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D019851: Thrombophilia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (13)


Name (Synonyms) Correlation
drug2612 Povidone-Iodine 0.6% NI Wiki 0.45
drug1826 Lift Wiki 0.45
drug846 Complete thrombophilic profile testing by multiplex PCR Wiki 0.45
Name (Synonyms) Correlation
drug1260 Extracorporeal blood purification using the oXiris® (AN69ST) hemofilter Wiki 0.45
drug2613 Povidone-Iodine 0.6% NS Wiki 0.45
drug2532 Placebo comparator: DW-NI Wiki 0.45
drug2611 Povidone-Iodine 0.5% NS Wiki 0.45
drug2533 Placebo comparator: DW-NS Wiki 0.45
drug1870 Low Molecular Weight Heparin Wiki 0.45
drug2610 Povidone-Iodine 0.5% NI Wiki 0.45
drug2608 Povidone-Iodine 0.4% NI Wiki 0.45
drug3142 Sonoclot Wiki 0.45
drug3765 blood sampling Wiki 0.20

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D020767 Intracranial Thrombosis NIH 0.45
D020246 Venous Thrombosis NIH 0.13
D013927 Thrombosis NIH 0.08
Name (Synonyms) Correlation
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.03

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0100724 Hypercoagulability HPO 0.89
HP:0002625 Deep venous thrombosis HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Study of the Vascular Compartment and Hypercoagulability During Coronavirus Infection COVID-19

Coronavirus COVID-19 is an emerging virus also called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Eighty percent of patients are poor or asymptomatic. However, there are major respiratory complications for some patients, requiring intensive care hospitalization and possibly leading to death in 5% of cases. One of the hypotheses put forward is that much of the pathophysiology is due to endothelial dysfunction associated with disseminated intravascular coagulation. The covid-19 pathology could induce coagulation impairment as observed during sepsis. An increase in D-dimer levels during covid-19 disease is itself associated with excess mortality. While D-dimers are highly sensitive, they are not specific for clotting activity. They may be increased in many other circumstances, particularly in inflammation. On the other hand, the infection stimulates the release of extracellular vesicles. These vesicles, of multiple cellular origin, are an actor of vascular homeostasis, and participate in the state of hyperactivation of coagulation. They have a major role in the prothrombotic state and the development of coagulopathy associated with sepsis. The aim of our monocentric prospective study would be to study early and more specific markers of hypercoagulability and markers of routine endothelial dysfunction, as soon as the patient is hospitalized, in order to predict the risk of hospitalization in intensive care.

NCT04367662
Conditions
  1. COVID-19
Interventions
  1. Procedure: blood sampling
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Thrombophilia
HPO:Hypercoagulability

Primary Outcomes

Measure: Clinical worsening (yes/no) of the patient during hospitalization

Time: in the 15 days from admission

Description: Biological analysis using initial blood sampling

Measure: D-DIMERS plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Fibrin monomers plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Antithrombin plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Prothrombin Fragment 1 plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Prothrombin Fragment 2 plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Thrombin generation test plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Microvesicles of platelet plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Cross-linked platelets plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Willebrand Factor plasma levels in blood

Time: 1 hour after admission

Description: Biological analysis using initial blood sampling

Measure: Factor VIII plasma levels in blood

Time: 1 hour after admission
2 Heparins for Thromboprophylaxis in COVID-19 Patients: HETHICO Study in Veneto

The HETHICO study aims to collect retrospectively documented clinical information on patients hospitalized in Veneto Region (Italy) for SARS-COVID-2 infection in 2 types of settings, medical environment (COORTE MED), and intensive / sub-intensive (COORTE ICU), to assess the safety and possible efficacy of the anticoagulant treatments used for thromboprophylaxis, or in preventing thrombotic complications related to hospitalization from COVID-19.

NCT04393805
Conditions
  1. COVID-19
  2. Hypercoagulability
Interventions
  1. Drug: Low Molecular Weight Heparin
MeSH:Thrombophilia
HPO:Hypercoagulability

Primary Outcomes

Description: Collect and evaluate in real-life the safety data of the anti-coagulant treatments used by estimating the incidence of bleeding complications during hospitalization.

Measure: Bleeding

Time: 28 days

Description: Collect and evaluate in real-life the efficacy data of the anti-coagulant treatments used by estimating the incidence of deep vein thrombosis and/or pulmonary embolism during hospitalization.

Measure: Thrombosis

Time: 28 days

Description: Collect and evaluate in real-life the data by estimating incidence of intra-hospital death.

Measure: Mortality

Time: 28 days

Secondary Outcomes

Description: clinical worsening with transfer to the intensive/sub-intensive ward

Measure: Worsening

Time: 28 days

Description: length of stay

Measure: LOS

Time: 60 days
3 Clinical Efficacy and Safety of Extracorporeal Blood Purification to Control Hyperinflammation and Hypercoagulability in COVID-19 Patients

Several studies have suggested a potential clinical benefit of controlling hyper inflammation triggered by SARS-CoV-2/COVID-19. Blood purification, the removal of excessive proinflammatory mediators may control disease progression and support clinical recovery. For this purpose, COVID-19 patients might benefit from treatment with AN69ST hemofilter based extracorporeal blood purification.

NCT04478539
Conditions
  1. Covid19
Interventions
  1. Device: Extracorporeal blood purification using the oXiris® (AN69ST) hemofilter
MeSH:Thrombophilia
HPO:Hypercoagulability

Primary Outcomes

Description: Systemic levels of IL-6, IL-8 and TNF-α are evaluated to assess the effect of blood purification. Measurement points: at admission, "before and after a blood purification cycle" and before discharge

Measure: Changes in cytokine levels of Interleukin (IL) 6, IL-8 and Tumor Necrosis Factor-α (pg/mL)

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Systemic levels of proinflammatory mediators are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.

Measure: Changes in inflammatory markers; C-Reactive Protein (CRP) (mg/L)

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Systemic levels of thrombocytes are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.

Measure: Changes in thrombocyte counts (10^3 counts/microL)

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge

Measure: Changes in the coagulation marker Fibrinogen (g/L)

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Duration of intensive care will be determined in relation to the number of blood purification cycles Patients will be followed for the duration of ICU stay.

Measure: ICU length of stay after admission (days)

Time: An expected average of 4 - 14 hospitalisation days or until hospital discharge (whichever comes first)

Secondary Outcomes

Description: Systemic levels of proinflammatory mediators are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.

Measure: Changes in Neutrophil-to-Lymphocyte Ratio

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge

Measure: Changes in the coagulation marker D-Dimers (ng/mL)

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)

Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge

Measure: Changes in the Activation Clotting Time (seconds).

Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)
4 Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events

An estimated 22% of the global population is at an increased risk of a severe form of COVID-19, while one in four coronavirus patients admitted to intensive care unit will develop a pulmonary embolism. A major public health question remains to be investigated: why COVID-19 is mild for some, critically severe for others and why only a percentage of COVID-19 patients develop thrombosis, despite the disease's proven hypercoagulable state? Patients' intrinsic characteristics might be responsible for the deep variety of disease forms. Our study aims to assess the validity of the hypothesis according to which underlining genetic variations might be responsible for different degrees of severity and thrombotic events risks in the novel coronavirus disease. Moreover, we suspect that prothrombotic genotypes occuring in the genes that encode angiotensin-converting enzyme (ACE-DEL/INS) and angiotensinogen (AGT M235T) are involved in the unpredictable evolution of COVID-19, both in terms of severity and thrombotic events, due to the strong interactions of SARS-CoV-2 with the renin-angiotensin-aldosterone system (RAAS). Therefore, we also aim to assess the validity of the theory according to which there is a pre-existing atypical modulation of RAAS in COVID-19 patients that develop severe forms and/or thrombosis. Our hypothesis is based on various observations. Firstly, there is a substantial similarity with a reasonably related condition such as sepsis, for which there is a validated theory stating that thrombophilic mutations affect patients' clinical response. Secondly, racial and ethnic genetic differences are responsible for significant dissimilar thrombotic risks among various nations. Thirdly, an increase in stroke incidence has been reported in young patients with COVID-19, without essential thrombosis risk factors, favoring the idea that a genetic predisposition could contribute to increase the thrombotic and thromboembolic risk. Fourthly, the plasminogen activator inhibitor (PAI)-1 4G/5G inherited mutation was found to be responsible for a thrombotic state causing post-SARS osteonecrosis.

NCT04519398
Conditions
  1. Covid19
  2. Corona Virus Infection
  3. Thrombosis
  4. ARDS
  5. Thrombophilia
  6. Thromboses, Intracranial
  7. Thromboses, Deep Vein
  8. RAAS
Interventions
  1. Genetic: Complete thrombophilic profile testing by multiplex PCR
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Intracranial Thrombosis Thrombosis Venous Thrombosis Thrombophilia
HPO:Deep venous thrombosis Hypercoagulability Venous thrombosis

Primary Outcomes

Description: The difference of prothrombotic genotypes frequency between the three groups

Measure: Number of patients with thrombophilic profile alterations

Time: One year

Secondary Outcomes

Description: The differences of RAAS components levels between the three groups

Measure: Number of patients with RAAS components alterations

Time: One year
5 Study of Coagulation Profile and Role of Heparin-like Effect in Patients With COVID-19

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a pandemic, which has affected approximately 4 lakhs individuals and claimed 16,362 deaths till now. SARS-CoV-2 has been associated with myocarditis and renal dysfunction. Patients hospitalized for Covid-19 severe infection are more prone to excessive coagulation activation leading to thrombotic events both in the venous and arterial circulations, due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis. Nearly 20% of COVID-19 patients present severe coagulation abnormalities, which may occur in almost all of the severe and critical ill COVID-19 cases. Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. The importance of high D-dimer and Fibrin degradation product level to determine the patient prognostic and the risk of thrombosis is known. In a French study, it was found that a high rate of thromboembolic events in COVID-19 patients treated with therapeutic anticoagulation, with 56% of VTE and 6 pulmonary embolisms. Preliminary reports on COVID-19 patients' clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation. COVID-19 patients with acute respiratory failure present a severe hypercoagulability rather than consumptive coagulopathy. Another study highlights this common finding in most COVID-19 patients with high D-dimer levels which are associated with a worse prognosis. Cases showed significantly higher fibrinogen and D-dimer plasma levels versus healthy controls (p < 0.0001). Markedly hypercoagulable thromboelastometry profiles were observed in COVID-19 patients, as reflected by shorter Clot Formation Time (CFT) in INTEM (p = 0.0002) and EXTEM (p = 0.01) and higher Maximum Clot Firmness (MCF). Fibrin formation and polymerization may predispose to thrombosis and correlate with a worse outcome. Global VE tests provide a more physiologic assessment of coagulation and should be considered to guide blood transfusion requirements in liver transplantation and other major surgery. Its application in patients with Covid19 or in a critical care setting requires more data. Viscoelastic tests, which include TEG, ROTEM, and Sonoclot, offer a means of assessing the activity of pro-and anticoagulant pathways, hyperfibrinolysis, and excessive clot lysis. Assessment of clot formation can be performed in 10 to 20 minutes as a point of care (POC) test; however, assessment of clot lysis takes 30 to 60 minutes. SIRS and sepsis trigger the release of endogenous heparinoids, or a heparin-like effect (HLE), due to small endothelium/mast cell-derived glycosaminoglycan's, which can be detected on heparinase-treated viscoelastic assays. Viscoelastic testing of global coagulation such as thromboelastometry and Sonoclot has been proposed as a superior tool to rapidly diagnose and help guide resuscitation with blood products and anticoagulation. it is deemed necessary to determine the influence of Covid 19 on coagulation parameters using point of care coagulation using sonoclot and conventional coagulation tests. In this prospective trial, the investigators aim to evaluate coagulation abnormalities via traditional tests and whole blood Sonclot profiles in a group of 50 consecutive patients with critically ill COVID-19 patients admitted to the Covid ICU OF Nehru Hospital extension, Postgraduate Institute of Medical Education and Research, Chandigarh.

NCT04668404
Conditions
  1. Covid19
  2. Hypercoagulable States Nec
Interventions
  1. Diagnostic Test: Sonoclot
MeSH:Thrombophilia
HPO:Hypercoagulability

Primary Outcomes

Description: To correlate conventional coagulation tests with point of care coagulation test using sonoclot

Measure: Correlation of of conventional coagulation tests with point of care coagulation test using sonoclot in COVID-19 patients.

Time: 1 month

Secondary Outcomes

Description: Coagulation Related Thromboembolic events

Measure: Clinical Evidence of thrombosis

Time: 1 month

Description: Coagulation-related Bleeding Event

Measure: Coagulation-related Bleeding Event

Time: 28 days

Description: Presence of Endogenous Heparinoids as demonstrated on POC test [ Time Frame 0, 3 days]

Measure: Presence of Endogenous Heparinoids as demonstrated on POC test [ Time Frame 0, 3 days]

Time: [ Time Frame 0, 3 days

Description: Intensive care admission duration

Measure: Intensive care admission duration

Time: 28 days

Description: 28 day mortality

Measure: 28 day mortality

Time: 28 days

HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook