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drug912 | Non-invasive cardiac imaging Wiki | 1.00 |
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There is one clinical trial.
Phase 1 safety study to determine the tolerability, clinical effects, and changes in laboratory parameters of short course oral or IV cyclosporine (CSA) administration in patients with COVID-19 disease requiring oxygen supplementation but not requiring ventilator support.
Description: Safety will be measured: By assessing the proportion of participants requiring increase in oxygen requirements, transfer to intensive care unit, and/or mechanical ventilation
Measure: Safety-oxygen, ICU transfer and ventilation Time: 3 monthsDescription: Safety will be assessed: By monitoring changes in absolute lymphocyte counts
Measure: Safety-changes in absolute lymphocyte count Time: 3 monthsDescription: Safety will be assessed: By monitoring changes in creatinine clearance. Creatinine clearance will be estimated using the Cockcroft-Gault formula.
Measure: Safety-changes in creatinine clearance Time: 3 monthsDescription: Safety will be assessed: By monitoring the incidence of secondary bacterial infections complicating COVID-19 hospitalization
Measure: Safety-secondary bacterial infections Time: 3 monthsDescription: To measure time to SARS-CoV-2 clearance (PCR negativity) at Days 7 and 14 by deep nasal swab
Measure: Laboratory measurements of safety and antiviral efficacy related to COVID-19-SARS-CoV-2 by measuring the clearance of SARS-CoV-2 from respiratory secretions Time: 3 monthsDescription: To measure the laboratory correlatives of CRS/ Hemophagocytic lymphohistiocytosis (HLH) by measuring: D-dimer levels
Measure: Laboratory measurements-D-dimer levels Time: 3 monthsDescription: To measure the laboratory correlatives of CRS/ Hemophagocytic lymphohistiocytosis (HLH) by measuring: ferritin levels
Measure: Laboratory measurements-ferritin Time: 3 monthsDescription: To measure the laboratory correlatives of CRS/ Hemophagocytic lymphohistiocytosis (HLH) by measuring: IL-6 levels
Measure: Laboratory measurements- IL-6 Time: 3 months