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D001172: Arthritis, Rheumatoid

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (24)


Name (Synonyms) Correlation
drug502 Breath Biopsy face masks with removable filters and fitted PVA strip Wiki 0.43
drug481 Blood sampling Wiki 0.32
drug500 Breath Biopsy Wiki 0.30
Name (Synonyms) Correlation
drug3014 Serological analyses to be lead on a pre-existing biobank Wiki 0.30
drug3186 Stools Wiki 0.30
drug484 Blood test for IgG antibodies against SARS-CoV-2 Wiki 0.30
drug3928 oropharyngeal swabs Wiki 0.30
drug3709 blood tests Wiki 0.30
drug493 Botulinum Neurotoxin Wiki 0.30
drug627 COVID-19 test Wiki 0.30
drug501 Breath Biopsy Analysis Wiki 0.30
drug3172 Standardised questionnaires Wiki 0.30
drug3067 Skin biopsy Wiki 0.30
drug3398 Traditional antirheumatic drugs Wiki 0.30
drug1523 Hydroxychloroquine/Chloroquine Wiki 0.30
drug499 Brazilian Green Propolis Extract (EPP-AF) Wiki 0.30
drug483 Blood test Wiki 0.21
drug2115 Nasopharyngeal swabs Wiki 0.21
drug2274 Online Questionnaire Wiki 0.21
drug3978 questionnaire assesment Wiki 0.13
drug2113 Nasopharyngeal swab Wiki 0.11
drug3132 Standard care Wiki 0.10
drug1472 Hydroxychloroquine Wiki 0.03
drug2448 Placebo Wiki 0.01

Correlated MeSH Terms (18)


Name (Synonyms) Correlation
D001168 Arthritis NIH 0.86
D025241 Spondylarthritis NIH 0.52
D013166 Spondylitis NIH 0.30
Name (Synonyms) Correlation
D013167 Spondylitis, Ankylosing NIH 0.30
D015535 Arthritis, Psoriatic NIH 0.30
D001167 Arteritis NIH 0.21
D003095 Collagen Diseases NIH 0.20
D012216 Rheumatic Diseases NIH 0.18
D012859 Sjogren's Syndrome NIH 0.17
D011111 Polymyalgia Rheumatica NIH 0.17
D013700 Giant Cell Arteritis NIH 0.17
D001327 Autoimmune Diseases NIH 0.13
D008180 Lupus Erythematosus, Systemic NIH 0.12
D059350 Chronic Pain NIH 0.10
D003141 Communicable Diseases NIH 0.04
D007239 Infection NIH 0.03
D045169 Severe Acute Respiratory Syndrome NIH 0.01
D018352 Coronavirus Infections NIH 0.01

Correlated HPO Terms (6)


Name (Synonyms) Correlation
HP:0001370 Rheumatoid arthritis HPO 0.95
HP:0001369 Arthritis HPO 0.81
HP:0012089 Arteritis HPO 0.21
Name (Synonyms) Correlation
HP:0002960 Autoimmunity HPO 0.13
HP:0002725 Systemic lupus erythematosus HPO 0.12
HP:0012532 Chronic pain HPO 0.10

Clinical Trials

Navigate: Correlations   HPO

There are 11 clinical trials


1 IMPACT RAPPORT: IMPact of Antimalarials on Covid Infections: a Case Control sTudy of RAPPORT

This study aims to evaluate the experience of Alberta patients with inflammatory arthritis who participate in the the RAPPORT-ONTRAAC registry during the COVID-19 pandemic, specifically comparing the experience of those taking anti-malarial medications compared to those who do not. This registry includes approximately 2500 northern Alberta patients with inflammatory arthritis who receive highly complex therapies which may be associated with side effects. This program of data collection and research has been evaluating the effectiveness and safety as well as associated health care costs of rheumatoid and psoriatic arthritis patients since 2004. The principle investigators are based at the University of Alberta while the co-investigators are academic rheumatologists at the University of Alberta. The registry has approximately 900 patients taking anti-malarials combined with their complex therapies and ~ 1500 not on anti-malarials in combination with their complex therapies. We aim to perform a case control study evaluating the impact of anti-malarial drugs (eg. hydroxychloroquine and chloroquine) on the development of COVID-19 compared to those patients who are not on anti-malarial drugs over the next 6-12 months. In addition to frequent e-mail surveys screening for the clinical symptoms of COVID-19 and understanding their concomitant arthritis medication use, we will compare the healthcare outcomes of both groups of arthritis patients with and without COVID-19 for the duration of the pandemic. This information will provide critical information beyond an anecdotal level on whether or not anti-malarials truly provide a protective benefit against COVID-19 or reduce the severity of infection. A blood sample from all participants (Covid-19 positive and negative) will be drawn approximately six months into the study for measurement of antibodies to Covid-19 and possible blood types and HLA alleles. Additionally, this study will be linked to another study "Persistence of SARS-Cov2 in immunocompromised patients" which will specifically evaluate COVID-19 serology and nasopharyngeal swab findings in the subset of patients who develop COVID-19.

