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D000856: Anorexia Nervosa

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

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Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug3616 Virtual Family-Based Treatment Wiki 0.71
drug390 BRII-196/BRII-198 Wiki 0.71
drug389 BRII-196 and BRII-198 Wiki 0.71
Name (Synonyms) Correlation
drug3571 VIR-7831 Wiki 0.50
drug1786 LY3819253 Wiki 0.29
drug2827 Remdesivir Wiki 0.12
drug2490 Placebo Wiki 0.07

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D000855 Anorexia NIH 1.00
D001068 Feeding and Eating Disorders NIH 0.32

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002039 Anorexia HPO 0.71

Clinical Trials

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There are 2 clinical trials


1 Reorganization of Care in Patients Hospitalized in Child Psychiatry for Anorexia Nervosa at the Time of the Coronavirus-19 Epidemic in France: Qualitative Study Carried Out on Patients and Their Parents

Anorexia nervosa is a severe psychiatric condition. On the nutritional level, one of the objectives recommended by the High Authority of Health is to "achieve and maintain an appropriate weight and nutritional status". It is recommended that, in the event of hospitalisation, this should be "as long as necessary" and be based on a weight contract as a condition for discharge. Within the Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent of the Centre Psychothérapique de Nancy, an inpatient unit takes care of children and adolescents with a specific valence in the management of patients suffering from eating disorders. Since the first quarter of 2020, France has been progressively affected by the pandemic of the coronavirus 2019, Covid-19. This pandemic has led to unprecedented containment measures in France and around the world. At the time of the announcement of the implementation of containment, the investigators proposed to the parents of patients hospitalized in the Child and Adolescent Psychiatry Department of the Nancy Psychotherapy Center who were approaching their discharge weight to be able to end their hospitalization prematurely. As a follow-up to this hospitalisation, intensive outpatient care was offered to the families, in accordance with State recommendations in connection with the pandemic. In this hospitalized unit, weekly outpatient consultations were maintained and coupled with telephone interviews, teleconsultation interviews and a telephone hotline for the healthcare team. The objective of the study is to explore, in a qualitative way, the experiences of patients hospitalized in the child psychiatry department for anorexia nervosa at the time of the coronavirus epidemic in France and those of their parents, in relation to the reorganization of care.

NCT04387708
Conditions
  1. Anorexia Nervosa
MeSH:Anorexia Anorexia Nervosa
HPO:Anorexia

Primary Outcomes

Description: Analyzing the discourse content regarding the experiences related to changes in the care of patients with anorexia nervosa hospitalized in a child and adolescent psychiatric ward in Nancy, France, and their parents, in the context of the Covid-19 crisis.

Measure: Content analysis concerning the reorganization of care for children or adolescent and thier parents

Time: 1 interview for each participant during 45 minutes
2 Adapting and Adopting Highly Specialized Pediatric Eating Disorder Treatment to Virtual Care: Implementation Research for the COVID-19 Context and Beyond

The COVID-19 pandemic has had detrimental effects on mental health. Individuals with eating disorders (EDs) are no exception, exhibiting increased symptoms and exacerbated feelings of isolation and anxiety. Across Canada, in-person outpatient services have been quickly replaced with virtual care, yet practitioners and patients have noted substantial challenges in adapting ED-related care virtually. Given the success of our previous research on Family-Based Treatment (FBT) for EDs, as well as the rapid transition to virtual care during COVID-19, there is an urgent need to adapt FBT to virtual formats and adopt it in the ED network. Using a multi-site case study with a mixed method pre/post design, this study aims to examine the implementation of virtual FBT (vFBT) as well as its impact within six ED programs in Ontario, building on the investigator's previous work, and further developing capacity in the system. The investigator will develop implementation teams at each site and provide a virtual training workshop on vFBT, with ongoing consultation during initial implementation. The investigator proposes to examine implementation success by studying fidelity to vFBT, as well as team and patient/family experience with virtual care, and patient outcomes. These findings for virtual care will not only be important in the COVID-19 context but are also vital in the North, where access to specialized services is extremely limited.

NCT04678843
Conditions
  1. Anorexia Nervosa
Interventions
  1. Behavioral: Virtual Family-Based Treatment
MeSH:Anorexia Feeding and Eating Disorders Anorexia Nervosa
HPO:Anorexia

Primary Outcomes

Description: Measured by a self-report questionnaire entitled Key Measure of Therapist Behaviours and Self-Efficacy in FBT (an indicator of therapist adherence to the key components of standard FBT within the vFBT model)

Measure: Key components of FBT

Time: Completed after session 4 of treatment, approximately 4 months

Description: Fidelity to vFBT, measured by FBT fidelity ratings of the first four sessions of vFBT using the FBT Fidelity and Adherence Check (experts in FBT fidelity rating will rate the recordings).

Measure: Fidelity

Time: Completed after the session 4 of treatment, approximately 4 months

Secondary Outcomes

Description: Experiences of the therapists, medical practitioners, administrators, and families in vFBT, qualitatively measured during semi-structured focus groups

Measure: Qualitative experience of participants

Time: Completed after session 4 of treatment, approximately 4 months

Description: Weight will be measured in kilograms.

Measure: Change in Weight

Time: At baseline before treatment, and at 1 week, 2 weeks, 3 weeks, and 4 weeks.

Description: The number of binge/purge episodes each week will be recorded by patients/their families.

Measure: Change in Number of Binge/Purge Episodes

Time: At baseline before treatment, and at 1 week, 2 weeks, 3 weeks, and 4 weeks.

Description: The Brief Individual Readiness to Change Scale will indicate how ready therapists feel they are to change. Higher scores indicate greater readiness to use research-based direct service techniques. Minimum score is 0, maximum score is 20.

Measure: Therapists' Change in Readiness

Time: At baseline, after training (approx. 1 month), and after 4 sessions of treatment (approx. 4 months)

Description: Their attitudes about evidence-based practice will be assessed using the Evidence Based Practice Attitudes Scale (EBPAS). The subscales include requirements, appeal, openness and divergence. The score for each subscale is created by computing a mean score for the items that load on a given subscale. Minimum score for each subscale is 0, maximum score for each subscale is 4.

Measure: Therapists' Change in Attitudes about Evidence Based Practice

Time: At baseline, after training (approx. 1 month), and after 4 sessions of treatment (approx. 4 months)

Description: Their confidence related to the intervention will be assessed by administering an adapted version of the Perceived Attributes of the Principles of Effectiveness Scale (MPAS). Higher scores are indicative of more favorable perception for adoption of the Family-Based Treatment model. The minimum score is 18, the maximum score is 90.

Measure: Therapists' Change in Confidence related to the Intervention

Time: At baseline, after training (approx. 1 month), and after 4 sessions of treatment (approx. 4 months)

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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