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D007676: Kidney Failure, Chronic

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (8)


Name (Synonyms) Correlation
drug3910 less-frequency hemodialysis Wiki 0.45
drug3819 dialysis Wiki 0.45
drug1168 Electronic survey Wiki 0.45
Name (Synonyms) Correlation
drug1304 Fenofibrate Wiki 0.45
drug3560 Usual care Wiki 0.26
drug425 Best Practice Wiki 0.20
drug3430 Tocilizumab Wiki 0.07
drug2490 Placebo Wiki 0.02

Correlated MeSH Terms (8)


Name (Synonyms) Correlation
D007674 Kidney Diseases NIH 0.40
D003324 Coronary Artery Disease NIH 0.22
D029424 Pulmonary Disease, Chronic Obstructive NIH 0.17
Name (Synonyms) Correlation
D008173 Lung Diseases, Obstructive NIH 0.16
D020521 Stroke NIH 0.12
D009369 Neoplasms, NIH 0.08
D007239 Infection NIH 0.04
D003141 Communicable Diseases NIH 0.03

Correlated HPO Terms (6)


Name (Synonyms) Correlation
HP:0000077 Abnormality of the kidney HPO 0.45
HP:0001677 Coronary artery atherosclerosis HPO 0.22
HP:0006510 Chronic pulmonary obstruction HPO 0.18
Name (Synonyms) Correlation
HP:0006536 Pulmonary obstruction HPO 0.17
HP:0001297 Stroke HPO 0.12
HP:0002664 Neoplasm HPO 0.08

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Tociluzumab for Cytokine Release Syndrome With SARS-CoV-2: An Open-Labeled, Randomized Phase 3 Trial

This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection. CRS is a potentially serious disorder caused by the release of an excessive amount of substance that is made by cells of the immune system (cytokines) as a response to viral infection. Tocilizumab is used to decrease the body's immune response. Adding tocilizumab to standard of care may work better in treating CRS in patients with SARS-CoV-2 infection compared to standard of care alone.

NCT04361552
Conditions
  1. Cerebrovascular Accident
  2. Chronic Obstructive Pulmonary Disease
  3. Chronic Renal Failure
  4. Coronary Artery Disease
  5. Diabetes Mellitus
  6. Malignant Neoplasm
  7. SARS Coronavirus 2 Infection
Interventions
  1. Other: Best Practice
  2. Biological: Tocilizumab
MeSH:Infection Neoplasms Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Stroke Kidney Failure, Chronic Coronary Artery Disease
HPO:Chronic pulmonary obstruction Coronary artery atherosclerosis Neoplasm Pulmonary obstruction Stroke

Primary Outcomes

Description: The 7-day length of invasive MV for each arm will be estimated with 95% confidence intervals (CIs) using the exact binomial distribution. Their difference by the arms will be tested by Cochran-Mantel-Haenszel (CMH) test stratified by the age group and Sequential Organ Failure Assessment (SOFA) score at significance level of 0.05.

Measure: 7-day length of invasive mechanical ventilation (MV)

Time: Up to 7 days

Description: Defined as death within 30-day after randomization. The 30-day mortality rate for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: 30-day mortality rate

Time: Up to 30-day after randomization

Secondary Outcomes

Description: The rate of ICU transfer for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of intensive care (ICU) transfer

Time: Up to 2 years

Description: The rate of invasive mechanical ventilation for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of invasive mechanical ventilation

Time: Up to 2 years

Description: The rate of tracheostomy for each arm will be estimated with 95% CIs using the exact binomial distribution. Their difference by the arms will be tested CMH test stratified by the age group and SOFA score at significance level of 0.05.

Measure: Rate of tracheostomy

Time: Up to 2 years

Description: Will first be described by median and inter-quartile, and then compared between two arms by Wilcoxon Sum-Rank test

Measure: Length of ICU stay

Time: Up to 2 years

Measure: Length of hospital stay

Time: Up 2 years
2 Reduced Frequency Hemodialysis in Prevalent Patients Due to the Coronavirus Disease

Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients

NCT04374058
Conditions
  1. End Stage Renal Disease
Interventions
  1. Other: less-frequency hemodialysis
MeSH:Kidney Failure, Chronic

Primary Outcomes

Description: Time to all-cause and cardiovascular death

Measure: Mortality

Time: From date of beginning of the study until the date of death assessed up to 52 weeks

Secondary Outcomes

Description: Time variation of the biological parameters mentioned in the title. Repeated measurements of laboratory variables will be averaged into patient quarterly means to minimize measurement variability.

Measure: Anemia, Nutrition, Adequation of dialysis, total ultrafiltration, ultrafiltration rate,

Time: From date of beginning of the study assessed up to 52 weeks

Description: Time to first hospitalization of any cause

Measure: Hospitalization

Time: From date of beginning of the study until the date of first hospitalization assessed up to 52 weeks

Description: Time to first endovascular or quirurgical intervention of the vascular access utilized at the start of the study

Measure: Vascular Access

Time: From date of beginning of the study until the date of first intervention assessed up to 52 weeks
3 A Comparative Study of Symptom-driven Surveillance vs. Cross-sectional Serological Screening of SARS-CoV-2 Infection of Patients With End-stage Kidney Disease Receiving Renal Replacement Therapy

Starting in late 2019, the world is facing a pandemic with the SARS-CoV-2 virus. Patients with end-stage kidney disease and on treatment with renal replacement therapy are high risk patients, as they are unable to maximize social distancing. We plan to gather epidemiological data using two different diagnostic approaches. We will compare a symptom-driven screening, in combination with a nasopharyngeal swab plus computed tomography (clinical approach) against serological surveillance.

NCT04378686
Conditions
  1. SARS-CoV 2
  2. End Stage Renal Failure on Dialysis
Interventions
  1. Other: dialysis
MeSH:Kidney Failure, Chronic

Primary Outcomes

Description: serology to test for IgG and IgM antibodies against SARS-CoV-2

Measure: Antibodies against SARS-CoV-2

Time: one year
4 The Impact of Coronavirus (COVID-19) Restrictions on Wellbeing, Quality of Life and Physical Activity in People With End-stage Renal Disease, Currently Dialysing In-centre Versus at Home in the UK and Their Experience of Telemedicine

To understand the impact of COVID-19 restrictions on the wellbeing, quality of life and physical activity of people with end-stage renal disease, currently dialysing in-centre versus at home in the UK and their experience of telemedicine.

NCT04422873
Conditions
  1. End Stage Renal Disease
  2. Sars-CoV2
MeSH:Kidney Diseases Kidney Failure, Chronic
HPO:Abnormality of the kidney Nephropathy

Primary Outcomes

Description: Participants will be asked during a qualitative interview about the effect of COVID-19 restrictions on their; well-being, quality of life and physical activity and sedentary behaviours

Measure: Qualitative assessment of the effect of COVID-19 restrictions on patients' well-being, quality of life and physical activity and sedentary behaviours

Time: Day 1

Secondary Outcomes

Description: Participants will be asked during a qualitative interview about their perceptions and experiences of telemedicine

Measure: Thematic analysis of qualitative interview exploring patients' experiences of telemedicine during the COVID-19 restrictions in the UK

Time: Day 1
5 COVID-19 Progression in End-Stage Kidney Disease

The purpose of this study is to collect genomic and clinical data among a cohort of hemodialysis patients and analyze the association between genetic markers and the development and severity of illness in response to SARS-CoV-2.

NCT04495907
Conditions
  1. SARS-CoV-2 Infection (Asymptomatic)
  2. SARS-CoV-2 Infection (Symptomatic)
MeSH:Infection Communicable Diseases Kidney Diseases Kidney Failure, Chronic
HPO:Abnormality of the kidney Nephropathy

Primary Outcomes

Measure: SARS-CoV-2 IgG

Time: An average of 6 months

Measure: Anti-SARS-CoV-2 IgG

Time: An average of 6 months

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

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