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  • HP:0005547: Myeloproliferative disorder
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    HP:0005547: Myeloproliferative disorder

    Developed by Shray Alag, The Harker School
    Sections: Correlations, Clinical Trials, and HPO

    Correlations computed by analyzing all clinical trials.

    Navigate: Clinical Trials and HPO

    Correlated Drug Terms (0)

    Name (Synonyms) Correlation

    Correlated MeSH Terms (2)

    Name (Synonyms) Correlation
    D009196 Myeloproliferative Disorders NIH 0.82
    D009369 Neoplasms, NIH 0.13

    Correlated HPO Terms (1)

    Name (Synonyms) Correlation
    HP:0002664 Neoplasm HPO 0.13

    Clinical Trials

    Navigate: Correlations   HPO

    There are 2 clinical trials

    1 Myeloproliferative Neoplasms (MPN) and COVID-19

    An increased risk of both venous and arterial thromboembolism was noted in reports from SARS-CoV-2-infected patients in China and has been confirmed in autopsy findings from patients who experienced sudden death. Myeloproliferative Neoplasms (MPNs), which encompass polycythemia vera, essential thrombocythemia and primary myelofibrosis, are thrombophilic disorders with a natural propensity to thrombosis that is fuelled by the intrinsic activation of inflammatory cytokines. It therefore follows that an underlying diagnosis of MPN may increase the risk of worse clinical outcomes and death during periods of active Covid-19 disease. This ambispective, observational study aims to elucidate the key factors which affect the clinical course of patients with MPN who develop Covid-19 disease.

    1. Myeloproliferative Neoplasm
    2. COVID
    MeSH:Neoplasms Myeloproliferative Disorders
    HPO:Myeloproliferative disorder Neoplasm

    Primary Outcomes

    Description: Incidence of cases of MPN patients with COVID-19 experiencing pulmonary embolism

    Measure: pulmonary embolism (PE)

    Time: 2 and a half months

    Secondary Outcomes

    Description: Incidence of cases reporting at least one fatal or non fatal thrombotic event reported in therapy of MPN

    Measure: fatal or non fatal thrombotic event

    Time: 2 and a half months

    Description: Incidence of cases reporting at least one COVID-19 worsening outcome as Continuous Positive Airway Pressure (CPAP)

    Measure: Continuous Positive Airway Pressure (CPAP)

    Time: 2 and a half months

    Description: Incidence of cases reporting at least one COVID-19 worsening outcome as invasive ventilation

    Measure: invasive ventilation

    Time: 2 and a half months

    Description: Incidence of cases reporting at least one COVID-19 worsening outcome as Intensive Care Unit (ICU)

    Measure: admission in Intensive Care Unit (ICU)

    Time: 2 and a half months

    Description: incidence of death

    Measure: death

    Time: 2 and a half months

    Description: Type of treatments and interventions applied for MPN during COVID-19 and any change reported in therapy of MPN

    Measure: treatments and interventions applied for MPN

    Time: 2 and a half months

    Description: Type of treatments and interventions applied for COVID-19

    Measure: treatments and interventions applied for COVID-19

    Time: 2 and a half months

    Description: Odds Ratios (ORs) of the outcome and 95% Confidence Intervals (CIs) associated with patients' characteristics and treatments

    Measure: thrombotic events association to patients characteristic and treatments

    Time: 2 and a half months
    2 Observational Study of the Impact of the COronaVirus Disease 2019 (COVID-19) Epidemic on Patients With Myeloproliferative Neoplasias

    The classic myeloproliferative neoplasias (MNP), including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) or secondary to PV or ET, are among the most frequent of malignant hemopathies, with overall prevalence estimated at around 10,000 patients followed in France. Due to the median age of patients around 65, the frequency of cardiovascular complications of these thrombogenic diseases and the impact of cytoreductive treatments on immune cells, these patients are considered to be at risk of developing forms severe of COVID-19. This study will assess the impact of MNPs on the risk of developing a severe form of COVID-19, identify new risk factors linked to the disease as well as the impact of treatments for MNPs according to their pharmacological class.

    1. Myeloproliferative Neoplasm
    2. COVID-19 Infection
    MeSH:Myeloproliferative Disorders
    HPO:Myeloproliferative disorder

    Primary Outcomes

    Description: The crude rate of cumulative incidence of serious infection proven to COVID-19, compared to the population of the same age, same sex, same region of residence during the epidemic period.

    Measure: Rate of serious coronavirus infection in different MNP patient subgroups

    Time: Through inclusion period, an average of 6 months

    Description: Number of MNP patients who had COVID-19 compared to general population in France

    Measure: Proportion of MNP patients who had COVID-19 infection during the 2020 epidemic.

    Time: Through inclusion period, an average of 6 months

    Description: Number of MNP patients who died from COVID-19

    Measure: Rate of death of MNP patients who had COVID-19

    Time: Through study completion, an average of 1 year

    Description: Number of MNP patients hospitalized in intensive care with need for mechanical ventilation

    Measure: Rate of passages in intensive care with need for mechanical ventilation

    Time: Through study completion, an average of 1 year

    HPO Nodes


    Data processed on December 13, 2020.

    An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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