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D000078064: Gestational Weight Gain

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1430 Healthy lifestyle advise Wiki 1.00
drug1235 Exercise program Wiki 1.00
drug4037 questionnaire Wiki 0.33

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D005317 Fetal Growth Retardation NIH 1.00
D046110 Hypertension, Pregnancy-Induced NIH 1.00
D015430 Weight Gain NIH 1.00
Name (Synonyms) Correlation
D011248 Pregnancy Complications NIH 0.33

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0004324 Increased body weight HPO 1.00
HP:0001511 Intrauterine growth retardation HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There is one clinical trial.


1 Active Pregnancy, Prevention Against the Effects of COVID-19

Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence. During some phases of history, pregnancy has meant a period of seclusion for women (not only physical). One of the adverse consequences has been the common recommendation of rest as a general rule for pregnant women. Scientific evidence from recent years has achieved a better understanding of the process of pregnancy and childbirth as well as maternal and fetal responses to exercise. Currently, both from a scientific and clinical/obstetric point of view, there is no doubt about the benefits of an active pregnancy for entire body of pregnant woman, and even her child. In fact, risks of a sedentary lifestyle are applicable to the pregnancy situation, even more with important associated complications during pregnancy and postpartum period. Unfortunately, the impact of COVID-19 has caused an unprecedented global crisis, in this sense the necessary measures taken by the different administrations, especially in terms of confinement causes (from now on) a large number of complications affecting different populations. In summary a complex situation without established prevention strategies exists. The pregnant population is, due to the nature of the gestation and delivery process, one of the population groups with the highest risk of adverse outcomes and associated complications and whose consequences include the mother, fetus, newborn and even children. According to an important body of scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining factor for the future human being to evolve regardless of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and observable postnatal pathologies in infants. In addition, current publications report the large number and variety of alterations that the COVID-19 situation causes in pregnant women and that includes the entire female organism. This complex situation does not only affect aspects of a physical or physiological nature, but also psychic and emotional factors. In summary, a new state of confinement or similar situations in the near future (impossibility of groupings, distance between people), avoid during the daily life of pregnant women one of the important and recent recommendations made by the international scientific community: a pregnancy physically active. This is especially relevant, due to the dangerous association between complications of a psychological or emotional nature during pregnancy with pre, peri and postnatal disorders (low birth weights, perinatal complications, altered and prolonged deliveries, etc.), which affect not only to the mother and can determine the health of the future human being. According to the scientific literature and based on an epigenetic effect, the intrauterine environment can be a determining aspect in the health of the future human being and the prevention of complications and pathologies (cardiovascular, metabolic, psychic, emotional). This is demonstrated by numerous and recent scientific evidences that confirm the unfortunate association between an adverse intrauterine environment (due to various factors) and different pathologies during and after pregnancy. It is evident the change that COVID-19 and its effects will generate in the lifestyle of the pregnant population and the increased probability of suffering associated pathologies in the next 24-36 months. No preventive actions have yet been planned in Spain and its public hospitals against the impact of COVID-19 on the quality of life of pregnant women. It is urgent to design and perform an adequate strategy of intervention for its possible prevention. From the scientific point of view, the recommendations are clear and concrete, an aerobic exercise program, designed and supervised by professionals from the Sciences of Physical Activity and Sports, is the best option for pregnant women. In this sense, in the last 30 years, physical exercise has proven to have many benefits for pregnant women, without causing risks or adverse effects on maternal-fetal well-being. This is confirmed by an important body of scientific literature on gestational physical exercise and its effects on pregnancy outcomes.

NCT04563065
Conditions
  1. Pregnancy Complications
  2. Pregnancy, High Risk
  3. Pregnancy Induced Hypertension
  4. Newborn Morbidity
  5. Fetal Growth Retardation
  6. Fetus Disorder
  7. Weight Gain, Maternal
  8. Maternal-Fetal Relations
Interventions
  1. Other: Exercise program
  2. Other: Healthy lifestyle advise
MeSH:Pregnancy Complications Fetal Growth Retardation Hypertension, Pregnancy-Induced Weight Gain Gestational Weight Gain
HPO:Increased body weight Intrauterine growth retardation

Primary Outcomes

Description: analyze the increase during pregnancy

Measure: Maternal weight gain

Time: 9 months

Description: analyze how it varies during pregnancy

Measure: blood pressure

Time: 9 months

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: OGTT-O'Sullivan test

Time: 1 month

Description: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (different measures in the questionnaire)

Measure: Urinary Incontinence Questionnaire (ICIQ-SF)

Time: 9 months

Description: analyze with a questionnaire the value and its interrelationship with physical exercise patterns (Likert scale 0-3)

Measure: State-Trait Anxiety Inventory (STAI)

Time: 9 months

Description: analyze with a questionnaire the variability during pregnancy (Likert scale 0-3)

Measure: depression scale (CES-D)

Time: 9 months

Description: analyze variability during pregnancy

Measure: Behavior of Fetal Heart Rate

Time: 3 months

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: gestational age

Time: 9 months

Description: analyze whether women have had a vaginal, instrumental or cesarean delivery and its interrelationship with physical exercise patterns

Measure: type of delivery (Vaginal, instrumental or cesarean)

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: duration of labor

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: birthweight

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy

Measure: child's weight

Time: 24 months

Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy

Measure: child's height

Time: 24 months

Description: analyze the value and its interrelationship with physical exercise patterns during pregnancy (Likert scale 0-3)

Measure: mental assessment of the child (depression questionnaire adapted to childhood)

Time: 24 months

Secondary Outcomes

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: Maternal pains during pregnancy (headache, back pain, pelvic pain, paravertebral, scapular, etc.)

Time: 9 months

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: fetal growth and development

Time: 9 months

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: Delivery tears

Time: 1 month

Description: analyze the appearance (descriptive: yes/no) and its interrelationship with physical exercise patterns

Measure: performing episiotomy during childbirth

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: Apgar Score

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: length

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: cranial perimeter

Time: 1 month

Description: analyze the value and its interrelationship with physical exercise patterns

Measure: Landau reflexes test

Time: 1 month

Description: analyze the number of admissions and its interrelationship with physical exercise patterns

Measure: neonatal intensive care unit (NICU)

Time: 1 month

Description: analyze how it varies during postpartum period

Measure: Postpartum recovery of pre-pregnancy weight

Time: 12 months

Description: analyze with a questionnaire how it varies during postpartum period (Likert scale 0-3)

Measure: Edinburgh Postpartum Depression Scale (EPDS)

Time: 12 months

Other Outcomes

Description: analyze the value and its interrelationship with physical exercise patterns (Likert scale)

Measure: Perception of health status - SF36 health scale

Time: 24 months

Description: analyze the diameter and thickness of muscles in the perineal area and its interrelationship with physical exercise patterns

Measure: Recovery of pelvic floor muscles ultrasound

Time: 6 months

Description: analyzewith a questionnaire how it varies during and after pregnancy

Measure: Maternal habits of physical activity - Pregnancy Physical Activity Questionnaire (PPAQ)

Time: 12 months

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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