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D013923: Thromboembolism

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (31)


Name (Synonyms) Correlation
drug4134 venous ultrasound Wiki 0.32
drug1036 Diagnostic examination for venous thromboembolism Wiki 0.23
drug2451 Peripheral venous ultrasound Wiki 0.23
Name (Synonyms) Correlation
drug1792 Laboratory test positive for SARS-CoV-2 virus Wiki 0.23
drug4119 thromboprophylaxis with low-molecular-weight heparin or fondaparinux Wiki 0.23
drug1078 Dose of Tinzaparin or Dalteparin Wiki 0.23
drug1914 MCN (Methylene blue, vitamin C, N-acetyl cysteine) Wiki 0.23
drug1440 Heparin Infusion Wiki 0.23
drug2880 Rivaroxaban 10 MG Wiki 0.23
drug3545 Unfractionated Heparin IV Wiki 0.23
drug3853 hAd5-S-Fusion+N-ETSD vaccine Wiki 0.23
drug3846 further processing of health data Wiki 0.23
drug1079 Dose of tinzaparin or dalteparin Wiki 0.23
drug1101 Duplex ultrasound and Computed Tomography Angiography Wiki 0.23
drug3547 Unfractionated heparin SC Wiki 0.23
drug1441 Heparin SC Wiki 0.23
drug4118 thromboprofylaxis protocol Wiki 0.23
drug1201 Enoxaparin/Lovenox Intermediate Dose Wiki 0.23
drug1194 Enoxaparin 1 mg/kg Wiki 0.23
drug3535 Ultrasonography Wiki 0.23
drug1199 Enoxaparin Prophylactic Dose Wiki 0.23
drug4091 standard protocol Wiki 0.23
drug3392 Therapeutic anticoagulation Wiki 0.16
drug58 50 mg/mL Virazole Wiki 0.16
drug1195 Enoxaparin 40 Mg/0.4 mL Injectable Solution Wiki 0.16
drug25 100 mg/mL Virazole Wiki 0.16
drug3762 blood sample Wiki 0.15
drug793 Clopidogrel Wiki 0.13
drug2284 Observational Wiki 0.11
drug599 COVID-19 Convalescent Plasma Wiki 0.10
drug1193 Enoxaparin Wiki 0.06

Correlated MeSH Terms (16)


Name (Synonyms) Correlation
D054556 Venous Thromboembolism NIH 0.69
D013927 Thrombosis NIH 0.35
D020246 Venous Thrombosis NIH 0.35
Name (Synonyms) Correlation
D011655 Pulmonary Embolism NIH 0.30
D004617 Embolism NIH 0.23
D054058 Acute Coronary Syndrome NIH 0.11
D016769 Embolism and Thrombosis NIH 0.11
D009205 Myocarditis NIH 0.08
D009203 Myocardial Ischemia NIH 0.07
D020141 Hemostatic Disorders NIH 0.06
D001778 Blood Coagulation Disorders NIH 0.06
D009369 Neoplasms, NIH 0.04
D016638 Critical Illness NIH 0.03
D045169 Severe Acute Respiratory Syndrome NIH 0.03
D018352 Coronavirus Infections NIH 0.02
D011014 Pneumonia NIH 0.02

Correlated HPO Terms (8)


Name (Synonyms) Correlation
HP:0001907 Thromboembolism HPO 0.91
HP:0002625 Deep venous thrombosis HPO 0.35
HP:0002204 Pulmonary embolism HPO 0.30
Name (Synonyms) Correlation
HP:0012819 Myocarditis HPO 0.08
HP:0001658 Myocardial infarction HPO 0.07
HP:0001928 Abnormality of coagulation HPO 0.06
HP:0002664 Neoplasm HPO 0.04
HP:0002090 Pneumonia HPO 0.02

Clinical Trials

Navigate: Correlations   HPO

There are 19 clinical trials


1 Cardiovascular Complications in Patients With COVID-19

Patients with COVID-19 in the Intensive Care Unit (ICU) or hospitalized with severe form have a poor prognosis (almost 30% rate of death). They present often a high cardiovascular risk profile (almost 30% of hypertension and 19% of diabetes). Troponin has been described to be elevated in a high proportion of patients (one fifth of all patients and 50% of non-survivors) suggesting the possibility of cardiomyopathies. High levels of DDimers (81% of non survivors) and fibrin degradation products are also associated with increased risk of mortality suggesting also the possibility of venous thromboembolism. Therefore, screening for cardiomyopathies and venous thromboembolism could represent an important challenge for patients with COVID-19 management.

NCT04335162
Conditions
  1. COVID
  2. Acute Coronary Syndrome
  3. Myocardial Infarction
  4. Myocarditis
  5. Venous Thromboembolism
  6. Deep Vein Thrombosis
  7. Pulmonary Embolism
MeSH:Pulmonary Embolism Myocardial Infarction Thrombosis Acute Coronary Syndrome Thromboembolism Embolism Venous Thromboembolism Venous Thrombosis Myocarditis
HPO:Deep venous thrombosis Myocardial infarction Myocarditis Pulmonary embolism Thromboembolism Venous thrombosis

Primary Outcomes

Description: Incidence of cardiomyopathies and/or venous thromboembolism at day 28

Measure: Determine the incidence of cardiomyopathies and venous thromboembolism

Time: 28 days

Secondary Outcomes

Description: Incidence of mortality at day 28

Measure: Mortality

Time: 28 days

Description: Number of day of using mechanical ventilation for each patients

Measure: Duration of mechanical ventilation

Time: hospitalisation duration

Description: Incidence of shock during hospitalisation

Measure: Shock

Time: hospitalisation duration

Description: Number of day at hospital

Measure: length of stay

Time: hospitalisation duration

Description: Setting up or not of mechanical ventilation

Measure: Mechanical ventilation

Time: hospitalisation duration

Description: Administration or not of renal replacement therapy

Measure: Renal replacement therapy

Time: hospitalisation duration
2 Increased Risk of Venous Thromboembolism and Higher Hypercoagulable State in Patients Recovered in Intensive Care Unit and in Medical Ward for Coronavirus Disease 2019 (COVID-19)

The aim of this study is to verify if patients admitted to hospital in a medical division and in the intensive care unit for a COVID-19 infection are at higher risk of developing a VTE complication and if they actually present an increased hypercoagulable state.

NCT04359212
Conditions
  1. COVID-19 Disease
  2. Thromboembolism, Venous
Interventions
  1. Drug: thromboprophylaxis with low-molecular-weight heparin or fondaparinux
MeSH:Thromboembolism Venous Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: the cumulative proportion of any distal or proximal deep venous thrombosis or of symptomatic pulmonary embolism

Measure: the cumulative proportion of any distal or proximal deep venous thrombosis or of symptomatic pulmonary embolism

Time: 28 days

Secondary Outcomes

Description: the cumulative proportion of any distal or proximal deep venous thrombosis or of symptomatic pulmonary embolism plus the asymptomatic incidentally detected pulmonary embolism

Measure: the cumulative proportion of any distal or proximal deep venous thrombosis or of symptomatic pulmonary embolism plus the asymptomatic incidentally detected pulmonary embolism

Time: 28 days
3 Thrombo Embolic Events in Critical Care Patients With Covid-19 Serious Acute Pneumopathy

The understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis. Complex and delicately balanced interaction between coagulation and inflammation involve all cellular and humoral components. Elements of the coagulation system such as activated thrombin, fibrinogen or factor Xa may increase inflammation by promoting the production of pro-inflammatory cytokines, chemokines, growth factors and adhesion molecules that lead to a procoagulant state amplifying the pathological process. Recent evidence supports inflammation as a common pathogenic contributor to both arterial and venous thrombosis, giving rise to the concept of inflammation-induced thrombosis. Patients with infection of COVID-19 and severe pneumoniae seem to have higher risk of thromboembolism. Very few data are available regarding the biological disorders of coagulation in these patients. Th purpose of this project is to analyze hemostasis and coagulation of patients with infection of COVID-19 and severe pneumonia.

NCT04366752
Conditions
  1. COVID-19
  2. Pneumonia
  3. ARDS
  4. Hemostasis
  5. Coagulation
Interventions
  1. Other: venous ultrasound
  2. Other: blood sample
MeSH:Pneumonia Thromboembolism
HPO:Pneumonia Thromboembolism

Primary Outcomes

Description: The reference range for the thrombin time is usually less than 20 seconds (ie, 15-19 seconds)

Measure: Variation of thrombin time (in secondes) in Covid-19 patients with pneumonia admitted in ICU.

Time: up to 6 weeks

Description: Variation of factor V concentration (U/dL) in Covid-19 patients with pneumonia admitted in ICU.

Measure: Variation of factor V concentration (U/dL) in Covid-19 patients with pneumonia admitted in ICU.

Time: up to 6 weeks

Description: Variation of factor II concentration (U/dL) in Covid-19 patients with pneumonia admitted in ICU.

Measure: Variation of factor II concentration (U/dL) in Covid-19 patients with pneumonia admitted in ICU.

Time: up to 6 weeks

Description: Variation of concentration of fibrin and fibrinogen degradation products (≥ 10 µgm/mL) in Covid-19 patients with pneumonia admitted in ICU.

Measure: Variation of concentration of fibrin and fibrinogen degradation products (≥ 10 µgm/mL) in Covid-19 patients with pneumonia admitted in ICU.

Time: up to 6 weeks
4 Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19: A Cluster Based Randomized Selection Trial (IMPROVE-COVID)

This study is being conducted to assess the effectiveness of intermediate versus prophylactic doses of anticoagulation (blood thinners) in patients critically ill with COVID-19 in the intensive care units (ICUs) throughout the hospital. Anticoagulation is part of the patient's usual standard of care but determining the dose of anticoagulation is based on physician preference. The investigators are conducting this study (a randomized trial with adaptive design employing cluster randomization) with the support of all of the ICUs to collect data in order to determine what should be the standard of care in terms of anticoagulation in these critically ill patients. The patients care will not be altered other than the choice of anticoagulation (both approved and used throughout the hospital as standard of care) based on the ICU bed they are assigned. Patient data will be collected until discharge.

NCT04367831
Conditions
  1. COVID-19
  2. Venous Thromboses
  3. Arterial Thrombosis
Interventions
  1. Drug: Enoxaparin Prophylactic Dose
  2. Drug: Heparin Infusion
  3. Drug: Heparin SC
  4. Drug: Enoxaparin/Lovenox Intermediate Dose
MeSH:Thrombosis Thromboembolism Venous Thrombosis
HPO:Deep venous thrombosis Thromboembolism Venous thrombosis

Primary Outcomes

Description: Composite of being alive and without clinically-relevant venous or arterial thrombotic events at discharge from ICU (without transfer to another ICU or palliative care unit/hospice) or at 30 days (if ICU duration lasted 30 days or longer).

Measure: Total Number of Patients with Clinically Relevant Venous or Arterial Thrombotic Events in ICU

Time: Discharge from ICU or 30 days

Secondary Outcomes

Description: Composite of being alive and without clinically-relevant venous or arterial thrombotic events at discharge from ICU (without transfer to another ICU or palliative care unit/hospice) or at 30 days (if ICU duration lasted 30 days or longer).

Measure: Total Number of Patients with In hospital Clinically Relevant Venous or Arterial Thrombotic Events

Time: Discharge from hospital or 30 days

Description: Length of stay measured in days.

Measure: ICU Length of Stay

Time: Discharge from ICU or 30 days

Description: The impact of intermediate-dose anti-coagulation compared with prophylactic anti-coagulation on rates of acute kidney injury and renal recovery in the ICU will be measured with the total number of patients who need of renal replacement therapy in the ICU.

Measure: Total Number of Patients with the Need for Renal Replacement Therapy in the ICU

Time: Discharge from hospital or 30 days

Description: Major bleeding will be assessed by BARC criteria, also explored by International Society on Thrombosis and Haemostasis (ISTH) and Thrombolysis in Myocardial Infarction (TIMI) criteria.

Measure: Total Number of Patients with Major bleeding in the ICU

Time: Discharge from hospital or 30 days

Description: Length of stay measured in days.

Measure: Hospital Length of Stay

Time: Discharge from hospital or 30 days
5 Effectiveness of Weight-adjusted Prophylactic Low Molecular Weight Heparin Doses Compared With Lower Fixed Prophylactic Doses to Prevent Venous Thromboembolism in COVID-2019. The Multicenter Randomized Controlled Open-label Trial COVI-DOSE

Worldwide observational studies indicate a significant prothrombogenic effect associated with SARS-CoV-2 infection with a high incidence of venous thromboembolism (VTE), notably life-threatening pulmonary embolism. According to recommendations for acute medical illnesses, all COVID-19 hospitalized patients should be given VTE prophylaxis such as a low molecular weight heparin (LMWH). A standard prophylactic dose (eg. Enoxaparin 4000IU once daily) could be insufficient in obese patients and VTE has been reported in patients treated with a standard prophylactic dose. In COVID-19 patients, guidelines from several international societies confirm the existence of an hypercoagulability and the importance of thromboprophylaxis but the "optimal dose is unknown" and comparative studies are needed. In view of these elements, carrying out a trial comparing various therapeutic strategies for the prevention of VTE in hospitalized patients with COVID-19 constitutes a health emergency. Thus, we hypothesize that an increased prophylactic dose of weight-adjusted LMWH would be greater than a lower prophylactic dose of LMWH to reduce the risk of life-threatening VTE in hospitalized patients. The benefit-risk balance of this increase dose will be carefully evaluated because of bleeding complications favored by possible renal / hepatic dysfunctions, drug interactions or invasive procedures in COVID-19 patients. This multicenter randomized (1:1) open-label controlled trial will randomize hospitalized adults with COVID-19 infection to weight-adjusted prophylactic dose vs. lower prophylactic dose of LMWH.

NCT04373707
Conditions
  1. COVID
  2. Thrombosis
  3. Pulmonary Embolism
  4. Deep Vein Thrombosis
Interventions
  1. Drug: Enoxaparin
  2. Drug: Enoxaparin
MeSH:Pulmonary Embolism Thrombosis Thromboembolism Emb Embolism Venous Thromboembolism Venous Thrombosis
HPO:Deep venous thrombosis Pulmonary embolism Thromboembolism Venous thrombosis

Primary Outcomes

Description: Risk of deep vein thrombosis or pulmonary embolism or venous thromboembolism-related death

Measure: Venous thromboembolism

Time: 28 days

Secondary Outcomes

Description: Risk of major bleeding defined by the ISTH

Measure: Major bleeding

Time: 28 days

Description: Risk of Major Bleeding and Clinically Relevant Non-Major Bleeding Defined by the ISTH

Measure: Major Bleeding and Clinically Relevant Non-Major Bleeding

Time: 28 days

Description: Risk of Venous Thromboembolism and Major Bleeding

Measure: Net Clinical Benefit

Time: 28 days and 2 months

Description: Risk of venous thrombosis at other sites: e.g. superficial vein, catheters, hemodialysis access, ECMO, splanchnic, encephalic, upper limb

Measure: Venous Thromboembolism at other sites

Time: 28 days

Description: Risk of arterial thrombosis at any sites

Measure: Arterial Thrombosis

Time: 28 days

Description: Risk of all-cause mortality

Measure: All-Cause Mortality

Time: 28 days and 2 months

Description: Identification of associations between the risk of venous thromboembolism and clinical (eg. past medical history of thrombosis, cardiovascular risk factors, treatments, severity of COVID-19) and laboratory variables (e.g. D-dimers, fibrinogen, CRP) collected in the eCRF

Measure: Factors associated with the risk of venous thromboembolism

Time: 28 days
6 Risk of Venous Thromboembolism in Critically Ill Patients With Severe COVID-19

Severe COVID-19 patients at a high risk of venous thromboembolism. We studied patients in 2 intensive care units of university hospitals in Barcelona and Badalona, Spain. We performed a cut-off screening of deep venous thrombosis (DVT) with bilateral duplex ultrasound to 230 patients.

NCT04374617
Conditions
  1. COVID-19
  2. Critical Illness
  3. Venous Thromboembolism
  4. Venous Thromboses
  5. Venous Thromboses, Deep
  6. Venous Thrombosis Pulmonary
  7. Pulmonary Embolism
  8. Pulmonary Embolism and Thrombosis
  9. Sars-CoV2
  10. SARS-CoV Infection
Interventions
  1. Diagnostic Test: Duplex ultrasound and Computed Tomography Angiography
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Pulmonary Embolism Thrombosis Thromboembolism Embolism Venous Thromboembolism Venous Thrombosis Embolism and Thrombosis Critical Illness
HPO:Deep venous thrombosis Pulmonary embolism Thromboembolism Venous thrombosis

Primary Outcomes

Description: Patients with symptomatic pulmonary embolism confirmed on the CT-angiography and those with a swollen limb and confirmed deep venous thrombosis on compression ultrasound were considered to have "symptomatic venous thromboembolisms". The remaining patients with positive limb ultrasound or CT-angiography were considered to have "asymptomatic venous thrombembolism"

Measure: Venous thromboembolisms

Time: 7 days

Secondary Outcomes

Description: Deaths from all causes during the follow-up

Measure: Deaths

Time: 7 days
7 Thrombo Embolic Events in Hospitalized Patients With Covid-19 Serious Acute Pneumopathy

The understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis. Complex and delicately balanced interaction between coagulation and inflammation involve all cellular and humoral components. Elements of the coagulation system such as activated thrombin, fibrinogen or factor Xa may increase inflammation by promoting the production of proinflammatory cytokines, chemokines, growth factors and adhesion molecules that lead to a procoagulant state amplifying the pathological process. Recent evidence supports inflammation as a common pathogenic contributor to both arterial and venous thrombosis, giving rise to the concept of inflammation induced thrombosis. Patients with infection of COVID-19 and severe pneumoniae seem to have higher risk of thromboembolism. The purpose of this project is to analyze hemostasis and coagulation of every hospitalized patient with infection of COVID-19. Blood sample for coagulation and hemostasis analysis will be collected on every patient hospitalized in Amiens hospital for COVID-19 infection. Thrombin time, factors V and II, fibrin/fibrinogen degradation products, antithrombin will be assessed every week. Anticardiolipin, anti-beta2 glycoprotein I and anti-annexin A2 antibodies IgG and IgM at day of admission and at fourth week after admission will be assessed. SARS-CoV2 viral load and serodiagnosis will be performed at the same time. At the same time venous ultrasound to diagnose thrombosis will be performed.

NCT04377490
Conditions
  1. COVID-19
  2. Hemostasis
  3. Coagulation
Interventions
  1. Other: venous ultrasound
  2. Biological: blood sample
MeSH:Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: Variation of thrombin time (in secondes) in Hospitalized Covid-19 patients. The reference range for the thrombin time is usually less than 20 seconds (ie, 15-19 seconds)

Measure: Variation of thrombin time (in secondes) in Hospitalized Covid-19 patients

Time: up to 6 weeks

Description: Variation of factor V concentration (U/dL) in Hospitalized Covid-19 patients.

Measure: Variation of factor V concentration (U/dL) in Hospitalized Covid-19 patients.

Time: up to 6 weeks

Description: Variation of factor II concentration (U/dL) in Hospitalized Covid-19 patients

Measure: Variation of factor II concentration (U/dL) in Hospitalized Covid-19 patients

Time: up to 6 weeks

Description: Variation of concentration of fibrin and fibrinogen degradation products (≥ 10 µgm/mL) in Hospitalized Covid-19 patients.

Measure: Variation of concentration of fibrin and fibrinogen degradation products (≥ 10 µgm/mL) in Hospitalized Covid-19 patients.

Time: up to 6 weeks
8 Impact of Implementation of an Intensified Thromboprofylaxis Protocol in in Critically Ill ICU Patients With COVID-19: a Longitudinal Controlled Before-after Study

The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified thromboprofylaxis protocol on 31st of March 2020. Patients in the before group are admitted at the ICU from 13/3/2020-30/3/2020 and patients in the after group are admitted to the ICU from 31/3 until 20/4/2020.

NCT04394000
Conditions
  1. COVID19
  2. Thromboembolism
Interventions
  1. Other: thromboprofylaxis protocol
  2. Other: standard protocol
MeSH:Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: mortality was assessed in all COVID 19 patients admitted to the ICU

Measure: 2 week mortality

Time: 2 weeks after admission at ICU

Secondary Outcomes

Description: the incidence of venous thromboembolism was evaluated in all COVID 19 patients admitted to the ICU

Measure: incidence of venous thromboembolism

Time: during ICU stay up till 3th of May 2020

Description: mortality was assessed in all COVID 19 patients admitted to the ICU

Measure: 1 week mortality

Time: 1 week after admission at ICU

Description: mortality was assessed in all COVID 19 patients admitted to the ICU

Measure: 3 week mortality

Time: 3 weeks after admission at ICU

Description: mortality was assessed in all COVID 19 patients admitted to the ICU

Measure: 1 month mortality

Time: 1 month after admission at ICU

Description: incidence of acute kidney failure in all COVID 19 patients admitted to the ICU

Measure: incidence of kidney failure

Time: during ICU stay up till 3th of May 2020

Description: incidence of continuous renal replacement therapy (CRRT) in all COVID 19 patients admitted to the ICU

Measure: incidence of continuous renal replacement therapy (CRRT)

Time: during ICU stay up till 3th of May 2020

Description: evaluation of the lowest P/F ratio in all COVID 19 patients admitted to the ICU

Measure: lowest PaO2/FiO2 (P/F) ratio

Time: during ICU stay up till 3th of May 2020

Description: evaluation of the highest SOFA score in all COVID 19 patients admitted to the ICU

Measure: highest Sequential Organ Failure Assessment (SOFA) score

Time: during ICU stay up till 3th of May 2020

Description: evaluation of the length of stay in ICU and hospital of all COVID 19 patients admitted to the ICU

Measure: length of stay

Time: during ICU and hospital stay up till 3th of May 2020

Description: evaluation of the highest bilirubine level in all COVID 19 patients admitted to the ICU

Measure: highest bilirubin

Time: during ICU stay up till 3th of May 2020

Description: evaluation of the highest AST level in all COVID 19 patients admitted to the ICU

Measure: highest ( AST

Time: during ICU stay up till 3th of May 2020

Description: evaluation of the highest ALT level in all COVID 19 patients admitted to the ICU

Measure: highest Aspartaat-Amino-Transferase (ALT)

Time: during ICU stay up till 3th of May 2020
9 Prevalence and Severity of Venous Thromboembolism in a General Population During the COVID-19 Pandemic

The purpose of this study is to investigate the prevalence of venous thromboembolism in a regional health care system (Region Östergötland, Sweden) before and during the SARS-COV-2 pandemic. In a retrospective observational study, we will review patient data, diagnostic data and treatment data over a three-month period since the onset of the SARS-COV-2 pandemic. This data will be compared with data from the corresponding time frame during the years 2015 to 2019.

NCT04400877
Conditions
  1. COVID-19
  2. Venous Thromboembolism
  3. Pulmonary Embolism
  4. Deep Vein Thrombosis
  5. SARS-CoV 2
Interventions
  1. Diagnostic Test: Diagnostic examination for venous thromboembolism
MeSH:Pulmonary Embolism Thrombosis Thromboembolism Embolism Venous Thromboembolism Venous Thrombosis
HPO:Deep venous thrombosis Pulmonary embolism Thromboembolism Venous thrombosis

Primary Outcomes

Measure: Is there an increased prevalence of venous thromboembolism in a regional healthcare system in Sweden during the SARS-CoV-2 pandemic?

Time: March to May in 2020

Measure: Is a SARS-CoV-2-infection an isolated risk factor for thromboembolism?

Time: March to May in 2020

Secondary Outcomes

Measure: Are there geographic differences in the prevalence of venous thromboembolism within the healthcare system?

Time: March to May in 2020

Measure: Is venous thromboembolism associated with increased mortality adjusted for relevant comorbidities?

Time: March to May in 2020

Measure: How long is the time between symptom onset of the SARS-CoV-2-infection and any subsequent venous thromboembolism?

Time: March to May in 2020

Measure: Is treatment with prophylactic antithrombotic or anticoagulant treatment associated with increased survival?

Time: March to May in 2020
10 Incidence of Thromboembolic Events and Prognosis of COVID-19 Patients Hospitalized in Intensive Care Units in France

The main objective of this study is to describe the incidence of thromboembolic events in a population of patients hospitalized in intensive care units in France for severe COVID-19. The secondary objective of this study is to describe the evolution of hemostasis parameters during the first two weeks of intensive care hospitalization and to evaluate the influence of different anticoagulation regimens on these parameters and on the incidence of thromboembolic events

NCT04405869
Conditions
  1. Pulmonary Thromboembolism
MeSH:Pulmonary Embolism Thromboembolism
HPO:Pulmonary embolism Thromboembolism

Primary Outcomes

Measure: Analysis of incidence of thromboembolic events in patients with Sars-CoV-2

Time: 1 month
11 A Multicenter, Randomized-Controlled Trial to Evaluate the Efficacy and Safety of Antithrombotic Therapy for Prevention of Arterial and Venous Thrombotic Complications in Critically-Ill COVID-19 Patients

This is a multicenter, open-label, 2x2 factorial, randomized-controlled trial in critically-ill patients with novel coronavirus disease 2019 (COVID-19) evaluating the efficacy and safety of full-dose vs. standard prophylactic dose anticoagulation and of antiplatelet vs. no antiplatelet therapy for prevention of venous and arterial thrombotic events.

NCT04409834
Conditions
  1. COVID-19
  2. Venous Thromboembolism
  3. Arterial Thrombosis
Interventions
  1. Drug: Unfractionated Heparin IV
  2. Drug: Enoxaparin 1 mg/kg
  3. Drug: Clopidogrel
  4. Drug: Unfractionated heparin SC
  5. Drug: Enoxaparin 40 Mg/0.4 mL Injectable Solution
MeSH:Thrombosis Thromboembolism Venous Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: Hierarchical composite: Death due to venous or arterial thrombosis, pulmonary embolism, clinically evident DVT, type 1 MI, ischemic stroke, systemic embolism or acute limb ischemia, or clinically silent DVT

Measure: Primary endpoint: Venous or arterial thrombotic events

Time: 28 days or until hospital discharge, whichever earlier

Secondary Outcomes

Description: Hierarchical composite: Death due to venous or arterial thrombosis, pulmonary embolism, clinically evident DVT, type 1 MI, ischemic stroke, systemic embolism or acute limb ischemia

Measure: Key secondary endpoint: Clinically evident venous or arterial thrombotic events

Time: 28 days or until hospital discharge, whichever earlier
12 Patient Characteristics, Outcome and Thromboembolic Events Among Adult Critically Ill COVID-19 Patients With Different Anticoagulant Regimes at One of the Biggest Emergency Hospitals in Northern Europe, Sweden

The aims of the study are to to associate anticoagulation (AC) regime with outcome in critically ill patients with Covid-19. This will be done by describe baseline characteristics and comorbidities before hospital admission, level of organ support and dose of AC treatment and associate this with 28 days survival, survival outside ICU, thromboembolic event and bleeding complications.

NCT04412304
Conditions
  1. Covid-19
  2. Thromboembolic Events
  3. Bleeding
Interventions
  1. Drug: Dose of Tinzaparin or Dalteparin
MeSH:Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: 28-days ICU mortality from admission to the ICU. Discontinue of ICU-care to palliative care counts as death.

Measure: 28-days ICU mortality

Time: 28 days from ICU-admission

Secondary Outcomes

Description: Thromboembolic events are defined as pulmonary emboli (PE), deep venous thrombus (DVT), ischemic stroke and other peripheral arterial emboli. PE is defined as PE verified by computer tomography or by findings of acute strain of the right heart on echocardiography combined with a clinical interpretation of the patients deteriorating as a probable PE stated in the medical records. DVT is defined as DVT verified with ultrasound. Ischemic stroke is defined as ischemic stroke verified by computer tomography. Peripheral arterial emboli are defined as peripheral arterial emboli verified by computer tomography.

Measure: Incidence of thromboembolic events

Time: 28 days from ICU-admission

Description: The event of bleeding will be defined by WHO modified bleeding scale as 1-4.

Measure: Incidence of bleeding events

Time: 28 days from ICU-admission

Description: ICU-free days alive during 28 days from ICU-admission. Counts as 0 days if discharged to ward for palliative treatment.

Measure: ICU-free days alive from ICU-admission.

Time: 28 days from ICU-admission

Other Outcomes

Description: D-dimer every day it is measured during first 28 days from ICU-admission.

Measure: D-dimer levels in the three groups groups

Time: 28 days from ICU-admission
13 Thrombosis Risk Assessment May Predict Clinical Presentation and Length of Hospital Stay in Covid-19 Pneumonia

Covid-19 mainly affects the respiratory system. Multiple organ dysfunction and a particularly progressive respiratory insufficiency along with a widespread coagulopathy presumed to be due to infection-associated inflammation and the resulting cytokine storm, are strongly associated with high mortality rates. In this study, the association between thrombosis risk and clinical presentation of Covid-19 is investigated.

NCT04423315
Conditions
  1. Corona Virus Infection
  2. Thromboembolic Disease
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Pneumonia Thrombosis Thromboembolism
HPO:Pneumonia Thromboembolism

Primary Outcomes

Description: from admission to discharge expressed in days

Measure: length of hospital stay

Time: 2 months
14 Utilização da Enoxaparina em Dose Anticoagulante em Pacientes Hospitalizados Com síndrome respiratória Aguda Grave Por COVID-19

Published papers evaluating coagulopathy on COVID-19 patients indicate a higher incidence of thromboembolic events, sometimes, as high as 20%. Such events increase ICU admissions and are associated with death. Considering the importance of thromboembolic events concurring to deteriorate clinical state, we propose to conduct a parallel pragmatic open-label randomized controlled trial to determine the effect of therapeutic anticoagulation compared to standard care in hospitalized patients with COVID-19 and with low oxygen saturation.

NCT04444700
Conditions
  1. COVID
  2. Coronavirus Infection
  3. Severe Acute Respiratory S
  4. Severe Acute Respiratory Syndrome
  5. Thromboembolism, Venous
  6. Anticoagulants and Bleeding Disorders
Interventions
  1. Drug: Therapeutic anticoagulation
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Thromboembolism Hemostatic Disorders Venous Thromboembolism Blood Coagulation Disorders
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Thromboembolism

Primary Outcomes

Description: Composite outcome of ICU admission (yes/no), non-invasive positive pressure ventilation (yes/no), invasive mechanical ventilation (yes/no), or all-cause death (yes/no) up to 28 days.

Measure: Composite main outcome

Time: up to 28 days

Secondary Outcomes

Description: All-cause death

Measure: All-cause death

Time: 28 days

Description: Composite outcome of ICU admission or all-cause death

Measure: Composite outcome of ICU admission or all-cause death

Time: 28 days

Description: Major bleeding

Measure: Major bleeding

Time: 28 days

Description: Red Blood Cell transfusion (greater than or equal to 1 unit)

Measure: Number of participants who received red blood cell transfusion

Time: 28 days

Description: Transfusion of platelets, frozen plasma, prothrombin complex concentrate, cryoprecipitate and/or fibrinogen concentrate

Measure: Number of participants with transfusion of platelets, frozen plasma, prothrombin complex concentrate, cryoprecipitate and/or fibrinogen concentrate.

Time: 28 days

Description: Hospital-free days alive up to day 28

Measure: Number of hospital-free days alive up to day 28

Time: 28 days

Description: ICU-free days alive up to day 28

Measure: Number of ICU-free days alive up to day 28

Time: 28 days

Description: Ventilator-free days alive up to day 28

Measure: Number of ventilator-free days alive up to day 28

Time: 28 days

Description: Venous thromboembolism

Measure: Number of participants with venous thromboembolism

Time: 28 days

Description: Arterial thromboembolism

Measure: Number of participants with arterial thromboembolism

Time: 28 days

Description: Heparin induced thrombocytopenia

Measure: Number of participants with heparin induced thrombocytopenia

Time: 28 days
15 Prevalence and Risk Factors for Venous Thromboembolic Events in Critically Ill Patients With SARS-CoV-2 Infection

The purpose of the study is to assess the frequency of the occurrence of a venous thrombosis in patients with the new Coronavirus disease, who are admitted to the Intensive Care Unit for impending respiratory failure requiring intubation and mechanical ventilation. Furthermore, the investigators aim at identifying potential risk factors for thrombosis and death.

NCT04567927
Conditions
  1. SARS Virus
Interventions
  1. Other: Ultrasonography
MeSH:Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: Percent (%) of patients with a DVT

Measure: Period prevalence of deep vein thrombosis (DVT)

Time: From date of inclusion in the study until the date of development of a DVT, date of death from any cause, or date of discharge from the ICU, whichever came first, assessed up to 3 months
16 COVID-19 and Venous Thromboembolism Risk

Coronavirus disease 2019 (Covid-19) is now a leading cause of death among U.S. adults. In addition to profound respiratory and multi-organ failure, hypercoagulable states and venous thromboembolism (VTE) have been increasingly reported in patients with severe Covid-19. The aim of this study is evaluate the risk of VTE related to Covid-19 infection in a real-world community-based population.

NCT04569344
Conditions
  1. Venous Thromboembolism
  2. Covid19
Interventions
  1. Other: Laboratory test positive for SARS-CoV-2 virus
MeSH:Thromboembolism Venous Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: VTE will be defined as a clinical encounter with evidence of acute VTE, identified by diagnosis codes, +/- radiology procedure codes

Measure: Acute venous thromboembolism (VTE)

Time: From the date of first positive test for SARS-CoV-2 virus occuring after January 1, 2020, until death, disenrollment from the health system, or the end of the planned outcome assessment (March 31, 2021)

Description: Death from any cause

Measure: Death

Time: From the date of first positive test for SARS-CoV-2 virus occuring after January 1, 2020, until disenrollment from the health system, or the end of the planned outcome assessment (March 31, 2021)
17 Dosing of Thromboprophylaxis and Mortality in Critically Ill COVID-19 Patients - More Patients Included and 90-day Follow up

The aim of the study is to associate dose of thromboprophylaxis with outcome in critically ill COVID-19 patients. This will be done by associating dose of thromboprophylaxis with 28-day mortality, survival outside ICU, thromboembolic event and bleeding complications.This was done in our earlier study for patients admitted in March and April (Clinicaltrials.gov NCT04412304 June 2 2020) but now we will include the patients admitted in May, June and half of July and we will ad the outcome of 90-day mortality.

NCT04593654
Conditions
  1. Covid19
  2. Thromboembolism
Interventions
  1. Drug: Dose of tinzaparin or dalteparin
MeSH:Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: 28-day mortality from admission to ICU. Discontinue of ICU-care to palliative care counts as death.

Measure: 28-day mortality

Time: 28 days from ICU-admission

Secondary Outcomes

Description: Thromboembolic events are defined as pulmonary emboli (PE), deep venous thrombus (DVT) and ischemic stroke. PE is defined as PE verified by computer tomography or by findings of acute strain of the right heart on echocardiography combined with a clinical interpretation of the patients deteriorating as a probable PE stated in the medical records. DVT is defined as DVT verified with ultrasound. Ischemic stroke is defined as ischemic stroke verified by computer tomography.

Measure: Incidence of thromboembolic events

Time: 28 days from ICU-admission

Description: The event of bleeding will be defined by WHO modified bleeding scale as 1-4

Measure: Incidence of bleeding events

Time: 28 days from ICU-admission

Description: ICU-free days alive during 28 days from ICU-admission. Counts as 0 days if discharged to ward for palliative treatment.

Measure: ICU-free days alive from ICU-admission

Time: 28 days from ICU-admission

Description: 90-day mortality from admission to ICU.

Measure: 90-day mortality

Time: 90 days from ICU-admission

Other Outcomes

Description: Median value of Fibrin-D-dimer

Measure: Fibrin-D-dimer levels

Time: 28 days from ICU-admission
18 Thromboembolic Risk Screening in Patients With Cancer and COVID-19

Study Rational Since December 2019, outbreak of COVID-19 caused by a novel virus SARS-Cov-2 has spread rapidly around the world and became a pandemic issue. First data report high mortality in severe patients with 30% death rate at 28 days. Exact proportions of the reasons of death are unclear: severe respiratory distress syndrome is mainly reported which can be related to massive cell destruction by the virus, bacterial surinfection, cardiomyopathy or pulmonary embolism. The exact proportion of all these causes is unknown and venous thromboembolism could be a major cause because of the massive inflammation reported during COVID-19. High levels of D-dimers and fibrin degradation products are associated with increased risk of mortality and some authors suggest a possible occurrence of venous thromboembolism (VTE) during COVID-19. Indeed, COVID-19 infected patients are likely at increased risk of VTE. In a multicenter retrospective cohort study from China, elevated D-dimers levels (>1g/L) were strongly associated with in-hospital death, even after multivariable adjustment. Also, interestingly,the prophylactic administration of anticoagulant treatment was associated with decreased mortality in a cohort of 449 patients, with a positive effect in patients with coagulopathy (sepsis-induced coagulopathy score ≥ 4) reducing the 28 days mortality rate (32.8% versus 52.4%, p=0.01). However the presence/prevalence of VTE disease is unknown in COVID-19 cancer patients with either mild or severe disease. Cancer patients are at a higher risk of VTE than general population (x6 times) and could be consequently at a further higher of VTE during COVID-19, in comparison with non-cancer patients. The exact rate of VTE and pulmonary embolism during COVID-19 was never evaluated, especially in cancer patients, and is of importance in order to understand if this disease needs appropriate prophylaxis against VTE. The largest series of cancer patients so far included 28 COVID-19 infected cancer patients: the rate of mortality was 28.6%. 78.6% of them needed oxygen therapy, 35.7% of them mechanical ventilation. Pulmonary embolism was suspected in some patients but not investigated due to the severity of the disease and renal insufficiency, reflecting the lack of data in this situation. The aim of the present study is to analyze the rate of symptomatic/occult VTE in a cohort of patients with cancer. Expected benefits Anticipated benefits of the research are the detection of VTE in order to treat it for the included patient. For all COVID-19 positive cancer patients it will enable to provide some guidelines and determine which patient are at risk for VTE and which will need ultrasound to detect occult VTE. Foreseeable risks Foreseeable risks for patients are non-significant because the additional procedures needed are ultrasound exam, and blood sample test. Methodology Retrospective and prospective (ambispective), multicentric study to evaluate the occurrence of venous thromboembolism during COVID-19 infection. Indeed, because the outbreak can end within the next 3-6 months, Investigators may not be able to answer the question if Investigators only focus on patients investigated prospectively. Investigators then decided to include patients from medical team who are already systemically screening patients with COVID-19 disease for VTE. Trial objectives Main objective To evaluate the rate of venous thromboembolism at 23 days during COVID-19 infection in cancer patients.

NCT04616846
Conditions
  1. Neoplasms Malignant
  2. Covid19
  3. Thromboembolism
Interventions
  1. Diagnostic Test: Peripheral venous ultrasound
MeSH:Neoplasms Thromboembolism
HPO:Neoplasm Thromboembolism

Primary Outcomes

Description: Deep venous thrombosis and/or pulmonary embolism.

Measure: Rate of venous thromboembolism

Time: From Day 9 to Day 42

Secondary Outcomes

Description: Rate of hospitalization

Measure: Hospitalization due to venous thromboembolism

Time: Day 23

Description: Time between the date of inclusion and the date of death for any reason.

Measure: Overall Survival

Time: Day 23

Description: Time between the date of inclusion and the date of death for venous thromboembolism.

Measure: Specific survival

Time: Day 23

Description: Common toxicity criteria from the NCI CTCAE V5.0

Measure: Safety profile using the common toxicity criteria from the NCI CTCAE V5.0

Time: Day 1 to Day 23

Description: Khorana score (low risk (score=0), medium risk (score=1 ou 2) and high risk (score ≥ 3)

Measure: Predictive factors for venous thromboembolism

Time: Day 1 to Day 23

Description: Caprini score (very low risk (score=0), low risk (score=1 or 2), medium risk (score=3 or 4)and high risk (score ≥ 5)

Measure: Predictive factors for venous thromboembolism

Time: Day 1 to Day 23

Description: Common toxicity criteria from the NCI CTCAE V5.0

Measure: rate of symptomatic venous thromboembolism between the COVID-19 negative and COVID-19 positive patients

Time: Day 1 to Day 23
19 Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial

The Michelle trial is expected to provide high-quality evidence around the role of extended thromboprophylaxis in COVID-19 and will help guide medical decisions in clinical practice.

NCT04662684
Conditions
  1. Covid19
  2. Venous Thromboembolism
Interventions
  1. Drug: Rivaroxaban 10 MG
MeSH:Thrombosis Thromboembolism Venous Thromboembolism
HPO:Thromboembolism

Primary Outcomes

Description: a composite efficacy endpoint of symptomatic VTE, VTE-related death, and/or VTE detected by mandatory bilateral lower limbs venous duplex scan and computed tomography pulmonary angiogram on day 35+/-4 post-hospital discharge

Measure: Venous thromboembolism and VTE related-death

Time: at day 35 +/- post hospital discharge

Secondary Outcomes

Description: Incidence of major bleeding according to ISTH criteria.

Measure: Major bleeding

Time: at day 35 +/- post hospital discharge

Other Outcomes

Description: A composite of myocardial infarction, stroke, arrhythmias, heart failure, venous thromboembolism (VTE), and all-cause death.

Measure: A composite of myocardial infarction, stroke, arrhythmias, heart failure, venous thromboembolism (VTE), and all-cause death.

Time: at day 35 +/- post hospital discharge

Description: Days alive out of the hospital (DAOH) at 35 +/-4 days

Measure: Days alive out of the hospital (DAOH) at 35 +/-4 days

Time: at day 35 +/- post hospital discharge

Description: plasma level of D-dimers in ng/mL

Measure: D-dimer (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

Description: plasma level of C Reactive Protein in μg/mL

Measure: C reactive protein (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

Description: plasma level of PAI-1 in units/mL

Measure: PAI-1 (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

Description: plasma level of TFPI in units/mL

Measure: TFPI (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

Description: plasma level of Thrombomodulin in nM/mL

Measure: Thrombomodulin (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

Description: plasma level of IL-6 in pg/mL

Measure: IL-6 (Biomarker)

Time: at day 35 +/- 4 post hospital discharge

HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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