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D015179: Colorectal Neoplasms

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (10)


Name (Synonyms) Correlation
drug882 Convalescent COVID 19 Plasma Wiki 0.71
drug827 Colorectal resections Wiki 0.50
drug880 Control swab Wiki 0.50
Name (Synonyms) Correlation
drug2679 Prototype swab Wiki 0.50
drug1270 FFP Wiki 0.50
drug881 ConvP Wiki 0.50
drug3047 Semi-structured interviews-Patients Wiki 0.50
drug1653 Informational videos and social media campaigns encouraging cancer screening. Wiki 0.50
drug826 Colonoscopy Wiki 0.50
drug3046 Semi-structured interviews-Health system Wiki 0.50

Correlated MeSH Terms (0)


Name (Synonyms) Correlation

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0100834 Neoplasm of the large intestine HPO 0.87

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Improving Cancer Screening and Prevention During the COVID-19 Pandemic in Underserved Populations of Rhode Island: A Community Based Quality Improvement Project of the Lifespan Cancer Institute

Lifespan Cancer Institute serves over 50% of cancer patients in the state. Rhode Island is known for strong medical care and high rates of cancer screening with mammography and colonoscopy. However, cancer screening has plummeted during the COVID-19 pandemic, in part to closing physician offices and stopping non-urgent medical procedures. In addition, anecdotal reports suggest the public remains concerned about returning to physician's offices and risking possible exposure to COVID-19. As in the United States as a whole, COVID-19 has disproportionately impacted ethnic and minority individuals within underserved communities; and in Rhode Island, African Americans, Hispanics and undocumented individuals living in communities such as Central Falls, Pawtucket, Providence, East Providence and North Providence have had the highest rate of COVID-19. These communities are also impacted by healthcare disparities to access and affordability of healthcare, and as such, may be among the least likely to resume cancer screening. The Lifespan Cancer Institute will institute a project to address health disparities in cancer screening during the pandemic through the use of a targeted campaign involving social media. The goals will be to re-establish screening in the era of COVID-19 and ensure timeliness of care for those found to be at risk, or are positive for, cancer.

NCT04587258
Conditions
  1. Breast Cancer
  2. Colorectal Cancer
  3. Covid19
Interventions
  1. Behavioral: Informational videos and social media campaigns encouraging cancer screening.
MeSH:Colorectal Neoplasms
HPO:Neoplasm of the large intestine

Primary Outcomes

Description: Increase screening rates for breast and colorectal cancer among underserved populations by 25% using March 9 through May 31 as a benchmark, coinciding the Executive Orders for COVID19 announced by Governor Raimondo.

Measure: Increase screening rates for breast and colorectal cancer

Time: 2 years

Description: Evaluate the impact of screening on timeliness of cancer care among these populations by comparing to the American Society of Clinical Oncology's Quality Oncology Performance Initiative (QOPI) guidelines in breast and colorectal cancer.

Measure: Impact of screening on cancer care

Time: 2 years

Secondary Outcomes

Description: Evaluate strategies of engagement in these communities as it relates to: -Social media platform (Twitter, Facebook, Instagram, TikTok) These metrics will be determined by social media statistics for engagement and the number of calls/queries to the designated information lines.

Measure: Community Engagement

Time: 2 Years

Description: Evaluate barriers to cancer screening in these populations as it particularly relates to COVID19.

Measure: Barriers to cancer screening during COVID19.

Time: 2 Years

Other Outcomes

Description: We will educate staff, community physicians and Rhode Island residents on the importance of cancer screening. We will use community-based partnerships to overcome distrust of institutions and develop an engaged community network. Long term academic goals include publication of data and successfully receiving local and federal funding for continued research.

Measure: Educate the community on the importance of cancer screening

Time: 5-10 years
2 Outcomes of Elective Colorectal Cancer Surgery During COVID 19 Pandemic: Implications for Cancer Care Policy

Due to COVID 19 (Corona virus disease)pandemic, majority of surgeries, including surgery for cancer patients got delayed across the globe. Surgeries were limited to emergency set up only. At our institute we tried to perform colorectal cancer surgeries through out the pandemic, albeit in less numbers, as we thought cancer in itself is an emergency setting. we are planning to analyse the prospectively managed database of this particular group of patients over a period of last six 6 months and look out at 30 day post operative morbidity and mortality. Besides we will try to analyse the implications of our decision to carry on with cancer surgeries in terms of number of health care workers who got infected while being involved in primary care of these patients.

NCT04588909
Conditions
  1. Colo-rectal
  2. Colo-rectal Cancer
Interventions
  1. Procedure: Colorectal resections
MeSH:Colorectal Neoplasms
HPO:Neoplasm of the large intestine

Primary Outcomes

Description: patients who died within 30 days following their surgery

Measure: Early post operative mortality

Time: 30 days

Secondary Outcomes

Description: post operative complications will be graded as per clavien dindo grading system

Measure: Early Post operative complications

Time: 30 days

Description: determine whether any health care worker involved with the care of this cohort of patients got infected with SARS CoV 2.

Measure: Incidence of SARS CoV2 infectivity among health care providers providing direct care to involved patients

Time: 30 days

Description: Determine whether any patient from the cohort got infected with SARS CoV 2 during their hospital stay or immediately after discharge

Measure: Rate of hospital acquired SARS CoV 2 infection among operated patients.

Time: 30 days
3 The Impact of Covid-19 Pandemic on Colorectal Cancer Prevention Due to Delays in Diagnosis: a Global Study

Screening programs have been associated with a substantial reduction in colorectal cancer (CRC) mortality through endoscopic resection of preneoplastic lesions and detection of early-stage invasive cancers. In March 2020, the World Health Organization declared as a pandemic the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. Since then, the SARS-CoV-2 have never stopped spreading, causing an unprecedented situation with highly restrictive considerations to be adopted by the majority of countries worldwide. Health-care facilities have been making an enormous effort to assist patients affected by COVID-19, while adopting measures to maintain a safe environment for patients and healthcare professionals. As a result, the usual workflow in endoscopy departments changed dramatically, leading to an increase in cancelled procedures, probably increasing the future burden of Colorectal Cancer due to delays in diagnosis.

NCT04637893
Conditions
  1. Colorectal Cancer
Interventions
  1. Other: Colonoscopy
MeSH:Colorectal Neoplasms
HPO:Neoplasm of the large intestine

Primary Outcomes

Description: To investigate the impact of COVID-19 pandemic on Colorectal Cancer prevention on a global scale.

Measure: Colorectal Cancer prevention

Time: 3 months
4 Facilitators and Barriers to Cancer Screening: Stakeholder Perspectives on Implementation

The rate of screening for colorectal cancer (CRC) in the U.S. remains low (under 65%), meaning that thousands of people die of colorectal cancer unnecessarily. Colorectal cancer screening tests range from more invasive and very sensitive for polyps and cancer (colonoscopy) to less invasive and less sensitive (e.g., fecal immunochemical testing (FIT)). Screening rates go up when patients consider all these tests, not just colonoscopy. Informing patients about their options for CRC screening could produce higher quality decisions, improve the match between patient preferences and tests performed, and increase uptake of CRC screening. Decision aids (DAs) are a promising tool for accomplishing this goal. Also, precision CRC prevention - providing information about an individual's specific risk for CRC - has great promise to increase uptake and improve decision making. Unfortunately, the COVID-19 pandemic is causing severe challenges to providing CRC screening and other prevention services. Health systems are trying to adapt, but these efforts have only begun and are poorly understood. Moreover, patient perceptions of disease risk and risk from COVID-19 are unknown.

NCT04683744
Conditions
  1. Colorectal Cancer Screening
Interventions
  1. Other: Semi-structured interviews-Patients
  2. Other: Semi-structured interviews-Health system
MeSH:Colorectal Neoplasms
HPO:Neoplasm of the large intestine

Primary Outcomes

Description: Semi-structured interviews with health system leadership, providers and staff conducted every 3-4 months

Measure: Identify facilitators and barriers to implementing decision aids, provider notifications, and personal risk calculation using an electronic health record to promote colorectal cancer screening.

Time: 2 years

Description: Semi-structured interviews with health system leadership, providers, and staff

Measure: Identify the challenges and facilitators of effective cancer screening and prevention in primary care during the COVID-19 pandemic among leadership, providers, and staff.

Time: 9 months

Description: Semi-structured interviews with primary care patients

Measure: Identify patient knowledge, attitudes, and beliefs that influence decisions to engage in cancer screening and prevention during the COVID-19 pandemic, and barriers to uptake

Time: 1 day

HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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Interventions

4,818 reports on interventions/drugs

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706 reports on MeSH terms

HPO

306 reports on HPO terms

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Alphabetical index of all Terms

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