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D055948: Sarcopenia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug2821 Rehabilitation by Eccentric exercises Wiki 0.71
drug2820 Rehabilitation by Concentric exercises Wiki 0.71

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D010291 Paresis NIH 0.71

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0001269 Hemiparesis HPO 0.71

Clinical Trials

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There are 2 clinical trials


1 Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise in Older Men With Osteosarcopenia A Randomized Controlled Trial

Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.

NCT04444661
Conditions
  1. Osteoporosis
  2. Sarcopenia
MeSH:Osteoporosis Sarcopenia

Primary Outcomes

Description: Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry

Measure: SMI

Time: Change from Baseline to 26 weeks

Secondary Outcomes

Description: Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry

Measure: BMD-LS

Time: Change from Baseline to 26 weeks

Description: Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry

Measure: BMD-hip

Time: Change from Baseline to 26 weeks

Description: Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity)

Measure: Sarcopenia-Z-Score

Time: Change from Baseline to 26 weeks

Description: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging

Measure: Fat infiltration thigh muscles

Time: Change from Baseline to 26 weeks

Description: Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging

Measure: Fat infiltration para-vertebral muscles

Time: Change from Baseline to 26 weeks

Description: Maximum hip-/leg extensor strength as determined by an isokinetic leg press

Measure: Maximum hip-/leg extensor strength

Time: Change from Baseline to 26 weeks

Description: Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure)

Measure: Metabolic Syndrome Z-Score

Time: Change from Baseline to 26 weeks

Description: Late-Life Function and Disability Index of McAuley et al.

Measure: Self rated physical performance

Time: Change from Baseline to 26 weeks
2 Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection: Research Protocol for Randomized Controlled Trial (CovExc)

With the COVID-19 pandemic, the number of patients to be treated in rehabilitation increased . Hospitalization for severe infection can induce muscular atrophy and muscular dysfunction that persists for several months and rehabilitation capacities may be exceeded. Exercises in eccentric mode could be performed, inducing greater muscular hypertrophy, muscle strength, power and speed than concentric exercises. The goal of this study was to compare functional recovery at 2 months after a training program in eccentric and concentric mode after severe COVID-19. An effective rehabilitation could help reduce costs and duration of care.

NCT04649086
Conditions
  1. Covid19
  2. Sarcopenia
  3. Muscle Weakness
Interventions
  1. Other: Rehabilitation by Eccentric exercises
  2. Other: Rehabilitation by Concentric exercises
MeSH:Muscle Weakness Sarcopenia Paresis
HPO:Hemiparesis

Primary Outcomes

Description: Average change from baseline walking capacity measured by the 6-minutes walk test (6MWT), expressed in meters. All patients will be asked to cover the longest distance over a 30-meters distance in 6 min with or without stopping and with standardized verbal encouragements according to standard recommendations; to take into account a learning effect, the test will be performed twice, with the longer distance retained, expressed in meters. To prevent adverse effect, pulsed oxygen saturation (% of pSO²) and heart rate (heartbeat per minute) will be monitored continuously throughout the test by using a digital oximeter.

Measure: Functional walking capacity

Time: Day 0, Month 1, Month 2 and Month 6

Secondary Outcomes

Description: this test consists of assessing balance in a standing position, lifting from a chair (5 stand to-sit repetitions) and measuring 4-m walking speed (20). The patient walks 4 m at a normal and comfortable speed. The "test zone" (4 m) is preceded by an "acceleration zone" (1 m) and is followed by a "deceleration zone" (1 m). The assessor starts and stops the timing when the subject's foot meets the ground when entering and leaving the "test area", respectively.

Measure: Evaluating of lower extremity functioning by Short Physical Performance Battery (SPPB) score

Time: Day 0, Month 2 and Month 6

Description: maximum muscle strength of the quadriceps, on the dominant limb, will be measured on a bench: - Strength during isometric contraction (at 90° knee flexion) - Standardized position with the arms crossed on the chest, the absence of back support during the measurement and the maintenance of the hips and the contralateral leg to avoid any compensating movement Three reproducible measurements (±10%) will be taken at 1-min intervals, with the highest value retained.

Measure: Evaluating the maximum muscle strength of the quadriceps by Quadriceps Isometric Maximum Strength (QIMS) test

Time: Day 0, Month 2

Description: this test consists of performing 10 knee extensions at 10% QIMS, then gradually increasing the load (10% by 10%) until exhaustion (cannot perform the movement 2 consecutive times). The value retained is the last level (% QIMS) performed.

Measure: Evaluating the fatigability of the quadriceps by Quadriceps Intermittent Fatigue (QIF) test

Time: Day 0, Month 2

Description: this scale explores cognitive (10 items), physical (9 items) and psychosocial (2 items) fatigue. The MFIS included 21 items with a total score ranging from 0 to 84 with higher scores indicating a greater impact of quality of life.

Measure: Evaluating the global fatigability by Modified Fatigue Impact Scale (MFIS)

Time: Day 0, Month 2 and Month 6

Description: This questionnaire explores 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. The EQ-5D-5L included 5 items independently scored from 1 to 5 (higher scores indicating a greater impact)and a 0-100 visual analogic scale exploring general health (0 means the worst heath patient can imagine, 100 means the best health patient can imagine).

Measure: Evaluating functional capacities with EuroQol - 5 Dimensions (EQ-5D) questionnaire

Time: Day 0, Month 2 and Month 6

Description: measurement is in 90° elbow flexion, wrist in neutral position. Three reproducible measurements (± 10%) will be taken at 1-min intervals, with the highest value retained.

Measure: Evaluating the handgrip strength by standard handgrip strength test

Time: Day 0, Month 2

Description: Plasma metabolome profile assessed by variation of number of blood metabolites. Changes from baseline to post-training intervention in plasma metabolome profile will be compared between excentric and concentric exercise groups.

Measure: Metabolomic Profile

Time: Day 0, Month 2 (post-training)

Description: Biopsy from the Vastus lateralis will be performed and the variation of cross sectional area measurement of muscle fibers (µm2) will be analysed and compared between excentric and concentric exercise groups from baseline to post-training intervention.

Measure: Cross sectional area measurement

Time: Day 0, Month 2 (post-training)

Description: Biopsy from the Vastus lateralis will be performed and the capillarization (variation of capillary to fiber ratio) will be analysed. Muscle adapations from baseline to post-training intervention will be compared between excentric and concentric exercise groups.

Measure: Capillary to fibre ratio.

Time: Day 0, Month 2 (post-training)

Description: Biopsy from the Vastus lateralis will be performed and the evolution of number of satellite cell per muscle fiber will be analysed and compared between excentric and concentric exercise groups from baseline to post-training intervention.

Measure: Satellite cell number

Time: Day 0, Month 2 (post-training)

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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