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Name (Synonyms) | Correlation | |
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drug53 | 3D Telemedicine Wiki | 0.37 |
drug47 | 2D Telemedicine Wiki | 0.30 |
drug78 | ADAM Sensor Wiki | 0.21 |
Name (Synonyms) | Correlation | |
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drug90 | ANNE One Wiki | 0.21 |
drug2778 | Racial Inequality Highlighted Wiki | 0.21 |
drug3707 | Zinc gluconate Wiki | 0.21 |
drug3719 | acute kidney injury Wiki | 0.21 |
drug2751 | Quinquina-Stevia/Azythromycin Wiki | 0.21 |
drug57 | 5-ALA-Phosphate + SFC (5-ALA + SFC) Wiki | 0.21 |
drug2583 | Plasma exchange and convalescent plasma Wiki | 0.21 |
drug4072 | serum NGAL and cystatin c Wiki | 0.21 |
drug1982 | Medical Record Review Wiki | 0.21 |
drug2231 | Non interventional study Wiki | 0.21 |
drug2564 | Placebo videos Wiki | 0.21 |
drug56 | 4Plants/Azythromycin Wiki | 0.21 |
drug1784 | LSALT peptide Wiki | 0.21 |
drug1928 | MRI scans Wiki | 0.21 |
drug52 | 38-questions questionnaire Wiki | 0.21 |
drug41 | 25-OH cholecalciferol Wiki | 0.21 |
drug86 | AMA Acknowledgement Drug Pricing Wiki | 0.21 |
drug71 | ACE inhibitor, angiotensin receptor blocker Wiki | 0.21 |
drug1351 | GAD-7 General anxiety disorder scale Wiki | 0.21 |
drug149 | Acknowledgement Racial Injustice AMA Wiki | 0.21 |
drug3128 | Sodium bicarbonate Wiki | 0.21 |
drug184 | African American Sender in Informational Videos. Wiki | 0.21 |
drug3667 | White Sender in Informational Videos Wiki | 0.21 |
drug3714 | [TIMP-2]*[IGFBP-7] Wiki | 0.21 |
drug183 | African American Sender Acknowledgement Wiki | 0.21 |
drug65 | AAZ Covid-19 rapid test Wiki | 0.21 |
drug88 | AN69-Oxiris Wiki | 0.21 |
drug74 | ACEIs Wiki | 0.21 |
drug2952 | SBI-101 Wiki | 0.21 |
drug1557 | Hydroxychloroquine/Azithromycine Wiki | 0.21 |
drug1704 | Intervention training: Wiki | 0.21 |
drug3666 | White Sender in Acknowledgement Wiki | 0.21 |
drug89 | AN69-Standard Wiki | 0.21 |
drug3626 | VitalTalk communication skills training Wiki | 0.21 |
drug2379 | PHQ-9 Depression Scale Wiki | 0.21 |
drug75 | ACP Decisions Video Program Wiki | 0.21 |
drug2584 | Plasma expansion with Ringer's Acetate Wiki | 0.21 |
drug79 | ADM03820 Wiki | 0.21 |
drug2213 | No Racial Inequality Highlighting Wiki | 0.21 |
drug49 | 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (cured Patients) Wiki | 0.21 |
drug50 | 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (hospitalized Patients ) Wiki | 0.21 |
drug84 | AKS-452 Wiki | 0.21 |
drug64 | A vignette intervention Wiki | 0.21 |
drug63 | A short video intervention Wiki | 0.21 |
drug80 | AG0301-COVID19 Wiki | 0.15 |
drug910 | Conventional treatment Wiki | 0.15 |
drug48 | 300 mg of omega3-FA Wiki | 0.15 |
drug4126 | unfractionated Heparin Wiki | 0.15 |
drug2796 | Ravulizumab Wiki | 0.12 |
drug81 | AG0302-COVID19 Wiki | 0.12 |
drug2215 | No intervention Wiki | 0.09 |
drug3191 | Standard of Care Wiki | 0.03 |
drug2490 | Placebo Wiki | 0.02 |
Name (Synonyms) | Correlation | |
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D014947 | Wounds and Injuries NIH | 0.39 |
D057049 | Thrombotic Microangiopathies NIH | 0.21 |
D009102 | Multiple Organ Failure NIH | 0.19 |
Name (Synonyms) | Correlation | |
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D018746 | Systemic Inflammatory Response Syndrome NIH | 0.12 |
D018805 | Sepsis NIH | 0.08 |
D013577 | Syndrome NIH | 0.04 |
D016638 | Critical Illness NIH | 0.03 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.03 |
D018352 | Coronavirus Infections NIH | 0.02 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.02 |
D055371 | Acute Lung Injury NIH | 0.02 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.02 |
Name (Synonyms) | Correlation | |
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HP:0001919 | Acute kidney injury HPO | 1.00 |
HP:0100806 | Sepsis HPO | 0.08 |
Navigate: Correlations HPO
There are 22 clinical trials
A study of renal blood flow and renal oxygenation measured by magnetic resonance after a standardized fluid challenge in critically ill, resuscitated, patients with sepsis due to COVID-19 or other agents.
Description: Measured with arterial spin labelling (ASL), Phase Contras, Blood oxygenation level dependent (BOLD) and T(2) -Relaxation-Under-Spin-Tagging (TRUST), compared to baseline measurement
Measure: Change in renal blood flow and renal oxygenation after standardized plasma expansion with fluid bolus Time: When achieved according to protocol, approximately 3-10 minutes after interventionDescription: Measured with arterial spin labelling (ASL), Phase Contras, Blood oxygenation level dependent (BOLD) and T(2) -Relaxation-Under-Spin-Tagging (TRUST) during baseline measurement.
Measure: Descriptive renal oxygenation and blood flow in critical illness due to sepsis Time: During Critical illness - at one time pointDescription: Measured with arterial spin labelling (ASL), Phase Contras, Blood oxygenation level dependent (BOLD) and T(2) -Relaxation-Under-Spin-Tagging (TRUST) images stratified in groups in regards to KDIGO grade during exam.
Measure: Descriptive renal oxygenation and blood flow in critical illness in no/low grade AKI or high grade AKI. Time: During Critical illness - at one time pointThe kidney may be affected in coronavirus-2019 disease (COVID-19). This study assessed the predictors and outcomes of acute kidney injury (AKI) among individuals with COVID-19.
Description: the incidence of Acute Kidney Injury
Measure: Rate of Acute Kidney Injury Time: From date of admission until the date of discharge or death from any cause, up to 60 daysDescription: death from any cause in the hospital
Measure: Rate of Death Time: From date of admission until the date of death from any cause, up to 60 daysDescription: days from admission to discharge or death
Measure: the length of hospital stay Time: From date of admission until the date of discharge or death from any cause, up to 60 daysThe study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
Description: KDIGO AKI score
Measure: Acute Kidney Injury Time: During Intensive Care, an estimated average of 10 days.Description: Acute Respiratory Distress Syndrome yes/no
Measure: ARDS Time: During intensive care, an estimated average of 10 days.Description: Death within 30 days of ICU admission
Measure: 30 day mortality Time: 30 daysDescription: Death within 1 year of ICU admission
Measure: 1 year mortality Time: 1 yearDescription: Development of Chronic Kidney Disease
Measure: Chronic Kidney Disease Time: 60 days and 1 year after ICU admissionDescription: Sequential Organ Failure Score as a continuous variable
Measure: SOFA-score Time: During Intensive Care, an estimated average of 10 days.Acute kidney injury (AKI) is reported to occur in 0.5-9% of severe acute respiratory distress coronavirus 2-positive patients and AKI has been identified as an independent risk factor for in-hospital mortality. The present study aims to investigate the incidence of renal outcome of in-hospital patients diagnosed with COVID-19.
Description: As determined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria
Measure: Incidence of chronic kidney disease Time: 6 months post-hospital admissionDescription: Serial biomarker assessment
Measure: Renal function changes during hospital stay Time: from hospital admission til discharge up to 3 monthsDescription: As determined by KDIGO criteria
Measure: Incidence of AKI Time: Within 7 days after admissionIn this study, critically ill patients with highly suspected or confirmed COVID-19 will be included. Main goal is the identification of noncoding RNAs in COVID-19 associated organ dysfunction with an emphasis on acute kidney injury.
Among patients with SARS-CoV-2 pneumonia, approximately 20% have an acute kidney injury (AKI) and 5% require renal replacement therapy. Occurrence of AKI in patients with COVID-19 is associated with increased morbidity and mortality. Early detection of patients at risk of AKI would allow to prevent onset or worsening of AKI. The aim of this study is to determine if urine biomarkers of renal tubular damage such as TIMP-2 and IGFBP7 could early identify patients with SARS-CoV-2 pneumonia at risk of developing AKI.
Description: Sensibility and specificity of urinary [TIMP-2]*[IGFBP-7] > 0,3 to predict AKI (KDIGO stage ≥ 1) in SARS-CoV-2 patients at day-7 after measurement
Measure: Sensibility and specificity of urinary Time: Occurence of AKI 7 days after urinary biomarkers measurementDescription: Sensibility and specificity of urinary [TIMP-2]*[IGFBP-7] > 0,3 to predict AKI worsening, renal replacement therapy requirement or persistant AKI
Measure: Sensibility and specificity of urinary Time: Occurnce of AKI worsening, renal replacement therapy requirement or persistant AKI, 7 days after urinary biomarkers mesurementTo evaluate the proportion of subjects alive and free of respiratory failure (e.g. need for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free of the need for continued renal replacement therapy (RRT) on Day 28. The need for continued RRT at Day 28 will be defined as either dialysis in the past 3 days (Day 26, 27, or 28) or an eGFR on Day 28 <10 mL/min/1.73 m2.
Description: To evaluate the efficacy of intravenous LSALT peptide plus standard of care to prevent the progression of COVID-19 to mild, moderate or severe ARDS, acute kidney injury, cardiomyopathy, acute liver injury, coagulopathy, or death in patients infected with SARS-CoV-2 compared with placebo plus standard of care.
Measure: Development of Acute Respiratory Distress Syndrome (ARDS) and Other Organ Injuries Time: 28 daysDescription: High-frequency oscillatory ventilation, with its rapid delivery of low tidal volumes and a respiratory rate in the range of 60 to 900 breaths/minute, has also been utilized in ARDS patients.
Measure: Ventilation-free days Time: 28 daysDescription: Oxygen therapy provided as non-invasive therapy for ARDS patients.
Measure: Time on nasal cannula or oxygen masks Time: 28 daysDescription: 28 day mortality - all cause and attributable
Measure: 28 day mortality - all cause and attributable Time: 28 daysDescription: ICU and hospitalization length of stay (days)
Measure: ICU and hospitalization length of stay (days) Time: 28 daysDescription: Swab (nasopharyngeal, nasal, throat, sputum, or lower respiratory tract) at baseline (Day 1) and every 3 days thereafter until eradication → virologic clearance rate
Measure: SARS-CoV2 testing Time: 28 daysDescription: Extracorporeal membrane oxygenation (ECMO) is often used for severe ARDS to allow lung healing/repair and reverse respiratory failure.
Measure: Need and duration for extracorporeal membrane oxygenation (ECMO) Time: 28 daysDescription: Vasopressor free days
Measure: Vasopressor free days Time: 28 daysDescription: Chest X-rays performed at Baseline, Day 3, at clinical improvement, and end-of-treatment (EOT) and study (EOS) to determine presence of bilateral opacities.
Measure: Radiographic pulmonary assessments Time: 28 daysDescription: Change in daily mMRC dyspnea and SOFA scores (0 to 4) with 4 being the most severe outcome
Measure: Change in modified Medical Research Council (mMRC) dyspnea and Sequential Organ Failure Assessment (SOFA) scores Time: 28 daysDescription: Incidence of other organ (non-lung) disorders
Measure: Incidence of non-lung disorders Time: 28 daysDescription: Change in liver function tests (ALT, AST, and total bilirubin levels) from baseline
Measure: Measures of liver dysfunction Time: 28 daysDescription: Change in SCr and eGFR from baseline
Measure: Measures of kidney dysfunction Time: 28 daysDescription: Change in highly-sensitive troponin (hs-troponin) from baseline
Measure: Measures of cardiac dysfunction Time: 28 daysDescription: Change from baseline ACT, aPTT, and/or PT/INR levels
Measure: Measures of coagulopathies Time: 28 daysDescription: Change in baseline antiviral immunoglobulins (IgG, IgM) at EOS.
Measure: Changes in immunogenic responses Time: 28 daysDescription: Changes in total healthcare costs from admission to discharge between treatment groups.
Measure: Healthcare outcomes Time: 28 daysDescription: Change in serum cytokines including IL-1α, IL-1ß, IL-1ra, IL-5, IL-6, IL-8, IL-12, TNFα, CXCL10/IP10, MCP-3, and ferritin drawn at the same time as LSALT peptide levels
Measure: Molecular changes in pro-inflammatory pathways Time: 28 daysDescription: Pharmacokinetics of LSALT peptide over the study period.
Measure: Pharmacokinetics of LSALT peptide Time: 28 daysThe two biomarkers determined in urine, "Tissue Inhibitor of Metalloproteinases 2 (TIMP-2)" and "Insulin-like Growth Factor-Binding Protein 7 (IGFBP7)", can indicate the occurrence of Acute kidney injury (AKI) in cardiac surgery and critically ill patients at an early stage. However, no data are available whether these parameters can also predict the occurrence of AKI in the context of COVID-19 infection. An early prediction of AKI can be helpful for the optimisation of therapeutic management to improve patient outcome and for the triage of patients. The aim of this observational study is to evaluate whether the biomarker [TIMP- 2]*[IGFBP7] can predict the occurrence of AKI in critically ill patients suffering from SARS-CoV2 associated acute respiratory distress syndrome.
Description: Occurence of moderate or severe AKI
Measure: Occurence of acute kidney injury (AKI) Time: within 7 days after beginning of moderate or severe ARDSDescription: e.g., Analysis of interleukin (IL) 6, IL8
Measure: Add-on analysis: pro- and antiinflammatory mediators Time: within 7 days after beginning of moderate or severe ARDSSevere Acute respiratory syndrome coronovirus (SARS-CoV-2) was first described in Wuhan in December 2019. It quickly spread to rest of the world and was declared pandemic by World health organisation. Initial case series focused on lung involvement in the form alveolar haemorrhages and respiratory failure. However, subsequently, there have been reports of kidney involvement resulting in severe acute kidney injury. However, the reported incidence from Chinese data has been less than 5% and detailed epidemiology of AKI in COVID-19 disease is lacking.
Description: This is the proportion of patients with Acute kidney injury in COVID-19
Measure: Incidence of Acute kidney injury in COVID-19 Time: 7 daysDescription: This is the number of deaths in COVID-19 AKI patients
Measure: All-cause mortality in AKI patients Time: 7 daysThis research aims to investigate the role of daily measurement of urinary cell cycle arrest markers and other serum and urinary biomarkers to predict the development of acute kidney injury in critically ill patients with COVID-19 and acute respiratory disease.
Description: As defined by Kidney Diseases: Improving Global Outcome
Measure: Any stage of acute kidney injury Time: 7 daysDescription: Renal replacement therapy requirement at the clinicians' discretion
Measure: need for RRT in first 7 days Time: 7 daysDescription: ICU mortality
Measure: Mortality Time: 7 and 28 daysDescription: Duration
Measure: Duration of mechanical ventilation Time: 7 and 28 daysDescription: Duration
Measure: Duration of vasopressor support Time: 7 and 28 daysThe purpose of this study is to assess the safety and tolerability of the investigational product, SBI-101, in COVID-19 subjects with Acute Kidney Injury (AKI). SBI-101 is a biologic/device combination product designed to regulate inflammation and promote repair of injured tissue using allogeneic human mesenchymal stromal cells. SBI-101 will be integrated into the renal replacement circuit and patients will be treated for up to 24 hours.
The aim is to describe the epidemiology and determine the independent risk factors for mortality and acute organ injury in AKI and to assess the impact of different treatment strategies on survival. This will allow the development of prevention strategies and design of appropriately powered intervention studies.
Description: As defined by Kidney Diseases: Improving Global Outcomes (KDIGO) criteria
Measure: Incidence of any stage of acute kidney injury Time: 14 daysDescription: Mortality
Measure: Mortality Time: 14-day, hospital, and intensive care unit (ICU) mortalityDescription: Defined by return of creatinine to < 1.5 times of baseline
Measure: Renal recovery Time: 14 daysDescription: Percentage
Measure: Percentage of patients who receive renal replacement therapy Time: 14 daysDescription: Percentage of participants who are dialysis dependent
Measure: Percentage of participants who are dialysis dependent Time: Through study completion, an average of 90 daysDescription: Days without vasoactive medications and mechanical ventilation
Measure: Free-days of vasoactive medications and mechanical ventilation Time: Day 30Description: Length of intensive care unit and hospital stay
Measure: Length of intensive care unit and hospital stay Time: Through study completion, an average of 90 daysDescription: Congestive heart failure, Arrhythmia, Acute respiratory distress syndrome, Septic shock, Acute cardiac injury, pneumonia
Measure: Number of participants with consequences following AKI Time: Through study completion, an average of 90 daysDescription: Time from illness onset to need for mechanical ventilator support
Measure: Time from illness onset to need for mechanical ventilator support Time: Through study completion, an average of 30 daysThe actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has appeared to be more frequent and more severe than expected. Some data suggested a potential direct renal tropism of the virus, or undirect injury by "cytokine storm". The aims of this study are: 1. To describe incidence, severity and mortality associated with AKI during covid-19 infection in ICU 2. To identify specific risk factors for AKI 3. To explore pathophysiologic mechanism of AKI during COVID-19 infection
Description: AKI will be defined according with KDIGO guidelines: increase in creatinine of more than 1,5 fold compared to baseline Severe CVOID-19 infection is defined as 1/ confirm COVID-19 infection (by TDM and/or qRT-PCR) 2/ Requirement of ICU support during more than 72h
Measure: Primary endpoint is the incidence, the severity and the mortality associated with AKI during COVID-19 severe infection Time: 7 monthsThis study is an observational registry of children with or suspected to have SARS CoV2 (COVID-19) admitted to pediatric intensive care units (PICU). This registry will help describe the prevalence, rate and severity of acute kidney injury (AKI) in children with Severe Acute Respiratory Syndrome Coronavirus-2(SARS CoV2) across the world. The registry will be developed using a point prevalence methodology and then full retrospective review. Once a week, from April through June 2020, data collection will occur in "real-time" to estimate a weekly point prevalence of AKI and renal replacement therapy (RRT). The operational definition of "patients under investigation" (PUIs) will be used to identify the denominator of patients to be studied. The PUIs will be cohorted into SARS CoV2 test positive, test negative, test pending, or test unavailable. The primary aim of this study is to deliver a global, objective data driven analysis of the burden of AKI in virus positive patients or patients under investigation (PUI) who are admitted to the pediatric intensive care unit.