NCT04347798
Conditions
  1. Covid-19 Infection
  2. Rheumatoid Arthritis
  3. Psoriatic Arthritis
  4. Hydroxychloroquine
Interventions
  1. Other: Hydroxychloroquine/Chloroquine
MeSH:Infection Communicable Diseases Arthritis Arthritis, Rheumatoid Arthritis, Psoriatic
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Number of patients developing signs and symptoms of Covid-19 or other infections

Measure: Impact of anti-malarials on the development and severity of Covid-19 in the anti-malarial group compared to the non-anti-malarial group

Time: 12 months

Secondary Outcomes

Description: Number of patients developing Covid-19 infection

Measure: Incidence of Covid-19 infection in the anti-malarial group compared to the non-anti-malarial group

Time: 12 months

Description: Incidence of Covid-19 infection in the sub-groups of patients on biologic agents with different mechanisms of action

Measure: Incidence of Covid-19 infection in the sub-groups of patients on biologic agents with different mechanisms of action

Time: 12 months

Other Outcomes

Description: Quantitative measurement of Covid-19 serology to understand possible differences in degree of immune response adjusted for anti-malarial and/or biologic exposure

Measure: Quantification of Covid-19 antibodies in anti-malarial vs non-anti-malarial groups of inflammatory arthritis patients

Time: 6 months
2 Psychological Impact of Quarantine in Rheumatoid Arthritis Patient During COVID-19 Outbreak

Clinical data about psychological impact of quarantine are well studied in transient event or more prolonged situation like jail incarceration. In recent metaanalysis, psychological impact of quarantine was well documented in a specific population during first SARS epidemy. Even after the end of quarantine several patients were still with symptom of avoiding mainly agoraphobia, frequent hand washing and a carefull return to normal life COVID-19 infection is already associated with psychological symptom like anxiety, depression, sleep disorders and symptoms of acute stress However psychological impact of quarantine is on none in chronic painful inflammatory rheumatism in France. The prevalence of rheumatoid arthritis is 0.5% of the population with frequent comorbidity such as anxiety and depression. During the quarantine secondary to COVID-19 pandemic it's possible to evaluated the psychological impact of adult RA patients. The present study is an "emergency" being realize before the end of the quarantine.

NCT04351399
Conditions
  1. Sars-CoV2
  2. Rheumatic Diseases
  3. Rheumatoid Arthritis
  4. Chronic Pain
Interventions
  1. Other: questionnaire assesment
MeSH:Arthritis Arthritis, Rheumatoid Rheumatic Diseases Collagen Diseases Chronic Pain
HPO:Arthritis Chronic pain Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Measure: Frequency of RA patients with emotional impact (feeling of isolation)

Time: maximum 1 week from baseline on

Secondary Outcomes

Description: Self reported questionnaire with questions to assess the characteristic,intensity of pain on quality of life, and consumption of analgesic.

Measure: self-reported questionnaire for painful

Time: maximum 1 week from baseline on
3 Antimalarial and Covid 19 in Rheumatoid Arthritis

The antimalarial agent hydroxychloroquine(HCQ) have been used widely used for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action differ them from glucocorticoids and nonsteroidal antiinflammatory agents. Among rheumatic diseases, the primary role of HCQ is in the management of articular and skin manifestations of systemic lupus erythematosus (SLE) and the treatment of mild to moderately active rheumatoid arthritis (RA).

