|D012127||Respiratory Distress Syndrome, Newborn NIH||0.09|
|D055371||Acute Lung Injury NIH||0.09|
There is one clinical trial.
Single blind randomized clinical trial designed to evaluate the efficacy of the combination of hydroxychloroquine and dexamethasone as treatment for severe Acute Respiratory Distress Syndrome (ARDS) related to coronavirus disease 19 (COVID-19). We hypothesize that dexamethasone (20 mg for 5 days followed by 10 mg for 5 days) combined with 600 mg per day dose of hydroxychloroquine for 10 days will reduce the 28-day mortality compared to hydroxychloroquine alone in patients with severe ARDS related COVID-19.
Description: Mortality rate evaluated 28 days after randomizationMeasure: Day-28 mortality Time: 28 days after randomization
Description: Ventilator-free days (VFDs) at 28 days are one of several organ failure-free outcome measures to quantify the efficacy of therapies and interventions. VFDs are typically defined as follows: VFDs = 0 if subject dies within 28 days of mechanical ventilation. VFDs = 28 - x if successfully liberated from ventilation x days after initiation. VFDs = 0 if the subject is mechanically ventilated for >28 days.Measure: Ventilator-free days Time: 28 days after randomization
Description: Mortality rate evaluated during Intensive care unit stayMeasure: Intensive Care Unit mortality Time: Up to 60 days after randomization
Description: Mortality rate evaluated 60 days after randomizationMeasure: Day-60 mortality Time: 60 days after randomization
Description: Number of patients with pneumonia diagnosed during intensive care unit stayMeasure: Nosocomial pneumonia Time: Up to 60 days after randomization
Description: Number of patients with bacteremia diagnosed during intensive care unitMeasure: Bacteremia Time: Up to 60 days after randomization
Description: Placement of ECMO during intensive care unit stayMeasure: Extra corporeal membrane oxygenation (ECMO) Time: Up to 60days after randomization
Description: Number of patients who underwent tracheostomy during intensive care unit stayMeasure: Tracheostomy Time: Up to 60 days after randomization
Description: Number of Prone position sessionMeasure: Prone Position Time: Up to 60 days after randomization
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports