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D001927: Brain Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (12)


Name (Synonyms) Correlation
drug616 COVID-19 Therapeutic Biologics - Spike-GM-CSF Protein Lactated Ringer's Injection Wiki 0.63
drug376 BIO101 Wiki 0.45
drug670 CT-scan Wiki 0.45
Name (Synonyms) Correlation
drug2703 Pulse oximetry Wiki 0.45
drug697 Cannabis, Medical Wiki 0.45
drug615 COVID-19 Swab Wiki 0.45
drug618 COVID-19 antibodies testing Wiki 0.45
drug1125 EP Wiki 0.45
drug1113 EEG Wiki 0.45
drug1335 Follow up Wiki 0.32
drug495 Blood tests Wiki 0.32
drug2490 Placebo Wiki 0.02

Correlated MeSH Terms (31)


Name (Synonyms) Correlation
D020196 Trauma, Nervous System NIH 0.45
D000070627 Chronic Traumatic Encephalopathy NIH 0.45
D009421 Nervous System Malformations NIH 0.45
Name (Synonyms) Correlation
D005879 Tourette Syndrome NIH 0.45
D003424 Crohn Disease NIH 0.45
D003693 Delirium NIH 0.40
D000070642 Brain Injuries, Traumatic NIH 0.32
D000690 Amyotrophic Lateral Sclerosis NIH 0.32
D012640 Seizures NIH 0.32
D000013 Congenital Abnormalities NIH 0.32
D016472 Motor Neuron Disease NIH 0.32
D006526 Hepatitis C NIH 0.32
D001714 Bipolar Disorder NIH 0.26
D005356 Fibromyalgia NIH 0.22
D000755 Anemia, Sickle Cell NIH 0.22
D001930 Brain Injuries, NIH 0.20
D010300 Parkinsonian NIH 0.18
D015212 Inflammatory Bowel Diseases NIH 0.17
D012598 Scoliosi NIH 0.16
D009103 Multiple Sclerosis NIH 0.16
D059350 Chronic Pain NIH 0.15
D016638 Critical Illness NIH 0.11
D040921 Stress Disorders, Traumatic NIH 0.09
D004194 Disease NIH 0.09
D013313 Stress Disorders, Post-Traumatic NIH 0.08
D014947 Wounds and Injuries NIH 0.08
D013577 Syndrome NIH 0.04
D003141 Communicable Diseases NIH 0.03
D007239 Infection NIH 0.02
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (9)


Name (Synonyms) Correlation
HP:0001298 Encephalopathy HPO 1.00
HP:0000707 Abnormality of the nervous system HPO 0.45
HP:0100280 Crohn's disease HPO 0.45
Name (Synonyms) Correlation
HP:0006802 Abnormal anterior horn cell morphology HPO 0.32
HP:0100754 Mania HPO 0.32
HP:0007354 Amyotrophic lateral sclerosis HPO 0.32
HP:0001250 Seizure HPO 0.26
HP:0002037 Inflammation of the large intestine HPO 0.17
HP:0012532 Chronic pain HPO 0.15

Clinical Trials

Navigate: Correlations   HPO

There are 5 clinical trials


1 Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

NCT03944447
Conditions
  1. Chronic Pain
  2. Chronic Pain Syndrome
  3. Chronic Pain Due to Injury
  4. Chronic Pain Due to Trauma
  5. Fibromyalgia
  6. Seizures
  7. Hepatitis C
  8. Cancer
  9. Crohn Disease
  10. HIV/AIDS
  11. Multiple Sclerosis
  12. Traumatic Brain Injury
  13. Sickle Cell Disease
  14. Post Traumatic Stress Disorder
  15. Tourette Syndrome
  16. Ulcerative Colitis
  17. Glaucoma
  18. Epilepsy
  19. Inflammatory Bowel Diseases
  20. Parkinson Disease
  21. Amyotrophic Lateral Sclerosis
  22. Chronic Traumatic Encephalopathy
  23. Anxiety
  24. Depression
  25. Insomnia
  26. Autism
  27. Opioid-use Disorder
  28. Bipolar Disorder
  29. Covid19
  30. SARS-CoV Infection
  31. COVID-19
  32. Corona Virus Infection
  33. Coronavirus
Interventions
  1. Drug: Cannabis, Medical
MeSH:Infection Communicable Diseases Hepatitis C Coronavirus Infections Severe Acute Respiratory Syndrome Fibromyalgia Crohn Disease Inflammatory Bowel Diseases Parkin Parkinson Disease Multiple Sclerosis Brain Injuries Brain Injuries, Traumatic Seizures Motor Neuron Disease Amyotrophic Lateral Sclerosis Brain Diseases Tourette Syndrome Chronic Traumatic Encephalopathy Anemia, Sickle Cell Disease Syndrome Sclerosis Chronic Pain Wounds and Injuries Stress Disorders, Traumatic Bipolar Disorder Stress Disorders, Post-Traumatic
HPO:Abnormal anterior horn cell morphology Amyotrophic lateral sclerosis Bilateral tonic-clonic seizure Bipolar affective disorder Chronic pain Crohn's disease Encephalopathy Focal-onset seizure Generalized-onset seizure Inflammation of the large intestine Mania Seizure

Primary Outcomes

Description: Covid-19 infection rates in cannabis users will be compared to rates in the general population. Our online questionnaire responses will compare infection rates of cannabis users in this study against the Johns Hopkins University Coronavirus Research Center data (https://coronavirus.jhu.edu).

Measure: Prevention of COVID-19

Time: Five years

Description: Severity of persistent symptoms in cannabis users testing positive for active infection and/or antibodies will also be compared to the general population. Patients will answer the widely used FLU-PRO questionnaire, which asks about flu symptoms and severity, to capture diagnoses, symptoms, and medical interventions related to COVID-19. The data from cannabis user patients will be compared with national and international data surveys, such as the Covid Symptom Study (https://covid.joinzoe.com/us-2).

Measure: Treatment of COVID-19

Time: Five years

Description: The primary objective is to assess the efficacy and safety of medical cannabis as medicine for treatment of chronic pain and other chronic debilitating diseases. Pain will be measured by Brief Pain Inventory (BPI) numeric scale. Change from baseline in BPI will be assessed at 3-month intervals. For prospective associations between cannabis use and outcomes, use of a lagged mixed-effects models will examine temporal associations between cannabis use and pain severity, opioid sparing, and patient satisfaction. Data will be analyzed from baseline and the annual follow-up waves.

Measure: Treatment of Symptoms

Time: Five years

Secondary Outcomes

Description: Secondary objectives include evaluating increases or decreases in quality of life, and increases or decreases in concomitant opioid use. Satisfaction with treatment will be measured by a Visual Analog Score (VAS). Change From baseline in Satisfaction with treatment measured by (VAS) be assessed at 3-month intervals.

Measure: Cannabis Impact on Quality of Life

Time: Five years

Description: Tertiary objectives will examine preferences for routes of administration, and preferences for THC / CBD ratios. Categorical factors will be summarized using frequencies and percentages, while continuous measure distributions will be described using means, standard deviations, and quartiles of interest.

Measure: Cannabis Route and Dosing

Time: Five years

Description: Incidence of Treatment-Related Adverse Events will be measured by Physician Global Assessment (PGA) numeric scale. Number of participants with Treatment-Related Adverse Events will be assessed by CTCAE v4.0.

Measure: Monitoring Adverse Events

Time: Five years
2 Outcomes in Patients With Acute Encephalopathy and SARS-Cov-2 Infection

Infection with SARS-CoV-2 or severe acute respiratory syndrome coronarvirus type 2 was highlighted in December 2019 in the city of Wuhan in China, responsible for an pandemic evolution since March 11, 2020. The infection affects all ages of life, although affecting children in a very small proportion of cases. The typical presentation of the disease combines fever (98%), cough (76%), myalgia and asthenia (18%) as well as leukopenia (25%) and lymphopenia (63%). Upper airway involvement rare. The main clinical presentation requiring hospitalization of infected patients is that of atypical pneumonia which may require critical care management (27%), and progress to an acute respiratory distress syndrome (67%) involving life-threatening conditions in almost 25% of patients diagnosed with SARS-CoV-2 infection. Other organ damage have been reported, mainly concerning kidney damage (29%) which may require renal replacement therapy in approximately 17% of patients. Neurological damage has been very rarely studied, yet reported in 36% of cases in a study including patients of varying severity. Finally, the mortality associated with this emerging virus is high in patients for whom critical care management is necessary, reported in 62% of patients. We therefore propose a prospective observational study which aim at reporting the prevalence of acute encephalopathy at initial management in Critical/Intensive care or Neurocritical care , to report its morbidity and mortality and to identify prognostic factors.

NCT04320472
Conditions
  1. COVID-19
  2. Encephalopathy
  3. Critically Ill
Interventions
  1. Other: Follow up
MeSH:Brain Diseases Critical Illness
HPO:Encephalopathy

Primary Outcomes

Description: ratio of patients with acute encephalopathy among the total of patients with SARS-Cov-2 infection at Critical/Intensive care or Neurocritical care admission

Measure: prevalence

Time: at Critical/Intensive care or Neurocritical care admission

Secondary Outcomes

Description: A favorable outcome is defined by a Glasgow Outcome Scale (GOS) of 5. The Glasgow Outcome Scale (GOS) will be determined patients charts review, phone call, and/or general practitioner interview conducted by an independent assessor. The GOS score : [1: Death, 2: Persistent vegetative state, 3: Severe disability, 4: Moderate disability, 5 : Low disability]

Measure: Favorable outcome

Time: 3 months

Description: A favorable outcome is defined by a Glasgow Outcome Scale Extended (GOSe) >= 5. The Glasgow Outcome Scale Extended (GOSe) will be determined patients charts review, phone call, and/or general practitioner interview conducted by an independent assessor. The GOSe score : [1: Death, 2: Persistent vegetative state, 3: Severe disability Lower, 4: Severe disability Upper, 5: Moderate disability Lower, 6: Moderate disability Upper, 7 : Good recovery lower, 8 : Good recovery Upper]

Measure: Favorable outcome

Time: 3 months
3 Biomarker-guided Assessment of Neurocognitive Impairment in Patients With COVID-19 - a Multicenter Case-control Study

Delirium and acute neurocognitive impairment are increasingly observed in adult and pediatric patients with COVID-19. Prospective clinical studies combining clinical and laboratory examinations including specific biomarkers of neuroaxonal injury were not performed for COVID-19. The value of biomarkers of neuroaxonal injury was proven in preliminary studies. These biomarkers could thus contribute to the systematic detection of neurocognitive impairment in patients with COVID-19. Due to worldwide increasing numbers of hospitalized patients with COVID-19, biomarkers of neuroaxonal injury are highly valuable to detect and monitor cognitive impairment, especially with regard to limited resources available to perform time-consuming brain imaging. Biomarkers of neuroaxonal injury are therefore not only of great interest to detect neurocognitive impairment but also to quantify the severity of brain injury in patients with COVID-19.

NCT04359914
Conditions
  1. Critical Illness
  2. COVID-19
  3. Central Nervous System Injury
  4. Delirium
  5. Encephalopathy
MeSH:Delirium Brain Diseases Trauma, Nervous System Critical Illness
HPO:Encephalopathy

Primary Outcomes

Description: Assessment of neurocognitive impairment using validated tools

Measure: Incidence of delirium/neurocognitive impairment in adult and pediatric patients with COVID-19 compared to patients without COVID-19

Time: Day 90

Description: Measurement of biomarker levels (e.g. NSE, S100B, neurofilament proteins) derived from blood samples

Measure: Change in neuroaxonal injury biomarker levels in patients with COVID-19 compared to patients without COVID-19

Time: Change from baseline biomarker levels at day 28

Description: Assessment of the neurocognitive performance of patients using validated tests (e.g. Short Blessed Test)

Measure: Neurocognitive 3-months outcome in patients with COVID-19 compared to patients without COVID-19

Time: Day 90

Description: Assessment of the change in the neurocognitive performance of patients using validated tests (e.g. IQCODE)

Measure: Neurocognitive 3-months outcome in patients with COVID-19 compared to patients without COVID-19

Time: Change from baseline IQCODE results at day 90

Secondary Outcomes

Description: Assessment of the overall quality of life using validated tests [e.g. Modified Rankin Scale with a range from 0 (no symptoms) to 6 (dead)]

Measure: Quality of life in patients with COVID-19 compared to patients without COVID-19 after hospital discharge

Time: Day 90

Description: Cumulative days in hospital

Measure: Length of hospital stay in patients with COVID-19 compared to patients without COVID-19

Time: 1 year

Description: Survival after 90 days

Measure: 90-day survival in patients with COVID-19 compared to patients without COVID-19

Time: Day 90
4 Determination of Acute Encephalopathy Predictors in Patients With COVID-19

The SARS-CoV-2 infection was detected in December 2019 in Wuhan City, China. The infection affects all age groups, although childhood is the lowest proportion of those affected. The main clinical manifestations that require hospitalization of infected patients are SARS pneumonia, which may require treatment in the intensive care unit (27%) and its progression into acute respiratory distress syndrome (67%) with life-threatening conditions in almost 25% of patients diagnosed with "SARS-CoV-2 infection". Nervous system damage with SARS-CoV-2 infection has been practically not investigated, but neurological disorders have been reported in 36% of these patients. Finally, the mortality rate associated with the new virus is high in patients who require treatment in intensive care units (62% of cases). Therefore, we are conducting a prospective study to identify acute encephalopathy predictors in patients with COVID-19.

