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D056912: Binge-Eating Disorder

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug574 COVID 19 diagnostic test by PCR Wiki 1.00
drug2822 Reward Re-Training Wiki 1.00
drug3206 Supportive Therapy Wiki 1.00

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D052018 Bulimia Nervosa NIH 1.00
D002032 Bulimia NIH 1.00
D001068 Feeding and Eating Disorders NIH 0.45

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0100739 Bulimia HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There is one clinical trial.


1 Reward Re-Training: A New Treatment to Address Reward Imbalance During the COVID-19 Pandemic

In the current study, the investigators will revise our existing 10-session group RRT treatment manual to specifically address the challenges in building social support and enhancing both momentary and sustained reward during the COVID-19 pandemic (Preliminary Aim 1). In months 2-18, the investigators will conduct a small pilot RCT that will randomize individuals to receive either 10-sessions of RRT (n=30) or supportive therapy (n=30), both delivered as group-treatments via videoconferencing software. The specific aims of the current study are to confirm the feasibility and acceptability of RRT for EDs (Primary Aim 1), evaluate the ability of RRT to engage critical targets including reward to day-to-day life activities, reward to palatable foods, social isolation, and loneliness (Primary Aim 2), and provide preliminary estimates of efficacy in reducing ED symptoms at both post-treatment and a 3-month follow-up (Primary Aim 3). the investigators will also evaluate the impact of RRT on secondary outcome variables including depression, substance use, and quality of life (Secondary Aim 1).

NCT04661410
Conditions
  1. Bulimia Nervosa
  2. Bulimia; Atypical
  3. Binge Eating
  4. Binge-Eating Disorder
Interventions
  1. Behavioral: Reward Re-Training
  2. Behavioral: Supportive Therapy
MeSH:Bulimia Feeding and Eating Disorders Binge-Eating Disorder Bulimia Nervosa
HPO:Bulimia

Primary Outcomes

Description: Frequency (number of instances) of binge eating over the past 28 days assessed by the Eating Disorder Examination

Measure: Binge eating frequency assessed by the Eating Disorder Examination

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Description: The Eating Disorder Examination is a semi-structured interview that measures eating. pathology. The EDE yields a total eating pathology score that will be used as an outcome variable. Global eating pathology is on a 0-6 point scale with higher scores indicating more significant eating pathology.

Measure: Global Eating Pathology

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Description: Presence or absence of eating disorder diagnosis. Not in remission; in partial remission; or in full remission.

Measure: Remission Status

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Description: Frequency ( number of instances) of compensatory behaviors assessed by the Eating Disorder Examination

Measure: Compensatory behavior frequency assessed by the Eating Disorder Examination (EDE)

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Secondary Outcomes

Description: Assesses the type (description of certain feelings or attitudes) and intensity (how often or how much the feelings and attitudes are present) of various depressive symptoms using a total score. The scale ranges from 0-63 with higher scores indicating worse depressive symptoms.

Measure: Depressive symptoms as assessed by the Beck Depression Inventory-II

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Description: Frequency of substance use (number of days/month)

Measure: Substance Use assessed by the NIDA-Modified ASSIST

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

Description: Assesses the importance of 16 given life domains have on influencing happiness and current satisfaction level regarding these 16 life domains. Scores range from 1-77 with higher scores indicating better quality of life.

Measure: Quality of Life assessed by the Quality of Life Inventory (QOLI)

Time: Changes from each assessment time point throughout treatment (3 assessments over 10 weeks) and 3-month post-treatment follow-up assessment

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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