMC2 UROS IKBKG MCCC2 CLDN1 PERP EPS8L3 GJA1 COL3A1 HLCS PORCN HFE STAT4 NOTCH1 KRT86 FOXP3 SLC30A2 ABCA12 LPAR6 CERS3 CD28 MBTPS2 EDNRA HRAS TRPV3 RNF113A MBTPS2 SNRPE NOP10 FAM111B KDSR RHOA HR KRT83 NRAS ERCC3 ABHD5 GJB6 ERCC2 DOCK6 BLM FOXN1 DVL1 ALX4 TERC KRT86 OFD1 ITGB4 TERT TNFRSF1B RTEL1 IL7R JUP TGM3 USB1 RPL21 ARHGAP31 LSS PKP1 LSS GJA1 HR MBTPS2 MGP IL2RA ALOXE3 LMNA EBP EOGT IKBKG KDM5C RNU4ATAC EXOSC2 SREBF1 AHSG COL17A1 GJA1 DCLRE1C ALMS1 RAG1 ABCD1 CLDN1 GJB3 TINF2 ECM1 ERCC2 DCAF17 DMPK CASR NFKB1 ERCC5 GJB4 LAMA3 BTD WRAP53 AHSG LMNA SLC29A3 DKC1 ALOXE3 AIRE DLL4 MBTPS2 LAMB3 RMRP RIPK4 SLITRK1 UQCRFS1 KRAS IRAK1 KANSL1 GTF2H5 TERT ZMPSTE24 RECQL4 PEX7 HTRA1 AP1B1 PNPLA6 RBM28 ALOX12B FGFR1 RIN2 BTK OFD1 LAMB3 SLC39A4 PNPLA1 ADA WNT10A NSDHL ATR CTLA4 SOX18 SNRPE KDM5C MBTPS2 APCDD1 FTL KRT17 NRAS KRT6A KRT14 TGM1 HFE CD28 SPP1 LSS PRKACA CTC1 RIPK4 UROD RBPJ WNT5A PTPN22 FOXP3 PORCN ACVR1 DMXL2 CTLA4 GJB6 ITGB6 KLHL24 CSTB KRT6B KANSL1 MBTPS2 COL18A1 GJB2 TERC KRT85 ZMPSTE24 ODC1 DSP HLA-DRB1 MMP1 AIRE NECTIN4 LIG4 PARN NFKB2 LIPH PRKCD DKC1 EPS8L3 TP63 DVL3 HR DCLRE1C PLEC ABHD5 GTF2E2 DSP VDR NHP2 NPM1 STUB1 KRT83 SASH1 ANAPC1 DSG4 IL2RG KRT81 TP63 IL7R ERCC4 DSP ERCC3 BCS1L NECTIN1 RAG2 TP63 NIPAL4 ROR2 BTNL2 XPC BTD
Protein Mutations 0
SNP 0

Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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