Description: Kidney Disease Improving Global Outcomes (KDIGO) Staged AKI by serum creatinine or urine output
Measure: Acute Kidney Injury (AKI) Time: 14 daysDescription: Survival to ICU discharge or Day 14
Measure: Survival Time: 14 daysDescription: The use of extracorporeal membrane oxygenation (ECMO) and/or renal replacement therapy
Measure: Rate of Extracorporeal Therapy Requirement Time: 14 daysDescription: >20% fluid overload as defined as the net fluid balance since ICU admission (in liters) divided by ICU admission weight
Measure: Fluid overload Time: Day of EnrollmentDescription: The exposure of enrolled patients to known nephrotoxic medications, including diuretics
Measure: Rate of nephrotoxic medication exposure Time: Day of EnrollmentSince the emergence of the new strain of betacoronavirus (SARS-CoV-2) and its important clinical repercussions, it has been described that patients with its associated pneumonia (COVID-19) have high rates of thrombotic events, including reduction in the dialyzers patency when undergoing renal replacement therapy. Several strategies for preventing the early loss of dialysers are described, and regional anticoagulation based on citrate is the preferred modality for preventing this complication. On the other hand, in patients with SARS-CoV-2 there are already descriptions of endothelial inflammation and activation of the coagulation cascade, including studies demonstrating the benefit of heparinization of these patients. Thus, this study aims to compare two different anticoagulation strategies in patients infected with COVID-19 with continued venovenous hemodialysis (CVVHD). From the indication of CVVHD, patients will be screened according to eligibility criteria and, if they fit these parameters, they will be randomized into two groups: Group A - Standard regional anticoagulation based on Citrate associated with infusion of low doses of unfractionated heparin 10ui/kg/hour and Group B - Standard regional anticoagulation based on Citrate only. Patients will be randomized in blocks and followed for 72 hours. The primary endpoint is dialyzer patency at the end of 72 hours of clinical follow-up. Secondary objectives will be mortality, bleeding rate, drop in hematimetric indices, urea sieving, filter time in hours, down time of therapy, system and dialyser pressures (PBE and PTM). All patients will undergo a standard procedure with a prescribed dose of 30mL/Kg/H, blood flow of 150mL/minute and polysulfone dialyzer.
Description: The percentage of clotted dialyzers within 72 hours in each of the studied groups.
Measure: Clotted dialyzers Time: Day 3 of dialysisDescription: Number of hours until a dialyzer clots in the first 72 hours of dialysis
Measure: Time-free of clotting Time: Day 3 of dialysisDescription: The amount of dialyzers used in the first 72 hours of hemodialysis
Measure: Number of dialyzers used Time: Day 3 of dialysisDescription: Variation in dialysis system and vascular access pressures in the first 72 h of dialysis
Measure: Pressure variation Time: Day 3 of dialysisDescription: Variation in urea sieving between the first, second and third days of dialysis
Measure: Urea sieving Time: Day 3 of dialysisDescription: Time of dialysis stop due to clotting in the first 72 hours
Measure: Downtime of dialysis Time: Day 3 of dialysisOur overarching goal is to improve the outcomes of critically ill COVID-19 patients with or at risk for development of acute kidney injury (AKI). The objective of this study is to determine the role of a protocol to manage urine alkalization using a simple medication that has been used for a very long time, is safe, and without significant side-effects. We aim to determine the feasibility and safety of a urine alkalinization protocol for the prevention of AKI in patients testing positive for COVID-19.
Description: Primary feasibility outcome will be the proportion of patients treated who achieve >50% of urine measurements pH ≥= 7.2 over the duration of treatment.
Measure: pH Time: 10 daysDescription: Primary efficacy outcome will be the number of days alive and free of stage 2-3 AKI (up to 28) in each group.
Measure: Number of Days Alive Free of Stage 2-3 AKI Time: 28 days post-treatmentDescription: proportion of patients developing stage 2-3 AKI (or stage 3 if already at stage 2 at enrollment).
