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Behavior (1) Oligospermia (1) Orbital Cellulitis (1) Osteoarthritis (1) Osteoarthritis, Hip (1) Osteoarthritis, Knee (1) Osteochondritis (1) Otitis Media with Effusion (1) Ovarian Neoplasms (1) Pain, Intractable (1) Pancreatitis (1) Paramyxoviridae Infections (1) Paraproteinemias (1) Paresis (1) Parkin (1) Perinatal Death (1) Periodontal Diseases (1) Periodontitis (1) Pharyngeal Diseases (1) Pn (1) Pneumon (1) Pneumonia, Bacterial (1) Pre-Eclampsia (1) Prediabetic State (1) Pregnancy in Diabetics (1) Primary Dysautonomias (1) Prostatic Hyperplasia (1) Protein Deficiency (1) Pseudomonas Infections (1) Psychophysiologic Disorders (1) Puerperal Infection (1) Pulmonary Alveolar Proteinosis (1) Pulmonary Atelectasis (1) Pulmonary Eosinophilia (1) Pulmonary Heart Disease (1) Purpura, Thrombocytopenic, Idiopathic (1) Recurrence (1) Renal Insufficie (1) Reperfusion Injury (1) Resp (1) Respi (1) Respiratory Distress Sy (1) Respiratory Syncytial Virus Infections (1) Retinal Vein Occlusion (1) Rupture (1) Sarcoidosis (1) Scleroderma, Localized (1) Se (1) Shock, Cardiogenic (1) Shoulder Fractures (1) Skin Manifestations (1) Skin Neoplasms (1) Skull Fractures (1) Somatoform Disorders (1) Spondylitis (1) Spondylitis, Ankylosing (1) Sprains and Strains (1) Status Epilepticus (1) Stomach Neoplasms (1) Stress Disorders, Traumatic, Acute (1) Subarachnoid Hemorrhage (1) Suicidal Ideation (1) Superinfection (1) Synovial Cyst (1) Tachycardia (1) Tachycardia, Ventricular (1) Tachypnea (1) Testicular Neoplasms (1) Thalassemia (1) Thoracic Diseases (1) Thrombocytopenia (1) Thrombophlebitis (1) Thrombotic Microangiopathies (1) Tobacco Use Disorder (1) Tonsillitis (1) Torsades de Pointes (1) Tourette Syndrome (1) Tracheal Stenosis (1) Trauma, Nervous System (1) Tuberculosis, Pulmonary (1) Urinary Tract Infections (1) Urogenital Neoplasms (1) Urologic Diseases (1) Uterine Neoplasms (1) Vaginal Neoplasms (1) Vascular Diseases (1) Ventricular Dysfunction, Right (1) Virus (1) Vitamin D Deficie (1) Voice Disorders (1) Vulvar Neoplasms (1) Waldenstrom Macroglobulinemia (1) Weight Gain (1) Weight Loss (1) Yellow Fever (1) beta-Thalassemia (1)

D003110: Colonic Neoplasms

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO

Correlated Drug Terms (11)

Name (Synonyms) Correlation
drug782 Clinical Trial Matching Wiki 0.50
drug1708 Intracorporeal left hemicolectomy anastomosis Wiki 0.50
drug2966 SLEDD with a L-MOD Wiki 0.50
Name (Synonyms) Correlation
drug3091 Shared Decision Making Wiki 0.50
drug879 Control patients Wiki 0.50
drug1261 Extracorporeal left hemicolectomy anastomosis Wiki 0.50
drug2029 Methylene Blue Wiki 0.50
drug875 Control Test Wiki 0.50
drug3250 Sublingual Methylene blue Wiki 0.50
drug877 Control group Wiki 0.29
drug623 COVID-19 convalescent plasma Wiki 0.22

Correlated MeSH Terms (21)

Name (Synonyms) Correlation
D016889 Endometrial Neoplasms NIH 0.50
D013274 Stomach Neoplasms NIH 0.50
D012878 Skin Neoplasms NIH 0.50
Name (Synonyms) Correlation
D009423 Nervous System Neoplasms NIH 0.50
D007680 Kidney Neoplasms NIH 0.50
D016543 Central Nervous System Neoplasms NIH 0.50
D005909 Glioblastoma NIH 0.50
D008113 Liver Neoplasms NIH 0.50
D007822 Laryngeal Neoplasms NIH 0.50
D013736 Testicular Neoplasms NIH 0.50
D002292 Carcinoma, Renal Cell NIH 0.35
D004938 Esophageal Neoplasms NIH 0.35
D002583 Uterine Cervical Neoplasms NIH 0.35
D012004 Rectal Neoplasms NIH 0.35
D018281 Cholangiocarcinoma NIH 0.35
D018358 Neuroendocrine Tumors NIH 0.35
D010190 Pancreatic Neoplasms NIH 0.29
D006258 Head and Neck Neoplasms NIH 0.29
D002277 Carcinoma NIH 0.25
D001943 Breast Neoplasms NIH 0.22
D008175 Lung Neoplasms NIH 0.20

Correlated HPO Terms (22)

Name (Synonyms) Correlation
HP:0003003 Colon cancer HPO 1.00
HP:0002896 Neoplasm of the liver HPO 0.50
HP:0008069 Neoplasm of the skin HPO 0.50
Name (Synonyms) Correlation
HP:0012114 Endometrial carcinoma HPO 0.50
HP:0100006 Neoplasm of the central nervous system HPO 0.50
HP:0010788 Testicular neoplasm HPO 0.50
HP:0009726 Renal neoplasm HPO 0.50
HP:0012174 Glioblastoma multiforme HPO 0.50
HP:0100751 Esophageal neoplasm HPO 0.50
HP:0004375 Neoplasm of the nervous system HPO 0.50
HP:0006753 Neoplasm of the stomach HPO 0.50
HP:0100605 Neoplasm of the larynx HPO 0.50
HP:0005584 Renal cell carcinoma HPO 0.35
HP:0100634 Neuroendocrine neoplasm HPO 0.35
HP:0100743 Neoplasm of the rectum HPO 0.35
HP:0030153 Cholangiocarcinoma HPO 0.35
HP:0030079 Cervix cancer HPO 0.35
HP:0002894 Neoplasm of the pancreas HPO 0.29
HP:0012288 Neoplasm of head and neck HPO 0.29
HP:0030731 Carcinoma HPO 0.25
HP:0003002 Breast carcinoma HPO 0.22
HP:0100526 Neoplasm of the lung HPO 0.20

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials

1 SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.

  1. Cancer, Metastatic
  2. Cancer
  3. Cancer of Pancreas
  4. Cancer of Liver
  5. Cancer of Stomach
  6. Cancer Liver
  7. Cancer of Rectum
  8. Cancer of Kidney
  9. Cancer of Esophagus
  10. Cancer of Cervix
  11. Cancer of Colon
  12. Cancer of Larynx
  13. Cancer, Lung
  14. Cancer, Breast
  15. Cancer, Advanced
  16. Cancer Prostate
  17. Cancer of Neck
  18. Cancer of Skin
  19. Neuroendocrine Tumors
  20. Carcinoma
  21. Mismatch Repair Deficiency
  22. BRCA Gene Rearrangement
  23. Non Hodgkin Lymphoma
  24. Leukemia
  25. Non Small Cell Lung Cancer
  26. Cholangiocarcinoma
  27. Glioblastoma
  28. Central Nervous System Tumor
  29. Melanoma
  30. Urothelial Carcinoma
  31. Bladder Cancer
  32. Ovarian Cancer
  33. Endometrial Cancer
  34. Testicular Cancer
  35. Breast Cancer
  36. COVID
  1. Other: Clinical Trial Matching
MeSH:Carcinoma Glioblastoma Endometrial Neoplasms Neuroendocrine Tumors Cholangiocarcinoma Nervous System Neoplasms Central Nervous System Neoplasms Testicular Neoplasms Pancreatic Neoplasms Breast Neoplasms Lung Neoplasms Stomach Neoplasms Esop Esophageal Neoplasms Colonic Neoplasms Liver Neoplasms Uterine Cervical Neoplasms Rectal Neoplasms Kidney Neoplasms Carcinoma, Renal Cell Head and Neck Neoplasms Skin Neoplasms Laryngeal Neoplasms
HPO:Breast carcinoma Carcinoma Cervical polyp Cervix cancer Cholangiocarcinoma Clear cell renal cell carcinoma Colon cancer Endometrial carcinoma Esophageal neoplasm Glioblastoma multiforme Neoplasm of head and neck Neoplasm of the breast Neoplasm of the central nervous system Neoplasm of the colon Neoplasm of the larynx Neoplasm of the liver Neoplasm of the lung Neoplasm of the nervous system Neoplasm of the pancreas Neoplasm of the rectum Neoplasm of the skin Neoplasm of the stomach Neuroendocrine neoplasm Papillary renal cell carcinoma Renal cell carcinoma Renal neoplasm Testicular neoplasm

Primary Outcomes

Description: CTE Accrual

Measure: Proportion of patients Eligible for CTE versus Actual CTE

Time: Through study completion, an average of 1 year

Secondary Outcomes

Description: OS

Measure: Impact of CTE on Overall Survival (OS), estimated by Kaplan-Meier and Cox multivariable survival analysis

Time: 4 years

Description: PFS

Measure: Impact of CTE on Progression-Free Survival (PFS), estimated by Kaplan-Meier and Cox multivariable survival analysis

Time: 4 years

Description: To identify barriers to accruals to clinical trials, as measured and reported by a questionnaire

Measure: Identification of Barriers to CTE

Time: Through study completion, an average of 1 year

Description: To Analyze Individual Standard of Care Chemotherapy Utilization (nominal), across treatment lines (numeric); data will be combined and aggregated to report chemotherapy utilization rate (%).

Measure: Real World Data Analytics

Time: Through study completion, an average of 1 year

Description: VTB Use Rate

Measure: Virtual Tumor Board Utilization

Time: Through study completion, an average of 1 year

Description: Time to CTE

Measure: Time from Intervention to Actual CTE (months)

Time: Through study completion, an average of 1 year
2 Patients' Preferences About Rescheduling Colonoscopies Delayed Due to COVID-19: Cross Sectional Study

The study is a cross-sectional survey study targeting patients aged 45-75 who had their screening or surveillance colonoscopy postponed or delayed due to the COVID pandemic. Study staff will survey a random subsample of patients to assess anxiety, COVID risk tolerance, cancer worry, willingness to screen and barriers to screening colonoscopy, and preference for colonoscopy and alternative colon cancer screening options. Eligible patients will be sent a survey packet in the mail that will include a cover letter, an information sheet describing the study, an incentive, and the survey. The cover letter will include information for participants to opt-out if they desire. Patients will be asked to complete the survey and return it back to study staff. Consent is implied with return of the survey. For the study, staff plan to invite 300 patients and expect to receive 195 completed surveys. Analyses will examine whether COVID-19 has changed patients' interest in colon cancer screening and the strength of patients' preferences for colonoscopy and other approaches to colon cancer screening. It will then examine factors associated with positive and negative views on rescheduling colonoscopies such as anxiety, worry, and risk perceptions.

  1. Colon Cancer
MeSH:Colonic Neoplasms
HPO:Colon cancer Neoplasm of the colon

Primary Outcomes

Description: Item with 5-point response assessing whether COVID-19 has increased, decreased or not changed interest in colon cancer screening

Measure: Interest in colon cancer screening

Time: at start of study--between one week and 2 months after start of study

Secondary Outcomes

Description: Item with 5-point response (definitely want to definitely do not want) measuring interest in having a stool test for colon cancer

Measure: Preference for stool testing

Time: at start of study--between one week and 2 months after start of study

Description: Item with 5-point response (definitely want to definitely do not want) measuring interest in postponing colonoscopy for one year

Measure: Preference for postponing colonoscopy for one year

Time: at start of study--between one week and 2 months after start of study

Description: Item with 5 point response (extremely worried to not at all worried) assessing worry about the delay of the colonoscopy on their colon cancer risk

Measure: Worry about delay

Time: at start of study--between one week and 2 months after start of study

Description: Item with 5-point response (very high to very low) assessing patients' perception about risk of getting COVID-19 from having a colonoscopy