NCT04389320
Conditions
  1. Rheumatoid Arthritis
Interventions
  1. Drug: Hydroxychloroquine
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: serum level

Measure: immunoglobulin mesurement

Time: 1 month
4 Drug Management of Rheumatoid Arthritis in Covid-19 Context : Impact on Therapeutic De-escalation

The current situation of Sars-Cov-2 pandemic generates fears in the general population. Among patients receiving long-term immunomodulatory drugs, especially in the context of auto-immune diseases, there may be legitimates interrogations about the appropriateness of continuing treatment, without modification, in the current context. Most patients with Juvenile Rheumatoid Arthritis benefit from long-term immunmodulatory therapy (DMARD - disease modifying anti-rheumatic drug), more or less combined with regular use of non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids.The present study will characterize this issue by defining the proportion of patients whose usual treatment of Rheumatoid Arthritis has been modified in relation to the actual sanitary crisis.

NCT04393233
Conditions
  1. Rheumatoid Arthritis
  2. COVID
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Reduction or discontinuation of treatment with sDMARD, bDMARD or tsDMARD

Measure: Reduction or discontinuation of the DMARD therapy in relation to the Covid-19 sanitary crisis

Time: 1 Day
5 Prevalence, Seroconversion and Impact of COVID-19 in Autoimmune Diseases in Europe

The coronavirus disease 2019 (COVID-19) pandemic is a potentially fatal disease that represents a great global public health concern. In European countries such as Spain, Italy, Germany, Portugal, England and France, the pandemic has been of utmost importance. To date, no treatment has been robustly validated, and two theoretically opposite therapeutic strategies are proposed, based either on antiretroviral therapy or on immunomodulating agents. In this complex context, people living with immune-mediated inflammatory diseases (IMID) raise specific concerns due to their potentially increased risk of infections or of severe infections. Among IMID, Sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, spondyloarthritis and giant cell arteritis are some key diseases. In this cross-sectional, observational, multi-centric study, the investigators aim to assess both clinical and serological prevalence of COVID-19 among samples of IMID patients in Europe. In parallel, the investigators aim to compare the prevalence of COVID-19 seroconversion across these five IMIDs, their penetration across different 6 European countries (France, Italy, Spain, Germany, United Kingdom and Portugal), and to assess the severity of COVID-19 in these patients. Moreover, changes in treatment will be assessed, including immunomodulatory tapering or discontinuation, its causes over the outbreak period, as well as the incidence of IMID flares and their severity over this same period. Finally, patient's perceptions towards the pandemic will be evaluated and compared to medication beliefs. Data will be collected through questionnaires during medical visit or phone consultation and serological tests will be performed within routine blood collection. As so, all study procedures are comprised within usual care. Through this study the investigators expect to have a better knowledge of the clinical and serological prevalence of COVID-19 in IMID across Europe, along with the psychological, clinical, and therapeutic impact of COVID-19 in this particular patient population.

NCT04397237
Conditions
  1. COVID-19
  2. Systemic Lupus Erythematosus
  3. Sjogren's Syndrome
  4. Axial Spondyloarthritis
  5. Rheumatoid Arthritis
  6. Giant Cell Arteritis
MeSH:Arthritis Arthritis, Rheumatoid Sjogren's Syndrome Spondylarthritis Polymyalgia Rheumatica Giant Cell Arteritis Arteritis Lupus Erythematosus, Systemic Autoimmune Diseases
HPO:Arteritis Arthritis Autoimmunity Polyarticular arthritis Rheumatoid arthritis Systemic lupus erythematosus

Primary Outcomes

Description: ELISA tests for COVID-19 antibodies

Measure: COVID-19 seroconversion

Time: 1 day, during routine blood collection

Description: Case report form filled by the health professional

Measure: COVID-19 infection

Time: During medical visit or phone consultation, up to 2 hours

Secondary Outcomes

Description: Descriptive analysis for each disease's rate

Measure: Seroconversion rate by disease

Time: 1 day, during routine blood collection

Description: Descriptive analysis for each country's rate

Measure: Penetration across Europe

Time: 1 day, during routine blood collection

Description: World Health Organization ordinal scale for clinical improvement at any given point of the infection, going from 0 to 8, where higher scores means worse outcome.

