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D005221: Fatigue

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (15)


Name (Synonyms) Correlation
drug4036 questionnair about Emerging Legal and Ehical Disputes Over Patient Confidentiality Wiki 0.45
drug4034 quesionnair Wiki 0.45
drug4023 prophylactic lactoferrin daily Wiki 0.45
Name (Synonyms) Correlation
drug4022 prophylactic heparin Wiki 0.45
drug1974 Maximal effort test Wiki 0.45
drug2352 Oxaloacetate Medical Food/Dietary Supplement Wiki 0.45
drug3411 Threshold IMT device Wiki 0.45
drug4035 questionaire to husband and wife Wiki 0.45
drug4112 theraputic heparin Wiki 0.45
drug908 Conventional physical therapy Wiki 0.45
drug2173 Neuromuscular evaluation Wiki 0.45
drug3718 actigraphy Wiki 0.45
drug3767 blood test Wiki 0.32
drug4099 survey Wiki 0.16
drug2744 Questionnaires Wiki 0.15

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D015673 Fatigue Syndrome, Chronic NIH 0.45
D012598 Scoliosi NIH 0.16
D009103 Multiple Sclerosis NIH 0.16

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0012378 Fatigue HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.

NCT04363606
Conditions
  1. Chronic Fatigue Syndrome
  2. Intensive Care Unit
  3. Muscle
Interventions
  1. Other: Questionnaires
  2. Biological: blood test
  3. Other: Maximal effort test
  4. Device: actigraphy
  5. Device: Neuromuscular evaluation
MeSH:Fatigue Syndrome, Chronic Fatigue
HPO:Fatigue

Primary Outcomes

Measure: voluntary maximum force reduction

Time: 6 weeks post-discharge

Secondary Outcomes

Description: Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation

Measure: Neuromuscular function : cortical activity

Time: 6 weeks post-discharge

Description: Peripheral function by electrical nerve stimulation

Measure: Neuromuscular function : Peripheral function

Time: 6 weeks post-discharge

Description: measured by effort test

Measure: Maximal oxygen uptake (VO2max)

Time: 6 weeks post-discharge

Description: measured by actigraphy

Measure: quality of sleep

Time: 6 weeks post-discharge

Description: with Magnetic resonance imaging

Measure: muscle volume

Time: 6 weeks post-discharge

Description: measured by a Phosphorus 31 Nuclear magnetic resonance test

Measure: metabolic fatigue

Time: 6 weeks post-discharge
2 Investigation of Fatigue, Physical Activity, Sleep Quality and Anxiety Levels of Multiple Sclerosis Patients in the COVID-19 Pandemic

Hundreds of thousands of confirmed cases have been reported worldwide, just 3 months after the first patients were identified in Wuhan, China. Just like other members of the community, MS patients are uncomfortable with the emotional distress and health anxiety caused by the COVID-19 outbreak. Most MS patients receive immunosuppressive or immunomodulatory therapies. Patients taking immunosuppressive agents are theoretically at increased risk of being affected by viral pandemics, and a higher health concern is expected in this group of patients. Moreover, MS patients lose social support. Patients with increased duration of stay can no longer access physical and cognitive rehabilitation therapies. We also know that increased anxiety and sleep disorders can cause MS patients to have an attack. When literature is examined, it is known that MS patients' physical activity levels decrease, fatigue, sleep quality and anxiety levels increase, so their quality of life and participation in daily life activities decrease. MS patients lose social support during the COVID-19 outbreak. For all these reasons, we think that the fatigue, physical activity level, anxiety level and sleep disturbances affected before the COVID-19 outbreak will be further affected for these reasons.

NCT04438954
Conditions
  1. Multiple Sclerosis
  2. Covid-19
MeSH:Multiple Sclerosis Sclerosis Fatigue
HPO:Fatigue

Primary Outcomes

Description: Fatigue was assessed by the Fatigue Severity Scale (FSS). This is a 9-item questionnaire that assesses the effect of fatigue on daily living. Each item is a statement on fatigue that the subject rates from 1 "completely disagree" to 7 "completely agree". A score of 4 or higher generally indicates severe fatigue

Measure: Fatigue

Time: 4 week

Description: Physical activity levels were assessed by the International Physical Activity Questionnaire (IPAQ): short form. The online self-reporting questionnaire consisted of questions investigating the respondents' PA practice in terms of frequencies and durations of sitting, walking, moderate-intensity physical activities and vigorous-intensity physical activities. The MET-minutes per week (MET-min/week) were calculated using the following formula: intensity (MET) x duration x frequency. Physical activity levels were classified as physically inactive (<600 MET-min/week), with low levels of physical activity (600-3000 MET- min/week) and physical activity level that is sufficient (> 3000 MET-min/week)

Measure: Physical activity

Time: 4 week

Description: The Pittsburgh Sleep Quality Index (PSQI) questionnaire was used to measure sleep quality using an 18-item scale containing seven items that included sleep quality, sleep duration, sleep latency, habitual sleep efficiency, sleep disturbance, use of sleeping medications, and daytime dysfunction. Each dimension scored between 0-3, with a total score ranging from 0-21, and a higher score indicating lower sleep quality.