Measure: Risk perception on COVID-19

Time: at start of study--between one week and 2 months after start of study

OBJECTIVE: The aim of the study is to demonstrate that the intracorporeal resection and anastomosis in left-sided colon cancer, sigma and upper rectum, is not inferior to extracoprporeal resection and anastomosis, in terms of anastomotic leakage. BACKGROUND: Due to the recent events of a pandemic respiratory disease secondary to infection by SARS-CoV-2 virus or coronavirus 19 (COVID19), surgeons have been forced to adapt our surgical procedures in order to minimize exposure to the virus as much as possible. Based on the recommendations in case of surgery in patients with highly contagious viral diseases, the latest studies suggest minimally invasive accesses to minimize the risk of contagion. One of the proposed measures is the performance of intracorporeal anastomoses. Therefore, given the extensive experience of our center in minimally invasive surgery and studies on the validation of intracorporeal anastomosis techniques in both laparoscopic surgery of the right colon and rectum (TaTME), and the study of advantages that they can provide to the patient, our intention is to apply it to surgery on the left colon, sigma and upper rectum. Our hypothesis is that exteriorization of the colon through an accessory incision increases the risk of tension at the mesocolon level, thus increasing the risk of vascular deficit at the level of the staple area and it may increase the rate of anastomotic leakage. In this sense, studies that validate a standard technique of intracorporeal anastomosis in left colon surgery and that demonstrate its benefit with respect to extracorporeal anastomosis are lacking. We intend to describe a new intracorporeal anastomosis technique (ICA) that is feasible and safe for the patient and that can be applied universally. Once the ICA technique is established, it will allow us to determine its non-inferiority compared to the standard technique performed up to now with extracorporeal anastomosis. METHODS: All consecutive patients with left-sided, sigma and upper rectum adenocarcinoma will be included into a prospective cohort and treated by laparoscopy with totally intracorporeal resection and anastomosis. They will be compared with a retrospective cohort of consecutive patients of identical characteristics treated by laparoscopy with extracorporeal resection and anastomosis, in the immediate chronological period.

  1. Colon Cancer
  1. Procedure: Extracorporeal left hemicolectomy anastomosis
  2. Procedure: Intracorporeal left hemicolectomy anastomosis
MeSH:Colonic Neoplasms
HPO:Colon cancer Neoplasm of the colon

Primary Outcomes

Description: Percentage of anastomic leak (defined in accordance with Peel et al.).

Measure: Percentage of anastomotic leak (AL)

Time: 30 days

Secondary Outcomes

Description: Dindo-Clavien Classification

Measure: Rate of global morbidity

Time: 30 days

Description: SSI in accordance with the Center for Disease Control (CDC) National

Measure: Rate of Surgical site infection

Time: 30 days

Description: Percentage of re-interventions due to surgical complications

Measure: Rate of Re-interventions

Time: 30 days
4 Engaging Patients in Colon Cancer Screening Decisions During COVID-19

The goal of the study is to examine whether a shared decision making intervention improves decision making about colon cancer screening for patients who had their colonoscopy delayed or postponed due to the COVID pandemic. Eligible patients (n=800) will be randomly assigned to either the intervention or control arm. A subset will be surveyed about 6 weeks post intervention to measure shared decision making, their intention to follow through with screening, and their decisional conflict. Study staff will conduct medical chart review to track receipt of colon cancer screening within 6 months. The statistician will test whether patients in the intervention arm report more shared decision making, less decisional conflict, higher intention to follow through on screening and have higher screening rates compared to those in the control arm.

  1. Colon Cancer
  1. Behavioral: Shared Decision Making
MeSH:Colonic Neoplasms
HPO:Colon cancer Neoplasm of the colon

Primary Outcomes

Description: short patient reported scale asks patients about discussion of options, pros and cons of colonoscopy and discussion of patients' preferences. Total scores range from 0-4 with higher scores indicating higher shared decision making.

Measure: Shared Decision Making (SDM) Process Scale Score

Time: 6 weeks after intervention

Secondary Outcomes

Description: the 4-item version of the decisional conflict scale, total score ranges from 0-4 with greater scores indicating less decisional conflict.

Measure: Decisional Conflict (SURE scale)

Time: 6 weeks after intervention

Description: One item will assess patients' preferred approach to screening (with responses of colonoscopy, stool card test, no screening, not sure).

Measure: Patient's preferred approach to screening

Time: 6 weeks after intervention

Description: One item will assess patients' intention to follow through with their preferred approach on a 5-point scale from not at all likely to extremely likely.

Measure: Intention to screen

Time: 6 weeks after intervention

Description: Percentage of patients who had completed colon cancer screening test

Measure: Colon cancer screening rate

Time: 6 months after randomization

HPO Nodes


Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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706 reports on MeSH terms


306 reports on HPO terms

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