Measure: COVID-19 severity

Time: During medical visit, up to 1 hour

Description: Descriptive analysis for overall and COVID-19-linked mortality rates

Measure: COVID-19 mortality rate

Time: During contact with family members, up to 1 hour

Description: Case report form filled by the health professional

Measure: COVID-19 impact on immunomodulatory treatment

Time: During medical visit, up to 1 hour

Description: Case report form filled by the patient

Measure: Patient-reported flares

Time: During medical visit, up to 1 hour

Description: Fear of COVID-19 scale, going from 7 to 35, where higher scores means worse outcome.

Measure: Patient's fears towards COVID-19

Time: During medical visit, up to 1 hour

Description: Beliefs about Medicines Questionnaire, going from 11 to 55, with higher scores indicating stronger beliefs regarding medicine.

Measure: Patient's beliefs in their medicines towards COVID-19

Time: During medical visit, up to 1 hour
6 Impact of the Rheumatoid Factor on Serological Testing Performance for Covid-19 in Rheumatoid Arthritis Patients

Due to the Covid-19 worldwide outbreak, fragile patients with immune diseases, notably rheumatoid arthritis (RA), have to be even more specifically and carefully followed-up. However, it has been shown that false postive serological results often occured while detecting antibodies directed against SARS-CoV-2 in patients with positive rheumatodoid factor (RF). The investigators propose here to investigated this issue. Therefore, the investigators will test three different immunoassays on this specific population. The investigators aim to establish these assays specificity and the levels of RF for which there is a risk of anti-SARS-CoV-2 false positivity and thus ensure a better follow-up of RA patients. The RF isotype will be analysed to determine whether there is a correlation and the impact of the presence of anti-CCP (citrullinated cyclic antipeptide antibodies) will be studied and assessed.

NCT04407559
Conditions
  1. COVID-19
  2. Rheumatoid Arthritis
Interventions
  1. Other: Serological analyses to be lead on a pre-existing biobank
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Evaluate the false positive results rate when using each one of the three SARS-CoV-2 serology tests in patients with rheumatoid factor plasma levels, so as to define the specificity of these tests in this RA population. all serum samples will be tested by the 3 different immunoassays. The RF plasma levels have already been measured (routine exam) and are written in the patients files. The results will be analysed, the data proceeded and hopefully we will be able to answer the question.

Measure: Evaluate the false positive results rate

Time: 4 months

Secondary Outcomes

Description: Characterize the RF isotype (IgG, IgM or IgA) associated with the false positivity of the test.all serum samples will be tested by the 3 different immunoassays. The RF isotype will be established using the routine method and the results of anti-CCP and RF plasma levels are already known and this information is available in the patients files. The results will be analysed, the data proceeded and hopefully we will be able to answer the questions

Measure: Characterize the RF isotype (IgG, IgM or IgA) associated

Time: 4 months

Description: Determine the influence of RA on the false positivity rate in subjects with negative RF titer. All serum samples will be tested by the 3 different immunoassays. The RF isotype will be established using the routine method and the results of anti-CCP and RF plasma levels are already known and this information is available in the patients files. The results will be analysed, the data proceeded and hopefully we will be able to answer the questions

Measure: Determine the influence of RA on the false positivity rate in subjects

Time: 4 months

Description: Assess the influence of the presence of anti-CCP on the false positivity of the SARS-CoV-2 test : all serum samples will be tested by the 3 different immunoassays. The RF isotype will be established using the routine method and the results of anti-CCP and RF plasma levels are already known and this information is available in the patients files. The results will be analysed, the data proceeded and hopefully we will be able to answer the questions.

Measure: Assess the influence of the presence of anti-CCP on the false positivity of the SARS-CoV-2 test

Time: 4 months

Description: Assess the relation between the RF plasma levels and the false positivity of the SARS-CoV-2 test : all serum samples will be tested by the 3 different immunoassays. The RF isotype will be established using the routine method and the results of anti-CCP and RF plasma levels are already known and this information is available in the patients files. The results will be analysed, the data proceeded and hopefully we will be able to answer the questions.

