Name (Synonyms) | Correlation | |
---|---|---|
drug1104 | Questionnaire Wiki | 0.32 |
drug1035 | Placebo oral tablet Wiki | 0.20 |
There is one clinical trial.
This is a double-blinded, randomized placebo-controlled trial to determine if pre-exposure prophylaxis (PrEP) with 400mg hydroxychloroquine (HCQ), taken orally once daily, for health care workers in the hospital reduces symptomatic and asymptomatic COVID-19 disease during the pandemic. 374 health care workers will be randomized at a 1:1 allocation between the intervention and placebo arms and followed for 90 days. The cumulative incidence of COVID-19 infection in the intervention group will be compared to the cumulative incidence of COVID-19 in the placebo group with relative (risk ratio and 95% CI) and absolute measures (risk difference and 95% CI).
Description: Incidence of symptomatic and asymptomatic COVID-19 infection in health care workers
Measure: Cumulative Incidence of COVID-19 Infection Time: 90 daysDescription: Incidence of reported and grade of adverse events
Measure: Adverse events incidence Time: 90 daysDescription: Duration in days of symptomatic COVID-19 disease in HCW who had disease
Measure: Duration of symptomatic COVID-19 disease Time: 90 daysDescription: Duration in days of hospitalization attributed to COVID-19 disease in HCW who had disease
Measure: Days hospitalized attributed to COVID-19 Time: 90 daysDescription: Number of HCW with respiratory failure attributable to COVID-19 disease requiring i) non-invasive ventilation or ii) intubation/mechanical ventilation in HCW who developed disease
Measure: Number or respiratory failure attributable to COVID-19 disease Time: 90 daysDescription: Cumulative Incidence of Mortality attributed to COVID-19 disease in HCW who developed disease
Measure: Mortality Incidence Time: 90 daysDescription: Number of days unable to work attributed to COVID-19 in HCW who developed disease
Measure: Days of work lost Time: 90 daysDescription: Proportion of participants with plasma able to neutralize SARS-CoV-2 virus (plaque reduction neutralization test) in vitro.
Measure: Proportion of HCW with plasma able to neutralize SARS-CoV-2 virus Time: 90 daysDescription: Number of participants with severity markers of host immune and endothelial activation measured at clinical presentation and their ability to predict severity and outcome.
Measure: Number of participants with severity markers of host immune and endothelial activation Time: 90 days