NCT04405544
Conditions
  1. Encephalopathy
  2. COVID
Interventions
  1. Diagnostic Test: CT-scan
  2. Diagnostic Test: EEG
  3. Diagnostic Test: EP
  4. Diagnostic Test: Pulse oximetry
  5. Diagnostic Test: Blood tests
MeSH:Brain Diseases
HPO:Encephalopathy

Primary Outcomes

Description: The percentage of patients who have developed encephalopathy

Measure: The percentage of patients who have developed encephalopathy

Time: 10 days
5 Neurological Abnormalities in SARS-CoV-2 ICU Patients. A Prospective Study. NeuroCOVID Study

The SARS-CoV-2 epidemic is leading to a large number of patients in intensive care units due to severe hypoxemic pneumonia. After an acute phase that may require controlled mechanical ventilation and deep sedation, removal of sedation often reveals a pathological awakening in the vast majority of patients. This encephalopathy state remains, to date and to our knowledge, unexplained. Clinical features do not appear to fully correlate with regular delirium. This encephalopathy might be explained by deep and prolonged hypoxemia, a wide use of sedation drugs, systemic inflammation or the hostile ICU environment.

NCT04643548
Conditions
  1. SARS-CoV-2 Infection
  2. Intensive Care Unit Patient
  3. Neurological Abnormality
  4. Delirium
  5. Encephalopathy
MeSH:Delirium Brain Diseases Nervous System Malformations Congenital Abnormalities
HPO:Abnormality of the nervous system Encephalopathy

Primary Outcomes

Description: Plasminogen activator inhibitor-1 (PAI-1), E-selectin and angiopoietin-2

Measure: Dosage of biomarkers typically explored in intensive care unit delirium

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every 2 days

Description: S100 β, Neuron Specific Enolase (NSE), GFAP, UCHL1, NFL

Measure: Dosage of neuronal injury markers

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every 2 days

Secondary Outcomes

Description: CAM-ICU (Confusion Assessment Method - Intensive Care Unit) scale

Measure: Delirium assessment

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: ICDSC (Intensive Care Delirium Screening Checklist) scale.

Measure: Delirium assessment

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: CRS-R (Coma Recovery Scale-Revised)

Measure: Coma assessment

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: Clinical observation

Measure: Pupils characteristics

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: Pupilometer assessment

Measure: Pupils characteristics

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: Electroencephalogram : epileptic activity (spikes, spike-waves) or encephalopathy activity (triphasic waves))

Measure: Neurological abnormalities

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: CT-scan

Measure: Neurological abnormalities

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

Description: MRI

Measure: Neurological abnormalities

Time: Change from Day 0 (= First day in ICU) until the end of the stay (up to 3 months) - Assessments every days

HPO Nodes


HP:0001298: Encephalopathy
Genes 363
GABRB1 CDKL5 ACSF3 ATAD3A DPM2 NAGS EEF1A2 TCF4 ND6 NDUFS4 GALC TRNL1 TREX1 TRNK NDUFAF4 AMT TRNC NECAP1 NDUFA11 TSFM LYRM7 NDUFB9 CNKSR2 D2HGDH TWNK SLC25A1 GABRG2 NECAP1 STAG1 TRNS2 ATP5F1A ITPA ARHGEF9 UGDH CNTNAP2 GABRA1 CACNA1A SLC2A1 MDH1 NBAS AARS1 NDUFS8 GCSH DNM1 STXBP1 AMACR GBA ND1 ATP1A3 NDUFAF2 CPT2 TCF4 NDUFS6 NDUFS6 GABRG2 NRXN1 SLC19A3 KCNT2 ACY1 PNPT1 SYNJ1 CPT2 CPLX1 COQ4 ARHGEF9 AARS1 ADAM22 AP3B2 WWOX GABRB3 DCX SYNJ1 DNM1L NDUFA6 GLDC TIMM50 NDUFS1 SLC13A5 CAD ROGDI NUS1 GRIN1 KCNQ2 NOTCH3 PAFAH1B1 NDUFAF1 COX1 PNPO ATP6V1A MEF2C NADK2 BSCL2 GABBR2 ARV1 HCN1 NDUFA6 TH PIGA ATP5F1A MTHFR CLTC SZT2 ND6 NDUFS2 NDUFV2 NDUFAF5 DLD SIK1 ND3 GABRA5 MST1 MECP2 SLC25A20 GPT2 SERAC1 TK2 MDH2 ACOX1 NDUFS3 FBLN1 SLC1A2 RANBP2 GABRB2 KCNQ5 CACNA1B PCK1 TRNQ PNPO TRNW RNF13 NDUFS7 BCS1L DNM1 NDUFA1 SCN3A COG8 PCCA NUBPL COX15 KMT2E PTPN23 TRIT1 SCN1A COX2 NTRK2 HNRNPU SLC25A12 PACS2 SERPINI1 COQ2 CDK19 TRNW TRAK1 ATP5F1D PLCB1 NDUFB3 COX3 GRIN2D COG8 HADH SUCLG1 COQ5 ACAD9 SYNGAP1 CHD2 CHD2 DENND5A RNASEH2B EEF1A2 NDUFB10 ACTL6B FADD KYNU SH2D1A RNF13 SLC12A3 KCNB1 CYFIP2 NDUFA11 NDUFS3 KCNA2 RINT1 YWHAG UNC80 CACNA2D2 TSEN54 SLC35A2 NTRK2 SLC19A3 TBC1D24 SLC25A13 CLCNKB TRNS1 IBA57 CNPY3 TRNH TBCE COX1 PARS2 SLC22A5 NADK2 LIPT2 NAXE GABRB2 PNKP DOCK7 ND2 PPP3CA NDUFAF2 CLCN4 NRXN1 WDR45 PHACTR1 NDUFS7 PSAP GABRB3 GCDH NDUFV1 TBC1D24 CLP1 ND1 GLUL TBCK ND4 GLS CPT1A FOXRED1 STAT2 DGUOK AP2M1 TRNF CACNA1E SCN2A CCDC88A DALRD3 CYFIP2 KCNA2 FADD TMEM126B WWOX KCNA2 TRNV CLPB TRNQ TRAK1 ARV1 RNASEH2C MAPK10 PIGP UBA5 HTRA1 TRNS1 TRAPPC12 COX2 SLC25A15 CUX2 CHD2 GRIN2B SLC25A15 BSCL2 NDUFB11 COQ9 CARS2 PARS2 HIBCH KCNQ2 GRIN2D SUCLA2 SCN8A CACNA1A NDUFAF8 KYNU TMEM70 PCCB NDUFAF4 SLC25A22 SCN1A ACAD9 SPTAN1 TRNK CYTB GABRA2 ND5 DHDDS ACY1 TGFB1 FBXL4 MMACHC HSD17B10 SLC22A5 CYC1 SLC35A1 SYNGAP1 SIK1 GBA SLC1A2 FCSK HADH TRNL1 UBA5 SZT2 ST3GAL3 SCN1B AP3B2 GUF1 TRNF NUS1 ALMS1 NEUROD2 TUFM NDUFV2 ND5 GNAO1 HMGCL PPP3CA STXBP1 FRRS1L FGF12 BOLA3 TRNS2 DNM1 PRNP TIMMDC1 ETHE1 CARS2 ND1 DLD SLC6A9 ETHE1 LIAS SCN3A NAXD MPC1 ZNHIT3 UGT1A1 TBCD SLC13A5 ATAD1 NDUFAF3 KCNB1 ALG9 GPR35 KCNT1 SCN2A ARX DHDDS CACNA1B NDUFS4 NDUFAF1 RANBP2 NDUFB3 COX3 SCN8A HCN1 ASNS ATP6V1A TBCE GLYCTK SLC6A1 XIAP PMPCB CUX2 FGF12
Protein Mutations 1
A3243G
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0001298: Encephalopathy
Genes 363
GABRB1 CDKL5 ACSF3 ATAD3A DPM2 NAGS EEF1A2 TCF4 ND6 NDUFS4 GALC TRNL1 TREX1 TRNK NDUFAF4 AMT TRNC NECAP1 NDUFA11 TSFM LYRM7 NDUFB9 CNKSR2 D2HGDH TWNK SLC25A1 GABRG2 NECAP1 STAG1 TRNS2 ATP5F1A ITPA ARHGEF9 UGDH CNTNAP2 GABRA1 CACNA1A SLC2A1 MDH1 NBAS AARS1 NDUFS8 GCSH DNM1 STXBP1 AMACR GBA ND1 ATP1A3 NDUFAF2 CPT2 TCF4 NDUFS6 NDUFS6 GABRG2 NRXN1 SLC19A3 KCNT2 ACY1 PNPT1 SYNJ1 CPT2 CPLX1 COQ4 ARHGEF9 AARS1 ADAM22 AP3B2 WWOX GABRB3 DCX SYNJ1 DNM1L NDUFA6 GLDC TIMM50 NDUFS1 SLC13A5 CAD ROGDI NUS1 GRIN1 KCNQ2 NOTCH3 PAFAH1B1 NDUFAF1 COX1 PNPO ATP6V1A MEF2C NADK2 BSCL2 GABBR2 ARV1 HCN1 NDUFA6 TH PIGA ATP5F1A MTHFR CLTC SZT2 ND6 NDUFS2 NDUFV2 NDUFAF5 DLD SIK1 ND3 GABRA5 MST1 MECP2 SLC25A20 GPT2 SERAC1 TK2 MDH2 ACOX1 NDUFS3 FBLN1 SLC1A2 RANBP2 GABRB2 KCNQ5 CACNA1B PCK1 TRNQ PNPO TRNW RNF13 NDUFS7 BCS1L DNM1 NDUFA1 SCN3A COG8 PCCA NUBPL COX15 KMT2E PTPN23 TRIT1 SCN1A COX2 NTRK2 HNRNPU SLC25A12 PACS2 SERPINI1 COQ2 CDK19 TRNW TRAK1 ATP5F1D PLCB1 NDUFB3 COX3 GRIN2D COG8 HADH SUCLG1 COQ5 ACAD9 SYNGAP1 CHD2 CHD2 DENND5A RNASEH2B EEF1A2 NDUFB10 ACTL6B FADD KYNU SH2D1A RNF13 SLC12A3 KCNB1 CYFIP2 NDUFA11 NDUFS3 KCNA2 RINT1 YWHAG UNC80 CACNA2D2 TSEN54 SLC35A2 NTRK2 SLC19A3 TBC1D24 SLC25A13 CLCNKB TRNS1 IBA57 CNPY3 TRNH TBCE COX1 PARS2 SLC22A5 NADK2 LIPT2 NAXE GABRB2 PNKP DOCK7 ND2 PPP3CA NDUFAF2 CLCN4 NRXN1 WDR45 PHACTR1 NDUFS7 PSAP GABRB3 GCDH NDUFV1 TBC1D24 CLP1 ND1 GLUL TBCK ND4 GLS CPT1A FOXRED1 STAT2 DGUOK AP2M1 TRNF CACNA1E SCN2A CCDC88A DALRD3 CYFIP2 KCNA2 FADD TMEM126B WWOX KCNA2 TRNV CLPB TRNQ TRAK1 ARV1 RNASEH2C MAPK10 PIGP UBA5 HTRA1 TRNS1 TRAPPC12 COX2 SLC25A15 CUX2 CHD2 GRIN2B SLC25A15 BSCL2 NDUFB11 COQ9 CARS2 PARS2 HIBCH KCNQ2 GRIN2D SUCLA2 SCN8A CACNA1A NDUFAF8 KYNU TMEM70 PCCB NDUFAF4 SLC25A22 SCN1A ACAD9 SPTAN1 TRNK CYTB GABRA2 ND5 DHDDS ACY1 TGFB1 FBXL4 MMACHC HSD17B10 SLC22A5 CYC1 SLC35A1 SYNGAP1 SIK1 GBA SLC1A2 FCSK HADH TRNL1 UBA5 SZT2 ST3GAL3 SCN1B AP3B2 GUF1 TRNF NUS1 ALMS1 NEUROD2 TUFM NDUFV2 ND5 GNAO1 HMGCL PPP3CA STXBP1 FRRS1L FGF12 BOLA3 TRNS2 DNM1 PRNP TIMMDC1 ETHE1 CARS2 ND1 DLD SLC6A9 ETHE1 LIAS SCN3A NAXD MPC1 ZNHIT3 UGT1A1 TBCD SLC13A5 ATAD1 NDUFAF3 KCNB1 ALG9 GPR35 KCNT1 SCN2A ARX DHDDS CACNA1B NDUFS4 NDUFAF1 RANBP2 NDUFB3 COX3 SCN8A HCN1 ASNS ATP6V1A TBCE GLYCTK SLC6A1 XIAP PMPCB CUX2 FGF12
Protein Mutations 1
A3243G
SNP 0

Reports

Data processed on January 01, 2021.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

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