Measure: Assess the relation between the RF plasma levels and the false positivity of the SARS-CoV-2 test

Time: 4 months
7 Anti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis Patients: A Retrospective, Case-control Study

Rheumatoid arthritis (RA) patients have an underlying immune deficiency and typically treated with immunosuppressive drugs, which may increase the risk of COVID-19 infection. Hydroxychloroquine (HCQ) has been found to possess antiviral activity against COVID-19. Thus, the aim of this study to investigate the ability of HCQ to reduce the risk of COVID-19 among RA patients.

NCT04434118
Conditions
  1. Rheumatoid Arthritis
  2. COVID
Interventions
  1. Drug: Traditional antirheumatic drugs
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Realtion between hydroxychloroquine use and COVID-19 infection

Measure: The risk of COVID-19 infection among RA patients

Time: 12 week

Secondary Outcomes

Description: Number of cases and number of hospitalization days

Measure: The incidence of hospitalization for Covid-19 patients.

Time: 12 week
8 Seroprevalence and Clinical Expression of SARS-CoV-2 Infection in Patients With Chronic Inflammatory Rheumatisms and Impact of Immuno-suppressive Drugs on the Persistence of Anti-SARS-CoV2 Antibodies During Two Years of Follow-up

A better understanding of the different phenotypes of COVID 19 in patients with inflammatory rheumatisms, and the persitence of antibodies against SARS CoV-2 in these patients under immunosuppressive drugs are required to propose appropriated recommendations for these patients in order to guide the strategy of vaccination in this immune-depressed population who is not immunized.

NCT04530682
Conditions
  1. Rheumatoid Arthritis
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Variation of anti-SARS-CoV2 antibodies titers between baseline

Measure: Seroprevalence of COVID-19 in patients with inflammatory rheumatisms

Time: 6 months

Description: Variation of anti-SARS-CoV2 antibodies titers between baseline

Measure: Seroprevalence of COVID-19 in patients with inflammatory rheumatisms

Time: 12 months

Secondary Outcomes

Description: Coagulation factors in patients with inflammatory rheumatisms compared to health professionals

Measure: Clinical expression of COVID-19 compared to health professionals : phenotypes, thrombo-embolic events and stress repercussion

Time: 6 months

Description: Coagulation factors in patients with inflammatory rheumatisms compared to health professionals

Measure: Clinical expression of COVID-19 compared to health professionals : phenotypes, thrombo-embolic events and stress repercussion

Time: 12 months

Description: Coagulation factors in patients with inflammatory rheumatisms compared to health professionals

Measure: Clinical expression of COVID-19 compared to health professionals : phenotypes, thrombo-embolic events and stress repercussion

Time: 24 months
9 Study of the Viral Load and Humoral and Cellular B and T Responses in Patients With Rheumatoid Arthritis and Spondyloarthritis Under Immunosuppressive Treatments

The purpose of this study is to assess whether immunosuppressive therapies used by patients with chronic inflammatory rheumatic diseases have an impact on the viral load and the humoral and cellular responses during viral infection with SarSCoV2, compared to members of their family cluster infected with the same viral strain.

NCT04584541
Conditions
  1. Spondyloarthritis
  2. Rheumatoid Arthritis
  3. Covid19
Interventions
  1. Biological: blood tests
  2. Biological: Nasopharyngeal swabs
  3. Biological: Stools
MeSH:Arthritis Arthritis, Rheumatoid Spondylarthritis
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Nasopharyngeal swabs : Detection of SarS-Cov-2 RNA

Measure: Detection of SarS-Cov-2 RNA in feces and nasopharyngeal swabs

Time: up to Day 30

Description: Nasopharyngeal swabs : Detection of SarS-Cov-2 RNA

Measure: Detection of SarS-Cov-2 RNA in feces and nasopharyngeal swabs

Time: between Day 30 and Day 90

Measure: Detection and quantification of IgG, IgM and IgA specific for SarS-Cov-2 N and S proteins in blood

Time: up to Day 30

Measure: Detection and quantification of IgG, IgM and IgA specific for SarS-Cov-2 N and S proteins in blood

Time: between Day 30 and Day 90

Measure: Detection and quantification of IgG, IgM and IgA specific for SarS-Cov-2 N and S proteins in blood

