Name (Synonyms) | Correlation | |
---|---|---|
drug2 | (Standard of Care) SoC Wiki | 0.71 |
drug1060 | Povidone-Iodine Wiki | 0.41 |
drug73 | Anakinra Wiki | 0.27 |
drug1146 | Remdesivir Wiki | 0.19 |
drug591 | Hydroxychloroquine Wiki | 0.08 |
Name (Synonyms) | Correlation | |
---|---|---|
D055371 | Acute Lung Injury NIH | 0.08 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.08 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.08 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.07 |
D018352 | Coronavirus Infections NIH | 0.06 |
Name (Synonyms) | Correlation |
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There are 2 clinical trials
This proposal addresses the problem of preventing the very high mortality and morbidity associated with the development of Cytokine Storm Syndrome (CSS) associated respiratory failure in Covid-19 infection.
Description: Supplemental oxygen requirement to maintain oxygen saturation >90% stable or decreased without escalation of respiratory measures (addition of CPAP, initiation of mechanical ventilation)
Measure: No increase in oxygen requirement and no increase in respiratory support measures Time: 48 hoursDescription: 25% decrease in noted baseline elevations of serum ferritin, LDH, CRP, and d-dimer.
Measure: Improvement in Cytokine Storm markers Time: 72 hoursDescription: Subjects discharged from hospital without the need for mechanical ventilation
Measure: No requirement for mechanical ventilation Time: Day 5 (120 hours)COVID-19 is highly infectious and transmission of the virus is thought to be similar to that of influenza which can be transferred through droplets released when a person coughs, sneezes or talks. Studies have shown that nasal rinsing and mouth washes may be an important way to deliver treatments that could reduce the amount of a virus that is present in the nose and mouth. This also could mean that there is less virus available to pass on to others. We want to see if the use of nose rinses and mouth washes using Povidone-Iodine will reduce the the amount of virus in the nose and throat of people who have tested positive for COVID-19 disease and also reduce the spread of infection within their household.
Description: viral load as measured by real time polymerase chain reaction (PCR)
Measure: Change in viral load in the oral and nasopharyngeal cavity Time: Day 0, 2, 3, 7, 14Description: Visual analogue score 1-5 per symptom via a smartphone app
Measure: Symptom severity in primary participants and co-residents Time: Days 0 to 14