Measure: Sleep quality

Time: 4 week

Description: The Hospital Anxiety and Depression Scale (HADS) was composed by two subscales (i.e., anxiety and depression), with 7-items each. The anxiety part of HADS was used to evaluate the anxiety levels of the patients. Each dimension scored between 0-3, with a total score ranging from 0-21, and a higher score indicating higher anxiety level.

Measure: Anxiety

Time: 4 week
3 Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors

We will conduct a double arm, randomized, double-blinded placebo controlled trial of oxaloacetate for treatment of fatigue in women with a history of COVID-19 infection, resolution of the infection, and remaining fatigue that interfere with everyday activities, based on use of a standardized questionnaire to screen for impairment. Participants will receive a 6-week supply of the active or placebo and will be asked to take one capsule twice a day with water and food. They will be contacted weekly for two weeks by the study coordinator to assess for any side effects or difficulty taking the medication. They will be asked to again to complete the standardized questionnaire to screen for impairment after 2 weeks, and again at the end of the study at 6 weeks. Finally, any adverse reactions and symptoms will be evaluated once again four weeks later to ensure that any symptoms that may have been present during treatment have resolved.

NCT04592354
Conditions
  1. Treatment of Fatigue After Resolution of COVID-19 Infection
Interventions
  1. Dietary Supplement: Oxaloacetate Medical Food/Dietary Supplement
MeSH:Fatigue
HPO:Fatigue

Primary Outcomes

Description: Evaluation of self-reported Fatigue with the Fatigue Questionnaire (FQ)

Measure: Fatigue

Time: 6 weeks

Secondary Outcomes

Description: Evaluation of self-reported Fatigue with the Fatigue Severity Scale (FSS)

Measure: Fatigue

Time: 6 weeks

Description: Evaluation of self-reported depression with Beck's Depression Inventory (BDI)

Measure: Depression

Time: 6 weeks
4 The Effects of Multi-modality Physiotherapy in Delaying or Preventing COVID-19 Patient From Admitting to ICU: A Pilot Study

This study aims to evaluate the effectiveness of respiratory muscle training with COVID-19 patient, who has underlying health conditions, in order to delay or prevent them from admitting to ICU.

NCT04617119
Conditions
  1. Covid19
  2. Severe Systemic Illness Respiratory Muscle Fatigue
Interventions
  1. Device: Threshold IMT device
  2. Other: Conventional physical therapy
MeSH:Fatigue
HPO:Fatigue

Primary Outcomes

Description: Changes in Respiratory muscle performance will be determined by using the Respiratory Pressure Meter device. Patient will perform full inspiration through this device for 1.5 seconds via the mouth (nose occluded). The reading of the negative peak pressure that is maintained for 1 second in the device is a maximal inspiration peak.

Measure: Changes in Respiratory muscle performance

Time: Baseline, 1st week, 2nd week, one month

Secondary Outcomes

Description: Blood pressure measured by electronic BP machine before and after session

Measure: Blood pressure

Time: Daily from baseline to hospital discharge (2 weeks)

Description: measured by heart rate monitor before and after session

Measure: Heart rate

Time: Daily from baseline to hospital discharge (2 weeks)

Description: Measured by pulse oximeter before and after session

Measure: Oxygen saturation

Time: Daily from baseline to hospital discharge (2 weeks)

Description: Number of % of oxygen patient on it before and after session

Measure: Oxygen supplementation

Time: Daily from baseline to hospital discharge (2 weeks).

Description: measuring the number of time where the oxygen above or below 4L/min.

Measure: Oxygen flow rate

Time: Daily from baseline to hospital discharge (2 weeks)

Description: By using Borg scale (rating of perceived exertion scale), Possible score range from 0 (nothing) to 10 ( Maximal exertion). Before and after session.

Measure: Dyspnoea level

Time: Daily from baseline to hospital discharge (2 weeks)

Description: By using visual analogue scale. Possible score range from 0 (no pain) to 10 (worst possible pain) Before and after session.