Time: 6 Months

Measure: Detection and quantification of IgG, IgM and IgA specific for SarS-Cov-2 N and S proteins in blood

Time: 12 Months

Measure: Detection and quantification of IgG, IgM and IgA specific for SarS-Cov-2 N and S proteins in blood

Time: 24 Months

Measure: Isolation and characterization of B and T lymphocytes in blood

Time: up to Day 30

Measure: Isolation and characterization of B and T lymphocytes in blood

Time: between Day 30 and Day 90

Measure: Isolation and characterization of B and T lymphocytes in blood

Time: 6 Months

Measure: Isolation and characterization of B and T lymphocytes in blood

Time: 12 Months

Measure: Isolation and characterization of B and T lymphocytes in blood

Time: 24 Months
10 Seroprevalence Study of CoV-2-SARS (COVID-19) Infection in Patients With Chronic Inflammatory Rheumatic Diseases

The prevalence of SARS-CoV-2 infection in chronic inflammatory rheumatic diseases has not yet been widely reported, and has been evaluated only in symptomatic patient samples. The proportion of asymptomatic or mildly symptomatic patients is unknown, in patients who share common symptoms with CoV-2-SARS infection. Our objective is to describe the prevalence of seroconversion to CoV-2-SARS by consecutive screening in routine care of patients with chronic inflammatory rheumatism with serological testing

NCT04655612
Conditions
  1. COVID-19
  2. SARS-CoV Infection
  3. Rheumatoid Arthritis
  4. Spondyloarthritis
  5. Ankylosing Spondylitis
  6. Psoriatic Arthritis
MeSH:Infection Communicable Diseases Spondylitis Coronavirus Infections Severe Acute Respiratory Syndrome Arthritis Arthritis, Rheumatoid Arthritis, Psoriatic Spondylitis, Ankylosing Rheumatic Diseases Spondylarthritis Collagen Diseases
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Proportion of patients with inflammatory chronic rheumatic diseases with positive SARS-CoV-2 serodiagnosis

Measure: Proportion of patients with inflammatory chronic rheumatic diseases with positive SARS-CoV-2 serodiagnosis

Time: 1 day

Secondary Outcomes

Description: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to current treatments.

Measure: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to current treatments.

Time: 1 day

Description: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to type of chronic inflammatory rheumatic disease

Measure: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to type of chronic inflammatory rheumatic disease

Time: 1 day

Description: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to demographic characteristics

Measure: Proportion of patients with a positive CoV-2 SARS serodiagnosis according to demographic characteristics

Time: 1 day
11 Prognostic Evaluation of COVID-19 in Rheumatoid Arthritis Patients : ProCOVRA

COVID-19 is an infectious disease caused by SARS-CoV2 virus. The objective of our study is to analyze the progression and the severity of COVID-19 in patients with RA. Indeed, few data are available on this subject, and this would allow us to improve management of COVID-19 in these potential at-risk patients.

NCT04679272
Conditions
  1. Covid19
  2. Rheumatoid Arthritis
MeSH:Arthritis Arthritis, Rheumatoid
HPO:Arthritis Polyarticular arthritis Rheumatoid arthritis

Primary Outcomes

Description: Proportion of hospitalized patients in RA group or control group. From first COVID-19 symtpoms, or first positive SARS-COV2 PCR result, to recovery.

Measure: Hospitalization rates for COVID-19

Time: 1 day

Secondary Outcomes

Description: Proportion of patients transferred in critical care for COVID-19 or deaths due to COVID-19 From first COVID-19 symtpoms, or first positive SARS-COV2 PCR result, to recovery.

Measure: Critical care transfer rate for COVID-19 and death due to COVID-19

Time: 1 day

Description: Type and severity of patients pulmonary comorbidities and treatment by corticosteroids or DMARDs in RA group From first COVID-19 symtpoms, or first positive SARS-COV2 PCR result, to recovery.

Measure: Pulmonary comorbidities, corticosteroids or DMARDs use

Time: 1 day

Description: Patients demographics, comorbidities, COVID-19 clinical presentation From first COVID-19 symtpoms, or first positive SARS-COV2 PCR result, to recovery.

Measure: Age, gender, co-morbidities, clinical presentation, associated treatments

Time: 1 day

HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook