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D014115: Toxemia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug3874 microcirculation recording Wiki 0.45
drug3187 Storage of operating waste Wiki 0.45
drug564 COR-101 Wiki 0.45
Name (Synonyms) Correlation
drug2419 Phage Therapy Wiki 0.45
drug176 Aerosolized All-Trans Retinoic acid plus oral Tamoxifen Wiki 0.45
drug1884 MMR vaccine Wiki 0.45
drug1746 LEAF-4L6715 Wiki 0.45
drug3166 Standard treatment Wiki 0.17
drug333 Azithromycin Wiki 0.07
drug2448 Placebo Wiki 0.04

Correlated MeSH Terms (18)


Name (Synonyms) Correlation
D018805 Sepsis NIH 0.79
D000071074 Neonatal Sepsis NIH 0.45
D011552 Pseudomonas Infections NIH 0.45
Name (Synonyms) Correlation
D011645 Puerperal Infection NIH 0.45
D066087 Perinatal Death NIH 0.45
D063130 Maternal Death NIH 0.45
D016470 Bacteremia NIH 0.32
D011251 Pregnancy Complications, Infectious NIH 0.26
D018746 Systemic Inflammatory Response Syndrome NIH 0.26
D003643 Death, NIH 0.22
D011024 Pneumonia, Viral NIH 0.05
D011014 Pneumonia NIH 0.05
D013577 Syndrome NIH 0.04
D007239 Infection NIH 0.04
D012127 Respiratory Distress Syndrome, Newborn NIH 0.04
D055371 Acute Lung Injury NIH 0.04
D012128 Respiratory Distress Syndrome, Adult NIH 0.03
D003141 Communicable Diseases NIH 0.03

Correlated HPO Terms (4)


Name (Synonyms) Correlation
HP:0100806 Sepsis HPO 0.79
HP:0003811 Neonatal death HPO 0.45
HP:0040187 Neonatal sepsis HPO 0.45
Name (Synonyms) Correlation
HP:0002090 Pneumonia HPO 0.05

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor (in Low- and Middle-income Countries): a Randomized Controlled Trial

Maternal and neonatal infections are among the most frequent causes of maternal and neonatal deaths, and current antibiotic strategies have not been effective in preventing many of these deaths. Recently, a randomized clinical trial conducted in a single site in The Gambia showed that treatment with oral dose of 2 g azithromycin vs. placebo for all women in labor reduced selected maternal and neonatal infections. However, it is unknown if this therapy reduces maternal and neonatal sepsis and mortality. The A-PLUS trial includes two primary hypotheses, a maternal hypothesis and a neonatal hypothesis. First, a single, prophylactic intrapartum oral dose of 2 g azithromycin given to women in labor will reduce maternal death or sepsis. Second, a single, prophylactic intrapartum oral dose of 2 g azithromycin given to women in labor will reduce intrapartum/neonatal death or sepsis.

NCT03871491
Conditions
  1. Maternal Death
  2. Maternal Infections Affecting Fetus or Newborn
  3. Neonatal SEPSIS
  4. Maternal Sepsis During Labor
  5. Neonatal Death
  6. Postpartum Sepsis
Interventions
  1. Drug: Azithromycin
  2. Drug: Placebo
MeSH:Infection Sepsis Toxemia Neonatal Sepsis Pregnancy Complications, Infectious Puerperal Infection Perinatal Death Maternal Death Death
HPO:Neonatal death Neonatal sepsis Sepsis

Primary Outcomes

Description: Incidence of maternal death or sepsis within 6 weeks (42 days) post-delivery in intervention vs. placebo group.

Measure: Maternal: Incidence of maternal death or sepsis within 6 weeks (42 days) post-delivery in intervention vs. placebo group.

Time: within 6 weeks (42 days)

Description: Incidence of intrapartum/neonatal death or sepsis within 4 weeks (28 days) post-delivery in intervention vs. placebo group

Measure: Neonatal: Incidence of intrapartum/neonatal death or sepsis within 4 weeks (28 days) post-delivery in intervention vs. placebo group

Time: 4 weeks (28 days) post-delivery

Secondary Outcomes

Description: Fever (>100.4°F/38°C) in addition to one or more of the following: fetal tachycardia ≥160 bpm, maternal tachycardia >100 bpm, tender uterus between contractions, or purulent/foul smelling discharge from uterus prior to delivery.

Measure: Incidence of chorioamnionitis

Time: prior to delivery

Description: Fever (>100.4°F/38°C) in addition to one or more of maternal tachycardia >100 bpm, tender uterine fundus, or purulent/foul smelling discharge from uterus after delivery.

Measure: Incidence of endometritis

Time: within 42 days post-delivery

Description: Wound infection (Purulent infection of a perineal or Cesarean wound with or without fever. In the absence of purulence, requires presence of fever >100.4°F/38°C and at least one of the following signs of local infection: pain or tenderness, swelling, heat, or redness around the incision/laceration); Abdominopelvic abscess (Evidence of pus in the abdomen or pelvis noted during open surgery, interventional aspiration or imaging); Pneumonia (Fever >100.4°F/38°C and clinical symptoms suggestive of lung infection including cough and/or tachypnea >24 breaths/min or radiological confirmation); Pyelonephritis (Fever >100.4°F/38°C and one or more of the following: urinalysis/dip suggestive of infection, costovertebral angle tenderness, or confirmatory urine culture); Mastitis/breast abscess or infection (Fever >100.4°F/38°C and one or more of the following: breast pain, swelling, warmth, redness, or purulent drainage).

Measure: Incidence of other infections

Time: within 42 days post-delivery

Description: Use of subsequent maternal antibiotic therapy after randomization to 42 days postpartum for any reason.

Measure: Incidence of use of subsequent maternal antibiotic therapy

Time: after randomization to 42 days post-delivery

Description: Time from drug administration until initial discharge after delivery (time may vary by site).

Measure: Maternal initial hospital length of stay

Time: within 42 days post-delivery

Description: Maternal readmissions within 42 days of delivery

Measure: Incidence of maternal readmissions

Time: within 42 days post-delivery

Description: Maternal admission to special care units

Measure: Incidence of maternal admission to special care units

Time: within 42 days post-delivery

Description: Maternal unscheduled visit for care

Measure: Incidence of maternal unscheduled visit for care

Time: within 42 days post-delivery

Description: Maternal GI symptoms including nausea, vomiting, and diarrhea and other reported side effects.

Measure: Incidence of maternal GI symptoms

Time: within 42 days post-delivery

Description: Maternal death due to sepsis using the Global Network algorithm for cause of death

Measure: Incidence of maternal death due to sepsis

Time: within 42 days post-delivery

Description: Incidence of other neonatal infections.

Measure: Incidence of other neonatal infections (e.g. eye infection, skin infection)

Time: within 42 days post-delivery

Description: Neonatal initial hospital length of stay, defined as time of delivery until initial discharge (time may vary by site).

Measure: Neonatal initial hospital length of stay

Time: within 28 days of delivery

Description: Neonatal readmissions within 42 days of delivery

Measure: Incidence of neonatal readmissions

Time: within 42 days of delivery

Description: Neonatal admission to special care units

Measure: Incidence of neonatal admission to special care units

Time: within 28 days of delivery

Description: Neonatal unscheduled visit for care

Measure: Incidence of neonatal unscheduled visit for care

Time: within 42 days post-delivery

Description: Neonatal death due to sepsis using the Global Network algorithm for causes of death

Measure: Incidence of neonatal death due to sepsis

Time: within 28 days of delivery

Description: Pyloric stenosis within 42 days of delivery, defined as clinical suspicion based on severe vomiting leading to death, surgical intervention (pyloromyotomy) as verified from medical records, or radiological confirmation.

Measure: Incidence of pyloric stenosis within 42 days of delivery

Time: within 42 days of delivery
2 A Study of Liposomal Trans Crocetin, LEAF-4L6715, in Patients With Acute Respiratory Distress Syndrome Due to COVID-19, Sepsis or Other Causes

This is an open label phase II study of treatment with LEAF-4L6715 in patients who experience severe acute respiratory distress syndrome (ARDS) and are receiving artificial respiratory support due to COVID-19, Sepsis or other Causes. The purpose of this study is to evaluate the improvement in PaO2/FiO2 by more than 25% in patients treated with LEAF-4L6715.

NCT04378920
Conditions
  1. COVID19, Sepsis or Other Causes
  2. Acute Respiratory Distress Syndrome
Interventions
  1. Drug: LEAF-4L6715
MeSH:Sepsis Toxemia Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Syndrome
HPO:Sepsis

Primary Outcomes

Measure: proportion of patients showing an increase of at least 25% of PaO2/FiO2 ratio

Time: 24 hours

Secondary Outcomes

Measure: proportion of patients with a PaO2/FiO2 ratio above 200 mm Hg

Time: 24, 48 and 72 hours

Measure: all cause mortality

Time: 28 days
3 Use of a Live Attenuated Vaccine Repurposed as an Innate Immune-based Preventive Against COVID-19-associated Sepsis/Inflammation

The objective of this randomized clinical trial is to test whether administration of live attenuated MMR vaccine (measles mumps rubella; Merck) to eligible adults at highest risk for contracting COVID-19 (healthcare workers, first responders), can induce non-specific trained innate immune leukocytes that can prevent/dampen pathological inflammation and sepsis associated with COVID-19-infection, if exposed.

NCT04475081
Conditions
  1. Sepsis Syndrome
Interventions
  1. Biological: MMR vaccine
MeSH:Sepsis Toxemia Systemic Inflammatory Response Syndrome
HPO:Sepsis

Primary Outcomes

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of myeloid-derived suppressor cells (MDSCs)

Time: 14 days post-vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 30 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 60 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 12 months post vaccination

Secondary Outcomes

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 14 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 30 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 60 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 12 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 14 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 30 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 60 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 3 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 4 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 5 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 6 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 7 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 8 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 9 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 10 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 11 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 12 months post-vaccination
4 Expanded Access Study of Phage Treatment in Covid-19 Patients on Anti-Microbials for Pneumonia or Bacteremia/Septicemia Due to A. Baumannii, P. Aeruginosa or S. Aureus

Bacteriophage treatment in Covid-19 patients being treated with Anti-Microbials for Pneumonia or Bacteremia/Septicemia.

NCT04636554
Conditions
  1. Covid19
  2. Bacteremia
  3. Septicemia
  4. Acinetobacter Baumannii Infection
  5. Pseudomonas Aeruginosa Infection
  6. Staph Aureus Infection
Interventions
  1. Other: Phage Therapy
MeSH:Infection Communicable Diseases Bacteremia Pseudomonas Infections Sepsis Toxemia Pneumonia
HPO:Pneumonia Sepsis

5 Circulatory and Endothelial Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis - Prospective, Observational Pilot Study

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

NCT04644302
Conditions
  1. Viral Pneumonia
  2. Sepsis
Interventions
  1. Diagnostic Test: microcirculation recording
MeSH:Sepsis Toxemia Pneumonia, Viral Pneumonia
HPO:Pneumonia Sepsis

Primary Outcomes

Description: PPV describes microcirculation dysfunction

Measure: change in Proportion of Perfused Vessels (PPV) parameter

Time: 1st, 2nd and 3rd day

Description: Syndecan-1 is a marker of endothelial glycocalyx

Measure: change in Syndecan-1 serum concentration

Time: 1st, 2nd and 3rd day

Secondary Outcomes

Description: albuminuria is a marker of glomerular endothelial cells dysfunction

Measure: change in albuminuria

Time: 1st, 2nd and 3rd day

Description: mortality in 28 days from ICU admission

Measure: mortality in 28 days

Time: 30 days

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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