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D045888: Ganglion Cysts

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (9)


Name (Synonyms) Correlation
drug3230 Stellate Ganglion Block Wiki 0.82
drug4113 this study is non- interventional Wiki 0.58
drug214 Anakinra Prefilled Syringe Wiki 0.58
Name (Synonyms) Correlation
drug4124 treated with hyperimmune plasma Wiki 0.58
drug3439 Tocilizumab Prefilled Syringe Wiki 0.58
drug3153 Sphenopalatine Ganglion Block with Placebo (Isotone NaCl) Wiki 0.58
drug3152 Sphenopalatine Ganglion Block with Local Anesthetic Wiki 0.58
drug2 "Sham"-block with Placebo (Isotone NaCl) Wiki 0.58
drug3223 Standard-of-care treatment Wiki 0.58

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D013581 Synovial Cyst NIH 0.58
D006261 Headache NIH 0.29
D013577 Syndrome NIH 0.06
Name (Synonyms) Correlation
D012127 Respiratory Distress Syndrome, Newborn NIH 0.05
D055371 Acute Lung Injury NIH 0.05
D012128 Respiratory Distress Syndrome, Adult NIH 0.04

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002315 Headache HPO 0.29

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 Stellate Ganglion Block (SGB) for COVID-19 Acute Respiratory Distress Syndrome (ARDS)

The purpose of this study is to understand if it is safe and useful to perform SGB (Stellate Ganglion Block) in patients who have severe lung injury Acute Respiratory Distress Syndrome (ARDS) due to COVID-19 infection.

NCT04402840
Conditions
  1. Acute Respiratory Distress Syndrome
  2. COVID-19
Interventions
  1. Procedure: Stellate Ganglion Block
MeSH:Ganglion Cysts Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Syndrome

Primary Outcomes

Description: Adverse events that can atleast unlikely be attributed to SGB

Measure: Adverse events related to SGB

Time: 3 Months

Description: All adverse events related to COVID-19

Measure: All Adverse events

Time: 3 Months

Description: Death due to any cause

Measure: Death

Time: 3 Months

Secondary Outcomes

Description: Change from baseline clinical respiratory/pulmonary function as assessed by change in PF ratio

Measure: Assessment of respiratory/ pulmonary function

Time: 3 Months

Description: Change from last imaging data obtained prior to SGB procedure

Measure: Radiographic criteria

Time: 3 Months

Description: Change from baseline clinical cardiac function as assessed by improvement in arrhythmia as measured by standard of care ECG ( rate, rhythm and / or any aberrant electro physiological changes)

Measure: Cardiac function

Time: 3 Months
2 Stellate Ganglion Blockade in COVID-19 Positive Patients

This study will establish the safety and efficacy of using stellate ganglion blocks in patients with ARDS due to COVID-19 disease.

NCT04445337
Conditions
  1. COVID 19
  2. ARDS
Interventions
  1. Procedure: Stellate Ganglion Block
MeSH:Ganglion Cysts

Primary Outcomes

Description: Adverse events related to SGB.

Measure: Evaluate the safety of a new modified stellate ganglia block (SGB) in ARDS

Time: 3 month

Secondary Outcomes

Description: All adverse events.

Measure: Evaluate the efficacy of a new modified stellate ganglia block (SGB) in ARDS

Time: 3 month
3 The Effect of Ganglion Sphenopalatine Block (SPG-block) Versus Placebo on Persistent Headache Following COVID-19 Infection: a Randomised, Blinded, Clinical Trial

The purpose of this study is to evaluate the effect of the ganglion sphenopalatine block (SPG block) on persistent headache following acute COVID-19 infection.

NCT04636034
Conditions
  1. Headache
  2. Covid19
  3. Sphenopalatine Ganglion Block
  4. Persistent Headache Following COVID-19
Interventions
  1. Procedure: Sphenopalatine Ganglion Block with Local Anesthetic
  2. Procedure: Sphenopalatine Ganglion Block with Placebo (Isotone NaCl)
  3. Procedure: "Sham"-block with Placebo (Isotone NaCl)
MeSH:Ganglion Cysts Synovial Cyst Headache
HPO:Headache

Primary Outcomes

Description: Pain intensity will be measured as worst experienced pain after the patient has been standing for 30 seconds or the worst experienced pain while attempting to stand if the rating has to be interrupted.

Measure: Hyperactivity in the sphenopalatine ganglion assessed by pain intensity (0-100mm on a visual analogue scale, VAS) of the postdural headache in standing position in the group Ropivacine-Lidocaine and "sham".

Time: 30 minutes after block

Secondary Outcomes

Description: Pain intensity measured as worst experienced pain after the patient has been standing for 30 seconds or the worst experienced pain while attempting to stand if the rating has to be interrupted.

Measure: Number of patients with pain rating below 30mm in standing position (0-100mm on a visual analogue scale, VAS)

Time: 30 minutes and 1 week after block

Description: The worst experienced pain reported during the week following the block as registered by the patient.

Measure: Worst experienced pain in standing position (0-10 on a numercial rating scale, NRS)

Time: During study period until completion of 1 week follow up

Description: The average pain intensity reported during the week following the block as registered by the patient.

Measure: Average pain intensity (0-10 on a numercial rating scale, NRS)

Time: During study period until completion of 1 week follow up

Description: If the patient at the 1 week follow up still needs further treatment a "rescue SPG-block" defined as a new SPG-block with "open label" analgetics will be offered.

Measure: Number of patients needing "rescue GSP-block"

Time: At 1 week follow up

Description: Pain intensity will be measured as worst experienced pain after the patient has been standing for 30 seconds or the worst experienced pain while attempting to stand if the rating has to be interrupted.

Measure: Hyperactivity in the sphenopalatine ganglion assessed by pain intensity (0-100mm on a visual analogue scale, VAS) of the postdural headache in standing position in all 3 groups.

Time: 30 minutes after block

Other Outcomes

Description: The use of analgesics during the week following the block as registered by the patient and the patient file.

Measure: Analgesics used daily in the week following the SPG-block

Time: During study period until completion of 1 week follow up

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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