CovidResearchTrials by Shray Alag

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Hydroxychloroquine Sulfate Regular doseWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (8)

Name (Synonyms) Correlation
drug618 Hydroxychloroquine Sulfate Loading Dose Wiki 1.00
drug283 Canakinumab Injection 300mg Wiki 0.71
drug284 Canakinumab Injection 600mg Wiki 0.71
drug1393 Thrombin Generation Assay (TGA) Wiki 0.71
drug1395 Thrombomodulin Modified Thrombin Generation Assay (TGA-TM) Wiki 0.71
drug308 Chloroquine Wiki 0.50
drug1042 Placebos Wiki 0.18
drug1016 Placebo Wiki 0.11

Correlated MeSH Terms (9)

Name (Synonyms) Correlation
D058070 Asymptomatic Diseases NIH 0.50
D004211 Disseminated Intravascular Coagulation NIH 0.41
D020141 Hemostatic Disorders NIH 0.29
D001778 Blood Coagulation Disorders NIH 0.29
D016638 Critical Illness NIH 0.14
D014777 Virus Diseases NIH 0.09
D007239 Infection NIH 0.05
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.03

Correlated HPO Terms (2)

Name (Synonyms) Correlation
HP:0005521 Disseminated intravascular coagulation HPO 0.41
HP:0001928 Abnormality of coagulation HPO 0.35

There are 2 clinical trials

Clinical Trials

1 Use and Dosage of Hydroxychloroquine and Chloroquine to Convert Real Time Polymerase Chain Reaction (RT-PCR) Positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Infectious Disease 2019 (COVID-19) Patients to RT- PCR-Negative as a Means to Reduce Hospitalization Rate

To create a protocol for treatment of Pakistani patients with SARS-CoV-2 infection with an intent to reduce burden on institutional healthcare services by determining efficacy of different quinone drug dosing regimens in controlling SARS-CoV-2 infection for asymptomatic patients.

NCT04346667 SARS-CoV-2 Coronavirus Infection Asymptomatic Condition COVID-19 Drug: Hydroxychloroquine Sulfate Regular dose Drug: Hydroxychloroquine Sulfate Loading Dose Drug: Chloroquine Drug: Placebo
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Asymptomatic Diseases

Primary Outcomes

Description: Percentage of patients who become RT-PCR negative with two RT-PCR tests performed at day 6 and day 7

Measure: RT-PCR negative status

Time: 6-7 days

Secondary Outcomes

Description: Time to progression to next stage of SARS-CoV-2 disease severity index

Measure: Progression of symptoms

Time: 7 days

Description: Time to onset of fever (temperature greater than 100 degree F), cough, or shortness of breath (respiratory rate >22 per minute).

Measure: Development of Symptoms

Time: 7 days

Description: Drug related adverse events as determined by data safety and monitoring board (DSMB)

Measure: Adverse events

Time: 7 days

2 Use and Dosage of Hydroxychloroquine and Chloroquine to Convert Symptomatic RT-PCR Positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Infectious Disease 2019 (COVID-19) Patients to RT- PCR-Negative as a Means to Reduce Hospitalization Rate

To treat Pakistani patients with non-life threatening symptomatic SARS-CoV-2 infection with an intent to reduce burden on institutional healthcare services by determining efficacy of different chloroquine and hydroxychloroquine dosing regimens in controlling SARS-CoV-2 infection.

NCT04351191 Sars-CoV2 Symptomatic Condition Covid-19 Drug: Hydroxychloroquine Sulfate Regular dose Drug: Hydroxychloroquine Sulfate Loading Dose Drug: Chloroquine Drug: Placebo

Primary Outcomes

Description: Percentage of patients who become RT-PCR negative with two RT-PCR tests performed at day 6 and day 7

Measure: RT-PCR result

Time: 6th and 7th day

Secondary Outcomes

Description: Time to progression to next stage of SARS-CoV-2 disease severity index

Measure: Progression of symptoms

Time: 7 days

Description: Death

Measure: Mortality

Time: 30 days

No related HPO nodes (Using clinical trials)