Measure: Stage 2-3 AKI Time: 28 daysDescription: Ventilator-free days to 28 days
Measure: Vent-Free Time: 28 daysDescription: Hospital-free days to 60 days
Measure: Hospital-Free Time: 60 days post-index hospitalizationUltomiris (Ravulizumab), is a monoclonal antibody that specifically targets terminal complement products and is proposed for the treatment of COVID-19 induced microvasculature injury and endothelial damage leading to thrombotic microangiopathy (TMA) causing acute kidney injury (AKI). Ravulizumab is to be used for participants with a confirmed diagnosis of COVID-19 who clinically or diagnostically present with deteriorating renal function. Ravulizumab causes immediate and sustained inhibition of the terminal complement cascade. The use of ravulizumab could ameliorate COVID-19 induced kidney injury due to TMA, shorten hospital stay, and improve the overall survival.
Description: 50% improvement in estimated glomerular filtration rate compared to conventional therapy within 30 days of treatment for COVID-19-induced acute kidney injury.
Measure: Assess the efficacy of ravulizumab to ameliorate SARS-CoV-2 (COVID-19)-induced acute kidney injury manifesting as thrombotic microangiopathy. Time: 30 daysDescription: Evaluation of pharmacokinetics of ravulizumab in participants with COVID-19 Changes in ravulizumab concentration in plasma
Measure: Evaluation of pharmacokinetics of ravulizumab in participants with COVID-19 Time: 120 daysThe COVID-19 pandemic has exposed the unwanted variation in outcomes as evidence by Public Health England's report on increased mortality in regions of the country. For example, UHDB, in East Midlands, has reported a high crude mortality as compared to other Trusts in the region.8 There may also have been variation in the incidence of complications of COVID-19 in the form of AKI, which may have influenced mortality. Variation in outcomes may be because of various factors - differing population demographics, underlying health conditions in the population, deprivation, physician preference and knowledge and ethnic diversity. Unwanted variation is care that is not consistent with a patient's preference or related to [their] underlying illness. It is important to understand the reason for unwanted variation in outcomes associated with COVID-19 to minimise patient harm and reduce morbidity and mortality.
Description: In-hospital all cause mortality in patients with acute kidney injury and COVID-19
Measure: All-cause mortality Time: 30 daysDescription: Incidence of acute kidney injury in patients with COVID-19
Measure: acute kidney injury Time: 30 daysDescription: Need for mechanical ventilation in patients with COVID-19
Measure: Mechanical ventilation Time: 30 daysThis is a prospective observational parallel group cohort study that will aim to recruit 220 participants who were admitted to the hospital with COVID-19 between 1st March 2020 and 30th June 2020 (Group A - 110 participants who had COVID-19 with AKI; Group B - 110 participants who had COVID-19 without AKI). Data from groups A and B will be compared with AKI and non-AKI groups from an existing study database (ARID study, n=1125) who were recruited before the outbreak of the COVID-19 pandemic (recruitment 2013-2016) and who have all completed at least three years of follow up. Participants who have recovered from COVID-19 will be matched for analysis to participants from the ARID study for AKI status, baseline estimated glomerular filtration rate (eGFR) stage, age (± 5 years) and presence of diabetes. Potential participants will receive a letter of invitation along with a comprehensive participant information sheet (PIS).
Description: Kidney disease progression will be defined as a decline in estimated glomerular filtration rate (eGFR; ml/min/1.73m2) of ≥30%
Measure: Incidence of kidney disease progression at 12 months. Time: 12 months after hospital discharge.Description: Albuminuria will be defined as a urine albumin to creatinine ratio (UACR) of >30mg/mmol.
Measure: Incidence of albuminuria at 6-9 months. Time: 6-9 months after hospital discharge.Description: Albuminuria will be defined as a urine albumin to creatinine ratio (UACR) of >30mg/mmol.
Measure: Incidence of albuminuria at 12-15 months. Time: 12-15 months after hospital discharge.Description: Combined kidney disease progression outcome of ≥30% decline in eGFR (ml/min.1.73m2) and/or albuminuria (UACR>30mg/mmol).
Measure: Incidence of combined kidney disease progression and albuminuria at 6-9 months. Time: 6-9 months after hospital discharge.Description: Combined kidney disease progression outcome of ≥30% decline in eGFR (ml/min.1.73m2) and/or albuminuria (UACR>30mg/mmol).
Measure: Incidence of combined kidney disease progression and albuminuria at 12-15 months. Time: 12-15 months after hospital discharge.Description: Multi-variable Cox proportional hazards models will be used to assess the factors associated with all-cause mortality
Measure: Factors associated with all-cause mortality at 6-9 months. Time: 6-9 months after hospital discharge.Description: Multi-variable Cox proportional hazards models will be used to assess the factors associated with all-cause mortality
Measure: Factors associated with all-cause mortality at 12-15 months. Time: 12-15 months after hospital discharge.Description: Number of hospital readmissions
Measure: Incidence of hospital readmissions at 6-9 months Time: 6-9 months after hospital discharge.Description: Number of hospital readmissions
Measure: Incidence of hospital readmissions at 12-15 months Time: 12-15 months after hospital discharge.This is a prospective observational cohort study that will aim to recruit 60 participants who have had COVID-19, were admitted to hospital, required intensive care, and/or developed AKI during their hospital stay. Potential participants will be approached either by telephone by a member of the research team or via clinics (nephrology, post-ICU follow up clinics).
Description: Global organ structure will be assessed through structural T1- and T2-weighted MRI scans which will provide information about automated segmentation and volume assessment of whole kidney (and both cortex and medulla) as well as other abdominal organs (including liver and spleen). Global organ structure will also be assessed through longitudinal (T1) and transverse (T2) relaxation time mapping. T1 and T2 increase with tissue inflammation, oedema and fibrosis. A respiratory-triggered inversion recovery (IR) spin-echo echo-planar scheme will be used for abdominal T1 mapping and a Gradient and spin echo (T2-GraSE) scheme for abdominal T2 mapping.
Measure: MRI assessment of global organ structure at 12 months. Time: 12 monthsDescription: R2* data will be acquired using a multi-echo fast field echo (mFFE) scheme to assess thrombi. Conventionally R2* mapping is used as a measure of oxygenation, but R2*is likely to be altered by other factors in COVID-19, including oedema and small vessel thrombotic processes.
Measure: MRI assessment of thrombi (R2*) at 12 months. Time: 12 monthsDescription: Mean transit time and perfusion depicting changes in microvascular blood flow and large vessel flow/thrombosis will be determined using a FAIR labelling scheme with a multi-slice spin-echo echo-planar imaging readout and multiple labelling delay times.
Measure: MRI assessment of organ perfusion (Arterial spin labelling [ASL]) at 12 months. Time: 12 monthsDescription: Global organ structure will be assessed through structural T1- and T2-weighted MRI scans which will provide information about automated segmentation and volume assessment of whole kidney (and both cortex and medulla) as well as other abdominal organs (including liver and spleen). Global organ structure will also be assessed through longitudinal (T1) and transverse (T2) relaxation time mapping. T1 and T2 increase with tissue inflammation, oedema and fibrosis. A respiratory-triggered inversion recovery (IR) spin-echo echo-planar scheme will be used for abdominal T1 mapping and a Gradient and spin echo (T2-GraSE) scheme for abdominal T2 mapping.
Measure: MRI assessment of global organ structure. Time: 3-6 and 24 monthsDescription: R2* data will be acquired using a multi-echo fast field echo (mFFE) scheme to assess thrombi. Conventionally R2* mapping is used as a measure of oxygenation, but R2*is likely to be altered by other factors in COVID-19, including oedema and small vessel thrombotic processes.
Measure: MRI assessment of thrombi (R2*). Time: 3-6 and 24 monthsDescription: Mean transit time and perfusion depicting changes in microvascular blood flow and large vessel flow/thrombosis will be determined using a FAIR labelling scheme with a multi-slice spin-echo echo-planar imaging readout and multiple labelling delay times.
Measure: MRI assessment of organ perfusion (ASL) Time: 3-6 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with estimated glomerular filtration rate (ml/min/1.73m2).
Measure: Correlations between MRI measures with estimated glomerular filtration rate. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with urine albumin creatinine ratio (mg/mmol) and urine protein creatinine ratio (mg/mmol).
Measure: Correlations between MRI measures with urine albumin and protein creatinine ratios. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the mental component score. A score between 0 and 100 is calculated from the 36-Item Short-Form Health Survey; the higher the score, the better the quality of life mental domain.
Measure: Correlations between MRI measures with mental component score. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the physical component score. A score between 0 and 100 is calculated from the 36-Item Short-Form Health Survey; the higher the score, the better the quality of life physical domain.
Measure: Correlations between MRI measures with physical component score. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the health state score calculated from the European Quality of Life 5-Dimensions questionnaire. The health state score ranges from -0.285 (for the worst health state) to 1 (for the best health state).
Measure: Correlations between MRI measures with health state score. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the visual analogue score from the European Quality of Life 5-Dimensions questionnaire. The visual analogue score uses a thermometer-like scale numbered from 0 to 100; the higher the score, the better the health state.
Measure: Correlations between MRI measures with visual analogue score. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the fatigue score from the Fatigue Severity Scale, a 9-item questionnaire scored on a 7-point scale (minimum score=9; maximum score=63); the higher the score, the greater the fatigue severity.
Measure: Correlations between MRI measures with fatigue severity. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with the fatigue score from the Visual Analogue Fatigue Scale, which uses an horizontal line scale numbered from 0 to 10; the higher the score, the higher the fatigue.
Measure: Correlations between MRI measures with fatigue score. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with skin autofluorescence levels (arbitrary units) measured with the validated Autofluorescence Reader Standard Unit (SU) version 2.4.3 (AGE Reader SU, DiagnOptics Technologies BV, Aarhusweg 4-9, Groningen, The Netherlands).
Measure: Correlations with MRI measures with skin autofluorescence levels. Time: 3-6, 12 and 24 monthsDescription: Mean change in mental component score. A score between 0 and 100 is calculated from the 36-Item Short-Form Health Survey; the higher the score, the better the quality of life mental domain.
Measure: Mean change in mental component score. Time: 3-6, 12 and 24 monthsDescription: Mean change in physical component score. A score between 0 and 100 is calculated from the 36-Item Short-Form Health Survey; the higher the score, the better the quality of life physical domain.
Measure: Mean change in physical component score. Time: 3-6, 12 and 24 monthsDescription: Mean change in health state score calculated from the European Quality of Life 5-Dimensions questionnaire. The health state score ranges from -0.285 (for the worst health state) to 1 (for the best health state).
Measure: Mean change in health state score. Time: 3-6, 12 and 24 monthsDescription: Mean change in visual analogue score from the European Quality of Life 5-Dimensions questionnaire. The visual analogue score uses a thermometer-like scale numbered from 0 to 100; the higher the score, the better the health state.
Measure: Mean change in visual analogue score. Time: 3-6, 12 and 24 monthsDescription: Mean change in fatigue score as assessed by the Fatigue Severity Scale, a 9-item questionnaire scored on a 7-point scale (minimum score=9; maximum score=63); the higher the score, the greater the fatigue severity.
Measure: Mean change in fatigue severity scale. Time: 3-6, 12 and 24 monthsDescription: Mean change in fatigue score as assessed by the Visual Analogue Fatigue Scale, which uses an horizontal line scale numbered from 0 to 10; the higher the score, the higher the fatigue.
Measure: Mean change in fatigue score. Time: 3-6, 12 and 24 monthsDescription: Mean change in skin autofluorescence levels (arbitrary units) measured with the AGE Reader.
Measure: Mean change in skin autofluorescence levels. Time: 3-6, 12 and 24 monthsDescription: Assessment of kidney disease progression defined as decrease in estimated glomerular filtration rate (eGFR) of ≥25% associated with a decline in eGFR stage.
Measure: Incidence of kidney disease progression. Time: 3-6, 12 and 24 monthsDescription: Recording of the number of participants who developed any cardiovascular events.
Measure: Incidence of cardiovascular events. Time: 3-6, 12 and 24 monthsDescription: Correlations between MRI measures (Cortical T1, ASL-perfusion, T2, R2*) with all-cause mortality using multi-variable Cox proportional hazards models.
Measure: Correlations between MRI measures with all-cause mortality. Time: 12 and 24 monthsRecent different biomarkers of acute kidney injury (AKI) have been manufactured by pharmaceutical industry. Studies proved that Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin c are effective predictive biomarkers for early acute kidney injury in septic patients and in children after cardiopulmonary bypass. This study hypothesize that both cystatin c and Neutrophil gelatinase-associated lipocalin can predict AKI in patients with COVID-19 before elevation of serum urea and creatinine which may help early interference.
Description: biochmical tests for detection of NGAL and Cystatin c in Covid 19 patients
Measure: measure both cystatin c and Neutrophil gelatinase-associated lipocalin every other day for 3 times (NGAL) as recent biomarkers in prediction of AKI in patients with COVID-19. Time: one week starting from hospital admissionDescription: increased serum creatinine or urea
Measure: development of acute kidney injury lipocalin (NGAL) to AKI severity and prognosis of AKI in patients with COVID-19 infection Time: one week starting from day of admissionThis Randomized Control Trial (RCT) proposes combination of extracorporeal cytokine removal by plasma exchange (PLEX) and additional infusion of convalescent plasma (CCP) collected from COVID-19 recovered individuals at the end of the PLEX procedure. The combination of cytokine removal by PLEX and CCP infusion is in onvestigators opinion more rational compared to CCP infusion alone and as such probably more effective in reducing the duration of mechanical ventilation, length of stay in the intensive care unit, and potentially also mortality.
Description: The primary outcome is days alive and out of hospital from randomisation to day 90.
Measure: Alive at Day 90th Time: 90 daysDescription: Serious adverse events - new episode of septic shock, anaphylactic reaction to CCP, invasive fungal infection, TACO, TRALI.
Measure: Day 8 serious adverse events Time: 8 daysDescription: All-cause mortality at day 28
Measure: Day 28 all cause mortality Time: 28 daysDescription: Days alive without life support at day 90
Measure: Days alive without life support at day 90 Time: 90 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports