Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
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Name (Synonyms) | Correlation | |
---|---|---|
drug3982 | online KKH Sports Singapore Program with Usual Care Wiki | 0.71 |
drug1251 | Exposure to the Dutch measures due to the Covid-19 pandemic. Wiki | 0.71 |
drug3557 | Usual Care Wiki | 0.22 |
Navigate: Correlations HPO
There are 2 clinical trials
Background: The Coronavirus 2019 (COVID-19) is an infectious disease, which was first identified in December 2019 and has then spread rapidly around the world. COVID-19 spreads mainly through respiratory droplets and causes people to experience mild to moderate respiratory illness. On 11 March 2020, the World Health Organisation (WHO) declared COVID-19 a pandemic. With the surge in cases and to contain the spread of this disease, Singapore implemented a circuit breaker to reduce movements and interactions in public and private places. People are advised to stay at home and practise social distancing. With restrictions in movements, parents and children are likely to be more sedentary in this pandemic. There is an urgent need to move face-to-face interventions to online interventions as it is important to be active in this period. Childhood obesity threatens the health of US and Singapore populations. In the US, 30% of children are overweight, 17% have obesity, and 8% have severe obesity. In Singapore, 13% of children have obesity, and approximately half of all overweight children live in Asia. In both countries the prevalence is increasing, especially amongst the lower income populations, and is associated with future cardiovascular and metabolic disease. In US, obesity is most prevalent in Black and Hispanic populations and in Singapore, obesity affects Malays and Indians disproportionately. The underlying drivers and potential solutions thus share many common factors. The current evidence shows a clear dose-response effect with increasing number of hours of treatment, with a threshold for effectiveness at > 25 hours over a 6-month period. A key gap in delivering this recommendation is meeting the intensity, and delivering comprehensive treatment that is culturally relevant, engaging to families, and integrated within the community context. The study is an online pilot randomised controlled trial among children aged 4-6 with obesity, in Singapore, to test a novel school-clinic-community online intervention, the KK Hospital (KKH) Sports Singapore program, for child obesity treatment with usual care. The primary outcome is intensity of treatment as measured by hours of exposure to intervention. The online KKH Sports Singapore program involves 3-4 weekly online sessions of physical activity and nutrition lessons for children and parents.
Description: Measure intensity of intervention from baseline to 6 months. Intensity is measured using the number of hours of exposure to intervention.
Measure: Intensity of intervention Time: 6 monthsDescription: Measure change in cardiorespiratory fitness at baseline, 3 months and 6 months using the 3 minute step test.
Measure: Change in cardiorespiratory fitness Time: Baseline, 3 months and 6 monthsDescription: Measure change in quality of life at baseline, 3 months and 6 months using the Paediatric Quality of Life Inventory (PedsQL; US version 4). PedsQL is a comprehensive and multi-dimensional construct that includes physical, emotional, and social functioning to assess quality of life in the children. It uses a 5-point Likert scale where 0= never, 1 = almost never, 2 = sometimes, 3 = often, 4 = almost always. Items will be reverse scored and linearly transformed to a 0-100 scale so that higher scores indicate better quality of life.
Measure: Change in quality of life Time: Baseline, 3 months and 6 monthsDescription: Measure the stabilisation or change in BMI at baseline, 3 months and 6 months. Body mass index (BMI) will be calculated as kg/m2.
Measure: Change in BMI Time: Baseline, 3 months and 6 monthsDescription: Measure change in self-esteem at baseline, 3 months and 6 months. Self-esteem is measured using the Behavioural Rating Scale of Presented Self-Esteem questionnaire. The first category of items consists of active displays of confidence, curiosity, initiative, exploration and independence while the second category consists of adaptive reactions to change or stress. It uses a four-point scale from 1-4 where higher scores indicate higher self-esteem.
Measure: Change in self-esteem Time: Baseline, 3 months and 6 monthsDescription: Measure change in eating behaviour at baseline, 3 months and 6 months. Eating behaviour is measured using the Child Eating Behaviour Questionnaire (CEBQ). The questionnaire consists of 35 items and measures food responsiveness, emotional over-eating, enjoyment of food, desire to drink, satiety responsiveness, slowness in eating, emotional under-eating and food fussiness using a 5-point Likert scale (1= never, 2 = rarely, 3 = sometimes, 4 = often, 5 = always). Higher scores indicate higher level of behaviour in the respective dimensions.
Measure: Change in eating behaviour Time: Baseline, 3 months and 6 monthsDescription: Measure change in gross motor skills at baseline, 3 months and 6 months. Gross motor skills is measured using the Test of Gross Motor Development (Ver. 3.0). The first subtest, Locomotor, measures the gross motor skills that require fluid coordinated movements of the body as the child moves in one direction or another. The second subtest, Ball Skills, measure the gross motor skills that demonstrate efficient throwing, striking, and catching movements.
Measure: Change in gross motor skills Time: Baseline, 3 months and 6 monthsDescription: Measure change in caloric intake using a three day food diary at baseline, 3 months and 6 months.
Measure: Change in caloric intake Time: Baseline, 3 months and 6 monthsDescription: Measure change in physical activity using results from accelerometer to assess time spent on sedentary and moderate to vigorous physical activity at baseline, 3 months and 6 months.
Measure: Change in physical activity Time: Baseline, 3 months and 6 monthsDescription: Measure change in blood pressure at baseline, 3 months and 6 months. Blood pressure will be measured in mmHg via an electronic sphygmomanometer. Both systolic and diastolic blood pressure will be measured.
Measure: Change in blood pressure Time: Baseline, 3 months and 6 monthsDescription: Measure change in waist circumference at baseline, 3 months and 6 months. Waist circumference is measured at the narrowest point between the lower costal (rib) border and the iliac crest using a non-extensible steel tape.
Measure: Change in waist circumference Time: Baseline, 3 months and 6 monthsDescription: Measure change in number of servings of fruits and vegetables using a three day food diary at baseline, 3 months and 6 months .
Measure: Change in servings of fruits and vegetables Time: Baseline, 3 months and 6 monthsThis study aims to evaluate the impact of the COVID-19 pandemic and its measures on lifestyle in Dutch children between 4 - 18 years.
Description: Weight development of the child. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight child Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Weight development of the parents. Weight (in kg) will be measured using scales at home, with clear instructions.
Measure: Change in weight parents Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs, hereafter: "coronacrisis-period"). Three months after the "measures"-period, 1 follow-up moment.Description: eating behaviour during measures due to the coronacrisis, measured with an online questionnaire.
Measure: Eating behaviour Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: COVID-19 related symptoms and adherence to governmental measures, measured with an online questionnaire.
Measure: Symptoms Time: Every 2 weeks until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Daystructure of children during the coronacrisis, measured with an online questionnaire.
Measure: Day structure Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Physical activity behaviour children during the coronacrisis, measured with the Baecke questionnaire.
Measure: Physical activity Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Screentime during the the coronacrisis, measured with an online questionnaire.
Measure: Screentime Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Online possibilities for working on a healthy lifestyle, such as challenges regarding nutrition and physical activity, measured with an online questionnaire.
Measure: Online possibilities Time: Every month until end of the Dutch governement measures affecting children (e.g. fully opening of the schools and sportclubs). Three months after the "measures"-period, 1 follow-up moment.Description: Quality of life during the coronacrisis, measured with the Kidscreen-27.
Measure: Quality of life in children Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.Description: Parenting practices regarding eating behaviour and physical activity, measured with a questionnaire.
Measure: Parenting practices Time: Once in first month of the study and once within three months after COVID-19 measures are scaled down.Description: Qualitative data on lifestyle in children during the coronacrisis, by semi-structured interviews.
Measure: Qualitative data on lifestyle in children Time: Up to approximately 1 yearAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on January 01, 2021.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports