CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Sample collectionWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug1671 telehealth applications Wiki 1.00

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D045169 Severe Acute Respiratory Syndrome NIH 0.06
D018352 Coronavirus Infections NIH 0.05

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Characterizing SARS-CoV-2-specific Immunity in Convalescent Individuals

The purpose of this study is to learn more about infection with and recovery from the virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some people know this virus by the name "coronavirus." It can cause the disease called COVID-19. The information gained from the study will be used to help develop better tests for SARS-CoV-2 infection and COVID-19 disease and may help in developing future vaccines and treatments by allowing researchers to determine the difference between the body's immune response to natural SARS-CoV-2 infection and immunization with a SARS-CoV-2 vaccine.

NCT04403880 SARS-CoV-2 COVID-19 Other: Sample collection

Primary Outcomes

Description: Measured by peptide microarray

Measure: Humoral responses to peptide antigens derived from SARS-CoV-2 structural proteins and regions of the spike protein not present in vaccines

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by binding antibody multiplex assay (BAMA)

Measure: SARS-CoV-2-specific antibody binding response rate

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by binding antibody multiplex assay (BAMA)

Measure: SARS-CoV-2-specific antibody binding response magnitude

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by binding antibody multiplex assay (BAMA)

Measure: SARS-CoV-2-specific antibody binding response epitope specificity

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by neutralizing antibody assay (NAb)

Measure: SARS-CoV-2-specific antibody neutralization response rate

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by neutralizing antibody assay (NAb)

Measure: SARS-CoV-2-specific antibody neutralization response magnitude

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by neutralizing antibody assay (NAb)

Measure: SARS-CoV-2-specific antibody neutralization response epitope specificity

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by antibody-dependent cellular cytotoxicity assay (ADCC)

Measure: SARS-CoV-2-specific Antibody-Dependent Cellular Cytotoxicity (ADCC) response rate

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by antibody-dependent cellular cytotoxicity assay (ADCC)

Measure: SARS-CoV-2-specific Antibody-Dependent Cellular Cytotoxicity (ADCC) response magnitude

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by antibody-dependent cellular cytotoxicity assay (ADCC)

Measure: SARS-CoV-2-specific Antibody-Dependent Cellular Cytotoxicity (ADCC) response epitope specificity

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by flow cytometry

Measure: SARS-CoV-2-specific CD4+ and CD8+ T cell responses

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by flow cytometry

Measure: SARS-CoV-2-specific CD4+ and CD8+ T cell response rate

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by flow cytometry

Measure: SARS-CoV-2-specific CD4+ and CD8+ T cell response magnitude

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by flow cytometry

Measure: SARS-CoV-2-specific CD4+ and CD8+ T cell response functional profiling

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by phenotyping and monoclonal antibody isolation

Measure: SARS-CoV-2-specific memory B cell characterization

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Tabulated overall and by group

Measure: SARS-CoV-2-specific infection presentation, including clinical course, along with demographics and corresponding medical history of participants

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Secondary Outcomes

Description: Measured by real-time reverse transcription polymerase chain reaction (RT-PCR) assay

Measure: Detection of viral RNA in nasopharyngeal or nasal swab samples

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by binding antibody multiplex assay (BAMA)

Measure: Response rate of SARS-CoV-2-specific binding antibodies in nasal samples

Time: Measured through participant's last visit at Month 0, 2, 4, or 12

Description: Measured by binding antibody multiplex assay (BAMA)

Measure: Response magnitude of SARS-CoV-2-specific binding antibodies in nasal samples

Time: Measured through participant's last visit at Month 0, 2, 4, or 12


No related HPO nodes (Using clinical trials)