Measure: Pain level

Time: Daily from baseline to hospital discharge (2 weeks)

Description: Measured by Respiratory rate monitor. Before and after session

Measure: Respiratory rate

Time: Daily from baseline to hospital discharge (2 weeks)

Description: Recording number for breath and sets daily.

Measure: Threshold IMT device

Time: Daily from baseline to 1 month from admission
5 Fatigue and Sleep in Patients With COVID-19

Recent studies show that patients who have contracted COVID-19 retain very significant fatigue after resolving the infectious episode. This fatigue may be explained by low-grade inflammation. There is more data for patients with COVID-19 who have been hospitalized than for non-hospitalized patients with milder forms. However, COVID-19 related fatigue would not only affect elderly people with severe cardiopulmonary consequences but also young subjects without severities. This notion is not very widespread and to date, COVID contracted by young subjects is considered to have very few consequences on their health. It is also known that the prevalence of sleep debt is significant in the general population and particularly in young people, and it is also known that sleep deprivation increases low-grade inflammation and facilitates the risk of viral contamination. The association between sleep deprivation, drowsiness and possibly low-grade inflammation raise questions about the mechanisms of fatigue in the general population. Investigators are also entitled to wonder to what extent the chronic sleep debt suffered by the French population can explain an increased risk of contamination by COVID 19 but also significant residual fatigue after COVID infection. Bordeaux University Hospital screens 2,000 subjects per day at risk of being infected by COVID, it would be very interesting to measure, in a population of young adults aged 18-45 years, frequently exposed to a sleep debt, sleep hygiene (bedtime and wake-up times, sleep and wake-up schedules, and overall sleep satisfaction), average sleep duration, level of fatigue and drowsiness and to compare these thresholds between subjects with or without COVID 19 according to nasopharyngeal PCR.

NCT04657419
Conditions
  1. Covid19
Interventions
  1. Other: survey
MeSH:Fatigue
HPO:Fatigue

Primary Outcomes

Description: Presence of significant fatigue as measured by the Fatigue Severity Scale (FSS) at 1 month. Score from 1 to 7 FSS is a 9-item questionnaire with questions related to how fatigue interferes with certain activities and rates its severity according to a self-report scale. The items are scored on a 7 point scale with 1 = strongly disagree and 7= strongly agree. The minimum score is 9 and maximum score possible is 63. Higher is the score, greater is the fatigue severity

Measure: Fatigue Severity Scale

Time: one month after inclusion (T0)

Secondary Outcomes

Description: Diagnosis of COVID-19 by nasopharyngeal PCR

Measure: COVID Diagnosis

Time: inclusion (T0)

Description: Fatigue measured by Fatigue Severity Scale FSS is a 9-item questionnaire with questions related to how fatigue interferes with certain activities and rates its severity according to a self-report scale. The items are scored on a 7 point scale with 1 = strongly disagree and 7= strongly agree. The minimum score is 9 and maximum score possible is 63. Higher is the score, greater is the fatigue severity

