Name (Synonyms) | Correlation | |
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drug88 | Anti-Sars-CoV-2 Convalescent Plasma Wiki | 1.00 |
Name (Synonyms) | Correlation | |
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D045169 | Severe Acute Respiratory Syndrome NIH | 0.06 |
D018352 | Coronavirus Infections NIH | 0.05 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
The investigators aim to characterise Coronavirus Disease 2019 (COVID-19) in every age group. On the one hand, emphasis is put on the initial presentation, clinical course, outcome and the therapy used. On the other hand further investigations regarding viral and bacterial coinfections, and response of the immune system will be conducted. This study should serve to improve the understanding of COVID-19, to identify risk factors for a severe clinical course and to obtain further insights into pathophysiology of this new infectious disease.
Description: Description of clinical course of COVID-19 in children, adolescents and adults
Measure: Clinical course of COVID-19 Time: 10/2020Description: Measurement of specific IgM- and IgG-antibody production
Measure: Analysis of development of antibodies to SARS-CoV-2 Time: 10/2020Description: Estimation of viral load at initial presentation and after two weeks
Measure: Estimation of viral load Time: 10/2020Description: A Multiplex PCR will be conducted to test for the most common respiratroy viruses. A naso- and oropharyngeal swab will be used for this
Measure: Detection of viral coinfections Time: 10/2020Description: Determination of cytokine and chemokine concentrations in serum by ELISA.
Measure: Measurement of cytokine and chemokine response Time: 12/2020Description: Characterisation of virus-host-interaction by HLA-typing
Measure: Characterisation of virus-host-interaction Time: 12/2020Description: Identification of disease patterns in proteome by analysis of the proteome in serum and urine
Measure: Identification of disease patterns in proteome Time: 12/2020Description: Detection of change in lymphocyte subtypes in blood and bronchoalveolar lavage
Measure: Analysis of change in lymphocyte subtypes Time: 10/2020Description: Analysis of histological changes in severe lung disease by lung biopsy
Measure: Analysis of histological changes in severe lung disease Time: 12/2020Description: A pharyngeal swab will be cultured to check for bacteria residing in the upper airways. Additionally, a blood culture will serve to detect bacteremia
Measure: Detection of bacterial coinfections Time: 10/2020