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D004211: Disseminated Intravascular Coagulation

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (13)


Name (Synonyms) Correlation
drug3414 Thrombin Generation Assay (TGA) Wiki 0.45
drug3785 chlorine dioxide 3000 ppm Wiki 0.45
drug299 Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay Wiki 0.45
Name (Synonyms) Correlation
drug1307 Fibrin generation markers assays Wiki 0.45
drug3415 Thrombin generation test assay Wiki 0.45
drug3416 Thrombomodulin Modified Thrombin Generation Assay (TGA-TM) Wiki 0.45
drug3786 chloroquine Wiki 0.45
drug292 Aspirin 81 mg Wiki 0.45
drug603 COVID-19 FACILITY Wiki 0.45
drug2722 Quantra System Wiki 0.45
drug594 COVID-19 Wiki 0.40
drug4084 standard care Wiki 0.22
drug3630 Vitamin D Wiki 0.13

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D020141 Hemostatic Disorders NIH 0.35
D001778 Blood Coagulation Disorders NIH 0.35
D012772 Shock, Septic NIH 0.32
Name (Synonyms) Correlation
D012769 Shock, NIH 0.17
D014808 Vitamin D Deficiency NIH 0.14
D016638 Critical Illness NIH 0.06
D014777 Virus Diseases NIH 0.05
D007239 Infection NIH 0.02

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0005521 Disseminated intravascular coagulation HPO 1.00
HP:0001928 Abnormality of coagulation HPO 0.35
HP:0100512 Low levels of vitamin D HPO 0.14

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Prospective Evaluation of PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock Patients. Impact of Platelets Metabolism to Inflammatory Response.

Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more particularly platelets inflammatory mediators content, coming from AA and lipids.

NCT04107402
Conditions
  1. Septic Shock
  2. Platelet Signal Processing Defect
  3. Inflammatory Response
  4. Disseminated Intravascular Coagulation
  5. Covid19
  6. Neutrophil Extracellular Trap Formation
Interventions
  1. Other: Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
MeSH:Shock, Septic Disseminated Intravascular Coagulation Shock
HPO:Disseminated intravascular coagulation

Primary Outcomes

Description: ACC phosphorylation on Ser79 (phosphoACC) in platelets of patients will be assessed using western blotting. Results will be expressed in arbitrary units (A.U). A signal above 0.5 A.U. has already been shown to be above 2 standard deviation in a healthy population.

Measure: Platelets Acetyl-CoA Carboxylase phosphorylation rate

Time: At the time of inclusion

Secondary Outcomes

Description: Sepsis severity will be assessed using the SOFA score (Sepsis-related Organ Failure Assessment). Range from 0( less severe) to 24 (more severe).

Measure: Sepsis severity

Time: At the time of inclusion

Description: Sepsis severity will be assessed using the APACHE II score) Acute Physiology And Chronic Health Evaluation) Range 0 (less severe) to 299 (more severe).

Measure: Sepsis severity

Time: At the time of inclusion

Measure: Mortality rate

Time: 30 days and 1-year follow-up

Description: Platelet function will be assessed using platelets aggregometry. The Aggregation (in AU), the maximum height of the curve during the measurement period will be assessed.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: Platelet function will be assessed using platelets aggregometry. Area Under the aggregation Curve (AUC) will be assessed and recorded as Units or U.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: Platelet function will be assessed using platelets aggregometry. Velocity (in AU/min), the maximum slope of the curve will be assessed.

Measure: Platelet function assessment

Time: At the time of inclusion

Description: D-Dimers (ng/ml)

Measure: Thrombin generation marker rate

Time: At the time of inclusion

Description: Urinary Thrombin-antithrombin complex (ng/mL)

Measure: Thrombin generation marker rate

Time: At the time of inclusion

Description: Tubulin acetylation will be assessed using western blotting. Results will be expressed in arbitrary units (A.U).

Measure: Tubulin acetylation rate

Time: At the time of inclusion

Description: Total platelets lipid content and composition will be assessed using metabolomics approach by Mass Spectrometry. Fold-change estimates and corresponding P values were derived from regression models for each lipid species and each predictor. To control for multiple testing, all P values will be further adjusted for Benjamini-Hochberg false discovery rate (FDR), with a FDR <0.05 considered statistically significant

Measure: Total platelets lipid content and composition

Time: At the time of inclusion

Description: Myeloperoxidase MPO (ng/mL)

Measure: Neutrophils extracellular trap formation

Time: At the time of inclusion

Description: Citrulinated Histon 3 H3-Cit (ng/mL)

Measure: Neutrophils extracellular trap formation

Time: At the time of inclusion

Description: Soluble CD62P (ng/mL)

Measure: Platelets activation

Time: At the time of inclusion

Description: PaO2/FiO2

Measure: Respiratory failure

Time: At the time of inclusion and through study completion up to day 30
2 Coagulation Assays in the Critically Ill Patient: a New Approach Using the Thrombomodulin-modified Thrombin Generation Assay (TGA-TM)

Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients. Coagulation disorders have also been reported in many patients with severe courses of Coronavirus disease 2019 (Covid-19). But it is difficult to assess these changes. Global coagulation tests have been shown to incorrectly assess in vivo coagulation in patients admitted to intensive care units. But other tests are available. Thrombin generation assay (TGA) is a laboratory test which allows the assessment of an individual's potential to generate thrombin. But also in conventional TGA the protein C system is hardly activated because of the absence of endothelial cells (containing natural thrombomodulin) in the plasma sample. Therefore the investigators add recombinant human thrombomodulin to a conventional TGA. Thereby the investigators hope to be able to depict in vivo coagulation more closely than global coagulation tests do.

NCT04356144
Conditions
  1. Disseminated Intravascular Coagulation
  2. Critical Illness
  3. Sars-CoV2
  4. Viral Infection
  5. Coagulation Disorder, Blood
  6. Covid19
Interventions
  1. Diagnostic Test: Thrombin Generation Assay (TGA)
  2. Diagnostic Test: Thrombomodulin Modified Thrombin Generation Assay (TGA-TM)
MeSH:Infection Virus Diseases Hemostatic Disorders Blood Coagulation Disorders Disseminated Intravascular Coagulation Critical Illness
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Disseminated intravascular coagulation

Primary Outcomes

Description: nM;

Measure: ETP (AUC) without rhThrombomodulin (rhTM)

Time: 6 months

Description: nM;

Measure: ETP (AUC) with rhThrombomodulin (rhTM)

Time: 6 months

Description: Ratio of endogenous thrombin potential (ETP) with rhTM to ETP without rhTM

Measure: ETP-ratio

Time: 6 months

Description: Comparison of ETP-ratios from ICU patients and ETP-ratios from citrated plasma samples from healthy donors

Measure: ETP-Normalisation

Time: 6 months
3 Analysis of the Coagulopathy Developed by COVID-19 Infected Patients: Thrombin Generation Potential in COVID-19 Infected Patients

Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death. Understanding this acquired coagulopathy is a prerequisite before specific interventional studies. The study investigators aim to apply a normalized and automated thrombin generation test (TGT), developed for testing the thrombotic risk (triggered by 5 pM Tissue Factor, with a purified thrombomodulin (TM) challenge) and to study its association with survival.

NCT04356950
Conditions
  1. Sepsis
  2. Blood Coagulation Disorders
  3. Thrombin
  4. Disseminated Intravascular Coagulation
  5. COVID-19
Interventions
  1. Other: Thrombin generation test assay
  2. Other: Fibrin generation markers assays
MeSH:Hemostatic Disorders Blood Coagulation Disorders Disseminated Intravascular Coagulation
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Disseminated intravascular coagulation

Primary Outcomes

Description: Death yes/no during hopstilization, 28 days after admittence

Measure: 28-day survival rate

Time: 1 month

Description: Seconds; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test latent period

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test latent period compared to reference plasma

Time: Day 0

Description: nmol/s; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test initial velocity

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test initial velocity compared to reference plasma

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test peak thrombin compared to reference plasma

Time: Day 0

Description: nmol/L; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test peak thrombin

Time: Day 0

Description: Seconds; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test peak thrombin time

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test peak thrombin time compared to reference plasma

Time: Day 0

Description: seconds; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test total thrombin generation time

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test total thrombin generation time compared to reference plasma

Time: Day 0

Description: Seconds; without (TM-) and with (TM+) purified thrombomodulin

Measure: Absolute thrombin generation test endogenous thrombin potential

Time: Day 0

Description: %; without (TM-) and with (TM+) purified thrombomodulin

Measure: Relative thrombin generation test endogenous thrombin potential compared to reference plasma

Time: Day 0

Secondary Outcomes

Description: Death yes/no

Measure: 3-month survival rate

Time: 3 months

Description: Yes/no

Measure: Transfer to intensive care unit during hospitalization

Time: 3 months

Description: Yes/no (deep vein thrombosis, pulmonary embolism, atherothrombosis flare, arterial thrombosis)

Measure: Thrombotic complication during hospitalization

Time: 3 months

Description: µg / L, assayed by automated enzyme linked fluorescent assay (Vidas® D-dimers Exclusion ™ II)

Measure: Plasma concentrations of D-dimers

Time: Day 0

Description: mg / L, measured by automated immunoagglutination (STA®-Liatest® FM)

Measure: Plasma concentrations of soluble fibrin monomers

Time: Day 0
4 The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations

Although the novel SARS-CoV-2 virus (COVD-19) is classified as an acute respiratory infection, emerging data show that morbidity and mortality are driven by disseminated intravascular coagulopathy. Untreated CAC leads to microangiopathic thromboses, causing multiple systems organ failure and consuming enormous healthcare resources. Identifying strategies to prevent CAC are therefore crucial to reducing COVID-19 hospitalization rates. The pathogenesis of CAC is unknown, but there are major overlaps between severe COVID-19 and vitamin D insufficiency (VDI). We hypothesize that VDI is a major underlying contributor to CAC. Preliminary data from severe COVID-19 patients in New Orleans support this hypothesis. The purpose of the proposed multi-center, prospective, randomized controlled trial is to test the hypothesis that low-risk, early treatment with aspirin and vitamin D in COVID-19 can mitigate the prothrombotic state and reduce hospitalization rates.

NCT04363840
Conditions
  1. COVID
  2. Vitamin D Deficiency
  3. Coagulopathy
  4. Disseminated Intravascular Coagulation
Interventions
  1. Drug: Aspirin 81 mg
  2. Dietary Supplement: Vitamin D
MeSH:Disseminated Intravascular Coagulation Vitamin D Deficiency
HPO:Disseminated intravascular coagulation Low levels of vitamin D

Primary Outcomes

Description: Hospitalization for COVID-19 symptoms

Measure: Hospitalization

Time: 2 weeks
5 Exploratory Assessment of the Coagulation Changes Associated With Severe Inflammation in COVID-19 Patients

This study will study the potential utility of the Quantra QPlus System in patients inflicted with COVID-19 disease.

NCT04460664
Conditions
  1. COVID
  2. Disseminated Intravascular Coagulation
  3. Coagulation Disorder
Interventions
  1. Diagnostic Test: Quantra System
MeSH:Hemostatic Disorders Blood Coagulation Disorders Disseminated Intravascular Coagulation
HPO:Abnormality of coagulation Abnormality of the coagulation cascade Disseminated intravascular coagulation

Primary Outcomes

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Time results

Time: Within 24 hours of admission to the hospital

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Time results

Time: 48 to 72 hours after transfer to ICU

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Time results

Time: 1 to 24 hours prior to discharge from hospital

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Stiffness results

Time: Upon arrival at hospital

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Stiffness results

Time: 48 to 72 hours after transfer to ICU

Description: Coagulation function assessed by the Quantra

Measure: Quantra Clot Stiffness results

Time: 1 to 24 hours prior to discharge from hospital

HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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