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D006505: Hepatitis

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Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug108 ART Therapy Wiki 1.00
drug2575 Placebos Wiki 0.24
drug1292 Favipiravir Wiki 0.21

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D055985 Latent Tuberculosis NIH 1.00
D006526 Hepatitis C NIH 0.71
D014376 Tuberculosis NIH 0.50
Name (Synonyms) Correlation
D003141 Communicable Diseases NIH 0.07
D007239 Infection NIH 0.05

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

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There is one clinical trial.


1 European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC): Paediatric Protocol

Across Europe and worldwide, there are many studies following groups (cohorts) of children living with human immunodeficiency virus (HIV) and other infections over time, to monitor their long-term health. Some of these infections are rare: for example, few children in Western Europe are living with HIV, so the studies often have fairly small numbers of participants. This can make it difficult to answer research questions in these cohorts and means that doctors and researchers working with these patients in different countries need to work together. This is particularly important as children are not often included in clinical trials of treatments and other interventions. The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) is an international network of researchers working together in this way. Researchers in the network represent cohort studies of pregnant women and children with, or at risk of, infections from across Europe and Thailand. The research focuses on infections in pregnant women and children, particularly HIV, hepatitis B and C virus, and tuberculosis, and, from 2020, novel coronavirus (COVID-19). By combining data from many cohorts, the researchers aim to answer questions that could not be answered by one study individually (for example, because a large number of pregnant women or children are needed to answer the question). This protocol focuses on the paediatric component of EPPICC's research, which focuses on the treatment of children at risk of and living with infections. For example, what medicines are used most often and how do they affect children's health? EPPICC is an observational study, which means that children do not receive any extra treatment as part of the study. Instead, children are "observed" during their routine medical care. Each cohort keeps records of the children's health collected at routine clinic visits, including information such as date of birth and sex, results of diagnostic tests, treatments received, and any illnesses or other events that the children have had. The EPPICC study combines and analyses data from all of the cohorts that take part, to answer questions about the risks and benefits of different diagnosis or treatment strategies, the long-term effects of infection and treatment during childhood and young adulthood, and regional variations (e.g. between Western and Eastern Europe) in the risk and management of infections. All of the data collected through the EPPICC Paediatric Protocol are stored securely at the Medical Research Council Clinical Trials Unit (MRC CTU) at UCL. Data collection and storage are governed by the General Data Protection Regulation. A Steering Committee guides the research to make sure it is relevant and of high quality. Public and patient involvement (PPI) may be provided by individual cohorts' own groups, as well as by the interlinked Penta organisation, which is a network of paediatricians and researchers working in infections in Europe and globally. The PPI groups help with release of the results of the research. The results are also published on the Penta Foundation's public website (https://penta-id.org/), and presented at conferences and published in Open Access scientific journals.

NCT04677842
Conditions
  1. HIV Infections
  2. Tuberculosis Infection
  3. Hepatitis C
  4. Covid19
Interventions
  1. Drug: ART Therapy
MeSH:Infection Communicable Diseases Tuberculosis Latent Tuberculosis Hepatitis C Hepatitis
HPO:Hepatitis

Primary Outcomes

Measure: CD4 count in adulthood of young people with HIV assessed using routine clinical data

Time: through study completion, an average of 5 year

Measure: 2. Viral suppression in adulthood of young people with HIV assessed using routine clinical data

Time: through study completion, an average of 5 year

Measure: Viral suppression defined as <50 copies, <400 copies and 1000 copies/mL) upto 144 weeks.

Time: up to 144 weeks

Measure: CD4 change from drug start up to 144 weeks

Time: up to 144 weeks

Measure: Cumulative incidence of virological failure (>1000 copies/mL)

Time: through study completion, an average of 5 years

Measure: From start of novel drug of interest through to earliest date of the following: death, loss to follow-up, discontinuation of drug or last visit

Time: From date of novel drug initiation until earliest date of death, loss to follow-up, discontinuation of drug or last visit assessed up to 36 months

HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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MeSH

706 reports on MeSH terms

HPO

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