Measure: Fatigue evolution

Time: Inclusion (T0) and one month after

Description: Sleep hygiene measured with questionnaire

Measure: Sleep hygiene

Time: Inclusion (T0) and one month after

HPO Nodes


HP:0012378: Fatigue
Genes 399
TLL1 SLC25A26 IGH SERPINA6 MEN1 COL1A1 NPM1 ZBTB16 ABCC2 DDB2 KIT SH2B3 IKZF1 MALT1 SOX3 ATM TCF4 HLA-DPA1 GATA6 TP53 SCNN1G NAB2 ALB DCTN1 PROKR2 TGFBR2 NLRP3 IGH TAZ HBA1 GNAS RARA ALAS2 VAPB SLC26A4 MORC2 TXNRD2 NKX2-5 TRAF3 PIK3CA MYD88 MYH6 TSC1 ATRX HLA-DPB1 KCNN4 SLC40A1 PMS2 DUOXA2 COL9A1 SLC22A4 CBL DLST TNPO3 MEN1 TCF3 DNMT3A HESX1 HESX1 AP2S1 PROP1 STAT5B TARDBP DNAJC6 CTLA4 EPAS1 TET2 MRAP MATR3 ERCC3 COL5A1 KCNE1 CDH23 CD46 CCDC78 BCL2 FOXP1 KRAS GLA CHRND PHKG2 NLRP3 PRPH NKX2-1 KIT SLC12A3 PYGM HNF4A NF1 IL12RB1 SDHAF2 SOX3 SLC25A4 PRKAR1A SLC18A2 CALR AIP FAN1 PRTN3 TET2 MDM4 SDHD SLC4A1 POU1F1 LHX4 ATP13A2 NEFH PDE8B HBA2 PREPL GATA2 ERCC2 STAR IYD BRCA1 DNM1L MET PODXL USP8 KIF1B ARNT2 PAX8 SCNN1A CCNF GPR101 C4A HNF1A MAX CCND1 INSR BTK MSH6 PDGFRA MEFV VCP PALLD TBX20 BCL10 TICAM1 TRNK BCL6 NUMA1 PADI4 GATA4 JAK2 KL MSH2 SDHC EIF2AK4 GBA CITED2 LBR HLA-DRB1 PTPN22 ERBB4 TNFSF15 SLC26A4 DAO SDHA CAV3 NLRP3 STAT6 CDC73 HAVCR2 HMGCL PTPN22 FGFR1 DUOX2 SDHB MMEL1 IL10 LRRC8A IL12A-AS1 EPHA4 CHCHD10 CHMP2B PIEZO1 TSHR NNT DMD KIF23 TSC2 TAF15 ERCC4 TSHB COL9A2 IL18BP TNXB IL12A NKX2-5 CD244 OPTN POLG2 SLC11A1 DBH IRF5 XPC SDHB NLRP3 NABP1 PNPLA8 PTPN22 MC2R CFI NAGS CTNNB1 RPS20 GLE1 ACTC1 OTX2 VHL PIGA UNC13A TBK1 CDH23 MYH7 PFN1 SPIB TRHR SLC2A10 PDE11A GLI2 CDH23 IL12B EPCAM XPA PON2 IL10 TBX19 ATP13A2 PLEC WIPF1 COMP SDHD FOXA2 PTPN3 BCOR LHX3 PROP1 PYGL RRM2B HESX1 FIG4 IL12A TWNK UNC93B1 MPL CDKN2A COL1A2 PMS1 CCND1 BRCA2 PROP1 MLX C9ORF72 SMAD3 IGLL1 MST1 TK2 SRSF2 IGHM CD79A PIK3R1 POMGNT1 OPA1 SDHB CD79B IVNS1ABP CFH CITED2 FTL CFAP410 MLH1 FOXE1 IL23R STAT3 PAX8 COQ2 STEAP3 PRKAR1A PON1 HNRNPA1 AGK SMAD4 GCK IGH TFR2 POLG OTX2 FGF23 ATXN2 NR3C1 HLA-B PIGT PGM1 TLR4 LHX4 ARMC5 SEMA4A SDHA BCR IRF2BP2 PALB2 TET2 ASXL1 WAS DMPK ERCC5 POU1F1 RET C1QBP TET2 ATP7A GLT8D1 KCNQ1 CARMIL2 ARMC5 SCNN1B KRAS JAK2 TSHR STAT4 TWNK SMAD3 TG ACADM TMEM127 RUNX1 SLC18A3 ANG TBX20 ANXA11 CCR1 GCH1 MDH2 UBAC2 HFE BIRC3 AIP EPOR PHKA2 BMPR1A MMADHC FAS CPT1A UBQLN2 NLRC4 PSTPIP1 SOX2 PON3 COL9A3 NR3C1 POU2AF1 ERAP1 PRKACA ALB TLR3 CDC73 SLC3A1 TET2 SLC5A5 PML VHL FIP1L1 MLH3 TBK1 ELANE JAK2 NEK1 TBL1XR1 TREM2 FH KLRC4 HLA-B PPARGC1A SQSTM1 HLA-DRB1 NFKB2 MPL VHL SOD1 TPO TLL1 HELLPAR ABL1 SYNJ1 GPR35 CIITA RUNX1 BLNK SLC25A11 FUS RET COL5A2 DYSF SDHC NFKBIL1 BTNL2 HLA-B
Protein Mutations 3
T25W V158M V18M
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0012378: Fatigue
Genes 399
TLL1 SLC25A26 IGH SERPINA6 MEN1 COL1A1 NPM1 ZBTB16 ABCC2 DDB2 KIT SH2B3 IKZF1 MALT1 SOX3 ATM TCF4 HLA-DPA1 GATA6 TP53 SCNN1G NAB2 ALB DCTN1 PROKR2 TGFBR2 NLRP3 IGH TAZ HBA1 GNAS RARA ALAS2 VAPB SLC26A4 MORC2 TXNRD2 NKX2-5 TRAF3 PIK3CA MYD88 MYH6 TSC1 ATRX HLA-DPB1 KCNN4 SLC40A1 PMS2 DUOXA2 COL9A1 SLC22A4 CBL DLST TNPO3 MEN1 TCF3 DNMT3A HESX1 HESX1 AP2S1 PROP1 STAT5B TARDBP DNAJC6 CTLA4 EPAS1 TET2 MRAP MATR3 ERCC3 COL5A1 KCNE1 CDH23 CD46 CCDC78 BCL2 FOXP1 KRAS GLA CHRND PHKG2 NLRP3 PRPH NKX2-1 KIT SLC12A3 PYGM HNF4A NF1 IL12RB1 SDHAF2 SOX3 SLC25A4 PRKAR1A SLC18A2 CALR AIP FAN1 PRTN3 TET2 MDM4 SDHD SLC4A1 POU1F1 LHX4 ATP13A2 NEFH PDE8B HBA2 PREPL GATA2 ERCC2 STAR IYD BRCA1 DNM1L MET PODXL USP8 KIF1B ARNT2 PAX8 SCNN1A CCNF GPR101 C4A HNF1A MAX CCND1 INSR BTK MSH6 PDGFRA MEFV VCP PALLD TBX20 BCL10 TICAM1 TRNK BCL6 NUMA1 PADI4 GATA4 JAK2 KL MSH2 SDHC EIF2AK4 GBA CITED2 LBR HLA-DRB1 PTPN22 ERBB4 TNFSF15 SLC26A4 DAO SDHA CAV3 NLRP3 STAT6 CDC73 HAVCR2 HMGCL PTPN22 FGFR1 DUOX2 SDHB MMEL1 IL10 LRRC8A IL12A-AS1 EPHA4 CHCHD10 CHMP2B PIEZO1 TSHR NNT DMD KIF23 TSC2 TAF15 ERCC4 TSHB COL9A2 IL18BP TNXB IL12A NKX2-5 CD244 OPTN POLG2 SLC11A1 DBH IRF5 XPC SDHB NLRP3 NABP1 PNPLA8 PTPN22 MC2R CFI NAGS CTNNB1 RPS20 GLE1 ACTC1 OTX2 VHL PIGA UNC13A TBK1 CDH23 MYH7 PFN1 SPIB TRHR SLC2A10 PDE11A GLI2 CDH23 IL12B EPCAM XPA PON2 IL10 TBX19 ATP13A2 PLEC WIPF1 COMP SDHD FOXA2 PTPN3 BCOR LHX3 PROP1 PYGL RRM2B HESX1 FIG4 IL12A TWNK UNC93B1 MPL CDKN2A COL1A2 PMS1 CCND1 BRCA2 PROP1 MLX C9ORF72 SMAD3 IGLL1 MST1 TK2 SRSF2 IGHM CD79A PIK3R1 POMGNT1 OPA1 SDHB CD79B IVNS1ABP CFH CITED2 FTL CFAP410 MLH1 FOXE1 IL23R STAT3 PAX8 COQ2 STEAP3 PRKAR1A PON1 HNRNPA1 AGK SMAD4 GCK IGH TFR2 POLG OTX2 FGF23 ATXN2 NR3C1 HLA-B PIGT PGM1 TLR4 LHX4 ARMC5 SEMA4A SDHA BCR IRF2BP2 PALB2 TET2 ASXL1 WAS DMPK ERCC5 POU1F1 RET C1QBP TET2 ATP7A GLT8D1 KCNQ1 CARMIL2 ARMC5 SCNN1B KRAS JAK2 TSHR STAT4 TWNK SMAD3 TG ACADM TMEM127 RUNX1 SLC18A3 ANG TBX20 ANXA11 CCR1 GCH1 MDH2 UBAC2 HFE BIRC3 AIP EPOR PHKA2 BMPR1A MMADHC FAS CPT1A UBQLN2 NLRC4 PSTPIP1 SOX2 PON3 COL9A3 NR3C1 POU2AF1 ERAP1 PRKACA ALB TLR3 CDC73 SLC3A1 TET2 SLC5A5 PML VHL FIP1L1 MLH3 TBK1 ELANE JAK2 NEK1 TBL1XR1 TREM2 FH KLRC4 HLA-B PPARGC1A SQSTM1 HLA-DRB1 NFKB2 MPL VHL SOD1 TPO TLL1 HELLPAR ABL1 SYNJ1 GPR35 CIITA RUNX1 BLNK SLC25A11 FUS RET COL5A2 DYSF SDHC NFKBIL1 BTNL2 HLA-B
Protein Mutations 3
T25W V158M V18M
SNP 0

Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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